799results about "Metallocenes" patented technology

The invention provides a novel chiral ferrocene bridged binaphthyl skeleton phosphine ligand and application thereof. The ligand has the advantages of low cost, simplicity in synthesis, air stability and the like. The ligands have good catalytic activity and enantioselectivity in the asymmetric hydrogenation reaction of ketone, and have certain industrial application prospects in the synthesis of pharmaceutical molecules.

To provide, e.g., a transition metal compound capable of producing an olefin polymer having a high molecular weight and a high melting point with high productivity, even under high-temperature conditions that are advantageous in industrial production methods.SOLUTION: A transition metal compound (A) is represented by the general formula [I] in the figure.SELECTED DRAWING: None

The invention relates to a nano assembly for self-synergistically enhancing ferroptosis as well as a preparation method and application of the nano assembly, and belongs to the technical field of pharmaceutical preparation combined treatment of new auxiliary materials and new dosage forms. The invention firstly provides a functional conjugate linker capable of automatically generating ROS, the functional conjugate linker comprises artesunate-ferrocene or dihydroartemisinin-ferrocene, and the structural formulas of the functional conjugate linker and the artesunate-ferrocene or dihydroartemisinin-ferrocene are respectively shown as a and b. According to the present invention, the ROS self-generating functional conjugate linker and the ferroptosis inducer are co-assembled to form the nanometer assembly, such that the ROS level in the tumor cells can be effectively and synergistically improved by the ROS self-generating functional conjugate linker and the ferroptosis inducer so as to cause the tumor cell lipid peroxidation storm, and the ferroptosis induction effect can be significantly improved. The co-assembled nano preparation provided by the invention provides a new strategy and more choices for developing the delivery of drugs, and meets the urgent requirements of efficient and diversified ferroptosis-based cancer treatment strategies on preparations in clinic. # imgabs0 #

Compounds with redox molecular cores and branched molecular tails comprising ionic functionalities for uses as electrolytes in redox flow batteries are described, as well as methods of synthesis and use thereof. The compounds have redox active perylene diimide or ferrocene molecular core decorated with the branched molecular tails having multiple ionic functionalities to improve water solubility of the molecular core, and, as such, its performance as the electrolyte.

The invention provides a preparation method and application of an asymmetric dicyclopentadienyl dialkoxy zirconium compound, and the preparation method comprises the following steps: (1) mixing a solvent with ZrCl4 and sodium cyclopentadienyl CpNa, and carrying out a reaction to obtain CpZrCl3; (2) the CpZrCl3 obtained in the step (1) and R1 substituted sodium cyclopentadienyl R1CpNa are subjected to a mixed reaction, and (R1Cp) CpZrCl2 is obtained; and (3) mixing the (R1Cp) CpZrCl2 obtained in the step (2) with alkoxy sodium salt R2Na, and carrying out a reaction so as to obtain the asymmetric dicyclopentadiene dialkoxy zirconium compound. According to the method, the substitution reaction of three sodium salts is used for replacing the ligand replacement reaction in the prior art, so that the reaction steps are shortened, the use of unnecessary raw materials is avoided, the production cost is reduced, and the obtained target product is high in yield and high in purity.

The present invention relates to a precursor for forming a thin film, comprising a compound represented by chemical formula 1, wherein the precursor for forming a thin film is a liquid at room temperature, and comprises an amidinate ligand capable of exhibiting chemical properties of the precursor, such as high structural stability, low viscosity, high volatility, high heat resistance, and room-temperature liquid form.

The invention provides a synthesis method of tris (dimethylamino) cyclopentadienyl hafnium, which comprises the following steps: reacting hafnium tetrachloride with sodium dimethylamino at a first temperature under the protection of inert gas to form an intermediate; heating and settling, cooling to a second temperature, dropwise adding cyclopentadiene, and filtering, distilling and purifying to obtain a target product. According to the method, high yield and high purity are achieved by optimizing the raw material ratio and controlling the dropwise adding temperature and the use amount of cyclopentadiene. The byproduct sodium chloride is large in particle and easy to filter, the post-treatment process is remarkably simplified, and the process safety, controllability and industrial adaptability are improved.

The invention provides a preparation method of dicarbonyl cyclopentadienyl cobalt, which comprises the following steps: adding cobalt salt, a reducing agent, methyl formate and a catalyst into a high-pressure reaction kettle, keeping the reaction kettle in an inert gas atmosphere, and heating and stirring; cooling the high-pressure reaction kettle to room temperature, discharging gas, filtering reaction liquid, and putting filtrate into a normal-pressure reaction device in an inert gas atmosphere; and adding a cyclopentadiene monomer into the normal-pressure reaction device, carrying out heating reaction, filtering after the reaction is finished, and carrying out post-treatment on the obtained filtrate to obtain a dicarbonyl cyclopentadienyl cobalt crude product. The operation risk is reduced, the operation is simple, and the synthesis efficiency is high; cheap and easily available cobalt salt is used as a raw material, and a relatively cheap catalyst is used, so that the synthesis cost is low, and the method is suitable for industrial large-scale popularization and application.

A semi-metallocene catalyst and a synthetic method and application thereof belong to the field of chemical engineering. The invention discloses a novel semi-metallocene catalyst which is stable in structure and excellent in heat resistance, and in the presence of a cocatalyst alkoxy aluminum or alkyl aluminum or organic boride, the heat resistance of the semi-metallocene catalyst is greatly improved. Ethylene homopolymerization, propylene homopolymerization, ethylene and alpha-olefin copolymerization, propylene and alpha-olefin copolymerization, ethylene and polar olefin monomer copolymerization, propylene and polar olefin monomer copolymerization or non-polar olefin monomer and polar olefin monomer multi-component copolymerization are efficiently catalyzed at a high polymerization temperature to efficiently prepare a high-end copolymerization olefin material. And synthesizing high-end propenyl elastomers and plastomers, vinyl elastomers and plastomers, styryl copolymers and the like. The method is simple in preparation process, safe, low in cost, convenient to operate, low in equipment requirement, small in energy consumption and small in environmental pollution.

The invention discloses a dicarbonyl cyclopentadienyl cobalt complex as well as a preparation method and application thereof, and belongs to the technical field of organic metal synthesis. The preparation method of the dicarbonyl cyclopentadienyl cobalt complex specifically comprises the following steps: (1) dissolving cobalt octacarbonyl in carbon monoxide pre-saturated dichloromethane, and continuously introducing carbon monoxide gas for protection to obtain a reaction system; (2) dissolving cyclopentadiene in dichloromethane, and continuously introducing carbon monoxide gas for protection to obtain a cyclopentadiene solution; (3) adding a cyclopentadiene solution into the reaction system, heating and stirring for reaction; and (4) carrying out pressurized distillation and rectification on the reaction system. According to the invention, the carbon monoxide protective gas is introduced and the cyclopentadiene solution is prepared in the whole process to reduce the decomposition of the raw materials and reduce the generation of byproducts, so that the subsequent purification difficulty is reduced, and the reaction yield and the economic benefit of the product are improved.

Yttrium complexes and related methods are provided. A method of making an yttrium complex comprising contacting a metal alkyl cyclopentadienyl compound with an yttrium trihalide compound in a non-coordinating solvent to obtain a tris (alkyl cyclopentadienyl) yttrium complex. A composition includes a tris (alkylcyclopentadienyl) yttrium complex.

The invention discloses a preparation method of a mono-substituted cyclopentadienyl yttrium precursor, and relates to the field of chemical product preparation, the preparation method of the mono-substituted cyclopentadienyl yttrium precursor comprises the following steps: S1, adding mono-substituted cyclopentadiene into a solution of an alkali metal compound, and then carrying out a heating reaction; s2, dropwise adding the mixture obtained in the step S1 into a solution containing yttrium halide, and carrying out a reflux reaction; and S3, filtering the mixture in S2, and carrying out reduced pressure distillation to remove the solvent. According to the preparation method disclosed by the invention, by changing the solvent and controlling the equivalent weight of reactants and the reaction temperature, the yield can be improved, the purification step can be simplified, and the high-efficiency and large-scale preparation of the mono-substituted cyclopentadienyl yttrium can be realized.

The invention relates to nitrogen-containing spirofulvene as well as a preparation method and application thereof, the chemical structural formula of the nitrogen-containing spirofulvene is # imgabs0 #, R is one of C1-C10 alkyl, alkenyl and aryl, n is equal to 0 or 1, and m is equal to 1 or 2. Compared with the prior art, the preparation method disclosed by the invention has the advantages of simple process, simplicity in operation, simplicity and convenience in separation, high reaction rate, adjustable spiro structure and the like.

The invention discloses a method for preparing a metal complex, the general structural formula of the metal complex is CpM (NR1R2) 3, R1 and R2 are Me or Et, and M is Zr or Hf; the preparation method comprises the following steps: S1, adding magnesium dicyclopentadienyl into a tetrahydrofuran solvent, and stirring to form a tetrahydrofuran solution of magnesium dicyclopentadienyl for later use; s2, adding a metal chloride, N, N-diisopropylethylamine and a tetrahydrofuran solvent into a reaction kettle, cooling to-10 to-5 DEG C, slowly introducing an amine compound, stirring for 2 hours after the amine compound is introduced, then slowly heating to 30-40 DEG C, stirring and reacting for 16 hours, and filtering to obtain filtrate; and S3, controlling the temperature of the filtrate at 20-30 DEG C, adding a tetrahydrofuran solution of magnesium dicyclopentadienyl, slowly heating to 50-60 DEG C, carrying out stirring reaction for 12 hours, filtering after stirring to obtain filtrate, and carrying out distillation and rectification separation to obtain the target product CpM (NR1R2) 3.

The invention provides ferrocenyl carboxylic acid anthracene methyl ester for photosensitive resin, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the ferrocenyl carboxylic acid anthracene methyl ester, a photosensitive dry film containing the ferrocenyl carboxylic acid anthracene methyl ester, and applications of the photosensitive resin composition and the photosensitive dry film. The ferrocenyl carboxylic acid anthracene methyl ester disclosed by the invention has the characteristics of photosensitivity and low migration, can improve the adhesive force of a photosensitive resin composition on various metal surfaces, and can be widely applied to the photocuring fields of dry films, paints, coatings, printing inks, molding materials and the like.

The invention relates to a preparation method of trimethoxy pentamethyl cyclopentadienyl titanium, which comprises the following steps: (1) vacuumizing a reactor for replacement, detecting the content of moisture and oxygen in gas in a reaction kettle by an instrument, and stopping vacuum replacement when the content is lower than 50ppm; (2) pentamethyl cyclopentadienyl titanium trichloride, ammonia and a solvent are added into a reactor, methanol is dropwise added into the reactor, a crude product trimethoxy pentamethyl cyclopentadienyl titanium is obtained through a reaction, the reaction temperature ranges from-30 DEG C to 50 DEG C, and the pressure ranges from-0.05 MPa to 0.05 MPa; (3) filtering and desalting the crude product trimethoxy pentamethyl cyclopentadienyl titanium obtained in the step (2) in an inert environment; and (4) the filtrate obtained in the step (3) is refined, pure trimethoxy pentamethyl cyclopentadienyl titanium is obtained, and the metal purity reaches 5N. Methanol is used as a raw material, the synthesis route can be shortened, the cost is reduced, and meanwhile, the material is relatively safe.

The invention discloses a preparation method of a monocyclopentadienyl trialkoxy titanium precursor, and belongs to the technical field of synthesis of metal organic compounds. The method comprises the following steps: S1, reacting a deprotonation product of RnCp, (R0) mSiXz and an accelerant to obtain an intermediate I; s2, reacting the intermediate I with TiX4 to obtain an intermediate II; s3, the intermediate II and R1OM are subjected to a reaction, and a monocyclopentadienyl trialkoxy titanium precursor is prepared; r and R1 are independently selected from C1-C5 straight-chain or branched-chain alkyl groups, Cp is cyclopentadienyl, R0 is C1-C3 alkyl groups, X is halogen and is selected from any one of F, Cl, Br and I, n is an integer of 0-5, m + z is equal to 4 and 1 < = z < = 2, and M is alkali metal. The synthesis route has good safety and economical efficiency, the yield of the industrial synthesis route is remarkably improved, the reaction time is short, the synthesis efficiency is high, and the industrial application value is high.

Compounds with redox molecular cores and branched molecular tails comprising ionic functionalities for uses as electrolytes in redox flow batteries are described, as well as methods of synthesis and use thereof. The compounds have redox active perylene diimide or ferrocene molecular core decorated with the branched molecular tails having multiple ionic functionalities to improve water solubility of the molecular core, and, as such, its performance as the electrolyte.

The invention relates to the technical field of concrete, and discloses mirror concrete and a preparation method thereof. Comprising the following components in parts by weight: 360 to 400 parts by weight of cement, 60 to 100 parts by weight of fly ash, 250 to 320 parts by weight of fine aggregate, 300 to 500 parts by weight of coarse aggregate, 1 to 3 parts by weight of a polycarboxylic acid water reducer, 4 to 6 parts by weight of an additive, 2 to 3 parts by weight of modified ferrocene, 80 to 100 parts by weight of water, 15 to 20 parts by weight of water-soluble acrylic resin and 2 to 3 parts by weight of carboxyl modified silane. The mirror concrete provided by the invention has good gloss and mechanical properties.

The invention discloses a ferrocene-based D-A type multi-system conjugated small molecule synthesis method, which comprises: carrying out a heating reaction in an organic solvent by using a ferrocenyl compound and a bromophenyl compound as raw materials and using a palladium complex as a catalyst, and after the reaction is completed, carrying out extraction, column chromatography and recrystallization to prepare an intermediate; the obtained intermediate and a 4-pyridine boric acid compound are used as raw materials, a palladium complex is used as a catalyst, a heating reaction is conducted in an organic solvent, and after the reaction is finished, cooling, extraction, column chromatography and recrystallization are conducted to prepare the D-A type multi-system conjugated small molecules. The invention also discloses a memory device with a sandwich structure and application of the memory device to ultra-high density information storage. The small molecular material prepared by the invention not only can realize ternary information storage performance, but also greatly improves the stability of the device through stable redox cycle of the ferrocene group, and realizes long-time stable ultrahigh-density information storage.

This invention relates to the field of olefin polymerization, and discloses a metallocene compound, a catalyst composition using the metallocene compound, an olefin polymerization method using the catalyst composition, and the application of the metallocene compound or the catalyst composition in olefin polymerization. The metallocene compound has the structure shown in formula (1), where M is a tetravalent transition metal atom; X 1 and X 2 Each group is independently a halogen atom, an alkyl group with 1-10 carbon atoms, an aromatic group with 6-12 carbon atoms, or an N,N-dialkylamine group with 2-8 carbon atoms. Using the catalyst composition of the present invention provides advantages such as high catalytic activity, good copolymerization performance, and high molecular weight of the obtained polymer.

The invention discloses a method for preparing adiponitrile from butadiene catalyzed by a chiral monodentate phosphine ligand. Specifically, the method adopts a flow reactor and is completed under a chiral monodentate phosphine ligand, a Lewis acid auxiliary agent and a zero-valent nickel catalytic system. The method of the invention has good selectivity and high conversion rate and is suitable for industrial production.

The invention provides a phosphorus-nitrogen coordinated metallocene compound and a preparation method and application thereof, the compound has a structure as shown in a formula I: in the formula I, M is selected from IVB group metals in the periodic table of elements; r1 is selected from hydrogen, halogen, C1-C10 direct or branched alkyl, and C1-C3 alkoxy; r2 is selected from hydrogen and C1-C6 straight chain or branched chain alkyl; y is selected from chlorine, C1-C3 alkyl substituted or unsubstituted by trimethylsilyl, and amino substituted by trimethylsilyl. The phosphorus-nitrogen coordinated metallocene compound provided by the invention has relatively high thermal stability, catalytic activity and comonomer insertion rate, and can realize high-temperature solution polymerization of ethylene and norbornene.

Compounds derived from celecoxib and valdecoxib, and methods of use thereof, are disclosed. The compounds are useful for, inter alia, identifying and localizing the site of pathology and / or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The compounds contain a radioactive agent which permits imaging. The compounds concentrate at sites of increased cyclooxygenase expression, such as areas of increased COX-2 expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and / or location. Identifying areas of increased COX expressing can also aid in screening for infections, assessing efficacy of diagnosis and treatment of rheumatoid arthritis, and assessing the need for treatment with opioid drugs.

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

The present invention relates to the field of olefin polymerization, and discloses a metallocene compound, a catalyst composition, and a method for preparing an ethylene-cyclic olefin copolymer. The metallocene compound has a structureas shown in formula (1), and in formula (1) M is a tetravalent transition metal atom; and X1 and X2 are each independently a halogen atom, an alkyl having 1 to 10 carbon atoms, an aromatic group having 6 to 12 carbon atoms or an N,N-dialkylamine group having 2 to 8 carbon atoms. Using the catalyst composition of the present invention in the preparation of an ethylene-cyclic olefin copolymer has the advantages of high catalytic activity, good copolymerization performance, and high molecular weight of an obtained polymer.

The invention discloses a novel method for synthesizing a ferrocenyl phosphine ligand compound, which comprises the following steps of: reacting a ferrocene compound serving as a starting material with a Grignard reagent and phosphorus trichloride under the action of tert-butyl lithium to generate a ferrocene phosphine ligand, and synthesizing a ferrocene diphosphine ligand in one step. The method is stable and high in practicability, and a novel method for synthesizing the ferrocene ligand compound is provided.

The present invention relates to an improved method of preparation for supported catalyst systems comprising a particular class of metallocene complexes that combine a boron-containing cocatalyst and an aluminoxane cocatalyst, and to uses of the new and improved catalyst systems.