9 results about "Pyrazolidine" patented technology

The invention discloses a synthesis method of 1-(4-chlorphenyl) pyrazolidine-3-ketone, which comprises the following steps: by taking p-chlorophenylhydrazine hydrochloride and acrylamide as raw materials and toluene as a solvent, carrying out azeotropic dehydration under the normal pressure condition, cooling, adding flaky sodium hydroxide or potassium hydroxide, adding acrylamide, carrying out condensation reaction at 40-80 DEG C, filtering, washing and drying to obtain the 1-(4-chlorphenyl) pyrazolidine-3-ketone. And after the reaction is finished, acidifying, desolventizing, crystallizing and filtering to obtain the high-purity 1-(4-chlorphenyl) pyrazolidine-3-ketone. Compared with the prior art, the method provided by the invention has the following advantages: firstly, the inorganic base is adopted to replace the traditional sodium alkoxide organic base, so that the problems of flammability, danger and the like are avoided, and the reaction safety is greatly improved; process conditions are mild, operation steps are simplified, and repeated heating and cooling or negative pressure maintaining are not needed; and thirdly, the process is more environment-friendly, the molecular utilization rate is higher, by-products of alcohols are not generated compared with the traditional process, and the burden of sewage treatment is reduced. Sodium alkoxide is replaced by inorganic base, production cost is saved, and economic benefits are good.

The invention discloses a preparation method of a 3-aryl pyrazolidine compound, which comprises the following steps: in an inert gas atmosphere, sequentially adding aryl cyclopropane, an azodicarboxylic acid derivative, NaBr and a photocatalyst into acetonitrile to obtain a mixture, reacting for 12 hours at room temperature under the irradiation of 5W blue light with the wavelength of 456nm, and separating from the reaction liquid to obtain the 3-aryl pyrazolidine-1, 2, 3-triazole compound. The invention relates to a 1, 2-dicarboxylic acid derivative. The preparation of the 3-aryl pyrazolidine compound can be carried out at room temperature, the reaction condition is mild, the adopted raw materials are simple and easy to obtain, and the cost is low.

Combination for Dyeing Keratin Fibers and its Use. The present invention relates to a dye combination comprising: A) a dye composition a), comprising: I) a coloring composition i), comprising: i) at least one oxidizing dye; wherein the oxidizing dye comprises one or more oxidizing bases selected from the group consisting of para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols, meta-aminophenols, ortho-aminophenols, and addition salts thereof, and mixtures thereof; and / or wherein the oxidizing dye comprises one or more couplers selected from the group consisting of meta-phenylenediamines, meta-aminophenols, and addition salts thereof, and mixtures thereof; and B) a pyrazolidine-3,5-dione compound of formula (1): (1). Figure for abstract: None

The application discloses a high-efficiency cyclization micro-reaction device for pyrazolidine ethyl formate, and relates to the technical field of reaction devices.The device comprises a bottom plate, a stirring unit, an acid-base unit, a heat exchange unit, a heat conduction unit and a heat preservation unit.The top of the bottom plate is provided with a reaction cylinder.The stirring unit is arranged on the top of the reaction cylinder.The acid-base unit is arranged on the top of the stirring unit.The heat exchange unit is arranged on one side of the reaction cylinder, and is used for recycling the temperature of the solution in the reaction cylinder.The heat conduction unit is arranged on one side of the heat exchange unit, and is used for accelerating the heat exchange speed between the solution in the reaction cylinder and the heat exchange unit.The heat preservation unit is used for storing the solution in the reaction cylinder, and can further reuse the temperature of the solution in the reaction cylinder.The device can transfer the heat of the solution in the reaction cylinder which has reacted to the raw material for the next reaction in the heat exchange box, realizes the recycling of the heat in the reaction cylinder, and saves electric energy.

The invention provides a method for preparing 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, which comprises the following steps: by taking 1, 2-disubstituted pyrazol-3-ketone as an initial raw material, 1, 2-dichloroethane as a reaction solvent and pyridinium chlorochromate as an oxidizing agent, carrying out dehydroaromatization reaction on the 1, 2-disubstituted pyrazol-3-ketone to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, and reacting the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone with 1, 2-dichloroethane to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone. The synthesis method comprises the following steps: preparing 1, 2-dihydro-3H-pyrazole-3-ketone. According to the present invention, the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone can be prepared, the reaction conditions are mild, the process is simple, the yield of the product 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone is high, and the method is suitable for industrial production.

The present invention relates to compounds of formula I as prostaglandin E2 receptor 4 (EP4) agonists for use in methods of treatment of gastrointestinal and pulmonary dis-cases or disorders. An exemplary compound is e.g. 4-(2-(2-(3-hydroxy-3-(4′-hydroxy-2′-methyl-[1,1′-biphenyl]-3-yl) propyl)-5-oxopyrazolidin-1-yl)ethyl)benzoic acid (Example 1) Pharmacological data is provided, e.g.

The application discloses a kind of green synthesis process of halogenated pyridyl pyrazole dithiocarboxylate, it is related to compound synthesis technical field, including the following steps: S1, compound 1 is placed in polar solvent, and manganese dioxide, an oxidizing agent, is added to stir and heat reaction, with sulfuric acid as catalyst, to obtain compound 2 solution and suspension;S2, compound 2 solution and suspension are filtered, separated to obtain the filter cake of manganese dioxide and manganese sulfate and reaction filtrate, the filtrate is concentrated to recover polar solvent, and water is filtered to obtain compound 2;S3, filter cake is added to sodium hydroxide solution, to generate manganese hydroxide solution, and contain manganese dioxide solid, after filtration and separation, to obtain manganese dioxide solid and manganese hydroxide filtrate.The process is regenerated by the selection of potassium permanganate manganese dioxide oxidation system, realizes the efficient use of oxidizing agent, high conversion rate and high selectivity of reaction system and the reduction of process three wastes, and completes the green synthesis of halogenated pyridyl pyrazole dithiocarboxylate.

This invention relates to activated carbon-supported multi-metal catalysts, their preparation methods, and applications, as well as a method for preparing 1-(4-chlorophenyl)-3-pyrazolol. The catalyst comprises an activated carbon support and an active metal component supported on the support, wherein the active metal component includes transition metal ions, alkaline earth metal ions, and rare earth metal ions. In the presence of oxygen, 1-(4-chlorophenyl)pyrazolidine-3-one is contacted with the catalyst, using an alkaline aqueous solution as a solvent, to oxidize 1-(4-chlorophenyl)pyrazolidine-3-one to 1-(4-chlorophenyl)-3-pyrazolol. This invention can improve the selectivity of 1-(4-chlorophenyl)-3-pyrazolol and the oxidation rate of 1-(4-chlorophenyl)pyrazolidine-3-one, reduce the hazards of the production process, reduce wastewater generation, reduce environmental pollution, and achieve green production of 1-(4-chlorophenyl)-3-pyrazolol.