36results about "Organic addition" patented technology

The invention relates to a synthesis method of an allyl tertiary amine compound, which comprises the following steps: under the protection of nitrogen, taking alkyne with different substitutions and alkylamine with different substitutions as raw materials, taking metal cobalt salt and organic ligand as catalysts, taking Hanus ester as a reducing agent, taking zinc trifluoromethanesulfonate as an additive, and reacting at the temperature of 60-80 DEG C to obtain the allyl tertiary amine compound. In the presence of an organic solvent and a photosensitizer, the allyl tertiary amine compound is prepared through illumination reaction. According to the method, reaction raw materials and reagents are simple and easy to obtain, conditions are mild and easy to control, atom economy is high, precious metal catalysis is not needed, the substrate application range is wide, regioselectivity is high, and wide application prospects are achieved.

The present invention relates to a method for forming C-C bonds using organolithium compounds under continuous flow conditions in a microreactor or mesoreactor system, wherein an organic substrate is reacted with an alkyllithium compound in the presence of a donor solvent to form a Li intermediate, which can be reacted with an electrophile in situ or in a subsequent second reaction step to form an organic secondary product, and the organolithium compound RLi is used as a hydrocarbon solution or hydrocarbon mixture solution, and the RLi concentration is at least 3M, preferably at least 4M. [Selection diagram] None

Disclosed is a rapid automated iterative cross-coupling platform that utilizes stable boronate building blocks and isolable boronate ester intermediates. Also disclosed are methods for activating boronate reagents.

The present disclosure aims to provide a method for producing an organic compound, etc. The object is to provide a compound of formula (1): [In the formula, X represents -O-, an imino group which may have a substituent, or -S-; R 1 represents a hydrogen atom or a hydrocarbyl group which may have one or more substituents, and R 2 represents a hydrogen atom or a monovalent organic group, or R 1 and R 2 may form a heterocycle optionally having one or more substituents, together with the adjacent X and one carbon atom; R 3 represents a hydrogen atom or a monovalent organic group; and R 4 is -CF2CH3 or -CH2CHF2. A method for producing a compound represented by the formula: Formula (2): [The symbols in the formula are as defined above.] A compound represented by A step A of reacting with vinylidene fluoride under light irradiation, Manufacturing method is solved by

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1):wherein X represents —O—, an optionally substituted imino group, or —S—, R1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R2 represents a hydrogen atom or a monovalent organic group, or R1 and R2, together with X and one carbon atom respectively adjacent to R1 and R2, may form a heterocyclic ring optionally having at least one substituent, R3 represents a hydrogen atom or a monovalent organic group, and R4 represents —CF2CH3 or —CH2CHF2; the method including step A of reacting a compound represented by formula (2):wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

A material comprising a plurality of gem-metal atom pairs supported on a polymeric support, as well as a method of making the material, is provided. In particular embodiments, the material comprises a plurality of pairs of copper atoms supported on a polymeric carbon nitride (PCN) support. Also provided is a catalyst comprising the material, and a method of catalyzing a coupling reaction.

The present invention discloses a class of alkyl zinc reagents and a preparation method and application thereof, belonging to the technical field of synthetic organic chemistry. The general structural formula of the alkyl zinc reagent of the present invention is: R‑znOPiv·Mg(OPiv)Br, wherein R is selected from a chain alkyl, a cyclic alkyl or a substituted alkyl. The present invention completes the preparation of a Grignard reagent by lithium salt catalysis or iodine element catalysis, and then completes the preparation of a zinc reagent by transmetallation and an inorganic salt activation strategy to synthesize an alkyl-substituted alkyl difluoro reagent, and the general structural formula of the alkyl-substituted alkyl difluoro reagent is: #imgabs0# wherein R1 is selected from an ester group, an alkyl group, an alkynyl group, an amide, a benzoxazole, diethyl phosphate or a perfluoro-substituted alkyl group; R is selected from a chain alkyl group, a cyclic alkyl group or a substituted alkyl group; R2, R3 are independently selected from a substituted alkyl group; and R4 is selected from an ester group. The alkyl zinc reagent is applied to the bifunctional reaction of olefins, and the alkyl-substituted alkyl difluoro reagent is applied in click chemistry reactions.

Disclosed is a process for preparing asymmetrically substituted bicyclic compound of formula (III) or (IV) from a compound of formula (I) by pairing a compound of formula (II) with a carbene ligated transition-metal catalyst or a precursor in the presence of a hydride source, wherein the structure of the compound of formula (II) is used as one of the key factors that can alter the selectivity of (III) and (IV) under a given condition.

There is provided a material comprising a plurality of geminal metal atom pairs supported on a polymeric carrier, and a method of preparing said material. In a particular embodiment, the material comprises a plurality of copper atom pairs supported on a polymeric carbon nitride (PCN) carrier. There is also provided a catalyst comprising said material, and a method of catalyzing coupling reactions.

An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1):wherein X represents —O—, an optionally substituted imino group, or —S—, R1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R2 represents a hydrogen atom or a monovalent organic group, or R1 and R2, together with X and one carbon atom respectively adjacent to R1 and R2, may form a heterocyclic ring optionally having at least one substituent, R3 represents a hydrogen atom or a monovalent organic group, and R4 represents —CF2CH3 or —CH2CHF2; the method including step A of reacting a compound represented by formula (2):wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

A method for the directed synthesis of tri (tetra) substituted alkenes comprising the reaction of a compound of formula (I) in the presence of a nickel catalyst, a ligand, a base, a hydrogen source and a solvent. Formula (I) wherein R 1 is selected from any one of substituted or unsubstituted C1-C8 alkyl, phenyl, naphthyl, said substituents including nitrogen containing groups, oxygen containing groups, aryl groups, halogens, R 2 is selected from any one of hydrogen, alkyl groups, R 3 is selected from C1-C8 substituted or unsubstituted alkyl groups, said substituents including C1-C4 alkyl groups substituted with a nitrogen atom or an oxygen atom; the nickel catalyst is a divalent nickel salt or a divalent nickel salt complex; the ligand is a bisoxazoline ligand; the hydrogen source is a silane based compound; the base is a metal salt containing fluoride ions, carbonate ions, bicarbonate ions, alkoxide ions.

The invention relates to ylide-functionalized phosphine ligands, their production and use in transition metal compounds, and their use as catalysts in organic reactions.

The application discloses a kind of polydifluoroalkylation derivatives of terpene olefin and preparation method thereof, the preparation method includes under inert gas protection, terpene olefin, photosensitizer, cobalt catalyst, organic reducing agent, base, fluorine reagent and organic solvent are sequentially loaded into reaction container, and the reaction system is obtained;Under inert gas protection, the reaction system is reacted at 40~60 ℃ under light condition;After reaction, the system is filtered, rotary evaporated and chromatographically purified, and the polydifluoroalkylation of terpene olefin is completed.The method of the application can efficiently, high selectivity and high yield realize the polydifluoroalkylation reaction of terpene olefin, without using precious metal catalyst, with good functional group compatibility, high yield, and the highest yield can reach 93%.

The application provides a chiral carbene ligand, a preparation method thereof and application in asymmetric synthesis, the chiral carbene ligand catalyzes asymmetric hydroarylation reaction of various kinds of olefin substrates such as aryl olefin, alpha-olefin and diene, and aryl bromine or aryl chloride, and synthesizes four kinds of drug molecules or drug molecule intermediates in one step. The chiral carbene ligand has a flexible chain structure, is self-adapting, can effectively adapt to different transition metal centers and substrate configurations, and improves the universality and selectivity of the catalytic system; the raw material used in the preparation method of the chiral carbene ligand is easy to obtain, the synthesis route is short, and post-treatment is simple; various reagents can exist stably at normal temperature and pressure without special treatment; only by regulating the nickel catalyst and the new chiral carbene ligand, high regioselectivity and enantioselectivity of the chiral benzyl-containing compound can be realized; the asymmetric synthesis method can obtain the target product in one step, and greatly reduces the production cost of synthesizing the compound.

A method includes reacting a carbonyl compound with an olefin compound in the presence of an iridium catalyst wherein the carbonyl compound comprises a nitrogen-based group at the alpha or beta position of the carbonyl group, and wherein the process comprises a step of alpha-alkylation of the carbonyl compound by forming a carbon-carbon bond between the carbon atom alpha of the carbonyl group and the carbon atom of the double bond of the olefin compound. The method allows the preparation of amino acid derivatives and other compounds. The method is flexible to produce compounds having a series of substituents, with a good level of steps and atom economy as well as selectivity.

The invention discloses a synthesis method of 1, 1-dialkyl substituted olefin, which comprises the following steps: taking terminal alkyne as an initial raw material, taking alkyl bromide as an alkyl source, adding a catalyst, a ligand, a hydrogen source, alkali and a solvent, and carrying out coupling reaction at specific temperature and reaction time under the protection of nitrogen to finally obtain the pharmaceutical and chemical intermediate 1, 1-dialkyl substituted olefin. The invention discloses a 1, 1-dialkyl substituted olefin compound. The method has the advantages that the raw materials are low in cost and easy to obtain, the reaction conditions are mild, the method can be implemented at room temperature, and the experimental operation is simple and convenient. In addition, the reaction also shows the characteristics of strong substrate adaptability, good functional group compatibility, excellent reaction selectivity, relatively high product yield, small influence on the environment and the like.

To provide methods for forming CC bonds with use of organolithium compounds under continuous flow conditions in a micro or meso reactor system.SOLUTION: An organic substrate is reacted with an alkyl lithium compound in the presence of a donor solvent to form an Li intermediate, which is reacted with an electrophile in situ or in a subsequent second reaction step to form an organic secondary product, and an organolithium compound RLi is used as a hydrocarbon solution or a hydrocarbon mixed solution, and the RLi concentration is at least 3 M, preferably at least 4 M.SELECTED DRAWING: None

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

The invention relates to ylide-functionalized phosphine ligands, their production and use in transition metal compounds, and their use as catalysts in organic reactions.

The application belongs to the technical field of chemical synthesis, and particularly relates to a method for synthesizing polysubstituted olefin compounds through olefin coupling. The method comprises the following steps: reacting compound A0 and compound B0 under the action of an imidazoline-2-imine rare earth metal complex and an activating agent boron salt to obtain a polysubstituted olefin compound shown in formula I. The synthesis method can obtain a series of polysubstituted olefin compounds in high yield and high cis-trans ratio, and has the advantages of simplicity, high efficiency, environmental friendliness, good substrate universality and wide application prospect.

A process comprises reacting a carbonyl compound with an alkene compound in the presence of an iridium catalyst, wherein the carbonyl compound comprises a nitrogen-based group in a position that is α or β to the carbonyl group and wherein the process comprises the step of α- alkylation of the carbonyl compound by carbon-carbon bond formation between the carbon atom α to the carbonyl group and a carbon atom of the double bond of the alkene compound. The process allows the preparation of amino acid derivatives and other compounds. The process has the flexibility to yield compounds with a range of substituents, with good levels of step and atom economy and selectivity.

The invention discloses an aromatic methylamine denitrification alkylation method which adopts a two-step method and comprises the following steps: firstly, taking aromatic methylamine and methylsulfonyl chloride as raw materials, obtaining aromatic methyl sulfonamide under the action of alkali, then taking the obtained aromatic methyl sulfonamide and aryl ethylene as raw materials, and reacting under the action of borane, mercaptan and a free radical initiator, thereby obtaining the aromatic methylamine denitrification alkylation method. The denitrification alkylation of the aromatic methylamine is realized. The innovation points of the method provided by the invention are as follows: 1) a brand new boron free radical mediated organic amine denitrification functionalization method is developed by utilizing an electron spin center transfer strategy, and a new route can be provided for functional molecule synthesis; and 2) compared with the reported method, the method has the advantages of excellent atom economy, no need of expensive transition metal, no need of toxic organic tin reagent and the like.

The invention discloses a method for synthesizing an allylamine compound from alkyne, and belongs to the technical field of organic decarboxylation application. According to the method, a carboxylic acid compound which is cheap and easy to obtain is used as a raw material, alpha-amino free radicals are generated through a visible light induced decarboxylation process, then the free radicals and phenylacetylene are subjected to a selective addition reaction, and an allylamine skeleton structure is efficiently constructed. The allylamine compound can be efficiently synthesized under the synergistic effect of alkali and the photocatalyst.

The invention relates to the technical field of visible light catalysis synthesis, in particular to a visible light catalysis carbon-hydrogen bond functionalization method. The method specifically comprises the following steps: taking an alkenyl-containing compound as a free radical trapping agent, taking a phosphinimine compound as a hydrogen atom transfer catalyst, and reacting a compound containing a carbon-hydrogen bond with the free radical trapping agent under the action of the phosphinimine compound and a photocatalyst under the condition of visible light irradiation to obtain the compound containing the carbon-hydrogen bond. And performing carbon-hydrogen bond functionalization on the compound containing the carbon-hydrogen bond. Under a mild condition, the phosphinimine compound is adopted as a hydrogen atom transfer catalyst, carbon-hydrogen bond functionalization of the organic compound is realized under the condition of visible light irradiation, and a target product is obtained at a relatively high yield.

The invention relates to ylide-functionalised phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

The present invention refers to new air-stable molybdenum alkylidyne catalysts, a process for the preparation thereof and their use for high performance alkyne metathesis.

PCNHCP pincer metal complexes are useful as catalysts in various chemical reactions such as hydrogen isotope exchange (HIE) in C(sp3)-H and / or C(sp2)-H bond of an organic compound, e.g., a pharmaceutically active compound. The complexes are also useful in hydroboration of alkynes with excellent selectivity; and alkene isomerization with high stereo- and regioselectivity.