The new benzoyl
urea derivatives of formula (I) wherein the meaning of X and Y independently are
hydrogen atom, hydroxy, benzyloxy, amino, nitro, C1-C4 alkylsulfonamido optionally substituted with a
halogen atom or
halogen atoms, C1-C4 alkanoylamido optionally substituted with a
halogen atom or halogen atoms, C1-C4 alkoxy, aroyl-carbamoyl optionally substituted with halogen atom or C1-C4
alkyl or C1-C4 alkoxycarbonyl group, or the neighboring X and Y groups optionally form together with one or more identical or different additional hetero atom and —CH═ and / or —CH2— groups an optionally substituted 4-7 membered homo- or heterocyclic ring, preferably
morpholine,
pyrrole,
pyrrolidine, oxo- or thioxo-
pyrrolidine,
pyrazole,
pyrazolidine,
imidazole,
imidazolidine, oxo- or thioxo-
imidazole or
imidazolidine, 1,4-oxazine,
oxazole,
oxazolidine,
triazole, oxo- or thioxo-
oxazolidine, or 3-oxo-1,4-oxazine ring, V and Z independently are
hydrogen or halogen atom, cyano, C1-C4
alkyl, C1-C4 alkoxy,
trifluoromethyl, hydroxy or optionally esterized carboxyl group, W is
oxygen atom, as well as C1-C4 alkylene, C2-C4 alkenylene, aminocarbonyl, —NH—, —N(
alkyl)-, —CH2O—, —CH2S—, —CH(OH)—, —OCH2— group, wherein the meaning of alkyl is a C1-C4 alkyl group—, when the dotted bonds () represent simple C—C bonds then U is
hydroxy group or
hydrogen atom or when W is C1-C4 alkylene or C2-C4 alkenylene group, then one of the dotted bonds () can represent a further double C—C bond and in this case U means an
electron pair, which participate in the
double bond and optical antipodes, racemates and the salts thereof are highly effective and selective antagonists of
NMDA receptor, and moreover most of the compounds are
selective antagonist of NR2B subtype of
NMDA receptor. Furthermore objects of the present invention are the pharmaceutical compositions containing new benzoyl
urea derivatives of formula (I) or optical antipodes or racemates or the salts thereof as active ingredients and processes for producing these compounds and pharmaceutical compositions.