The invention relates to a preparation method for sulfur-containing 3-methylene isoindoline-1-one. The preparation method comprises the steps that N-(2-(methylthio)phenyl) benzamide and methyl acrylate serve as substrates, Pd(OAc)2 serves as a catalyst, anhydrous copper acetate serves as an oxidizing agent, a mixture is put into a mixed solution of 1,2-dichloroethane and glacial acetic acid in anoil bath at 110 DEG C for reaction for 24 hours, after the reaction is ended, a solvent of the glacial acetic acid of the mixture is neutralized by using a sodium bicarbonate saturated solution, thena water layer is extracted by using ethyl acetate, a combined organic layer is dried by using anhydrous magnesium sulfate, the solvent is removed under reduced pressure, and residues are purified through a rapid column chromatography method so as to obtain a required product. The preparation method has the advantages that the raw materials are simple and easy to obtain, a preparation process is novel and simple, the pollution is less, the energy consumption is low, and the yield is high.