Method for synthesizing 2,3-dihydrobenzofurans compound

A technology of dihydrobenzene and compounds, applied in the direction of steroids, chemical instruments and methods, compounds of group 4/14 elements of the periodic table, etc., which can solve the problems of poor reaction selectivity, poor universality of epoxy substrates, and raw material synthesis Difficulty and other issues
CN108329285AInactive Publication Date: 2018-07-27WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV
Publication Date
2018-07-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for synthesizing a 2,3-dihydrobenzofurans compound. The method comprises the following steps: dissolving aromatic iodide, an epoxy compound, a palladium catalyst, a phosphine ligand and a norborene derivative in an organic solvent together; then carrying out stirring reaction at the temperature of 30-120 DEG C; and carrying out separation and purification after reaction to obtain the 2,3-dihydrobenzofurans compound. By the method, the 2,3-dihydrobenzofurans compound can be synthesized efficiently, economically and environmentally friendly. The method is gentle in condition, good in substrate universality and high in yield, and the prepared 2,3-dihydrobenzofurans compound is widely applied to the fields of medicinal chemistry and organic chemistry.
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Description

technical field

[0001] The invention relates to a method for synthesizing 2,3-dihydrobenzofuran compounds, belonging to the field of organic synthesis. Background technique

[0002] 2,3-Dihydrobenzofuran is an important structural unit widely present in many biologically active natural products and pharmaceutical molecular structures[a) Nichols,D.E.; Hoffman,A.J.; Oberlender,R.A.; Riggs,R.M.J. Med.Chem.1986,29,302.b) Saito, M.; Ueo, M.; Kametaka, S.; Saigo, O.; Uchida, S.; Mori, A.; Ishii, K. Biol. Pharm. Bull. 2008, 31, 1959.c) Huang, Z.; Cui, Q.; Xiong, L.; Wang, Z.; Wang, K.; Zhao, Q.; Bi, F.; Wang, Q.J. Agric. FoodChem. 2009, 57, 2447.d) Lee, I.-S.; Kim, H.-J.; Youn, U.-J.; .-C.; Kim, J.-P.; Ha, D.T.; Ngoc, T.M.; Min, B.-S.; Lee, S.-M.; K.; Bae, K.-H. Helv. Chim. Acta. 2010, 93, 272. e). Radadiya, A; Shah, A. Eur. J. Med. Chem. 2015, 97, 356.]. At present, there are many reports on the synthesis methods of 2,3-dihydrobenzofuran compounds [a) Bertolini, F.; Pineschi, ...

Claims

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