The invention discloses a preparation method of
nitenpyram. The method comprises the steps: carrying out a catalytic reaction in a low-grade chlorinated
hydrocarbon solvent by taking N-ethyl-2-chloro-5-pyridinemethylamine and 1,1-dichloro-2-
nitroethylene as starting raw materials and anion exchange resin as an acid binding catalyst, ending the reaction, and carrying out
filtration to remove the anion exchange resin to obtain a solution of an intermediate compound (II); introducing
methylamine gases to the solution of the intermediate compound (II), ending the reaction, and carrying out
filtration; and concentrating a filtrate, and separating out a
crystal to obtain a target compound (I). The invention provides the preparation method of a synthesis process of
nitenpyram, the preparation method is few in reaction steps, simple in process as well as green and environment-friendly in process, and
nitenpyram is high in yield and quality. Compared with an existing technical process, the preparation method is simple and convenient in
process operation, low in operation cost, free of
wastewater discharge, capable of realizing recycle of the catalyst, green and environment-friendly in process, high in product quality and yield, low in cost, very suitable for industrial production and extremely high in industrial application value.