35results about How to "The synthesis process is simple and fast" patented technology

The invention discloses a co-catalyzing preparation method of alpha, betal-diamino acid derivative of alpha-quaternary carbon. The alpha, betal-diamino acid derivative of alpha-quaternary carbon is synthesized by a reaction of three components: aryl acetic acid ester diazonium, arylamine, and sulfamide imine under co-catalysis of rhodium acetate squaric acid amide or metal magnesium salt. The alpha, betal-diamino acid derivative of alpha-quaternary carbon comprises a threo form alpha, betal-diamino acid derivative of alpha-quaternary carbon and an erythro form alpha, betal-diamino acid derivative of alpha-quaternary carbon shown as formula (II). The raw material provided by the invention is low in cost and easily available, and two chiral carbons are constructed at the same time by a one-pot method. The method is short in preparation line, simple to operate, mild in reaction condition, easy to synthesize the catalyst, high in atomic economy, high in yield and free from environmental pollution, and the threo form or / and the erythro form alpha, betal-diamino acid derivative of alpha-quaternary carbon can be conveniently obtained at the same time. A diversified compound framework is provided, and the method has important meaning on new medicine screening and pharmaceutical preparation technology.

The invention belongs to the field of heavy metal adsorbents, and specifically discloses a heterogeneous condensation adsorbent for heavy metal adsorption, a preparation method and application thereof. The heterogeneous coagulation adsorbent comprises the following components in terms of mass percentage: 0.005% to 0.01% of polyacrylamide, 0.0005% to 0.001% of calcium chloride, 0.001% to 0.01% of coconut oil fatty acid diethanolamide, The balance is water. In the heterogeneous coagulation adsorbent provided by the present invention, calcium ions can promote the heterogeneous adsorption of gaseous heavy metals to be fixed on the heterogeneous coagulation adsorbent; at the same time, polyacrylamide dissolved in water can be absorbed between fine particles enriched in heavy metals Electrical neutralization occurs, and two or more particles are coagulated by "bridging" to improve the removal efficiency of fine particle heavy metals; in addition, coconut oil fatty acid diethanolamide can reduce the surface tension of water , thereby increasing the solubility of organic compounds.

The invention relates to a swirl-convergence agglomeration tower and a method for agglomeration and dust removal using the swirl-convergence agglomeration tower. The swirl-convergence agglomeration tower includes a cylindrical tower body, and at least one guide pipe for introducing flue gas is provided at the lower part of the tower body. The diversion pipe is connected tangentially to the tower body, and the top of the tower body is provided with a flue gas outlet; the tower body is provided with multiple spray layers for spraying the agglomeration liquid in sequence from bottom to top, at least two spray layers at the bottom A swirl device is provided between them to form a turbulent state after the flue gas passes through. The invention can achieve better agglomeration effect and dust removal effect, effectively reduce the subsequent dust removal burden, and even cancel the subsequent dust removal process, and reduce equipment investment and operation cost while meeting the national flue gas emission standard.

The invention discloses a chemical agglomeration accelerator for removing coal-burning fine particles, which is composed of polydimethyldiallylammonium chloride, sorbitan fatty acid ester and water, wherein the agglomeration accelerator Among them, the mass percentage of the polydimethyldiallylammonium chloride is 0.001%-0.01%, and the mass percentage of the sorbitan fatty acid ester is 0.001%-0.1%. The invention also discloses the use method of the chemical aggregation accelerator. The chemical agglomeration accelerator can not only effectively promote the agglomeration and flocculation of fine particles in the flue gas channel to form large particles, but also perform integrated removal of heavy metals in the flue gas, improve the efficiency of fine particle removal by the dust collector, and effectively alleviate environmental problems.

The present invention relates to a kind of flat mycin analogue and its preparation method and application, by taking flatmycin as raw material, taking acid as catalyst, using water and / or alcohol as solvent, through heating reaction to obtain flatmycin acid analogue of the present invention things. The invention has short preparation route, safe and simple operation, is convenient for obtaining platymycin analogues, provides diverse compound skeletons, and can be widely used in the fields of new drug screening and pharmacy.

The present invention relates to an optically active α-amino-β-hydroxy amino acid derivative as shown in formula (I) and its preparation method and application. , 3-dichloro-5, 6-dicyano-1, 4-benzoquinone and water as raw materials, with rhodium acetate and chiral phosphoric acid as catalyst, with organic solvent as solvent, through three components at -10°C reaction to obtain the optically active α-amino-β-hydroxyl amino acid derivative of the present invention. The raw materials of the invention are cheap and easy to obtain, two chiral carbons are constructed simultaneously, the preparation route is short, the operation is safe and simple, the reaction conditions are mild, the atom economy is high, and the selectivity is high, and it is convenient to obtain α-amino-β-hydroxy amino acid derivatives It provides a variety of compound skeletons and is widely used in new drug screening and pharmaceutical fields.

The invention belongs to the technical field of advanced nano composites and particularly relates to a high-dispersion silica nanotube-supported nickel catalyst and a preparation method thereof. A silica precursor is hydrolyzed first under alkaline conditions by means of microemulsion process to coat the surface of nanotubes with a uniform layer of silica, and carbon nanotube-silica core-shell structure is formed; the carbon nanotube-silica core-shell structure and a nickel precursor are treated under alkaline conditions by means of hydrothermal process to obtain carbon nanotube-silica-nickelsilicate precursor tri-layer core-shell structure; a carbon nanotube template is removed by high temperature calcining to obtain silica-nickel silicate core-shell structure; finally, the nickel silicate precursor is decomposed in situ by means of high temperature reduction to obtain high-dispersion nickel nano particles supported on the surface of the silica nanotubes. The preparation method can ensure high dispersion of the nickel nano particles under high nickel load.

The invention provides a hollow microsphere molecular sieve, a preparation method thereof and application thereof to arene preparation through methyl alcohol conversion. The hollow microsphere molecular sieve provided by the invention comprises a shell and a macroporous structure, wherein the shell is formed by stacking ZSM-5 crystalline grains, and the macroporous structure is formed by being wrapped with the shell. The hollow microsphere molecular sieve is of a multi-stage pore structure. Multi-stage pores comprise macropores, mesopores formed by stacking the ZSM-5 crystalline grains, and micropores of the ZSM-5 crystalline grains. The hollow microsphere molecular sieve provided by the invention is of the multi-stage pore structure, and can be used as a catalyst for reaction during arene preparation through methyl alcohol conversion; reactant molecules enter an inner space through the shell, and generated products are further diffused through the shell; compared with other molecular sieves, the reactant molecules are subjected to a larger number of multi-stage reactions on hollow microspheres, and accordingly the selectivity of arene is improved; and since the mesopores formed by stacking the ZSM-5 crystalline grains and the internally hollow macropores in the shell are beneficial to diffusion of the products, the service life of the catalyst is greatly prolonged.

The invention discloses a preparation method of multi-substituted indanol derivatives. The diazo compound, alcohol and o-formyl chalcone are used as raw materials, a metal catalyst is used as a catalyst, an organic solvent is used as a solvent, and a molecular sieve is used as a water absorbent; and the multi-substituted indanol derivatives are obtained by one-step reaction. According to the preparation method disclosed by the invention, the raw materials are easily available, the operation is simple and safe, and the method is suitable for industrial production.

The invention discloses a synthetic method of a polysubstituted tetrahydroisoquinoline derivative, which takes diazonium, oxygen alkyl amide, arylamine, o-acrylate benzaldehyde and potassium tert-butoxidea as raw materials, takes chiral phosphoric acid, an acid additive and dichloro(p-cymene) ruthenium as catalysts, takes an organic solvent as a solvent, and takes a molecular sieve as a water absorbing agent; the above materials are reacted, a solvent is removed to obtain crude product, after column chromatography, the high-diastereomeric selectivity high-optical purity tetrahydroisoquinoline derivative pure product can be obtained. The synthetic method has the advantages of easy and simple acquisition of raw materials, safe and easy operation, and the product has the advantages of high atom economy, high yield and high selectivity.