253results about How to "Increase local concentration" patented technology

The present invention relates to compositions and methods for inducing cell death or stasis in cancer cells or other hyperproliferative cells using anti-EphA2 or anti-EphA4 antibodies conjugated to toxins.

The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.

The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.

The invention relates to a preparation method of a loading iron based metal organic skeleton out-phase Fenton catalyst and an application thereof. The preparation method comprises the following steps of by taking MIL-100 (Fe) as a basal body, loading a ferrous component through a hydrothermal method so as to obtain the loading iron based metal organic skeleton out-phase Fenton catalyst, namely Fell@ MIL-100 (Fe). The catalyst is used for degrading an organic pollutant in waste water by using an out-phase Fenton catalyst system. Compared with the prior art, the loading catalyst prepared by the invention fully utilizes the advantages of MIL-100 (Fe) and a ferrous component in an out-phase Fenton reaction, so that the loading catalyst has high porosity, large specific surface area, and is stable in a water phase, catalytic activity sites are uniformly dispersed, the capacity is controllable and the like, meanwhile, the mutual circulation action of the Fe<2+> component in a carrier and a Fe<3+> in the basal body are utilized to further strengthen the Fenton reaction activity, the catalyst is suitable for removing refractory organics in waste water by catalytic oxidation of out-phase Fenton, the operation of the technology is simple, the cost is low, the preparation method is an efficient and energy-saving new technology, and the catalyst has the far-reaching application prospect and wide social and economic benefits.

Effective in-situ injection technology for the remediation of dense nonaqueous phase liquids (DNAPLs) such as trichloroethylene (TCE) benefits from the use of decontamination agents that effectively migrate through the soil media, and react efficiently with both dissolved TCE and bulk TCE. A novel decontamination system contains highly uniform carbon microspheres preferably in the optimal size range for transport through the soil. The microspheres are preferably enveloped in a polyelectrolyte (such as carboxymethyl cellulose, CMC) to which preferably a bimetallic nanoparticle system of zerovalent iron and Pd is attached. The carbon serves as a strong adsorbent to TCE, while the bimetallic nanoparticles system provides the reactivity. The polyelectrolyte serves to stabilize the carbon microspheres in aqueous solution. The overall system resembles a colloidal micelle with a hydrophilic shell (the polyelectrolyte coating) and a hard hydrophobic core (carbon). In contact with bulk TCE, there is a sharp partitioning of the system to the TCE side of the interface due to the hydrophobicity of the core. These multifunctional systems appear to satisfy criteria related to remediation and are relatively inexpensive and made with potentially environmentally benign materials. An aerosol process is preferably used to produce zerovalent iron particles supported on carbon. A method of lubricating includes creating carbon microspheres produced from a monosaccharide or polysaccharide, the carbon microspheres having a diameter of 50 nm to 6 microns, coating the microspheres with a surface coating and using the carbon microspheres as a lubricant.

The invention provides modified gold nanoparticles that enable a non-invasive, real time, targeted cancer imaging-therapeutic in one step. After reaching the cancer targets, the designed targeted gold nanoparticles significantly enhance conventional treatment modalities at the cellular level. In this aspect the gold nanoparticles of the invention are modified to be bound to a Positron Emission Tomography (PET) tracer.

The invention relates to a graphene / titanium dioxide composite material, a preparation method and application thereof. The graphene / titanium dioxide composite material comprises: graphene and titaniumdioxide particles closely attached to the graphene sheet. According to the invention, graphene and titanium dioxide are selected for compounding to obtain an efficient photocatalyst with the excellent properties of graphene and titanium oxide simultaneously.

The invention relates to a vehicle-mounted air purifier. Air inlets are formed on the front side and the rear side of a shell, and an air outlet is formed on the bottom surface; an air duct, a fan, an air purification module and a power supply system are arranged in the shell; the fan is arranged at the central position of the air duct; cold catalyst plates, stainless steel plates and photocatalyst plates of the air purification module are symmetrically arranged from the air inlets on the front side and the rear side of the shell to the inside of the shell sequentially by taking the fan as a symmetric center parallel to an arc-shaped plate and are fixed on the four walls of the air duct through supporting frames respectively; plasma generating electrodes are parallelly arranged on the air duct walls between the stainless steel plates and the photocatalyst plates; ultraviolet lamps are symmetrically arranged on both sides of the fan; the air outlet of the shell is provided with a high efficiency particulate air (HEPA) filtering material; a transformer and a ballast of the power supply system are arranged on the inner wall of the shell above the fan; the input ends of the transformer and the ballast are connected with a vehicle-mounted power supply on a vehicle, and the output ends of the transformer and the ballast are connected with the positive poles of the plasma generating electrodes and the ultraviolet lamps; and the negative poles of the plasma generating electrodes are grounded. The vehicle-mounted air purifier can effectively clean pollutants in carriages.

The present invention relates to compositions and methods for inducing cell death or stasis in cancer cells or other hyperproliferative cells using anti-EphA2 or anti-EphA4 antibodies conjugated to toxins.

The invention discloses a compound growth factor collagen sustained-release carrier material for promoting repair of various traumas in oral and maxillofacial regions and a method for preparing the same. In order to overcome the defect of poor curative effect existing in the conventional medicaments for treating the traumas of various tissues such as an oral cavity and a face, a bioactive collagen sustained-release material is prepared by combining collagen modified by liposome, chitosan, glycosaminoglycan and the like with one or more of a basic fibroblast growth factor (bFGF), a platelet derived growth factor (PDGF-BB), a vascular endothelial growth factor (VEGF) and a keratinocyte growth factor (KGF). The bioactive collagen sustained-release material is characterized in that: each gram of bioactive collagen sustained-release material contains not less than 10ng of growth factors, and the bioactive collagen sustained-release material has the obvious effect of treating various facial tissue traumas such as tooth extraction wound, oral ulcer, facial nerve injury, mandibular defect and the like. The collagen sustained-release carrier material can continuously release an effective amount of the growth factors to the wound for a long time, fully exert the inducing effect of the growth factors and obviously shorten the time for wound healing so as to fulfill the aim of treatment.

A method and apparatus are provided for the controlled application of ultrasonic energy for conditioning of mixtures of gas and liquids by evolving and / or agglomerating gas bubbles existing with or in a liquid or for coalescing droplets of liquid dispersed in another liquid. The invention in preferred embodiments thereof comprises a coalescing apparatus for Increasing the droplet size of a mixture formed as a liquid dispersed in another liquid, and a de-gassing apparatus arranged to evolve and / or agglomerate gaseous bubbles in a gas / liquid mixture. In the apparatuses, ultrasonic transducers are used to impart vibrational energy to the mixtures.

The invention relates to an artificial trachea cannula made of nano materials in the technical field of medical appliance and a preparation method thereof; the artificial trachea cannula comprises a respirator joint, an air supply tube, an inflation tube, an inflation gasbag, a drain pipe and a lubricant coating, wherein, the inflation tube is in the air supply tube, the output end of the air supply tube is connected with the respirator joint; an inserting section of the air supply tube is cuniform; the external wall of the air supply tube is provided with inflation gasbags; the position where the inflation tube is correspondingly arranged is provided with holes; the drain pipe is embedded on the external wall of the air supply tube and is adjacent to the inflation gasbag; the side of the drain pipe close to the inflation gasbag is provided with a liquid outlet, the other side thereof is connected with an injector; the lubricant coating is arranged on the external wall of the inflation gasbag and the air supply tube, the air supply tube and the inflation gasbag are made of modified plastics. With the method of the invention adopted, damage to lumen tissue when the tube is inserted is reduced, pain is reduced, complicating disease is prevented from occurring; in addition, the preparation process is easy and controllable, the cost is low, as a result, the method is applicable to batch production.

The invention discloses a method and a device for removing phosphorous from glyphosate production wastewater, and belongs to the field of wastewater treatment. The method comprises the steps as follows: adjusting the pH value of the wastewater to be 2-3, adding a ferrous salt A for uniformly mixing, then adding hydrogen peroxide for performing catalytic oxidation reaction, after the catalytic oxidation reaction is ended, adding a calcium salt for performing one-stage sedimentation, separating to remove sediments, and adding a ferrous salt B for performing two-stage sedimentation. The device for realizing the method comprises an adjusting pond, a homogenizing pond, a catalytic oxidation pond, a first sedimentation pond and a second sedimentation pond, which are communicated through a pipeline with a pump in sequence. The method and the device are used for treating the glyphosate production wastewater, and have the characteristics of thoroughly removing the phosphorous, effectively utilizing a catalyst and the like.

A compound Cu(DDC)2 with relatively high tumor-inhibiting activity can be used for treating cancers such as melanoma, breast cancer, lung cancer, liver cancer, and the like. The treatment effect is broad, and the compound has certain selective killing effect against tumor cells. The invention relates to an Cu(DDC)2 injection protein nano-particle preparation used for treating tumor, and a preparation method thereof. Therefore, problems of poor water-solubility and difficulty in intravenous administration of Cu(DDC)2 are solved. According to the invention, with an ultrasonic method, a high-pressure homogenization method, and a micro-jet method, the Cu(DDC)2 injection protein nano-particles are prepared. The Cu(DDC)2 protein nano-particles are prepared from the components that (Cu(DDC)2 + organic solvent) :(protein + water) = 1:2-1:30, wherein the specification of Cu(DDC)2 is 0.01-5mg / mL, the specification of protein is 0.05-25% (w / v), and a ratio of organic solvent to water is 1:2-1:30. Proteins such as human serum albumin (HSA), bovine serum albumin (BSA), hydrophobic protein, glycoprotein, and lipoprotein or polypeptide is adopted as a carrier and a stabilizer for coating medicine particles, such that the particles have good biocompatibility and high security. Cu(DDC)2 tumor-inhibiting treatment effect is improved, and adverse reaction is reduced.

The invention relates to a composite developing thermosensitive gel embolizing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a mixed aqueous solution of an anticancer active substance, a thermosensitive material and a developing agent into composite developing thermosensitive gel; secondly, forming a composite developing thermosensitive gel embolizing agent by the composite developing thermosensitive gel and a coagulant on the scene, wherein the thermosensitive material is hydroxyl C1-4 alkyl cellulose, Pluronic, alginate or a mixture of the substances; the anticancer active substance is arsenic trioxide, docetaxel, cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin, miriplatin, siRNA or a mixture of the substances; the developing agent is a water-soluble developing agent of iodixanol, ioversol or iohexol and the like. The preparation method disclosed by the invention is simple and convenient, is suitable for industrial large-scale production, is particularly suitable for preparing an embolizing agent which is biodegradable and good in biocompatibility and is used for hemorrhagic diseases, and is especially suitable for preparing the composite developing thermosensitive gel embolizing agent for treating liver cancer, kidney cancer, lung cancer, prostate cancer, uterine myoma or splenic tumor and the like.

The aquogel type thiamazole plaster includes a back lining layer, a medicine matrix layer and a protecting film. The medicine matrix layer contains medicine thiamazole in 0.2-20 wt% of the medicine matrix layer, aquogel type contact adhesive material, cross-linking agent, pH regulator, humectant, tackifier medicine, transdermal promoter and water, . The present invention has high transdermal effect of medicine, good skin compatibility, high air and moisture permeability, lowered toxicity and side effect of medicine and other advantages, and is used for treating hyperthyroidism.

The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin / mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting diagnostic, prophylactic and therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and / or lower effective maintenance doses, and / or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both. The present invention also relates to methods and materials for modulating a host humoral immune response, especially reducing, inhibiting, or preventing a host humoral immune response.

The invention provides a preparation method of a glass fiber titanium-dioxide-loaded composite material. According to the method, an organic or inorganic titanium compound is used as a titanium source and a glass fiber is used as a carrier to prepare a glass fiber titanium-dioxide-loaded nano grain composite material under an acidic condition through using a direct hydrolysis method; the shape controllability of glass fiber titanium-dioxide-loaded nano grains is realized by adjusting parameters of acid concentration, reaction time and the like of a reaction system. According to the method provided by the invention, the surface modification of the glass fiber is realized by using a one-step method; meanwhile, titanium dioxide with photocatalytic activity is uniformly loaded on the surface glass fiber; the method has the advantages of simplicity and convenience for operation, easiness of large-scale production and the like. The composite material has the characteristics of nano / micron multilayered-grade structure, large specific surface area, high catalytic performance and the like, and lays a foundation for the application to the fields of photocatalysis, antibiosis, phase-separation materials and the like.

The invention relates to a method for administrating preparations containing peramivir and / or derivatives thereof. Administration is carried out through inhalation. The method can be used for treating cold caused by influenza viruses. By adopting the administration method provided by the invention, not only can dependence on the single variety of drugs such as oseltamivir and zanamivir be reduced and new drug resistant virus strains generated by using the single variety in quantity be avoided but also the method which is favorable for greatly improving the bioavailability compared with oral administration or intravenous drip is provided for peramivir and / or derivatives thereof; more importantly, the method which has the advantages of small drug dose, less side effects and high effect taking speed is provided.

The invention discloses a preparation method of L-proline-loaded temperature / magnetism double responsive functional hybrid microspheres. The technical point is as follows: a temperature-sensitive amphipathic block polymer is obtained by polymerizing functional L-proline ProlA, a temperature-sensitive monomer N-isopropylacrylamide NIPAM and a hydrophilic monomer oligomeric ethylene glycol acrylate OEGA by virtue of a reversible addition fragmentation chain transfer (RAFT) polymerization method and is loaded to magnetic Fe3O4 nanoparticles by virtue of a ''click chemistry'' method so as to obtain the temperature / magnetism double responsive hybrid microspheres. The hybrid microspheres can be used for catalyzing direct asymmetric Aldol reaction in a water phase, and the temperature of a reaction system is higher than a lower critical solution temperature (LCST) of the block polymer, so that the improvement of the catalytic efficiency of the Aldol reaction and the release of organic products are benefited; and by virtue of the magnetism, the hybrid microspheres can be efficiently separated and recycled and repeatedly used.

The invention relates to a local oxygen-enriched combustor for a cement kiln furnace. Through the arrangement of an oxygen-enriched air passage outside an axial flow air passage of the combustor and the arrangement of a spray nozzle at an outlet of the oxygen-enriched air passage, the spray nozzle is arranged at the lower part of the outer side circumference of the air flow air spray nozzle and is near the clinker or analogue side, so the local concentration of the oxygen gas at the contact side of the lower part of the combustor and the oxygen-enriched air passage is raised, the combustion speed of the fuel can be accelerated, the local heat accumulation is directly caused, the adjacent fuel also begins to combust along with the proceeding of the diffusion, heat transfer and heat radiation processes, the temperature of the direct contact side of the clinker or analogue of a rotary kiln with the oxygen-enriched air passage is obviously raised, and the response to the raw material mass fluctuation caused by proportioning can be realized. In addition, a center angle corresponding to a distribution region in the circumferential direction is set to be smaller than or equal to 270 degrees, the angle range can completely cover the region of the fuel and the cement clinker or analogue rotating along with the rotary kiln, and the use precision and the economization of oxygen-enriched air can be ensured.

The invention provides an embolism material composition as well as preparation method and use thereof, and the embolism material is prepared from reactant raw materials through polymerization, wherein the reactant raw materials comprise a magnetic resonance imaging substance, and a monomer containing unsaturated double bonds and anion groups; in the polymer produced through the polymerization of the reactant raw materials, the magnetic resonance imaging substance is combined to the anion group of the produced polymer or dispersed in the polymer. According to the embolism material provided by the invention, a doctor is capable of monitoring and positioning the embolism material through the MRI in and after the embolization, thereby improving the curative effect and security of the embolization therapeutic.

The invention relates to the technical field of medical appliance. Ventilator associated pneumonia results from inhalation of secretion with pathogene, wherein, bacterial pollution of gas circuit of the ventilator is a key factor which causes the ventilator associated pneumonia. The invention aims at providing an artificial trachea cannula with broad-spectrum antibacterium property and controllable slowly-releasing drugs; an air providing tube (2), an air bag (4), an air tube (3) and a liquid discharging tube (5) of the artificial trachea cannula of the invention are coated with nanometre anti-microbial coatings (6) on inner and outer surfaces; the nanometre anti-microbial coatings are mainly blended by macromolecule polymers, nanometre inorganic antimicrobial and slowly-releasing drugs. The artificial trachea cannula with nanometre anti-microbial coatings of the invention not only satisfies traditional functions of artificial trachea in providing air path and maintaining respiratory tract clear, but also has functions of excellent bacteriostasis and slowly releasing of controllable drugs, thereby providing wide application prospect to clinical application of the artificial trachea cannula.

The invention relates to a preparation method for activated carbon aerogel electrode loaded with iron with mixed valences and applications. Iron with mixed valences obtained through hydro-thermal oxidation process is loaded on a surface of a matrix with high specific surface area and prepared through CO2 activating treatment, A Fe(mix) / ACA combined electrode is constructed. The electrode is used as a cathode in electro-adsorption auxiliary electro-Fenton, and degrades organic pollutants rapidly. Compared to the prior art, the activated carbon aerogel electrode loaded with iron with mixed valences has advantages of high poriness, large specific surface area, high conductivity, controllable appearance shape and the like. In addition, the electrode has good electro-Fenton catalytic activity, and is suitable for rapid degradation of organic waste water by electro-adsorption-Fenton catalytic oxidation. Under the action of electro-adsorption auxiliary enhancement, pollutants in sewage is degraded and removed efficiently and thoroughly. The technology has simple operation, is low-cost, is a new, efficient and energy saving technology and has wide economic and social benefits.

Synovial villi derived explants and related surgical tools used to repair or prevent damage to injured or diseased tissue, including connective tissue. The tools including a harvesting tool for selectively harvesting synovial villi from the joint of patient and a delivery tool having a bulbous end for delivering the synovial villi derived explants while reducing damage to surrounding tissue.

The invention discloses an assisted initiator amine-containing polymerizable thioxanthone carbazole visible light photoinitiator and a preparation method thereof. The preparation method comprises that a compound containing polymerizable and epoxy groups is added into an amine compound, the mixture undergoes a reaction, the amine is removed so that alcohol containing polymerizable and assisted initiator amine groups is obtained, the alcohol or the alcohol and pyridine are added into chloroform, a mixture of PBr3 and chloroform is dropwisely added into the mixture, the mixture undergoes a reaction, the reaction product is treated to form a bromo-compound containing polymerizable and assisted initiator amine groups, thioxanthone carbazole and alkali are added into N, N-dimethyl formamide (DMF), the mixture is stirred to form a uniform mixture, the bromo-compound, cupferron and the N, N-dimethyl formamide mixture are dropwisely added into the reaction system, the reaction system undergoes a reaction, and the reaction product is treated to form a product. The visible light photoinitiator avoids yellowing and toxicity caused by the micromolecule assisted initiator, reduces oxygen inhibition influences and improves a curing rate and cured film stability.

The invention discloses a gel type dexketoprofen plaster and method for preparation, which comprises backing material, gel type medicament material and anti-sticking material, wherein the medicament material contains 0.5-30.0 wt% of active medicinal constituents, 0.5-40.0 wt% of medicinal solvent, 0.5-30.0 wt% of humectant, and 0.5-8.0 wt% of transderrnal absorption promoting agent, the gel type medicinal material includes high- and low-molecular-weight poly vinyl pyrrolidone or copolymer containing vinyl pyrrolidone unit, polyvinyl alcohol, or polyvinyl alcohol and polyethylene glycol, cross linking agent and water. The invention also discloses its preparation.

The invention relates to oligomeric peptides with biological activity against HIV infection having the amino acid sequence (Z1-LE-X1-IP—X2—X3—X4—P—X5—X6—X7—X8—X9—X10—K—X11—X12—X13—X14—X15-Z2)n, wherein n indicates the number of monomeric peptide chains, whereby n is 2, 3 or 4; X1 is a lysine, alanine, or aspartic acid; X2 is a cysteine, methionine or isoleucine; X3 is a serine, cysteine, lysine or glycine; X4 is an isoleucine, alanine, phenylalanine or cysteine; X5 is a proline, D-proline or a substituted L- or D-proline; X6 is a cysteine or glutamic acid; X7 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X8 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X9 is an amino acid with an aromatic side chain; X10 is a glycine, alanine or asparagine; X11 is a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X12 is a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X13 is an amino acid with a hydrophobic or an aromatic side chain; X14 is an amino acid with a hydrophobic or an aromatic side chain; X15 is a phenylalanine or deletion; Z1 is NH2 or a sequence of 1 to 10 amino acid residues; Z2 is COOH or a sequence of 1 to 10 amino acid residues; and oligomeric peptides which are fragments thereof and / or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and / or glycosylated derivatives, and mutants thereof; and with the proviso that (a) if X12 is alanine, glycine, glutamic acid, or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid than X13, X14 and X15 are phenylalanine, valine and phenylalanine respectively; and / or (b) if X12 is phenylalanine, than X13, X14 and X15 are valine, phenylalanine and a deletion, respectively; and (c) there are at maximum three cysteine residues in a peptide; and (d) the oligomeric peptide has not the sequence (LEAIPCSIPPEFLFGKPFVF)2 (VIR-576); and (e) the monomeric peptide chains are not linked by peptide bonds between the N-terminus of one peptide chain to the C-terminus of another peptide chain.

The invention discloses a magnetic resonance imaging (MRI) detectable liquid embolism composition which comprises the following components: an MRI water-soluble or water-insoluble contrast medium, an embolism material, a physiological acceptable water-soluble organic solvent and water. The following components can be added according to the treatment goal and the clinical demand: an X ray-impermeable water-soluble or water-insoluble contrast medium and / or drugs. The MRI detectable liquid embolism composition disclosed by the invention has the characteristics of low viscosity, no toxicity, low cost and fast curing, can be injected, and is mainly used in local embolism treatment and relevant imageological examination of tumors, vascular malformation and hemostasis.

The invention relates to a ciclopirox olamine pessary capable of reducing toxic and side effects of a medicament caused by systemic delivery, increasing local concentration of the medicament, fully playing the therapeutic effectiveness of the medicament and improving the adaptability of patients. The pessary can realize zero order release and is prepared by the following materials by weight portion: 1 portion of ciclopirox olamine, 65 to 90 portions of substrate, 0.2 to 3 portions of stearic acid, 0.1 to 5 portions of hydrogenated castor oil and 0.05 to 2 portions of sodium benzoate.