Crystal form of 6, 7-dihydro-6-mercapto-5H-pyrazolo[1,2-alpha][1,2,4] triazoliumchloride and preparation method thereof
A chloride, 2-a technology, applied in organic chemistry and other directions, can solve the problems of high equipment requirements, complicated operation, long production cycle, etc., and achieve the effects of high crystal purity, simple operation and low cost
Active Publication Date: 2010-06-16
石药集团中诺药业(石家庄)有限公司 +1
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Abstract
The invention relates to a crystal form of 6, 7-dihydro-6-mercapto-5H-pyrazolo [1,2-alpha][1,2,4] triazoliumchloride and a preparation method thereof. The 6, 7-dihydro-6-mercapto-5H-pyrazolo [1,2-alpha][1,2,4] triazoliumchloride is a key intermediate for synthesizing the carbapenem antibiotic biapenem. The crystal form of 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-alpha][1,2,4] triazoliumchloride is characterized in that the X-ray diffraction spectrum of powder of the crystal form is represented by an angle of 2theta, and has peaks at 27.487+/-0.2 and 26.707+/-0.2, the intensity of the peak is 100% when 2theta is 27.487+/-0.2, and the ratio of intensity of the peak I/I0 is no less than 60% when 2theta is 26.707+/-0.2. The 6, 7-dihydro-6-mercapto-5H-pyrazolo[1,2-alpha][1,2,4] triazoliumchloride is prepared by the recrystallization method which abandons the column chromatography and has high efficiency and low cost and is more suitable for industrialized production.
Application Domain
Organic chemistry
Technology Topic
Column chromatographyDiffraction spectrum +5
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