The invention relates to a
biapenem compound and a preparation method thereof, which comprises the following steps: 1) dissolving crude
biapenem in water, then adding
activated carbon, keeping warm, fully stirring, filtering the deactivated carbon, and collecting the filtrate; 2) dissolving The filtrate obtained in the previous step is separated and purified by
column chromatography, and the eluent is collected; 3) the temperature is increased to concentrate the above-mentioned eluent solution, and then adding
ethanol and
acetone with a volume ratio of 1: 0.5~2 mixed
solvent solvent, and control temperature for
crystallization, the precipitated crystals are centrifuged, washed, and dried to obtain a refined
biapenem compound; 4) Optionally, the
crystallization mother liquor is returned to step 3), that is, added to the eluting solution obtained in step 2) together with a mixed
solvent. By adopting the method of the invention, the purity of crude biapenem can be greatly improved, the quality of preparation products can be improved, and toxic and side effects can be reduced.