1105results about "Metallocenes" patented technology

The invention discloses tris (dimethylamino) cyclopentadienyl hafnium and a preparation process thereof.The preparation process of the tris (dimethylamino) cyclopentadienyl hafnium comprises the following steps that S1, an n-hexane solution of n-butyllithium and dimethylamine are subjected to a reaction, and a lithium dimethylamino emulsion is obtained; s2, adding hafnium tetrachloride into the lithium dimethylamino emulsion for reaction, and separating to obtain a liquid-phase product; s3, the liquid-phase product is heated, a tetra (dimethylamino) hafnium concentrated solution is obtained, and the volume of the tetra (dimethylamino) hafnium concentrated solution is 20%-30% of the volume of the liquid-phase product; and S4, obtaining cyclopentadiene, adding the cyclopentadiene into the tetra (dimethylamino) hafnium concentrated solution to react, and filtering to obtain tris (dimethylamino) cyclopentadienyl hafnium. According to the preparation process of the tris (dimethylamino) cyclopentadienyl hafnium, complex solvent components are not needed, the preparation efficiency is improved, and the use amount of the solvent and the preparation cost are reduced.

The 5-OMe-6-tBu substitution of the indenyl fragment of the C1 symmetric catalyst is crucial to improve the EP molecular weight capability. The catalyst described in this document is also capable of producing other conventional polyolefins such as iPP, PE and EO copolymers. The added capability of high molecular weight EP copolymers can broaden the possibilities of the C1 symmetric system in the fields of RCP and ICP where such capability is required.

The invention provides a novel chiral ferrocene bridged binaphthyl skeleton phosphine ligand and application thereof. The ligand has the advantages of low cost, simplicity in synthesis, air stability and the like. The ligands have good catalytic activity and enantioselectivity in the asymmetric hydrogenation reaction of ketone, and have certain industrial application prospects in the synthesis of pharmaceutical molecules.

The invention belongs to the field of electronic materials, and particularly relates to a synthesis method of a high-purity metal complex precursor. Compared with a synthesis method in the prior art, the synthesis method provided by the invention changes a reaction route, substituted cyclopentadiene is prepared firstly, then the substituted cyclopentadiene reacts with butyl lithium and metal chloride in sequence to obtain a substituted cyclopentadienyl metal trichloride intermediate, and finally the substituted cyclopentadienyl metal trichloride intermediate reacts with lithium dialkylamino to obtain the substituted cyclopentadienyl metal trichloride. The target product substituted cyclopentadienyl tri (dialkylamino) metal complex is obtained, and the prepared product is high in yield and purity. The synthesis method provided by the invention is convenient for large-scale production in factories, improves the productivity, and meets the ever-increasing market demand.

The invention discloses an osthole compound, a metal complex and a preparation method and application of the osthole compound, the osthole compound (OST-Alkyne) has remarkable anti-tumor biological activity, osthole (OST) and a cyclometalated iridium precursor are further connected through a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, higher anti-tumor activity is shown, and the osthole compound has a good application prospect. Mitochondria is targeted, and tumor is killed by reducing mitochondrial membrane potential and inducing cell autophagy and necrotic apoptosis; according to the invention, natural products are combined with metals, so that not only are good selectivity and anti-proliferation ability to brain glioma cells realized, but also toxic and side effects to normal cells are overcome, a new design idea is provided for novel metal drugs to treat brain glioma, and the application prospect is wide.

The disclosure relates to a metallocene complex of formula (I), wherein Mt is Zr or Hf; X is a sigma ligand; R1 are each independently, same or different from each other, C1-C20-hydrocarbyl, optionally containing up to two heteroatoms of Group 14-16 of the Periodic Table, or form, together with the Si atom they are attached to, a C4-C8-ring; R2 and R2' are each independently, same or different from each other, C6-C10-aryl, heteroaryl, or CH2-R21, with R21 being H or C1-C10-hydrocarbyl; n are each independently, same or different from each other, an integer from 1 to 5; R3 and R4 are each independently, same or different from each other, H, linear or branched C1-C6-alkyl, C7-C20-arylalkyl, C7-C20-alkylaryl, C6-C20-aryl, or -OR31, with R31 being C1-C10-hydrocarbyl, whereby at least one R3 per present phenyl group and at least one R4 is not H; R5 and R6 are each independently C1-C10-hydrocarbyl or form together with neighbouring oxygen atoms -O(R61)m-O-, wherein R61 is independently -CH2-, -CHR*-, or -C(R*)2- group, with R* being C1-C2-alkyl and m being an integer from 2 to 4; R5' and R6' are each independently C1-C10-hydrocarbyl or form together with neighbouring oxygen atoms –O(R61')m-O-, wherein R61' is independently -CH2-, -CHR*-, or –C(R*)2- group, with R* being C1-C2-alkyl and m being an integer from 1 to 4; R7 is H, Me, OMe, or C6-C20-aryl, whereby the C6-C20-aryl is substituted 1 to 5 times with R3, whereby at least one R3 per said aryl group is not H.

Diaryl silane bridged metallocene catalysts, methods of making the same, and propylene polymers (copolymers) made therefrom. The obtained silane-bridged metallocene catalyst has very high activity in the polymerization of olefins, especially ethylene and propylene. The diarylsilane bridged metallocene may be synthesized by substituting a dichlorocyclopentadienyl fragment with lithium indenyl. Direct lithiation / substitution with an aryl or alkyl lithium reagent provides a dilithiated ligand that undergoes metallization with a Group IV metal precursor.

To provide, e.g., a transition metal compound capable of producing an olefin polymer having a high molecular weight and a high melting point with high productivity, even under high-temperature conditions that are advantageous in industrial production methods.SOLUTION: A transition metal compound (A) is represented by the general formula [I] in the figure.SELECTED DRAWING: None

The invention relates to a nano assembly for self-synergistically enhancing ferroptosis as well as a preparation method and application of the nano assembly, and belongs to the technical field of pharmaceutical preparation combined treatment of new auxiliary materials and new dosage forms. The invention firstly provides a functional conjugate linker capable of automatically generating ROS, the functional conjugate linker comprises artesunate-ferrocene or dihydroartemisinin-ferrocene, and the structural formulas of the functional conjugate linker and the artesunate-ferrocene or dihydroartemisinin-ferrocene are respectively shown as a and b. According to the present invention, the ROS self-generating functional conjugate linker and the ferroptosis inducer are co-assembled to form the nanometer assembly, such that the ROS level in the tumor cells can be effectively and synergistically improved by the ROS self-generating functional conjugate linker and the ferroptosis inducer so as to cause the tumor cell lipid peroxidation storm, and the ferroptosis induction effect can be significantly improved. The co-assembled nano preparation provided by the invention provides a new strategy and more choices for developing the delivery of drugs, and meets the urgent requirements of efficient and diversified ferroptosis-based cancer treatment strategies on preparations in clinic. # imgabs0 #

Compounds with redox molecular cores and branched molecular tails comprising ionic functionalities for uses as electrolytes in redox flow batteries are described, as well as methods of synthesis and use thereof. The compounds have redox active perylene diimide or ferrocene molecular core decorated with the branched molecular tails having multiple ionic functionalities to improve water solubility of the molecular core, and, as such, its performance as the electrolyte.

The invention relates to the technical field of chemical engineering, and discloses a metallocene compound, a preparation method, a metallocene catalyst and an application of the metallocene catalyst. The chemical structure of the metallocene compound provided by the invention comprises a fluorenyl ligand, a metallocene ligand, a bridging structure and a metal part, and an adsorption group with a micropore effect is introduced into the fluorenyl ligand, so that when the metallocene compound provided by the invention interacts with cocatalysts such as organic boron, organic aluminum and the like, the metallocene compound has the advantages that the adsorption efficiency is improved; compared with the prior art, the catalyst provided by the invention has the advantages of high saturated adsorption capacity, increase of the concentration of the cocatalyst around the metal center, and substantial enhancement of the activity and thermal stability of the catalyst, so high-activity catalysis of alpha-olefin polymerization can be realized, the usage amount of the cocatalyst is reduced, and the production cost of polyolefin is reduced.

The invention provides a preparation method and application of an asymmetric dicyclopentadienyl dialkoxy zirconium compound, and the preparation method comprises the following steps: (1) mixing a solvent with ZrCl4 and sodium cyclopentadienyl CpNa, and carrying out a reaction to obtain CpZrCl3; (2) the CpZrCl3 obtained in the step (1) and R1 substituted sodium cyclopentadienyl R1CpNa are subjected to a mixed reaction, and (R1Cp) CpZrCl2 is obtained; and (3) mixing the (R1Cp) CpZrCl2 obtained in the step (2) with alkoxy sodium salt R2Na, and carrying out a reaction so as to obtain the asymmetric dicyclopentadiene dialkoxy zirconium compound. According to the method, the substitution reaction of three sodium salts is used for replacing the ligand replacement reaction in the prior art, so that the reaction steps are shortened, the use of unnecessary raw materials is avoided, the production cost is reduced, and the obtained target product is high in yield and high in purity.

Compounds of general formula I wherein Fc and Fc′ may be the same or different and are substituted ferrocenyl moieties having at least one ring substituent selected from sulfur-containing groups, phosphorus-containing groups, iodo, chloro, silyl, fluoroalkyl groups containing two or more fluorine atoms, heteroaryl, substituted phenyl, and cyano, wherein if present as sole substituent the cyano group is located on the proximal cyclopentadienyl ring; X is a spacer, Y is a spacer, Z is a spacer; and R is a linker group. Compound I may be used to make labelled substrates, functionalised compounds for making labelled substrates and may be used as labels in an electrochemical assay.

The present invention relates to a precursor for forming a thin film, comprising a compound represented by chemical formula 1, wherein the precursor for forming a thin film is a liquid at room temperature, and comprises an amidinate ligand capable of exhibiting chemical properties of the precursor, such as high structural stability, low viscosity, high volatility, high heat resistance, and room-temperature liquid form.

The invention provides a synthesis method of tris (dimethylamino) cyclopentadienyl hafnium, which comprises the following steps: reacting hafnium tetrachloride with sodium dimethylamino at a first temperature under the protection of inert gas to form an intermediate; heating and settling, cooling to a second temperature, dropwise adding cyclopentadiene, and filtering, distilling and purifying to obtain a target product. According to the method, high yield and high purity are achieved by optimizing the raw material ratio and controlling the dropwise adding temperature and the use amount of cyclopentadiene. The byproduct sodium chloride is large in particle and easy to filter, the post-treatment process is remarkably simplified, and the process safety, controllability and industrial adaptability are improved.

The invention provides a series of novel monomolecular resin based on the metallocene compound, the monomolecular resin is used as a single-component non-chemical amplification photoresist, the problems of non-uniform distribution of an acid generator and an anti-acid diffusion agent, non-uniform acid diffusion and the like in a chemical amplification photoresist are avoided, and an obtained pattern has high resolution and low line width roughness. # imgabs0 #

The invention provides a preparation method of dicarbonyl cyclopentadienyl cobalt, which comprises the following steps: adding cobalt salt, a reducing agent, methyl formate and a catalyst into a high-pressure reaction kettle, keeping the reaction kettle in an inert gas atmosphere, and heating and stirring; cooling the high-pressure reaction kettle to room temperature, discharging gas, filtering reaction liquid, and putting filtrate into a normal-pressure reaction device in an inert gas atmosphere; and adding a cyclopentadiene monomer into the normal-pressure reaction device, carrying out heating reaction, filtering after the reaction is finished, and carrying out post-treatment on the obtained filtrate to obtain a dicarbonyl cyclopentadienyl cobalt crude product. The operation risk is reduced, the operation is simple, and the synthesis efficiency is high; cheap and easily available cobalt salt is used as a raw material, and a relatively cheap catalyst is used, so that the synthesis cost is low, and the method is suitable for industrial large-scale popularization and application.

A semi-metallocene catalyst and a synthetic method and application thereof belong to the field of chemical engineering. The invention discloses a novel semi-metallocene catalyst which is stable in structure and excellent in heat resistance, and in the presence of a cocatalyst alkoxy aluminum or alkyl aluminum or organic boride, the heat resistance of the semi-metallocene catalyst is greatly improved. Ethylene homopolymerization, propylene homopolymerization, ethylene and alpha-olefin copolymerization, propylene and alpha-olefin copolymerization, ethylene and polar olefin monomer copolymerization, propylene and polar olefin monomer copolymerization or non-polar olefin monomer and polar olefin monomer multi-component copolymerization are efficiently catalyzed at a high polymerization temperature to efficiently prepare a high-end copolymerization olefin material. And synthesizing high-end propenyl elastomers and plastomers, vinyl elastomers and plastomers, styryl copolymers and the like. The method is simple in preparation process, safe, low in cost, convenient to operate, low in equipment requirement, small in energy consumption and small in environmental pollution.

The disclosure relates to a metallocene complex of formula (I) wherein Mt is Zr or Hf; X is a sigma ligand; R1 are each independently, same or different from each other, C1-C20-hydrocarbyl, optionally containing up to two heteroatoms of Group 14-16 of the Periodic Table, or form together with the Si atom they are attached to a C4-C8-ring; R2 and R2' are each independently a C1-C10-hydrocarbyl, provided that at least one of R2 and R2' is an alpha-branched C3-C10-hydrocarbyl; n are each independently, same or different from each other, an integer from 1 to 5; R3 and R4 are each independently, same or different from each other, H, linear or branched C1-C6-alkyl, C7-C20-arylalkyl, C7-C20-alkylaryl, C6-C20-aryl, -OR31, SR31, or N(R31)2,with R31 being C1-C10-hydrocarbyl, whereby at least one R3 per phenyl group and at least one R4 is not H; R5 and R6 are each independently, same or different from each other, H or C1-C10- hydrocarbyl, or may form together with the C atoms they are attached to a C5-C7 carbocycle; R51' is C1-C10-hydrocarbyl; and R6' is C(R61)3, with R61 being linear or branched C1-C6-alkyl.

The invention discloses a dicarbonyl cyclopentadienyl cobalt complex as well as a preparation method and application thereof, and belongs to the technical field of organic metal synthesis. The preparation method of the dicarbonyl cyclopentadienyl cobalt complex specifically comprises the following steps: (1) dissolving cobalt octacarbonyl in carbon monoxide pre-saturated dichloromethane, and continuously introducing carbon monoxide gas for protection to obtain a reaction system; (2) dissolving cyclopentadiene in dichloromethane, and continuously introducing carbon monoxide gas for protection to obtain a cyclopentadiene solution; (3) adding a cyclopentadiene solution into the reaction system, heating and stirring for reaction; and (4) carrying out pressurized distillation and rectification on the reaction system. According to the invention, the carbon monoxide protective gas is introduced and the cyclopentadiene solution is prepared in the whole process to reduce the decomposition of the raw materials and reduce the generation of byproducts, so that the subsequent purification difficulty is reduced, and the reaction yield and the economic benefit of the product are improved.

Some embodiments relate to precursors, including intermediate precursors, and related methods. To produce the intermediate precursor, a mixture of bis(arene) metal complexes is combined with a first arene. The mixture of bis(arene) metal complexes first arene is heated and then cooled. Upon cooling, the bis(first arene) metal complexes precipitate out of solution to produce the high purity intermediate precursor. To produce the precursor, the bis(first arene) metal complexes are contacted with a second arene to produce the high purity precursor.

Yttrium complexes and related methods are provided. A method of making an yttrium complex comprising contacting a metal alkyl cyclopentadienyl compound with an yttrium trihalide compound in a non-coordinating solvent to obtain a tris (alkyl cyclopentadienyl) yttrium complex. A composition includes a tris (alkylcyclopentadienyl) yttrium complex.

An organotin photoresist composition and a method of forming photolithography pattern are described. The organotin photoresist composition comprises a bridged-(stannocenyl)tin compound, a solvent, and / or an additive. Stannocenyl comprises bis(cyclopentadienyl)tin, or substituted bis(cyclopentadienyl)tin, wherein cyclopentadienyl is cyclopentadienyl C5H5 group, or substituted cyclopentadienyl C5H3R, C5H2R2, C5HR3, or C5R4 group. A method of forming the pattern comprises: depositing bridged-(stannocenyl)tin compound photoresist over a substrate to form a photoresist layer, exposing the photoresist layer to actinic radiation to form a latent pattern, and then developing to form photolithography pattern.

The invention discloses a preparation method of a mono-substituted cyclopentadienyl yttrium precursor, and relates to the field of chemical product preparation, the preparation method of the mono-substituted cyclopentadienyl yttrium precursor comprises the following steps: S1, adding mono-substituted cyclopentadiene into a solution of an alkali metal compound, and then carrying out a heating reaction; s2, dropwise adding the mixture obtained in the step S1 into a solution containing yttrium halide, and carrying out a reflux reaction; and S3, filtering the mixture in S2, and carrying out reduced pressure distillation to remove the solvent. According to the preparation method disclosed by the invention, by changing the solvent and controlling the equivalent weight of reactants and the reaction temperature, the yield can be improved, the purification step can be simplified, and the high-efficiency and large-scale preparation of the mono-substituted cyclopentadienyl yttrium can be realized.

The invention relates to nitrogen-containing spirofulvene as well as a preparation method and application thereof, the chemical structural formula of the nitrogen-containing spirofulvene is # imgabs0 #, R is one of C1-C10 alkyl, alkenyl and aryl, n is equal to 0 or 1, and m is equal to 1 or 2. Compared with the prior art, the preparation method disclosed by the invention has the advantages of simple process, simplicity in operation, simplicity and convenience in separation, high reaction rate, adjustable spiro structure and the like.

Platinum group metal containing chemical precursors suitable for vapor deposition are disclosed. Methods of using these precursors for Platinum depositions are also disclosed. The chemical precursors and methods are particularly suitable for depositing catalyst material on electrodes.

The invention discloses a method for preparing a metal complex, the general structural formula of the metal complex is CpM (NR1R2) 3, R1 and R2 are Me or Et, and M is Zr or Hf; the preparation method comprises the following steps: S1, adding magnesium dicyclopentadienyl into a tetrahydrofuran solvent, and stirring to form a tetrahydrofuran solution of magnesium dicyclopentadienyl for later use; s2, adding a metal chloride, N, N-diisopropylethylamine and a tetrahydrofuran solvent into a reaction kettle, cooling to-10 to-5 DEG C, slowly introducing an amine compound, stirring for 2 hours after the amine compound is introduced, then slowly heating to 30-40 DEG C, stirring and reacting for 16 hours, and filtering to obtain filtrate; and S3, controlling the temperature of the filtrate at 20-30 DEG C, adding a tetrahydrofuran solution of magnesium dicyclopentadienyl, slowly heating to 50-60 DEG C, carrying out stirring reaction for 12 hours, filtering after stirring to obtain filtrate, and carrying out distillation and rectification separation to obtain the target product CpM (NR1R2) 3.

The invention provides ferrocenyl carboxylic acid anthracene methyl ester for photosensitive resin, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the ferrocenyl carboxylic acid anthracene methyl ester, a photosensitive dry film containing the ferrocenyl carboxylic acid anthracene methyl ester, and applications of the photosensitive resin composition and the photosensitive dry film. The ferrocenyl carboxylic acid anthracene methyl ester disclosed by the invention has the characteristics of photosensitivity and low migration, can improve the adhesive force of a photosensitive resin composition on various metal surfaces, and can be widely applied to the photocuring fields of dry films, paints, coatings, printing inks, molding materials and the like.

The disclosure relates to a metallocene complex of formula (I) wherein Mt is Zr or Hf, preferably Zr; X is a sigma ligand R1 are each independently, same or different from each other, C1-C20-hydrocarbyl, optionally containing up to two heteroatoms of Group 14-16 of the Periodic Table, or form together with the Si atom they are attached to a C4-C8-ring; R2 is linear C1-C20-hydrocarbyl; R2' is alpha-branched C3-C10-hydrocarbyl or SiH(R21')2, with R21' being each independently, same or different from each other, C1-C10-hydrocarbyl; n are each independently an integer from 1 to 5; R3 and R4 are each independently, same or different from each other, H, C1-C10- hydrocarbyl group, or a –OR31, -SR31 or -NR31 2 group in which R31 is C1-C10- hydrocarbyl, whereby at least one R3 and at least one R4 is not hydrogen; L is O or S; R51 and R51' are each independently, same of different from each other, C1-C10- hydrocarbyl; and R6 and R6' are each independently, same or different from each other, C(R61)3 or - OR61, with R61 being each independently, same of different from each other, linear or branched C1-C6-alkyl; or adjacent LR51 and R6 and / or LR51' and R6' form together a -O[C(R62)2]mO- group, with each R62 being independently, same or different from each other, H or linear or branched C1-C6-alkyl, with m being 1 to 3.

The invention relates to a preparation method of trimethoxy pentamethyl cyclopentadienyl titanium, which comprises the following steps: (1) vacuumizing a reactor for replacement, detecting the content of moisture and oxygen in gas in a reaction kettle by an instrument, and stopping vacuum replacement when the content is lower than 50ppm; (2) pentamethyl cyclopentadienyl titanium trichloride, ammonia and a solvent are added into a reactor, methanol is dropwise added into the reactor, a crude product trimethoxy pentamethyl cyclopentadienyl titanium is obtained through a reaction, the reaction temperature ranges from-30 DEG C to 50 DEG C, and the pressure ranges from-0.05 MPa to 0.05 MPa; (3) filtering and desalting the crude product trimethoxy pentamethyl cyclopentadienyl titanium obtained in the step (2) in an inert environment; and (4) the filtrate obtained in the step (3) is refined, pure trimethoxy pentamethyl cyclopentadienyl titanium is obtained, and the metal purity reaches 5N. Methanol is used as a raw material, the synthesis route can be shortened, the cost is reduced, and meanwhile, the material is relatively safe.