Biapenem dimer and preparation method thereof

Abstract

The invention relates to a biapenem dimer with a structure shown in the following formula and a preparation method and an application thereof. The preparation method comprises the steps of: weighing biapenem raw material, dissolving in acidic water solution as solvent to obtain a solution; standing at 25-100DEG C (at 25-50DEG C for 24 hours and at 51-100DEG C for 1-4 hours), and filtering to obtain filtrate; and separating the filtrate with reversed phase high performance liquid chromatography, and preparing the dimer. The biapenem dimer can be used as a reference substance of biapenem impurities to facilitate the control of the amount of biapenem and related preparations thereof.

Description

Biapenem dimer and preparation method thereof field of invention The present invention relates to biapenem dimer and its preparation method and use. Background technique Biapenem belongs to carbapenem antibiotics, which is a class of atypical β-lactam antibiotics, and its structural formula is shown in formula I: Formula I As a commonly used clinical drug, the common adverse reaction of β-lactam antibiotics is anaphylaxis. Studies have shown that the real cause of allergic reactions is not the drug itself, but the polymer formed by the drug itself during its production, storage, and use. The separation and analysis methods of typical β-lactam antibiotic polymers such as penicillins and cephalosporins have been discussed comprehensively at home and abroad, but there are few reports reflecting the research status of carbapenem antibiotic polymers. methods are rarely reported. The commonly used polymer analysis and preparation method in the literature is gel chromato...

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Problems solved by technology

The polymer analysis and preparation method often used in the literature is gel chromatograph

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