18results about "Organic addition" patented technology

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1):wherein X represents —O—, an optionally substituted imino group, or —S—, R1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R2 represents a hydrogen atom or a monovalent organic group, or R1 and R2, together with X and one carbon atom respectively adjacent to R1 and R2, may form a heterocyclic ring optionally having at least one substituent, R3 represents a hydrogen atom or a monovalent organic group, and R4 represents —CF2CH3 or —CH2CHF2; the method including step A of reacting a compound represented by formula (2):wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

Disclosed is a process for preparing asymmetrically substituted bicyclic compound of formula (III) or (IV) from a compound of formula (I) by pairing a compound of formula (II) with a carbene ligated transition-metal catalyst or a precursor in the presence of a hydride source, wherein the structure of the compound of formula (II) is used as one of the key factors that can alter the selectivity of (III) and (IV) under a given condition.

An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1):wherein X represents —O—, an optionally substituted imino group, or —S—, R1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R2 represents a hydrogen atom or a monovalent organic group, or R1 and R2, together with X and one carbon atom respectively adjacent to R1 and R2, may form a heterocyclic ring optionally having at least one substituent, R3 represents a hydrogen atom or a monovalent organic group, and R4 represents —CF2CH3 or —CH2CHF2; the method including step A of reacting a compound represented by formula (2):wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

A method for the directed synthesis of tri (tetra) substituted alkenes comprising the reaction of a compound of formula (I) in the presence of a nickel catalyst, a ligand, a base, a hydrogen source and a solvent. Formula (I) wherein R 1 is selected from any one of substituted or unsubstituted C1-C8 alkyl, phenyl, naphthyl, said substituents including nitrogen containing groups, oxygen containing groups, aryl groups, halogens, R 2 is selected from any one of hydrogen, alkyl groups, R 3 is selected from C1-C8 substituted or unsubstituted alkyl groups, said substituents including C1-C4 alkyl groups substituted with a nitrogen atom or an oxygen atom; the nickel catalyst is a divalent nickel salt or a divalent nickel salt complex; the ligand is a bisoxazoline ligand; the hydrogen source is a silane based compound; the base is a metal salt containing fluoride ions, carbonate ions, bicarbonate ions, alkoxide ions.

The invention relates to ylide-functionalized phosphine ligands, their production and use in transition metal compounds, and their use as catalysts in organic reactions.

The application discloses a kind of polydifluoroalkylation derivatives of terpene olefin and preparation method thereof, the preparation method includes under inert gas protection, terpene olefin, photosensitizer, cobalt catalyst, organic reducing agent, base, fluorine reagent and organic solvent are sequentially loaded into reaction container, and the reaction system is obtained;Under inert gas protection, the reaction system is reacted at 40~60 ℃ under light condition;After reaction, the system is filtered, rotary evaporated and chromatographically purified, and the polydifluoroalkylation of terpene olefin is completed.The method of the application can efficiently, high selectivity and high yield realize the polydifluoroalkylation reaction of terpene olefin, without using precious metal catalyst, with good functional group compatibility, high yield, and the highest yield can reach 93%.

The application provides a chiral carbene ligand, a preparation method thereof and application in asymmetric synthesis, the chiral carbene ligand catalyzes asymmetric hydroarylation reaction of various kinds of olefin substrates such as aryl olefin, alpha-olefin and diene, and aryl bromine or aryl chloride, and synthesizes four kinds of drug molecules or drug molecule intermediates in one step. The chiral carbene ligand has a flexible chain structure, is self-adapting, can effectively adapt to different transition metal centers and substrate configurations, and improves the universality and selectivity of the catalytic system; the raw material used in the preparation method of the chiral carbene ligand is easy to obtain, the synthesis route is short, and post-treatment is simple; various reagents can exist stably at normal temperature and pressure without special treatment; only by regulating the nickel catalyst and the new chiral carbene ligand, high regioselectivity and enantioselectivity of the chiral benzyl-containing compound can be realized; the asymmetric synthesis method can obtain the target product in one step, and greatly reduces the production cost of synthesizing the compound.

A method includes reacting a carbonyl compound with an olefin compound in the presence of an iridium catalyst wherein the carbonyl compound comprises a nitrogen-based group at the alpha or beta position of the carbonyl group, and wherein the process comprises a step of alpha-alkylation of the carbonyl compound by forming a carbon-carbon bond between the carbon atom alpha of the carbonyl group and the carbon atom of the double bond of the olefin compound. The method allows the preparation of amino acid derivatives and other compounds. The method is flexible to produce compounds having a series of substituents, with a good level of steps and atom economy as well as selectivity.

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

A process comprises reacting a carbonyl compound with an alkene compound in the presence of an iridium catalyst, wherein the carbonyl compound comprises a nitrogen-based group in a position that is α or β to the carbonyl group and wherein the process comprises the step of α- alkylation of the carbonyl compound by carbon-carbon bond formation between the carbon atom α to the carbonyl group and a carbon atom of the double bond of the alkene compound. The process allows the preparation of amino acid derivatives and other compounds. The process has the flexibility to yield compounds with a range of substituents, with good levels of step and atom economy and selectivity.

The invention discloses a method for synthesizing an allylamine compound from alkyne, and belongs to the technical field of organic decarboxylation application. According to the method, a carboxylic acid compound which is cheap and easy to obtain is used as a raw material, alpha-amino free radicals are generated through a visible light induced decarboxylation process, then the free radicals and phenylacetylene are subjected to a selective addition reaction, and an allylamine skeleton structure is efficiently constructed. The allylamine compound can be efficiently synthesized under the synergistic effect of alkali and the photocatalyst.

The invention relates to the technical field of visible light catalysis synthesis, in particular to a visible light catalysis carbon-hydrogen bond functionalization method. The method specifically comprises the following steps: taking an alkenyl-containing compound as a free radical trapping agent, taking a phosphinimine compound as a hydrogen atom transfer catalyst, and reacting a compound containing a carbon-hydrogen bond with the free radical trapping agent under the action of the phosphinimine compound and a photocatalyst under the condition of visible light irradiation to obtain the compound containing the carbon-hydrogen bond. And performing carbon-hydrogen bond functionalization on the compound containing the carbon-hydrogen bond. Under a mild condition, the phosphinimine compound is adopted as a hydrogen atom transfer catalyst, carbon-hydrogen bond functionalization of the organic compound is realized under the condition of visible light irradiation, and a target product is obtained at a relatively high yield.

The present invention refers to new air-stable molybdenum alkylidyne catalysts, a process for the preparation thereof and their use for high performance alkyne metathesis.

A fast automated iterative cross-coupling platform utilizing stable borate structural units and separable borate intermediates is disclosed. Methods for activating boronic acid ester reagents are also disclosed.

The present invention relates to novel air-stable molybdenum alkyl Carbayer catalysts, processes for their preparation and their use in high performance alkyne metathesis.

The application discloses a method for preparing difluoromethyl compounds by using a photocatalytic LMCT strategy and belongs to the technical field of catalytic synthesis, in particular to a method for preparing difluoromethyl compounds by using a photocatalytic LMCT strategy. The application solves the problems of the existing synthesis method, such as being too complicated, needing pre-activation and a stoichiometric oxidant. The method comprises the following steps: adding olefin compounds, difluoroacetic acid, 2,4,6-triisopropylbenzenethiol and Fe(acac)3 into a solvent to obtain a reaction mixed solution, irradiating the reaction mixed solution by using an LED light source under room temperature and in an inert gas atmosphere, and obtaining difluoromethyl compounds. The application embodies the green reaction and the mild reaction. The method is very simple to operate, various raw materials are commercially available, olefins are easy to prepare, and the reaction can be efficiently realized by using a catalytic amount of a cheap metal catalyst through a one-pot method, so that the method has potential industrial application value. The application can be applied to the field of organic synthesis.

Disclosed is a rapid automated iterative cross-coupling platform that utilizes stable boronate building blocks and isolable boronate ester intermediates. Also disclosed are methods for activating boronate reagents.