Synthetic method of beta-iodo-alkenyl sulfone compound

The technology of an iodoalkenyl sulfone and a synthesis method is applied in the field of synthesizing β-iodoalkenyl sulfones, which can solve the problems of potential safety hazards, lack of environmental friendliness, etc. Adaptability, mild effect of reaction conditions
CN108997178AActive Publication Date: 2018-12-14GUANGZHOU YUEWANG AGRI CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU YUEWANG AGRI CO LTD
Publication Date
2018-12-14

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Abstract

The invention discloses a synthetic method of a beta-iodo-alkenyl sulfone compound. The synthesis method comprises the following steps: mixing an alkyne derivative, a sulfonyl hydrazine derivative, iodine pentoxide and a solvent to obtain a mixed solution, carrying out stirring for a reaction, carrying out cooling after the reaction is finished, and carrying out column chromatography separation toobtain the beta-iodo-alkenyl sulfone compound represented by a formula III. According to the synthesis method, the iodine pentoxide is used as an iodine source and an initiator, the raw materials arecheap and are simple and easy to obtain, the application range of alkyne and sulfonhydrazide compounds is wide, reaction conditions are mild, post-treatment is simple, and the product yield is high.In addition, use of peroxides is avoided, so that the method is safe and is friendly to the environment, and reaction toxicity is low.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a synthesis method of β-iodoalkenyl sulfone compounds. Background technique

[0002] Functionalized olefin compounds are important organic intermediates in organic chemistry, and their functional group structures can be further transformed into other useful chemical products. Addition reactions via alkynes are one of the important routes to prepare functionalized alkenes. In recent years, the 1,2-difunctionalization reaction of alkynes has attracted great attention of chemists because of the advantages of one-step introduction of two functional groups, high selectivity and simple post-treatment. Among them, β-iodoalkenyl sulfone, as a multi-substituted olefin compound, has attracted great attention because of its rich conversion properties between iodine atom and sulfone functional group, and various chemical reactions can occur.

[0003] Generally, β-iodo...

Claims

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