3 results about "Diamino acid" patented technology

A computing system for fragment-based quantum mechanical calculation of protein properties is provided. The processor implements a protein fragmentation module that separates the computer-readable polypeptide sequence into a plurality of data units. For each sub-sequence of three adjacent amino acids in the polypeptide sequence, a first amino acid, a second amino acid, and a third amino acid are identified, each amino acid having a respective backbone comprising an amino group, a carbon, and a carboxyl group, and a side chain attached to an alpha carbon. The protein fragmentation module generates data units representing the first alpha carbon, the first carboxyl group, the second amino group, the second alpha carbon, the second carboxyl group, the second side chain, the third amino group, and the third alpha carbon, and stores the generated data units in a memory.

This invention pertains to fusion protein mutants comprising a Prime Editing enzyme having a first amino acid sequence and a second amino acid sequence, wherein the first amino acid sequence comprises a SpCas9 H840A nickase mutant protein of SEQ ID NO:152 and the second amino acid sequence comprises a Moloney Murine Leukemia Virus reverse transcriptase protein mutant (MMLV RTase mutant), wherein the fusion protein mutant displays at least the equivalent or greater activity of a reference Prime Editing enzyme in genome editing.

An immunogenic complex comprising i) an amino acid sequence of an N-terminal region of a group B Streptococcus surface protein selected from the group consisting of: a first amino acid sequence having at least 98%, such as 99%, identity to SEQ ID NO: 16 and a length of 172 amino acids to 178 amino acids; a second amino acid sequence having at least 98%, such as 99%, identity to SEQ ID NO: 18 and a length of 167 amino acids to 173 amino acids; and a third amino acid sequence consisting of SEQ ID NO: 20; and ii) a capsular polysaccharide, is provided. An immunogenic product, a vaccine, and the immunogenic complex, the immunogenic product or the vaccine for use in a method of preventing or treating a group B Streptococcus infection, are also provided.