Synthesis method of phenanthridine and derivative of phenanthridine

A synthesis method and technology of derivatives, applied in the field of synthesis of phenanthridine and its derivatives, can solve the problems of not being universally applicable, difficult to obtain reaction raw materials, harsh reaction conditions, etc., and achieve strong substrate universality, economical Effects of energy consumption and mild reaction conditions
CN107778239AInactive Publication Date: 2018-03-09ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2018-03-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthesis method of phenanthridine as shown in a formula (I) and a derivative of the phenanthridine. In the synthesis method, o-arylphenylsulfimide shown as a formula (II) isused as a raw material and reacts in an organic solvent under the action of a [Cu] / Selectfluor catalyst to obtain a corresponding target product (I). The synthesis method disclosed by the invention has the advantages of cheap and easily available and low-toxicity catalyst, environmental friendliness, mild reaction conditions, high universality of functional group and easiness and convenience in operation. The formulas (I) and (II) are shown in the description.
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Description

(1) Technical field

[0001] The invention relates to a synthesis method of organic compounds, in particular to a synthesis method of phenanthridine and derivatives thereof. (2) Background technology

[0002] As a representative heterocyclic unit widely present in some natural products, alkaloids and functional material molecules, phenanthridine exhibits a wide range of biological activities, such as antimalarial, antitumor, anticytotoxic, antibacterial, etc. . Therefore, exploring efficient and selective synthesis methods of phenanthridine and its derivatives is of great significance in the fields of medicinal chemistry and materials science.

[0003] Among the reported synthetic methods of phenanthridine and its derivatives, intramolecular cyclization of ortho-substituted diaryl compounds is the main synthetic method. At present, the synthetic methods of relevant phenanthridine and its derivatives reported at home and abroad mainly contain the following methods: benzyne me...

Claims

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