66results about How to "Conducive to follow-up reactions" patented technology

The invention relates to a bi-functional polyethylene glycol derivative and a preparation method thereof. The preparation method of the difunctional polyethylene glycol derivative comprises following steps: conducting esterification, hydrazinolysis and Curtius rearrangement in dibasic acid with disulfide bond at first to generate diisocyanate containing disulfide bond, then conducting a reaction of the diisocyanate and the polyethylene glycol to generate isocyanat-terminated polyethylene glycol and obtaining the bi-functional polyethylene glycol derivative through hydrolysis reaction of the resultant. In the invention, the preparation method has the advantages that raw materials can be gotten easily, reaction conditions are gentle, yield and product purity are high and the method is beneficial to mass production. Meanwhile, the bi-functional polyethylene glycol derivative is beneficial to both consequent reactions and controlled release of drugs and transfer of the drugs from endosome to cytoplasm. Application prospects of the bi-functional polyethylene glycol derivative are wide in surface finish of a nano-drug carrier, preparation of pro-drug and control of drug release speed etc.

The invention provides a synthesis method of o-cresol formaldehyde epoxy resin, which comprises steps that: at 0.01-0.1Mpa vacuum degree, the o-cresol formaldehyde epoxy resin is dissolved by epichlorohydrin and a catalyzer is added for circumfluence and etherification reaction; at the 0.02-0.1Mpa vacuum degree, alkali is added for catalyzing cyclization reaction; the epichlorohydrin is recycled and processed after refining reaction. The o-cresol formaldehyde epoxy resin obtained by the synthesis method of the invention can reach a scheduled softening point and has high epoxy value and low content of easily saponifiable chlorine.

The invention relates to the field of graphene composite materials and discloses a nano silver loaded graphene antibacterial composite material and a preparation method thereof. A single-layer graphene oxide solution is obtained through a secondary ultrasonic dispersion technology and a discontinuous sheet layer is prevented; a carbon cake formed by mutually mixing a plurality of layers of graphene oxide sheets is innovatively subjected to secondary hydrothermal method reaction; green reduction agents including glucose and ascorbic acid and a green stabilizer soluble starch are adopted respectively and the hydrothermal method reaction is matched, so that the reduction rate is extremely improved and a sealing system with relatively high temperature and inner pressure is adopted; the recycling of dehydrated p conjugation is also promoted and the minimization of defects is facilitated; after heat treatment is carried out, the structure of graphene is easy to recover; the antibacterial activity of free Ag nanoparticles is remained in the composite material. The loading amount of silver particles in the nano silver loaded graphene antibacterial composite material reaches 58.0 percent and the antibacterial rate on escherichia coli reaches 99.9 percent.

The invention relates to a crystal form of 6, 7-dihydro-6-mercapto-5H-pyrazolo [1,2-alpha][1,2,4] triazoliumchloride and a preparation method thereof. The 6, 7-dihydro-6-mercapto-5H-pyrazolo [1,2-alpha][1,2,4] triazoliumchloride is a key intermediate for synthesizing the carbapenem antibiotic biapenem. The crystal form of 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-alpha][1,2,4] triazoliumchloride is characterized in that the X-ray diffraction spectrum of powder of the crystal form is represented by an angle of 2theta, and has peaks at 27.487+/-0.2 and 26.707+/-0.2, the intensity of the peak is 100% when 2theta is 27.487+/-0.2, and the ratio of intensity of the peak I/I0 is no less than 60% when 2theta is 26.707+/-0.2. The 6, 7-dihydro-6-mercapto-5H-pyrazolo[1,2-alpha][1,2,4] triazoliumchloride is prepared by the recrystallization method which abandons the column chromatography and has high efficiency and low cost and is more suitable for industrialized production.

The invention relates to the field of graphene composite materials, and discloses a high-density graphene/silver composite material and a preparation method thereof. The high-density graphene/silver composite material and its preparation method obtain a single-layer graphene oxide solution through a secondary ultrasonic dispersion process, which prevents discontinuity of the lamellae, and is a "carbon" composed of multi-layer graphene oxide sheets mixed with each other. and using the substrate as the graphene oxide solution substrate, by growing silver or nano-silver on the surface of the graphene oxide substrate; at the same time, in order to obtain silver or nano-silver with higher density and lower particle size, the present invention impregnates the substrate. Multiple reactions are carried out, and finally a highly dense graphene/composite is obtained.

The invention discloses a method for synthesizing a key intermediate [4-(4-fluorophenyl)-6-isopropyl-2-alkylsulfanyl-5-yl] formate III of rosuvastain calcium, which takes fluorobenzaldehydes and ethyl isobutyrylacetate as raw materials, comprises the steps of condensation, cyclization, salification and oxidation, and adopts a reaction route as shown on the right, wherein R1 is selected from C1 to C6 alkyls and C6 to C12 aryls; and R2 is selected from C1 to C6 alkyls and C6 to C12 aryls. The method has the advantages that: as a compound I reacts with an acid to form a solid compound II which is a salt, the product quality is improved, the yield is increased, the package, storage, transportation and use of products are convenient, the consequent reactions are smooth, and low-efficiency, high consumption and trivial operation of rectification, column chromatography and the like is avoided; and a compound III can be obtained in one oxidation process.

The invention discloses halogen-free catalytic polyphenylene sulfide and a preparation method thereof. Concentration of a sodium hydroxide solution in a reaction kettle is 400 g/mL, at the moment, sodium hydroxide has maximum absorbing rate on hydrogen sulfide, and yield of sodium sulfide is highest. Vacuum degree in a polymerization kettle is 0.098 MPa. Dewatered sodium sulfide obtained at the vacuum degree is loose, free of melting and boiling and wall sticking and conducive to subsequent reaction. Sectional heating is adopted, so that conversion of sodium sulfide in the heating process can be prevented, and vacuum dewatering time can be shortened. Polycondensation is performed in two steps to enable further reaction of active end group of oligomer and enable further growth of molecular chains.4, 4'-dihydroxybiphenyl is added into polycondensation, so that the polyphenylene sulfide is enabled to be oxidation-resistant. Therefore, by adopting the preparation method, the halogen-free catalytic polyphenylene sulfide is high in quality, little in pollution, great in market potential and promising in prospect.

The invention relates to the field of organic synthesis and medicine, and discloses a preparation method for 4-substituted-7-azaindole. Firstly, N-oxide-7-azaindole is prepared by employing 7-azaindole as a raw material and hydrogen peroxide as an oxidizing agent; then 4-halogenated-7-azaindole is synthesized by adding acetonitrile and phosphorus oxyhalides (POX3) and by using diisopropyl ethyl amine as a catalyst; and 4-methoxy-7-azaindole is synthesized by reacting the synthesized 4-halogenated-7-azaindole and alkoxide. The 4-substituted-7-azaindole synthesized by the method has high yield and low cost, and the method is easy for industrialization.

The invention relates to a kit for detecting mycoplasma pneumonia. The kit comprises an R1 reagent and an R2 reagent. The R1 reagent comprises a first buffer, a first stabilizer, a first protectant, afirst preservative, an opacifier and water. The R2 reagent comprises mycoplasma pneumonia antigens, polystyrene latex microspheres, a second buffer, a second stabilizer, a second protectant, a secondpreservative and water. The kit of the invention has the advantages of high sensitivity, high detection speed, stable result, wide linear range, good repetition, easy to standardize and specimen collection, and small in specimen usage amount and the like. Also, the kit of the invention has the advantages that it provides a novel method for early, rapid, high sensitivity and specificity for the diagnosis of clinical mycoplasma pneumonia infection.

The invention discloses nitrogen-doped carbon quantum dots and a preparation method thereof, and reduced graphene oxide and a preparation method and application thereof. When nitrogen-doped carbon quantum dots prepared from vinegar residues are directly used as a catalyst in water electrolysis hydrogen evolution, the effect of obviously accelerating the catalytic process in the water electrolysis process is not achieved, therefore, vertical graphene oxide with a stable structure is selected as a substrate material, nitrogen-doped carbon quantum dots are loaded on graphene oxide to form a nitrogen-doped carbon quantum dot loaded reduced graphene oxide material, and the material is used as a catalyst in a water electrolysis process. The material has good catalytic performance and conductive performance, the overpotential in the water electrolysis hydrogen production process can be reduced, the water electrolysis process can be catalyzed and accelerated, and the utilization rate of waste can be increased. Therefore, the material is applied to water electrolysis hydrogen evolution to replace a noble metal catalyst, the preparation cost of the catalyst is reduced, and large-scale production of hydrogen prepared by water electrolysis is realized.

The invention discloses a preparation method of a high-energy graphene battery negative electrode material, and belongs to the technical field of energy storage materials. The preparation method comprises the following steps: enabling graphene oxide to react with a dimethylformamide solution of isocyanate and sodium azide, lithium aluminum hydride and concentrated hydrochloric acid in sequence andpreparing hydrolyzed and reduced graphene oxide; equally dividing the hydrolyzed and reduced graphene oxide into two parts, enabling the two parts to respectively react with silicate ester and ferricsalt to respectively prepare concentrated acidic dispersion liquid and concentrated alkaline dispersion liquid, and mixing the two solutions to prepare a dry filter cake; performing reaction under ahigh-temperature condition, and performing cleaning with hydrofluoric acid to obtain the high-energy graphene battery negative electrode material. The obtained high-energy graphene battery negative electrode material is uses as a battery negative electrode material and has excellent cycling stability; after multiple times of charging and discharging cycling tests, the electrochemical performance and the volume expansion rate are kept at the optimal level.

The invention provides a battery negative electrode modified by an element-doped diamond-like carbon film. The battery negative electrode comprises a metal foil material and an element-doped diamond-like carbon film arranged on any surface of the metal foil material, and doped elements in the element-doped diamond-like carbon film are selected from at least one of F, N, P, Fe, Co, Ni and W; the metal foil material serves as a current collector and a negative electrode active material at the same time. The element-doped diamond-like carbon film is used for modifying the battery negative electrode, so that the problems that when a metal material is directly used as the battery negative electrode, the volume of the metal material is easy to expand, and the metal material is easy to react withelectrolyte at an interface to form an SEI film are solved, the stability of battery performance is improved, and the service life is prolonged.

The invention provides a preparation method of silk fibroin lyophilized powder. The preparation method includes that small molecular silk fibroin is formed after silk fibroin is enzymatically hydrolyzed, starch is introduced and enzymatically hydrolyzed, viscous small molecular substance is generated after starch enzymolysis and adhered to the surface of the small molecular silk fibroin, and induction action of alcohol, crosslinking action of polyethylene glycol diglycidyl ether and freeze-thawing action are combined to enable the silk fibroin lyophilized powder to be in nanoscale size, supportive of transdermal absorption and good in cosmetic effect. The silk fibroin lyophilized powder is a lyophilized powder product and is high in activity and convenient to use.

The invention discloses a preparation method of a graphene composite material, and the method comprises the following steps: mixing an aqueous solution of gamma-Fe2O3 with at least one alkaline solution under a constant-temperature stirring condition to obtain a first mixed solution; dissolving chitosan in an acetic acid solution to obtain a second mixed solution; stirring and reacting the first mixed solution and the second mixed solution under a heating condition, performing cooling to room temperature after the reaction is completed, washing precipitated substances with an organic solvent and water in sequence, and performing drying to obtain chitosan-modified gamma-Fe2O3; and dissolving graphene oxide in water, carrying out ultrasonic dissolution to obtain a graphene oxide suspension,carrying out ultrasonic mixing treatment on chitosan-modified gamma-Fe2O3 and the graphene oxide suspension, adjusting the pH value to neutrality, and carrying out separation, washing and drying underthe condition of an external magnetic field to obtain the chitosan-modified gamma-Fe2O3/graphene oxide composite material. The preparation method is simple, and the obtained composite material is good in adsorption performance and separability and low in cost and can be applied to the technical field of wastewater treatment.

The invention discloses a method for treating an inferior oil product by a combined process. The method comprises the following steps: allowing an inferior oil raw material and hydrogen to enter a mixer for saturated hydrogen dissolution, and allowing an obtained mixture to pass through a hydropretreating zone; and separating a reaction effluent, allowing a separated reaction effluent and catalytic-cracked circulating oil to enter a hydrotreating reaction zone, separating an obtained reaction effluent, allowing obtained hydrotreated residual oil to undergo a catalytic cracking reaction, allowing obtained circulating oil and/or an oil slurry to be circulated to a hydropretreating reaction zone, and allowing a part of obtained circulating oil to be circulated to the hydrotreating reaction zone; wherein the reaction temperature t1 of the hydropretreating reaction zone is higher than the reaction temperature t2 of the hydrotreating reaction zone. The method provided by the invention can increase the utilization rate of a main hydrotreating catalyst, prolongs the operation cycle of a combined device, and increases the operation efficiency of a device.

The invention relates to a preparation method for synthesizing a vitamin A intermediate tetraethyl methylenediphosphonate. The preparation method comprises the following steps: adding an organic solvent into metallic sodium or a metallic sodium compound, uniformly stirring, dropwise adding diethyl phosphite at 10-60 DEG C, and keeping the temperature at 10-60 DEG C after the diethyl phosphite is dropwise added, so as to obtain a sodium diethyl phosphite solution; removing the organic solvent, and recovering the organic solvent to obtain a sodium diethyl phosphite solid; adding dichloromethaneinto the sodium diethyl phosphite salt for dissolving, and carrying out a substitution reaction at 20-55 DEG C, so as to obtain the tetraethyl methylenediphosphate. The method is simple and convenientto operate, short in process flow, less in involved solvent, simple and convenient to recycle, economic, environment-friendly, good in product quality and high in yield. Industrial production conditions can be met.