13 results about "Pyrazolidine" patented technology

The invention discloses a synthesis method of 1-(4-chlorphenyl) pyrazolidine-3-ketone, which comprises the following steps: by taking p-chlorophenylhydrazine hydrochloride and acrylamide as raw materials and toluene as a solvent, carrying out azeotropic dehydration under the normal pressure condition, cooling, adding flaky sodium hydroxide or potassium hydroxide, adding acrylamide, carrying out condensation reaction at 40-80 DEG C, filtering, washing and drying to obtain the 1-(4-chlorphenyl) pyrazolidine-3-ketone. And after the reaction is finished, acidifying, desolventizing, crystallizing and filtering to obtain the high-purity 1-(4-chlorphenyl) pyrazolidine-3-ketone. Compared with the prior art, the method provided by the invention has the following advantages: firstly, the inorganic base is adopted to replace the traditional sodium alkoxide organic base, so that the problems of flammability, danger and the like are avoided, and the reaction safety is greatly improved; process conditions are mild, operation steps are simplified, and repeated heating and cooling or negative pressure maintaining are not needed; and thirdly, the process is more environment-friendly, the molecular utilization rate is higher, by-products of alcohols are not generated compared with the traditional process, and the burden of sewage treatment is reduced. Sodium alkoxide is replaced by inorganic base, production cost is saved, and economic benefits are good.

The invention discloses a preparation method of a 3-aryl pyrazolidine compound, which comprises the following steps: in an inert gas atmosphere, sequentially adding aryl cyclopropane, an azodicarboxylic acid derivative, NaBr and a photocatalyst into acetonitrile to obtain a mixture, reacting for 12 hours at room temperature under the irradiation of 5W blue light with the wavelength of 456nm, and separating from the reaction liquid to obtain the 3-aryl pyrazolidine-1, 2, 3-triazole compound. The invention relates to a 1, 2-dicarboxylic acid derivative. The preparation of the 3-aryl pyrazolidine compound can be carried out at room temperature, the reaction condition is mild, the adopted raw materials are simple and easy to obtain, and the cost is low.

Combination for Dyeing Keratin Fibers and its Use. The present invention relates to a dye combination comprising: A) a dye composition a), comprising: I) a coloring composition i), comprising: i) at least one oxidizing dye; wherein the oxidizing dye comprises one or more oxidizing bases selected from the group consisting of para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols, meta-aminophenols, ortho-aminophenols, and addition salts thereof, and mixtures thereof; and / or wherein the oxidizing dye comprises one or more couplers selected from the group consisting of meta-phenylenediamines, meta-aminophenols, and addition salts thereof, and mixtures thereof; and B) a pyrazolidine-3,5-dione compound of formula (1): (1). Figure for abstract: None

The application discloses a high-efficiency cyclization micro-reaction device for pyrazolidine ethyl formate, and relates to the technical field of reaction devices.The device comprises a bottom plate, a stirring unit, an acid-base unit, a heat exchange unit, a heat conduction unit and a heat preservation unit.The top of the bottom plate is provided with a reaction cylinder.The stirring unit is arranged on the top of the reaction cylinder.The acid-base unit is arranged on the top of the stirring unit.The heat exchange unit is arranged on one side of the reaction cylinder, and is used for recycling the temperature of the solution in the reaction cylinder.The heat conduction unit is arranged on one side of the heat exchange unit, and is used for accelerating the heat exchange speed between the solution in the reaction cylinder and the heat exchange unit.The heat preservation unit is used for storing the solution in the reaction cylinder, and can further reuse the temperature of the solution in the reaction cylinder.The device can transfer the heat of the solution in the reaction cylinder which has reacted to the raw material for the next reaction in the heat exchange box, realizes the recycling of the heat in the reaction cylinder, and saves electric energy.

The invention provides a method for preparing 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, which comprises the following steps: by taking 1, 2-disubstituted pyrazol-3-ketone as an initial raw material, 1, 2-dichloroethane as a reaction solvent and pyridinium chlorochromate as an oxidizing agent, carrying out dehydroaromatization reaction on the 1, 2-disubstituted pyrazol-3-ketone to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, and reacting the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone with 1, 2-dichloroethane to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone. The synthesis method comprises the following steps: preparing 1, 2-dihydro-3H-pyrazole-3-ketone. According to the present invention, the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone can be prepared, the reaction conditions are mild, the process is simple, the yield of the product 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone is high, and the method is suitable for industrial production.

The application discloses a tail gas resource utilization and urea co-production system in a pyrazole alcohol production process, relates to the technical field of tail gas treatment, and comprises a pyrazole ketone oxidation product purification module, an oxygen-argon recycling module and a co-production urea and potassium salt recycling module; the pyrazole ketone oxidation product purification module comprises a first gas-liquid separation unit and a hydrochloric acid generation unit, the former receives the material at the outlet of a production system, separates a first separation liquid, a first separation mixed gas and condensed water, and the latter prepares hydrochloric acid by using part of the condensed water; the oxygen-argon recycling module separates oxygen and argon from the first separation mixed gas by sequentially connecting oxygen and argon separation units, and discharges a first remaining mixed gas; the co-production urea and potassium salt recycling module is provided with a urea preparation reactor into which the first remaining mixed gas is fed to generate a urea crude product solution; and a second gas-liquid separation unit separates the urea crude product solution into a second separation mixed gas and a second separation liquid. The application reduces pollutant emission and realizes resource cascade utilization.

The present invention relates to compounds of formula I as prostaglandin E2 receptor 4 (EP4) agonists for use in methods of treatment of gastrointestinal and pulmonary dis-cases or disorders. An exemplary compound is e.g. 4-(2-(2-(3-hydroxy-3-(4′-hydroxy-2′-methyl-[1,1′-biphenyl]-3-yl) propyl)-5-oxopyrazolidin-1-yl)ethyl)benzoic acid (Example 1) Pharmacological data is provided, e.g.

The invention discloses a synthesis method of 3-pyrazolidone and seven-membered nitrogen heterocyclic ring derivatives, and belongs to the field of organic synthesis. According to the method, isatin-derived alpha-trifluoromethacrylate is taken as a raw material, and reacts with hydrazine or o-phenylenediamine in an organic solvent, so that two different types of nitrogen-containing heterocyclic compounds, namely 3-pyrazolidone and seven-membered nitrogen-containing heterocyclic compounds, can be obtained. The method does not need any catalyst, the reaction is green, simple, convenient and efficient, the substrate is good in universality, and a new thought is provided for synthesis of the heterocyclic compound.

The invention discloses a high-efficiency green synthesis process of halogenated pyridyl pyrazolidine carboxylate, and relates to the technical field of compound synthesis, and the high-efficiency green synthesis process comprises the following steps: S1, putting a compound 1 into a polar solvent, adding an oxidant manganese dioxide, stirring, heating and reacting, and taking sulfuric acid as a catalyst to obtain a compound 2 solution and a suspended matter; s2, filtering and separating the compound 2 solution and the suspended matter to obtain a filter cake of manganese dioxide and manganese sulfate and a reaction filtrate, concentrating the filtrate to recover the polar solvent, adding water, and filtering to obtain a compound 2; and S3, adding the filter cake into a sodium hydroxide solution to generate a manganese hydroxide solution containing a manganese dioxide solid, and filtering and separating to obtain the manganese dioxide solid and a manganese hydroxide filtrate. According to the technological process, through selection of a potassium permanganate regenerated manganese dioxide oxidation system, efficient utilization of an oxidizing agent, high conversion rate and high selectivity of a reaction system and reduction of three wastes in the process are achieved, and green synthesis of halogenated pyridyl pyrazolidine carboxylate is completed.

The application discloses a kind of green synthesis process of halogenated pyridyl pyrazole dithiocarboxylate, it is related to compound synthesis technical field, including the following steps: S1, compound 1 is placed in polar solvent, and manganese dioxide, an oxidizing agent, is added to stir and heat reaction, with sulfuric acid as catalyst, to obtain compound 2 solution and suspension;S2, compound 2 solution and suspension are filtered, separated to obtain the filter cake of manganese dioxide and manganese sulfate and reaction filtrate, the filtrate is concentrated to recover polar solvent, and water is filtered to obtain compound 2;S3, filter cake is added to sodium hydroxide solution, to generate manganese hydroxide solution, and contain manganese dioxide solid, after filtration and separation, to obtain manganese dioxide solid and manganese hydroxide filtrate.The process is regenerated by the selection of potassium permanganate manganese dioxide oxidation system, realizes the efficient use of oxidizing agent, high conversion rate and high selectivity of reaction system and the reduction of process three wastes, and completes the green synthesis of halogenated pyridyl pyrazole dithiocarboxylate.

The invention discloses a method for preparing 1-(4-chlorphenyl)-3-pyrazole alcohol, and belongs to the technical field of organic synthesis and catalysis. According to the method, CeO2-CuO / TiO2 is used for catalyzing oxygen to oxidize 1-(4-chlorphenyl) pyrazolidine-3-ketone to prepare 1-(4-chlorphenyl)-3-pyrazole alcohol, after the reaction time is 2.0-8.0 h under the conditions that the initial pressure of oxygen is 3 MPa and the reaction temperature is 120-180 DEG C, pressure relief is conducted, a catalyst is filtered out and reused, an obtained filtrate is distilled to remove a reaction solvent and byproduct water, then a crude product is obtained, and the 1-(4-chlorphenyl)-3-pyrazole alcohol is obtained. The yield of the product is 94.5%-98.6%, and the purity of the product is 99.2%-99.6%. Compared with the traditional method, the CeO2-CuO / TiO2 catalyst used in the invention realizes efficient catalysis by virtue of the synergistic effect of CeO2 and CuO, can realize high yield of the reaction and high selectivity of the target product under mild reaction conditions, and has good reusability.

This invention relates to activated carbon-supported multi-metal catalysts, their preparation methods, and applications, as well as a method for preparing 1-(4-chlorophenyl)-3-pyrazolol. The catalyst comprises an activated carbon support and an active metal component supported on the support, wherein the active metal component includes transition metal ions, alkaline earth metal ions, and rare earth metal ions. In the presence of oxygen, 1-(4-chlorophenyl)pyrazolidine-3-one is contacted with the catalyst, using an alkaline aqueous solution as a solvent, to oxidize 1-(4-chlorophenyl)pyrazolidine-3-one to 1-(4-chlorophenyl)-3-pyrazolol. This invention can improve the selectivity of 1-(4-chlorophenyl)-3-pyrazolol and the oxidation rate of 1-(4-chlorophenyl)pyrazolidine-3-one, reduce the hazards of the production process, reduce wastewater generation, reduce environmental pollution, and achieve green production of 1-(4-chlorophenyl)-3-pyrazolol.