19results about How to "Increase local concentration" patented technology

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

The invention belongs to the technical field of environmental pollution treatment and water treatment, and particularly relates to a method for degrading organic pollutants by coupling a nano confinement catalytic membrane with micro-nano bubbles. The method comprises the following steps: adding micro-nano bubble water and an oxidizing agent into an organic pollutant solution, regulating the pH value to prepare a pretreatment mixed solution, and enabling the pretreatment mixed solution to pass through a nano confinement catalytic membrane to catalytically degrade the organic pollutants, the nano confinement catalytic membrane comprises an organic polymer membrane substrate and a catalyst loaded in the organic polymer membrane substrate; the loading capacity of the catalyst is 5 to 30 mg. The problems that antibiotics are difficult to degrade, pollutant concentration is easily caused by membrane separation, a catalyst is difficult to recycle, and membrane flux and catalytic activity are difficult to balance are solved, the method has the advantages of being high in degradation efficiency, stable in membrane flux, easy to recycle the catalyst and wide in application range, and wastewater containing organic pollutants can be efficiently treated.

The invention provides a composition for improving the thrombolysis capacity of a human body, a preparation method and application thereof.The composition is prepared from, by weight, 5-30 parts of earthworm protein, 30-120 parts of hippophae rhamnoides total flavone extract, 50-150 parts of silymarin extract, 20-80 parts of maltodextrin and 15-60 parts of pregelatinized starch, the earthworm protein activates a fibrinolytic system to promote t-PA to release and dissolve thrombus, and the hippophae rhamnoides total flavone extract activates the fibrinolytic system to promote t-PA to release and dissolve thrombus; the hippophae rhamnoides total flavonoids regulate the ratio of PGI2 / TXA2 to inhibit platelet aggregation and reduce blood fat, the silymarin protects the liver function to enhance LDL-C metabolism clearing, the hippophae rhamnoides total flavonoids, the silymarin and the hippophae rhamnoides total flavonoids cooperate to form a thrombolysis-antithrombosis-metabolism regulation three-dimensional intervention system, a whole-course low-temperature mixing direct tabletting process is adopted

The utility model belongs to the technical field of waste treatment, and discloses a demisting device for an absorption tower, the demisting device comprises a demisting assembly I and a demisting assembly II, the demisting assembly I is coaxially mounted in an air inducing pipeline, a backflow cavity I is positioned between the side wall of a reaction cavity and the inner side wall of the absorption tower, the top end of the backflow cavity I is open, and the air inducing pipeline is communicated with the backflow cavity I; a second backflow cavity is formed between the outer side wall of the air inducing pipeline and the outer cavity wall of the top end of the reaction cavity, the second backflow cavity is communicated with the air inducing pipeline, a hydrophilic semi-permeable membrane is arranged at the communication position, and the side end of the second backflow cavity is communicated with the first backflow cavity; the bottom of the exhaust cavity communicates with an air inlet pipeline, and the lower end of the air inlet pipeline communicates with the air inducing pipeline and the first backflow cavity. The second demisting assembly is installed in the air inlet pipeline, and an exhaust port communicating with the outside is formed in the top of the exhaust cavity. According to the demisting device, the flowing path of liquid is changed, the situation that the liquid and gas are repeatedly mixed to generate mist again can be reduced, secondary demisting is conducted through the second demisting assembly, and the demisting effect is improved.

The invention discloses an electrically-mediated iron-carbon composite filler constructed wetland system for removing sulfonamide antibiotics and resistance genes as well as a construction method and a use method of the electrically-mediated iron-carbon composite filler constructed wetland system, and belongs to the technical field of water treatment. Coconut shell biochar is modified by hydrochloric acid and then compounded with pyrite to form a composite filler with targeted adsorption, efficient electron conduction and multi-mechanism catalysis functions, and the composite filler is used as a core matrix to construct a vertical flow constructed wetland system applying an external direct-current electric field. The system realizes efficient, synchronous and stable removal of sulfonamide antibiotics and resistance genes thereof in a water body by virtue of directional enrichment of the filler on pollutants, an electron transfer network formed by a composite material and an electrochemical-microorganism synergistic effect jointly excited by a direct-current electric field and the filler.

The application discloses a kind of phosphogypsum leachate processing method and device, it is related to sewage treatment technical field, comprising: reaction tank and fixedly connected in the inside of the reaction tank support seat, the inside of the support seat is rotatably connected with stirring rod, the top of the support seat is equipped with first drive motor, and the output of the first drive motor is fixedly connected with the stirring rod;Suction aid, located in the inside of the reaction tank, for auxiliary with the sewage at the bottom of the reaction tank is pumped to top and mixed reagent discharge.The application is by being provided with suction aid, so that sewage forms the circulating flow of "bottom-top", this process can avoid the local concentration of bottom sewage due to gravity deposition (or pollutant enrichment) too high, while let top not fully mixed sewage and bottom circulating sewage again contact, so that the sewage concentration in the whole reaction tank is more uniform.

The utility model discloses an organic matter purifying agent raw material pretreatment device, and the device includes the stirring tank with the cone bottom and is arranged in the agitator of stirring tank, wherein, the agitator includes stirring shaft and sets up the intermediate stirring structure, the outer periphery stirring structure and the bottom stirring structure on stirring shaft, the outer periphery stirring structure includes the extension arm fixed in stirring shaft both sides, the extension arm end is provided with the stirring column and is provided with the stirring arc plate between stirring column, the stirring arc plate shape is semicircular arc plate, and one end is fixed in the upper end of one stirring column, and the other end is fixed in the lower end of another stirring column. The device is through multilayer stirring and optimization feeding design, improves the utilization of medicine, reduces the operating cost, prevents the equipment from blocking, is applicable to industrial wastewater and domestic sewage treatment, and significantly improves the mixing uniformity and process efficiency.

The invention relates to the technical field of lead ion detection, in particular to a lead ion detection colorimetric sensor and application thereof.The lead ion detection colorimetric sensor comprises hemin, a substrate chain S, an enzyme chain Dz and a DNA chain DS with three palindromic structures; in the absence of Pb < 2 + >, the substrate chain S and the enzyme chain Dz are hybridized to form a stable S-Dz double chain; when Pb is introduced, an enzyme chain Dz can be activated, and lead ions are specifically recognized and used as cofactors. Through an annealing process, the DNA chain DS is subjected to intramolecular hybridization and self-folding so as to be self-assembled into a definitely-defined and monodisperse DNA nanosphere; the substrate chain S and the enzyme chain Dz can be hybridized to form a stable S-Dz double chain; a plurality of S-Dz are concentrated on a limited nanosphere surface (DS-S-Dz), the catalysis direction is optimized, side reactions are reduced, and a signal DNAzyme can be quickly formed, so that a color signal is remarkably amplified, and lead ion detection with higher sensitivity, lower background and higher stability is realized.

This invention discloses the application of a fullerol-supported palladium nanowire composite material in the electrocatalytic dechlorination of 2,4-dichlorophenol. The fullerol-supported palladium nanowire composite material is loaded onto a conductive substrate to form a working electrode. This working electrode is used as the cathode of an electrochemical reactor to perform an electrocatalytic dechlorination reaction on wastewater containing 2,4-dichlorophenol. This invention, by modifying fullerol-modified palladium nanowires, yields a highly promising electrocatalyst for the dechlorination of 2,4-dichlorophenol, which enhances the adsorption and activation capacity for 2,4-dichlorophenol, thereby improving catalytic selectivity and reaction rate.

The invention belongs to the technical field of the crossing field of nano biological materials and intelligent drug delivery systems, and discloses a dual-power liposome nano motor and a preparation method and application thereof, the dual-power liposome nano motor comprises liposome, metal nanoparticles and DNAzyme, the metal nanoparticles have catalase-like activity, and the DNAzyme has the activity similar to catalase. The metal nanoparticles and the DNAzyme are entrapped by the lipidosome. The dual-power liposome nano-motor provided by the invention is applied to tumor treatment, gene therapy regulates gene expression to inhibit tumor growth, chemodynamic therapy can destroy tumor cells through chemical reaction of drugs, and photodynamic therapy energy is transmitted to surrounding oxygen, so that the tumor cells are prevented from being damaged. According to the present invention, the three treatment modes are combined to form the complementary advantages, such that the treatment effectiveness is improved, and the occurrence of the adverse reaction is reduced; the singlet oxygen with the strong activity is subjected to the oxidation reaction with the nearby biological macromolecules, and the generated cytotoxicity can kill the cancerous cells; and the three treatment modes are combined together so as to form the complementary advantages, such that the treatment effectiveness is improved, and the occurrence of the adverse reaction is reduced.

This invention discloses a magnetic drug-loaded liposome for nerve repair and its preparation method. The magnetic drug-loaded liposome prepared by this method contains magnetic nanoparticles and a drug. The mass fractions of egg yolk lecithin, cholesterol, DSPE-MPEG 2000, BFe3O4, and the drug in 1 mL of the liposome solution are 0.5%–1.5%, 0.15%–0.35%, 0.1%–0.35%, 0.1%–0.2%, and 0.1%–0.2%, respectively. The drug is one or more of the natural antioxidants such as piracetamine, resveratrol, or tea polyphenols. The multifunctional magnetic drug-loaded liposome provided by this invention, combined with magnetic field loading, can be used for the repair of damaged nerve cells.

This invention relates to the field of microneedle drug delivery technology, specifically to a soluble microneedle and its preparation method. The soluble microneedle includes a needle hub and at least one needle body located on the needle hub. The needle body includes a first intermediate segment, a second intermediate segment, and a needle tip. The first intermediate segment is located on the needle hub, and the second intermediate segment is located between the first intermediate segment and the needle tip. The density of the second intermediate segment is greater than that of the first intermediate segment. The needle tip contains a drug active ingredient. The soluble microneedle provided by this invention has the drug active ingredient concentrated in the needle tip. Furthermore, the second intermediate segment, which is in contact with the needle tip, is a high-density segment, which can prevent the drug active ingredient in the needle tip from diffusing into the second intermediate segment and the first intermediate segment. Therefore, the soluble microneedle of this invention can significantly increase the local drug delivery concentration, achieving precise, targeted, and quantitative drug delivery.

This invention relates to the field of rare earth allicin complex technology, and particularly to a rare earth allicin complex, its preparation method, and its application. The method includes the following steps: dissolving a rare earth nitrate in a mixed solvent of water and acetonitrile to obtain a rare earth nitrate solution; dissolving allicin in ethanol to obtain an allicin solution; adjusting the pH of the rare earth nitrate solution; adding a surfactant and auxiliary ligand to the rare earth nitrate solution to obtain a first reaction solution; slowly adding the allicin solution dropwise to the first reaction solution; heating and stirring; collecting the precipitate by vacuum distillation to obtain a crude product; washing the crude product; and purifying it by column chromatography to obtain the rare earth allicin complex. This invention, using the above-mentioned rare earth allicin complex, its preparation method, and its application, significantly increases the thermal decomposition temperature of allicin. The redox bactericidal effect of rare earth ions synergistically combines with the broad-spectrum antibacterial activity of allicin, resulting in the rare earth allicin complex exhibiting excellent antibacterial effects.

This invention belongs to the field of air purification materials technology, specifically relating to a high-purity spherical zinc oxide-silica synergistic photocatalytic air purification material. By weight, it comprises 100 parts of silica-coated high-purity spherical zinc oxide, 1-3 parts of a silanized porphyrin trifluoromethyl functional polymer, 2400-2950 parts of ethanol, 101.5-204 parts of deionized water, and 0.006-0.06 parts of glacial acetic acid. The high-purity spherical zinc oxide-silica synergistic photocatalytic air purification material prepared by this invention exhibits improved interface stability, a broadened spectral response range, and pollutant degradation capabilities.

The invention relates to the technical field of micro-nano, and discloses a drug-loaded microalgae motor as well as a preparation method and application thereof. The drug-loaded microalgae motor comprises a microalgae motor and a nano-particle drug loaded on the microalgae motor, the microalgae motor is connected with the nano-particle drug through electrostatic adsorption, and microalgae is natural or engineered unicellular algae with movement ability. The nanoparticle drug is formed by self-assembling natural polysaccharide and natural active substances after covalent cross-linking. According to the invention, the microalgae motor can autonomously move in the gastrointestinal tract by utilizing the flagellum movement of the microalgae, and is actively targeted to the colitis disease part, so that the local concentration of the medicine is improved, and the curative effect is enhanced. The microalgae motor combines the strong anti-oxidation / anti-inflammatory activity of astaxanthin and the biological activity of microalgae, and can synergistically relieve colitis in multiple ways.

The application belongs to the technical field of water treatment, and particularly relates to an ultrasonic-assisted micro-nano bubble dispersion and dissolution system for water treatment, which comprises an ozone generation unit, an ultrasonic generation unit, a micro-nano bubble generation unit, a circulating fluidized bed reaction unit and a temperature and pressure control unit. The ozone generation unit comprises an ozone generator, an ozone concentration detector and an ozone conveying pipeline, and the ozone concentration detector is arranged on the ozone conveying pipeline and used for monitoring the ozone concentration conveyed to the micro-nano bubble generation unit in real time. The application integrates the functions of ultrasonic-assisted micro-nano bubble generation, an efficient catalyst system, a circulating fluidized bed reaction and precise temperature and pressure control, realizes efficient dispersion and dissolution of ozone, strengthens the synergistic effect of adsorption and catalytic oxidation, significantly improves the removal efficiency of refractory organic pollutants in water, realizes cyclic utilization of ozone resources, and reduces operation cost and environmental risk.

The invention belongs to the technical field of functional materials, and particularly relates to a phosphoric acid functionalized nickel porphyrin covalent organic framework / carbon nanotube composite material, which comprises: a nickel porphyrin covalent organic framework, which is a polymer formed by connecting a plurality of nickel porphyrin monomers through a covalent organic framework ligand; the carbon nano tube and the nickel porphyrin covalent organic framework form a heterojunction through in-situ growth; and the phosphoric acid functional group is chemically bonded on the covalent organic framework ligand of the nickel porphyrin covalent organic framework in the form of an alpha-phosphoramidate bond. The composite material provided by the invention integrates the photocatalytic reduction of nickel porphyrin, the photothermal conversion of carbon nanotubes and the selective adsorption function of phosphate groups on uranium, and the three components cooperate to form a virtuous cycle of rapid mass transfer, efficient capture, in-situ reduction and active site regeneration, so that the efficiency and rate of extracting uranium from seawater are greatly improved.

The present application belongs to the technical field of flame-retardant materials, and particularly relates to a prismatic aluminum hypophosphite compound, a preparation method and application thereof. The prismatic aluminum hypophosphite compound comprises aluminum hypophosphite, layered montmorillonite and nano-silicon dioxide, wherein the weight percentage of the layered montmorillonite is 0.043-0.087 wt% and the weight percentage of the nano-silicon dioxide is 0.0036-0.0181 wt% based on 100% of the weight of the aluminum hypophosphite; the D10 particle size of the prismatic aluminum hypophosphite compound is 1-3 microns, the D50 particle size is 5-8 microns, the D90 particle size is 10-15 microns, and the D97 particle size is less than 20 microns; and the prismatic aluminum hypophosphite compound has a single prismatic crystal structure or a regular structure in which multiple prismatic crystals are embedded with each other. The prismatic aluminum hypophosphite compound has a specific morphology and is particularly suitable for a polyurethane flame-retardant system.

This invention belongs to the field of acyclic compound technology, specifically relating to a method for preparing tert-butyl peroxide. An alkaline solution is added to acetic anhydride, and the mixture is stirred to obtain a reaction solution. A composite catalyst is added to a purified tert-butyl hydrogen peroxide solution, and the mixture is stirred to obtain a mixture. The reaction solution is added to the mixture, and the mixture is stirred to obtain an organic phase. The organic phase is acid-washed to obtain an oil phase. The oil phase is then alkali-washed, salt-washed, and freeze-dried to obtain tert-butyl peroxide. This invention purifies the tert-butyl hydrogen peroxide solution, effectively removing di-tert-butyl peroxide impurities. A composite catalyst composed of p-toluenesulfonic acid, perfluorosulfonic acid resin, and sulfonated carbon is used as the catalyst, reducing the destructive effect on the product tert-butyl peroxide and significantly improving the yield of tert-butyl peroxide, thus possessing industrial production significance.