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62 results about "Nitroethylene" patented technology
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Nitroethylene (also known as nitroethene) is a liquid organic compound with the formula C₂H₃NO₂. It is the simplest nitroalkene, which are unsaturated carbon chains with at least one double bond and a NO₂ functional group. Nitroethylene serves as a useful intermediate in the production of various other chemicals.
Improved preparation method of nitenpyram
The invention relates to an improved preparation method of nitenpyram. The method comprises steps as follows: firstly, 1,1-dichloroethylene has a reaction with a nitration agent comprising hydrochloric acid and sodium nitrate to generate 1,1,1-trichlorine-2-nitroethane, and the 1,1,1-trichlorine-2-nitroethane has an elimination reaction with NaHCO3 to generate a 1,1-dichlorine-2-nitroethylene intermediate; secondly, 2-chlorine-5-chloromethylpyridine has a reaction with ethylamine, and an ethylamine intermediate is prepared; thirdly, the ethylamine intermediate has a reaction with 1,1-dichlorine-2-nitroethylene intermediate and monomethylamine, and the final product nitenpyram is generated. NaNO3 is used to replace traditional nitric acid to serve as a target phase transfer catalyst, the reaction selectivity is improved, the yield is higher, and the operation is safer.
Owner:SHANGHAI JINJING CHEM CO LTD
Preparation method of Rucaparib intermediate
The invention belongs to the field of medicine synthesis, and in particular relates to a preparation method of a Rucaparib intermediate 6-fluoro-3-[(E)-2-nitroethylene]-1H-indole-4-methyl formate. 3-amino-5-methyl fluorobenzoate is used as a raw material in the method, which reacts with a zinc reagent of 2-(2-bromoethyl)-1,3-dioxolane after being diazotized, then is hydrolyzed, and reacts with nitromethane. The preparation method has cheap and easily available materials, a refined reaction route, high reaction selectivity and high yield.
Owner:伦俊杰
Method for preparation of 1,1-diamino-2,2-dinitroethylene
ActiveUS20120178968A1Avoid reactionDecreased reaction timeOrganic compound preparationAmino compound preparationCombinatorial chemistryLab scale
Disclosed is a method for preparation of 1,1-diamino-2,2-dinitroethylene (DADNE) through the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine (DHDNDP) obtained by the nitration of 4,6-dihydroxy-2-methylpyrimidine (DHMP), which can avoid eruption or sudden frothing of a reaction solution on a lab scale and even a large scale preparation as well as reduce the reaction time.
Owner:AGENCY FOR DEFENSE DEV
Difluoroethyl-containing nitrosamine compounds and preparation method thereof
InactiveCN107827774AEasy to derivatizeMild reaction conditionsCarboxylic acid nitrile preparationOrganic compound preparationNitroethyleneCarboxylic acid
The invention discloses difluoroethyl-containing nitrosamine compounds and a preparation method thereof. A series of difluoroethyl-containing nitrosamine derivatives are obtained by taking carboxylicacid as a catalyst and carrying out an aza-Michael addition / nitrosation tandem reaction on three components, i.e., difluoroethylamine, tert-butyl nitrite and 1-aryl 2-nitroethylene at room temperaturein absence of other organic solvents. Molecular skeletons of the compounds contain potentially bioactive difluoroethyl and nitrosamine groups, thus establishing a material basis for drug discovery and druggability evaluation, and having an important application value. The preparation method provided by the invention adopts the easy-to-obtain raw materials, does not need an additional organic solvent, and has the advantages of mild reaction conditions, simple operation, high yield and good substrate universality.
Owner:ZUNYI MEDICAL UNIVERSITY
Method for synthesizing 4-aryl-4,5-dihydrofuran
The invention discloses a method for synthesizing 4-aryl-4,5-dihydrofuran under the catalysis of alkali, In the method aryl substituted nitroethylene and a 1,3-dicarbonyl compound taken as raw materials and dimethylsulfoxide taken as a solvent are reacted for 0.5 to 8 hours at the temperature of between 30 and 80 DEG C under the catalysis of the alkali to directly obtain the 4-aryl-4,5-dihydrofuran by a one pot method.
Owner:SICHUAN UNIV
1-methylamino-1- methylthio-2-nitroethylene synthesis method
InactiveCN1962626AEmission reductionProcess safetySulfide preparationChemical synthesisSynthesis methods
The invention discloses a new chemical synthesizing method of 1-motol-1-methylmercapto-2-nitroethylene as one intermediate of ulcer drug ranitidine, which comprises the following steps: adopting nitromethane, carbon bisulphide and potassium hydroxide as initial reacting material; synthesizing 1, 1-dimethyldisulphide-2-nitro ethylene to dissolve in the water; reacting with aminomethane to synthesize new intermediate product; filtering to obtain the product.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Preparation technology for 3-aryl-4-nitro isoxazole compound
InactiveCN107382892ARaw materials are cheap and easy to getEasy to purifyOrganic chemistryN dimethylformamideDimethyl acetal
The invention discloses a preparation technology for a 3-aryl-4-nitro isoxazole compound. The preparation technology comprises the following steps: synthesizing a compound shown as formula II through the nucleophilic addition of hydroxylamine hydrochloride and the compound shown as formula I used as the raw material; acquiring the compound shown as formula III through the substitution reaction of the compound shown as formula II and N-chlorosuccinimide; preparing 1-dimethyl amino-2-nitro ethylene through the reaction of N,N-dimethylformamide dimethyl acetal and nitromethane used as the raw material; and acquiring a target product 3-aryl-4-nitro isoxazole compound through the cyclization reaction of the compound shown as formula III and 1-dimethyl amino-2-nitro ethylene. The raw materials in the synthesis route are low in cost and easily acquired, the operation condition is mild and is easily controlled, the product is easily purified and the preparation technology is a new method for synthesizing the 3-aryl-4-nitro isoxazole compound.
Owner:GUIZHOU UNIV
Nanometer flaky 1,1-diamido-2,2-binitro ethylene explosive and preparation method thereof
ActiveCN105503487ASimple processShort preparation cycleNanotechnologyExplosive working-up apparatusOrganic solventExplosive Agents
The invention discloses a nanometer flaky 1,1-diamido-2,2-binitro ethylene explosive and a preparation method thereof. The preparation method includes the following steps that a 1,1-diamido-2,2-binitro ethylene explosive and surfactant are dissolved in an organic solvent, heated and stirred to be completely dissolved, then cooling is conducted at the speed of 0.5-10 DEG C / min under stirring for crystallization, and through filtering, washing and drying, the nanometer flaky 1,1-diamido-2,2-binitro ethylene explosive can be obtained. The nanometer flaky 1,1-diamido-2,2-binitro ethylene explosive prepared through the method is of an orderly nanometer flaky structure and is uniform in particle morphology, the sheet layer diameter is 1-2 micrometers, the sheet layer thickness is 80-120 nm, the crystal purity of the explosive is larger than 99%, and important application prospects are achieved in the field of booster explosives and the like. The preparation technological process is simple, the preparation period is short, the solvent can be recycled, reaction conditions are moderate, and good safety is achieved.
Owner:INST OF CHEM MATERIAL CHINA ACADEMY OF ENG PHYSICS
Sugar ester derivatives, reagents for measurement of hydrolase activity and methods for measurement of hydrolase activity
InactiveUS6162614ASugar derivativesMicrobiological testing/measurementNitroethyleneHydrolase activity
A sugar ester derivative of the general formula (I) wherein G stands for a group of the formula (A) or a group of the formula (B) wherein lambda means 0 or 1; at least one of R1 and R2 means an ester residue of a saturated or unsaturated fatty acid having 1-30 carbon atoms and the other group means hydrogen atom or acetyl group, and R3 means a group of the formula (C) wherein X means a halogen atom, m means an integer of 0 to 4, Y means hydroxy group, an alkoxy group, a carboxyl group or sulfonic acid group, n means 0 or 1 and Z means nitro group or nitrovinyl group and its use. The sugar ester derivative of the general formula (I) is useful as a substrate for the measurement of lipase or esterase activities, and the reagents and the methods for measuring lipase or esterase activities which comprise said sugar ester derivative as the substrate are excellent in terms of reproducibility and sensitivity and enable the measurement of lipase or esterase activities in accordance with rate-assay method by an easy procedure.
Owner:TOYO TOYOBO CO LTD
Synthetic method of 2-(2-nitroethylenyl)-furan and its purpose as anti-coccidium agent
InactiveCN1571780ASatisfied with the resultOrganic active ingredientsOrganic chemistry methodsFuranActivated carbon
The invention relates to a method of obtaining and purifying 2-(2-nitrovinyl)furane consisting in reacting furfural and nitromethane, using isobutylamine as a catalyst and activated carbon as an adsorbent, in order to obtain a product of pharmaceutical quality. Said technique considerably reduces the environmental impact by eliminating the gaseous waste from the system by means of absorption in water. The inventive pharmaceutical composition contains 2-(2-nitrovinyl)furan and has powerful action against low concentrations of coccidia.
Owner:CENT DE BIOACTIVOS QUIMICOS CBQ
Synthetic method of 2-thiofuran ethylamine
Owner:TAIYUAN UNIV OF TECH
Method for synthesizing 2-thienyl ethylamine by means of biological catalysis
ActiveCN106947795ALow costMild reaction conditionsBacteriaMicroorganism based processesBacillus licheniformisPhosphate
The invention relates to a method for synthesizing 2-thienyl ethylamine by means of biological catalysis. The method comprises the steps of preparing glucose, disodium hydrogen phosphate and potassium dihydrogen phosphate into a water solution according to a certain proportion, sterilizing and cooling to obtain a bacillus licheniformis culture medium; activating the obtained bacillus licheniformis culture medium in a shaking table at the constant temperature according to a certain cell concentration; then, dissolving 2-nitro vinyl thiophene, adding the solution into the activated culture medium, carrying out a biological catalysis reaction, and then carrying out centrifugal separation; extracting supernatant by using ethyl acetate, washing, drying, and carrying out reduced pressure distillation to obtain the product 2-thienyl ethylamine. The method has the remarkable characteristics and progress of being simple in technology, high in synthetic yield, low in cost and less in environmental pollution.
Owner:TAIYUAN UNIV OF TECH
Anti-beta-farnesene analog containing guanidine or nitro-ethylene as well as preparation method and applications thereof
InactiveCN102030685AReduce manufacturing costImprove biological activityBiocideOrganic compound preparationSulfurNitroethylene
The invention discloses an anti-beta-farnesene analog containing guanidine or nitro-ethylene, belonging to the field of organic compound synthesis. The compound is in a structure in a general formula (1) and is obtained by making raw materials, such as S-methyl-N-nitro phthalic acyl isothiourea, cyano imine dimethyl dithiocarbamate or 1,1-dimethyl sulfur-2-nitroethylene react with different amines under alkaline condition. The compound has favorable aphid killing chemical activity. Compared with anti-beta-farnesene, the compound has high activity and good stability and can be practically applied to agricultural production.
Owner:CHINA AGRI UNIV
Synthesis method of 2-nitroethenyl thiophene
The invention relates to a synthesis method of 2-nitroethenyl thiophene. The synthesis method comprises the following steps: adding 2-thiophenecarboxaldehyde, nitromethane, beta-alanine dissolved with acetonitrile and a solvent into a reaction flask, reacting for 1h under unltrasound irradiation; after reaction, removing acetonitrile, filtering out beta-alanine, concentrating, and recrystallizing residues to obtain 2-nitroethenyl thiophene. The synthesis method provided by the invention has the characteristics of low cost, simpleness and convenience in operation, high yield and the like, and is suitable for industrial production.
Owner:山西瑞谱德科技有限公司
Preparation method and application of 1-amino-1-hydrazino-2,2-dinitroethylene bismuth salt
InactiveCN102161628AReduce Burn Rate Pressure IndexBoost energy levelsHydrazine preparationPressure gas generationHydrazine compoundSynthesis methods
The invention relates to a preparation method of 1-amino-1-hydrazino-2,2-dinitroethylene bismuth salt. The method comprises the following steps: synthetizing 1-amino-1-hydrazino-2,2-dinitroethylene potassium salt by using 1,1-diamino-2,2-dinitroethylene, hydrazine hydrate and KOH as raw materials, then reacting with soluble metal salts such as bismuth nitrate to prepare 1-amino-1-hydrazino-2,2-dinitroethylene bismuth salt. The synthesis method is simple; the industrialized production is easy to operate; and the synthesized 1-amino-1-hydrazino-2,2-dinitroethylene bismuth salt is a new high-energy compound, is used as green and energetic combustion catalyst and can be used to greatly reduce the burning rate pressure exponents of the double-base propellant and the modified double-base propellant.
Owner:SHAANXI NORMAL UNIV
Preparation method of nitenpyram
InactiveCN108822025AMild reaction conditionsEasy to operateOrganic chemistryChemical recyclingFiltrationNitroethylene
The invention discloses a preparation method of nitenpyram. The method comprises the steps: carrying out a catalytic reaction in a low-grade chlorinated hydrocarbon solvent by taking N-ethyl-2-chloro-5-pyridinemethylamine and 1,1-dichloro-2-nitroethylene as starting raw materials and anion exchange resin as an acid binding catalyst, ending the reaction, and carrying out filtration to remove the anion exchange resin to obtain a solution of an intermediate compound (II); introducing methylamine gases to the solution of the intermediate compound (II), ending the reaction, and carrying out filtration; and concentrating a filtrate, and separating out a crystal to obtain a target compound (I). The invention provides the preparation method of a synthesis process of nitenpyram, the preparation method is few in reaction steps, simple in process as well as green and environment-friendly in process, and nitenpyram is high in yield and quality. Compared with an existing technical process, the preparation method is simple and convenient in process operation, low in operation cost, free of wastewater discharge, capable of realizing recycle of the catalyst, green and environment-friendly in process, high in product quality and yield, low in cost, very suitable for industrial production and extremely high in industrial application value.
Owner:SHANGHAI JINJING CHEM CO LTD
Method for preparing spherical 1,1-diamino-2,2-dinitroethylene crystal assisted by ultrasonic assistance
InactiveCN110698350ALess transparent defectsImprove fluidityAmino compound purification/separationNitrated acyclic/alicyclic/heterocyclic amine explosive compositionsUltrasonic assistedNitroethylene
The invention discloses a method for preparing spherical 1,1-diamino-2,2-dinitroethylene crystals by ultrasonic assistance, and the method comprises the following steps of: 1) adding Fox-7, an organicsolvent and an additive into a crystallization kettle to be fully dissolved to prepare a saturated solution, wherein the water temperature of the crystallization kettle is controlled at 20-40 DEG C;(2) adding an antisolvent dropwise to the saturated solution while stirring to form a supersaturated solution and then performing crystal nuclei generating and crystal growth; 3) after the crystal iscompletely separated out, performing ultrasonic treatment on the crystal in mother liquor while stirring, wherein the ultrasonic treatment time is 1-3 hours, and the ultrasonic frequency is 30-70 khz;and 4) filtering, washing and drying to obtain a spherical FOX-7 crystal. The spherical FOX-7 crystal prepared by the method has smooth surface, few transparent defects in the crystal and good fluidity; the process is simple and easy to control, the anti-solvent consumption is small and recyclable, the reaction conditions are mild, safe and reliable, green and efficient, and industrialization iseasy to realize.
Owner:ZHONGBEI UNIV +1
Method for preparing (E)-1, 3-diphenyl-4-nitro-1-butene
ActiveCN109796344AHigh yieldEasy to operateOrganic chemistryOrganic compound preparationNitroethyleneRoom temperature
A method for preparing (E)-1, 3-diphenyl-4-nitro-1-butene comprises the following steps: using (E)-1-dimethylamino-2-nitroethylene (I), (E)-1, 3-diphenyl propylene (II) as raw materials, using 1, 2-dichloroethane as a solvent, reacting at room temperature to be complete under the combined action of DDQ and an acidic catalyst, and then carrying out post-treatment on the reaction solution to obtaina target product (III); the method has the advantages of high yield, simple and safe operation, easily obtained raw materials and the like.
Owner:ZHEJIANG UNIV OF TECH
Nitroethylene-containing ester compound as well as preparation method and application thereof
InactiveCN106831437AEnhanced inhibitory effectOrganic compound preparationMetabolism disorderDiseaseNitroethylene
The invention relates to the field of fructose-1,6-biphosphatase inhibitors, and specifically discloses a nitroethylene-containing ester compound. The ester compound is the compound as shown in a formula (1). The invention further discloses a preparation method of the compound as shown in the formula (1). The invention further discloses another nitroethylene-containing ester compound which is the compound as shown in the formula (2). The invention further discloses a preparation method of the compound as shown in the formula (2). The invention further provides application of the nitroethylene-containing ester compounds or pharmaceutically acceptable salt in preparation of medicines such as the medicine for inhibiting fructose-1,6-biphosphatase, and the medicine for treating or preventing gluconeogenesis metabolic disease or thrombus diseases.
Owner:HUAZHONG NORMAL UNIV
A kind of preparation method of 5-hydroxytryptamine hydrochloride
The invention discloses a preparation method of 5-hydroxytryptamine hydrochloride, in particular to the high-efficiency synthesis of 5-hydroxytryptamine salt in two steps of addition reaction and reduction reaction using 5-hydroxyindole and nitroethylene as raw materials salt, the preparation method of 5-hydroxytryptamine hydrochloride provided by the invention is a preparation method with high yield, low cost, less waste, good product purity and suitable for industrialization.
Owner:南京法恩化学有限公司
Method for synthesizing 2-amino-5-nitrothiazole
The invention discloses a method for synthesizing 2-amino-5-nitrothiazole, which comprises the following steps: (1) in an inert atmosphere, adding diethylamine, acetyl chloride and triethyl orthoacetate into a reaction container, uniformly mixing, stirring to react for 12-24 hours, and distilling and purifying the reaction product to obtain N, N-dimethylformamide dimethyl acetal, (2) in an inert atmosphere, mixing N, N-dimethylformamide dimethyl acetal with nitromethane, heating the mixture to 80-100 DEG C for reflux reaction, carrying out reduced pressure distillation on the reaction productto remove the solvent, and purifying to obtain N, N-dimethyl nitroethylene, and (3) in an inert atmosphere, putting N, N-dimethyl nitroethylene into a reaction container, sequentially adding ethanol,liquid bromine and thiourea, reacting at room temperature, after the reaction is finished, filtering a reactant, washing with ice ethanol, drying to obtain a white solid, adding water, and filtering to obtain the 2-amino-5-nitrothiazole. According to the method for synthesizing 2-amino-5-nitrothiazole, the raw materials are easy to obtain, the cost is low, and the yield can reach 60%.
Owner:苏州煜佳生物医药技术有限公司
3-4'-5-trihydroxystilbene nitroethylene compound as well as preparation method and application thereof
InactiveCN110041204AStrong inhibitory activityOrganic compound preparationCarbonyl compound preparationCancer cell linesNitroethylene
The invention discloses a 3-4'-5-trihydroxystilbene nitroethylene compound as well as a preparation method and application thereof, and relates to the technical field of drug design and synthesis. The3-4'-5-trihydroxystilbene nitroethylene compound has the following general formula (the formula is shown in the description). According to the 3-4'-5-trihydroxystilbene nitroethylene compound as wellas the preparation method and application thereof, the 3-4'-5-trihydroxystilbene nitroethylene compound is designed and prepared, and the prepared 3-4'-5-trihydroxystilbene nitroethylene compound isapplied to the preparation of anti-cancer drugs; the results of biological activity tests show that the 3-4'-5-trihydroxystilbene nitroethylene compound has good inhibiting activity on a human gastriccancer cell line MGC 803, a human liver cancer cell line SMMC-7721 and a human breast cancer cell line MDA-MB-231, and thus, the preparation of the 3-4'-5-trihydroxystilbene nitroethylene compound isof great significance for screening out novel anti-cancer drugs.
Owner:HEFEI UNIV OF TECH
1, 1-diamino-2, 2-dinitroethylene/nano aluminum powder composite energetic particle as well as preparation method and application thereof
ActiveCN114874060AInhibition of spontaneous agglomerationNarrow particle size distributionExplosive working-up apparatusBulk chemical productionExplosive AgentsAdhesive
Owner:ZHONGBEI UNIV
Clean fuel gas generating agent
The invention relates to a clean fuel gas generating agent, which is characterized in that chlorine-free 1,1-diamino-2,2-dinitroethylene is introduced into a formula of the fuel gas generating agent,and serves as a clean oxidizing agent to replace ammonium perchlorate, and the problems that the fuel gas generating agent is large in combustion smoke and large in residue amount are solved. The clean fuel gas generating agent disclosed by the invention has the characteristics of being clean in gas, low in residue, low in characteristic signal, safe, insensitive and the like. The fuel gas generating agent is applied to a power source of an aircraft, so that the combat effectiveness and the war survival ability of the aircraft are greatly improved, and the fuel gas generating agent has an extremely wide application prospect.
Owner:HUBEI INST OF AEROSPACE CHEMOTECHNOLOGY
Synthesis method of 2-nitroethenyl thiophene
The invention relates to a synthesis method of 2-nitroethenyl thiophene. The synthesis method comprises the following steps: adding 2-thiophenecarboxaldehyde, nitromethane, beta-alanine dissolved with acetonitrile and a solvent into a reaction flask, reacting for 1h under unltrasound irradiation; after reaction, removing acetonitrile, filtering out beta-alanine, concentrating, and recrystallizing residues to obtain 2-nitroethenyl thiophene. The synthesis method provided by the invention has the characteristics of low cost, simpleness and convenience in operation, high yield and the like, and is suitable for industrial production.
Owner:山西瑞谱德科技有限公司
A kind of synthetic method of 2-chloro-5-((2-(nitromethylene)imidazolin-1-yl)methyl)pyridine
The invention provides a synthetic method of 2-chlorine-5-((2-(nitromethylene)imidazoline-1-yl)methyl)pyridine. The method comprises the steps of taking 2-chlorine-5-nitrapyrin as a starting material, enabling the starting material to be subjected to a substitution reaction with ethylenediamine in the presence of a phase transfer catalyst and alkali to generate chloropyridine ethylenediamine, adding 1,1-dimethoxy-2-nitroethylene into the same reaction vessel, performing a reflux reaction, performing after-treatment to prepare a target product, i.e., the 2-chlorine-5-((2-(nitromethylene)imidazoline-1-yl)methyl)pyridine is synthesized by a one-pot method. By adopting the synthetic method, the target product of high content can be obtained, an intermediate of the first-step reaction does not need separation and purification, the two-step synthesis unit operation is completed in the same reaction vessel, the equipment utilization rate is high, the after-treatment is simple in process, the operation conditions are mild, thus a prospect of industrial production is achieved.
Owner:SHANGHAI SHENGNONG PESTICIDE
Preparation method of 5-hydroxytryptamine hydrochloride
The invention discloses a preparation method of 5-hydroxytryptamine hydrochloride, and particularly relates to a method for efficiently synthesizing the 5-hydroxytryptamine hydrochloride by taking 5-hydroxyindole and nitroethylene as raw materials through addition reaction and reduction reaction. The preparation method of the 5-hydroxytryptamine hydrochloride provided by the invention is a preparation method which is high in yield, low in cost, less in three wastes, good in product purity and suitable for industrialization.
Owner:南京法恩化学有限公司
(Arylamidoanilino)nitroethylene compounds
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis / mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer / T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
Owner:OSI PHARMA INC
Process for synthesizing 1- methylamino-1-methoxy-2-nitroethylene
ActiveCN101462969BAdvantages of production operationSecurity advantageOrganic compound preparationAmino-hyroxy compound preparationWater methanolPtru catalyst
A method for synthesizing 1-methyl amino-1-methoxy-2-nitroethylene relates to a compound. The invention provides a method of high yield coefficient and purity quotient for synthesizing 1-methyl amino-1-methoxy-2-nitroethylene, the method is applicable to large-scale industrial production. A catalyst is dissolved in absolute methanol solution; 1-methyl amino-1-methyl mercapto-2-nitroethylene are added in, stirred and heated up to reflow; the methyl alcohol is processed by reduced pressure evaporation to dryness to obtain a yellow solid matter; and the solid matter obtained by recrystalization by ethyl alcohol is the target product. The invention does not need to use methylene dichloride highly toxic solvent, thereby having advantages in production operation safety and environmental protection. The used raw materials are low in cost and available, unit operations are less, the steps like extraction and dryness, and the like, are saved, the operation safety of operating personnel is improved, the unit operation production period is shortened, and the production cost is greatly reduced, thus being suitable for industrial production. The yield coefficient of the reaction can be increased from 35.2% to 40-65%, thus obviously reducing the cost.
Owner:福建深纳生物工程有限公司
Water-soluble cationic polyamidine and preparation method thereof
The invention relates to a preparation method of water-soluble cationic polyamidine, which comprises the following steps that S1, in an organic solvent, dinitrovinyl benzene, N, N-dibromocarbamate and bis-secondary amine react to prepare t-butyloxycarbonyl substituted polyamidine, the reaction temperature is 40-80 DEG C, and the reaction time is 6-72 hours; the molar ratio of the dinitrovinyl benzene to the N, N-dibromocarbamate to the bis-secondary amine is 1: 2: (0.5-2), and the concentration of the dinitrovinyl benzene is 0.01-10 mol / L; and S2, the t-butyloxycarboryl is removed to obtain the water-soluble cationic polyamidine. The water-soluble cationic polyamidine is prepared by using dinitrovinyl benzene, N, N-dibromocarbamate and bis-secondary amine as raw materials through reaction, the preparation method is simple to operate, mild in reaction condition, environment-friendly and free of a metal catalyst, the prepared water-soluble cationic polyamidine has water solubility, the biocompatibility is improved, and the gene can be effectively entrapped.
Owner:JIANGSU ZHONGLI GRP CO LTD +1
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