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146 results about "Aryne" patented technology
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Arynes or benzynes are highly reactive species derived from an aromatic ring by removal of two substituents. The most common arynes are ortho but meta- and para-arynes are also known. o-Arynes are examples of strained alkynes.
Aryne resin containing silicone
InactiveCN1709928AImprove flexibilityGood high temperature ceramic performanceSilanesGrignard reagent
The invention relates to a kind of arylenealkyne resin containing siloxanes. The said resin makes diethynylene benzene (DEB) and silicon alkyl chloride as raw materials, firstly make use of the reaction of magnesium and alkyl bromide to produce Grignard reagentú¼then react with DEB to produce alkyne Grignard reagent; then react with silicon alkyl chloride, finally hydrolyze and condense in alkaline water liquor, or extend chain with siloxanes chloride, to form a kind of arylenealkyne resin containing siloxanes of new-style structure. The resin designed and synthesized by the invention has good processing property, and can be solidified into crosslinked resin of good thermostability under heat, light or radiative condition. Besides it has good machine capability, electric insulation capability and ceramic performance. So it can be used as the base material of high performance compound material resin, insulation material, the ceramic precursors and so on, and also has wide application prospect in such high technology fields as spaceflight, aviation, navigation and so on.
Owner:EAST CHINA UNIV OF SCI & TECH
Therapeutic agent for FGFR inhibitor-resistant cancer
The problem to be solved by the present invention is to provide an anticancer agent for treating tumors resistant to other antitumor agents that inhibit FGFR, and a method for treating such tumors. The present invention provides an antitumor agent for administration to a tumor patient resistant to an FGFR inhibitor, the antitumor agent comprising a 3,5-disubstituted benzene alkynyl compound represented by Formula (I) below or a salt thereof. The present invention also provides a therapeutic method using the anticancer agent.
Owner:TAIHO PHARMA CO LTD
Aryne resin containing polysilicone and preparation method thereof
The invention relates to a polysilane-containing aryne resin represented as right, wherein n is 0-20, x and y are 0-20, R1, R2, R3 and R4 are CH3 and C6H5, or R1 is H, R2, R3 and R4 are CH3 and C6H5, or R1 and R3 are H, R2 and R4 are CH3 and C6H5. The preparation method of polysilane-containing aryne resin uses aryne Grignard reagent to be reacted with terminated chlorine polysilane, while terminated chlorine polysilane is prepared by chlorination process and sodium condensation method. The inventive polysilane-containing aryne resin has better processing character, mechnical character, heat endurance, oxidation resistance and fire-retardancy, which can form ceramic material in high temperature and own better cementation with reinforcing fiber, with wide application in resin substrate and ceramic boving precursor.
Owner:EAST CHINA UNIV OF SCI & TECH
Aryne modified resin containing silicon
The invention relates to a modified resin with silicon aryne modified by aryne ethynylbenzene and oxazine compound, which is copolymerized by 50-95wt% aryne ethynylbenzene and 5-50wt% oxazine compound, wherein the silicon aryne polymeric compound has the structure as formula (1). The invention improves the modified resin including silicon aryne to be good thermostable property, which displays good dynamic property and fabric recombination property. R is hydrocarbyl group of fatty group or aromatic and R' is hydrocarbyl group of H or C1-C6 fatty group or aromatic in formula (1), n is 1-15.
Owner:EAST CHINA UNIV OF SCI & TECH +1
Bisphenol benzoxazine modified silicon-contained aryne resin and preparation method thereof
The invention discloses bisphenol benzoxazine modified silicon-contained aryne resin and a preparation method thereof. The preparation method comprises the following step: 50 to 95 percent (by mass) of silicon-contained aryne resin and 5 to 50 percent (by mass) of bisphenol benzoxazine resin are put into a reactor and stirred for 10 to 60 minutes at 100 to 120 DEG C to prepare the bisphenol benzoxazine modified silicon-contained aryne resin. The resin can synchronously form cured resin with a simultaneous interpenetrating network (SIN) structure through thermal polymerization. The bisphenol benzoxazine modified silicon-contained aryne resin prepared by the preparation method is high-performance resin with excellent high-temperature resistance and mechanical property and favorable adhesive property with fiber, and can be widely applied to the fields of spaceflight, aviation, electronics and the like.
Owner:EAST CHINA UNIV OF SCI & TECH
Propargyl ether modified silicon-containing aryne resin
The invention relates to a propargyl ether compound modified silicon-containing aryne resin, which is prepared by stirring 5-80 weight parts of propargyl ether compound and 50-95 weight parts of silicon-containing aryne resin (of which the degree of polymerization is 2-6) to react at the temperature of 90-180 DEG C for 0.5-4.0 hours in the presence of inert gas. The modified silicon-containing arylacetylene resin of the invention has the advantages that the combined resin structure can be properly controlled by designing (molecular structure); resin has favourable processability, low softening point and low molten resin viscosity, can be dissolved in various common solvents and is convenient to use; the resin and the fiber have favourable caking property; and resin can carry out cure reaction under the action of heat and radiation, even light to form high-degree crosslinking polymer, and no micromolecules are discharged when being solidified.
Owner:EAST CHINA UNIV OF SCI & TECH
Siliceous aromatic ether and aryne polymer and preparation method thereof
The invention relates to a siliceous aromatic ether and aryne polymer and a preparation method thereof. The polymer is structurally characterized by comprising silicon atoms, aryne groups and an aromatic ether structure on a main chain. The siliceous aromatic ether and aryne polymer is polymerized from diacetylene-benzene or a dyhydroxy aromatic compound and dichlorosilane by Grignard reaction under an inert atmosphere. The preparation method of the polymer comprises the following steps of: firstly reacting haloalkane with magnesium powder to produce an alkyl magnesium halide Grignard reagent; and then reacting with the dyhydroxy aromatic compound to obtain an alkyl magnesium halide Grignard reagent of the dyhydroxy aromatic compound or reacting with diacetylene-benzene to obtain an alkyl magnesium halide Grignard reagent of diacetylene-benzene; and finally reacting with dichlorosilane to obtain the siliceous aromatic ether and aryne polymer. The invention has the advantages of simple process, short reaction time, easily controlled process condition and simple subsequent processing and is convenient to operate; in addition. The product of the method is stable at room temperature and easy to store, the condensate of the polymer has excellent heat-resisting stability and mechanical property and is a high-performance thermosetting resin with good heat-resisting property.
Owner:EAST CHINA UNIV OF SCI & TECH
Organic ligand and Pd/Pb-based bi-metal organic framework as well as synthetic method and application thereof
InactiveCN105348327AHarm reductionPlay a catalytic roleOrganic-compounds/hydrides/coordination-complexes catalystsOrganic chemistry methodsHalohydrocarbonReactive site
The invention discloses an organic ligand and a Pd / Pb-based bi-metal organic framework as well as a synthetic method and application of the organic ligand and the Pd / Pb metal organic framework. A structural formula of the Pd / Pb-based bi-metal organic framework (Pd / Pb-MOF) is [Pb4(C42H28N8O8Pd)(C2O4)Br4]n, wherein n is a nonzero natural number. The Pd / Pb-based bi-metal organic framework (Pd / Pb-MOF) is used as a catalyst to be applied to catalyzing benzyne homocoupling and catalyzing three-component coupling reaction of benzyne, boracic acid and allyl halohydrocarbon. The MOF catalyst with active sites can be used for replacing some heavy metals to achieve a catalytic effect, so that the harm of the heavy metals to the environment is reduced. The MOF catalyst with the active sites is used for catalysis, so that heterocatalysis is realized; additionally, the bi-metal organic framework catalyst can be recycled for more than four times, and the catalyst is easy to recycle, so that the utilization rate of the catalyst is increased, and the cost is reduced.
Owner:SHANDONG NORMAL UNIV
C/C-SiC composite material prepared by using silicon-containing aryne resin, and preparation method thereof
Owner:EAST CHINA UNIV OF SCI & TECH
Silica aryne resin containing carborane unit in main chain framework and preparation method thereof
ActiveCN104072779AImprove heat resistanceHigh ceramization rateSilicon organic compoundsPolymer scienceGrignard reagent
The invention relates to a silica aryne resin containing carborane unit in main chain framework and a preparation method thereof. The method comprises the following steps: preparing a silica aryne resin from diacetylene-benzene and dihalogenated siloxane by an alkynyl Grignard reagent process, and reacting decaborane with the silica aryne resin under the action of a Lewis base to prepare the silica aryne resin containing carborane unit in main chain framework. The silica aryne resin containing carborane unit in main chain framework is soluble in common organic solvents, and has excellent workability; the resin solidified substance has excellent heat resistance and thermal oxygen stability; and the fiber-reinforced composite material has excellent mechanical properties, and has wide application prospects in the fields of aerospace and the like.
Owner:EAST CHINA UNIV OF SCI & TECH
Siliceous alkynes fragrant polytriazoles resin and method for making same
The invention relates to an aromatic poly-triazole containing silicon and alkyne and the preparation method, a novel aromatic poly-triazole containing silicon and alkyne which can be solidified with low temperature is prepared by the addition polymerization of the aryne resin containing silicon and the azide. The resin is of low viscosity (less than 1Pa.s) and good wetting quality for fiber, and can be solidified at low temperature such as 70 to 80 DEG C; the glass-transition temperature of the solidified resin is more than 300 DEG C, the solidified resin has good resistance to effect of heat; the common temperature bending strength of the composite material of the aromatic poly-triazole containing silicon and alkyne of unilateral carbon fiber reinforcement is 1800 MPa, the bending modulus is about 120 GPa, the retention rate of the bending strength achieves about 70 percent at 250 DEG C, the bending modulus is almost not changed, the aromatic poly-triazole containing silicon and alkyne has excellent mechanical property and resistance to effect of high temperature. As resin basal body of the composite material of high temperature resistance, the aromatic poly-triazole containing silicon and alkyne has extensive application prospect in the high technology field such as aeronautics, spaceflight, electron apparatus, and chemical industry, etc.
Owner:EAST CHINA UNIV OF SCI & TECH +1
Aryne-based substituted indolizine derivative and preparation method and applications thereof
InactiveCN102977097AGood reaction selectivityMild reaction conditionsOrganic chemistryAntineoplastic agentsNitrogenPalladium catalyst
The invention discloses an aryne-based substituted indolizine derivative and a preparation method and applications thereof. The preparation method is characterized by comprising the following steps: under the condition of stirring, adding indolizine compounds, 2, 2-ethylene dibromide aromatic compounds, inorganic alkali and a metallic palladium catalyst into N, N-dimethyl formamide; and under the protection of nitrogen, carrying out complete reaction on the obtained mixture at a temperature of 80-100 DEG C, and carrying out post-treatment on the obtained product so as to obtain the aryne-based substituted indolizine derivative. According to the aryne-based substituted indolizine derivative and the preparation method, the aryne-based substituted indolizine derivative is prepared by using easily-available raw materials, the reaction selectivity is good, the reaction conditions are mild, the preparation process is simple, and the production cost is low.
Owner:SHAOXING UNIVERSITY
Heteroatom-containing organic microporous material as well as preparation and application thereof
The invention relates to a heteroatom-containing organic microporous material as well as preparation and an application thereof. The structural general formula of the heteroatom-containing organic microporous material is as shown in the specification, wherein R is independently selected from one of hydrogen, a hydrophobic group, a hydrophilic group, a chiral group, an ester group, a cyano group, an amino group and a sulfhydryl group. The preparation method comprises the following steps: (1) synthesizing a dehydrobenzene derivative through Sonogashira reaction and Suzuki coupled reaction by taking m-bromoiodobenzene or 2-bromine-4-iodine-pyridine as an initial raw material, and then synthesizing a precursor through trimerization reaction catalyzed through cobalt octacarbonyl; (2) preparing the heteroatom-containing organic microporous material by carrying out Scholl reaction which takes ferric trichloride as an oxidizing agent on the obtained precursor. The heteroatom-containing organic microporous material disclosed by the invention can be used for preparing energy environment-friendly materials which store gases and absorb the hydrogen, carbon dioxide, methane and nitrogen oxides in the environment and has the advantages of good optical property, simple preparation method and excellent property.
Owner:DONGHUA UNIV +1
Method for preparing propiolic acid compounds
ActiveCN105585473AClear structureSimple structureCarboxylic acid nitrile preparationOrganic compound preparationPhenyl-acetyleneAlkyne
The invention discloses a method for preparing propiolic acid compounds. An ionic type iron (III) complex containing monoimide functionalized imidazolium cations is taken as the single-component catalyst, carbon dioxide is taken as the carboxylation reagent, and various propiolic acid compounds are prepared through carboxylation reaction of terminal alkyne under normal pressure. The terminal alkyne substrate relates to phenylacetylene, substituted phenylacetylene, heterocyclic aryne, aromatic diyne or aliphatic series terminal alkyne. The method for preparing the propiolic acid compounds through carboxylation reaction of terminal alkyne and carbon dioxide under the catalysis of the iron-based catalyst is provided for the first time. Compared with the prior art, the method has the advantages that the catalyst is more environmentally friendly, synthesis is easier, reaction conditions are mild, and catalytic activity and functional group tolerance are unchanged or improved.
Owner:东营悦来湖园区运营管理有限公司
Oxazine and alkyne compound modified silicon-containing aryne resin and preparing method thereof
The invention relates to modified silicon-containing aryne resin. A preparing method of the modified silicon-containing aryne resin includes the following steps: (1) preparing silicon-containing aryne polymer, (2) preparing benzoxazine compound, (3) preparing propargyl ether compound, and (4) preparing the modified silicon-containing aryne resin, mixing 50-90 parts by weight of the silicon-containing aryne polymer obtained through the step (1), 5-25 parts by weight of the benzoxazine compound obtained through the step (2) and 5-25 parts by weight of the propargyl ether compound obtained through the step (3), and leading the mixture to be stirred for reacting in a reactor comprising a stirrer, a thermometer and a reflux condensing pipe with inert gases to obtain the modified silicon-containing aryne resin. The oxazine and alkyne compound modified silicon-containing aryne resin and the preparing method of the modified silicon-containing aryne resin have the advantages that the modified silicon-containing aryne resin can be dissolved in many common solvents, is low in softening point and melting resin viscosity, and can generate solidifying reaction under heat, irradiation and even light effect. Resin condensates are good in heat resistance and can be well bonded with reinforcing fiber, and compound materials of the modified silicon-containing aryne resin have good mechanical performance and heat resistance.
Owner:EAST CHINA UNIV OF SCI & TECH
Synthetic method of spiro-oxoindole ethylene oxide derivative
The invention discloses a spiro-indolone ethylene oxide derivative obtained with an o-trimethylsilylphenyl triflate, an N-methyl isatin derivative and aryl thioether as raw materials, CsF as an alkali and an organic solvent as a solvent and through a one-pot method, wherein an active intermediate benzyne is obtained by allowing o-trimethylsilylphenyl triflate to generate 1,2- elimination under fluorinion induction. In the synthetic method, the whole reaction adopts the one-pot method, reaction substrates are friendly to the environment, operations are simple, conditions are mild, product structures are diverse, and the product is widely applied in natural products and clinical medicines.
Owner:广东和博制药有限公司
Synthetic method for phenanthridone compound
Owner:SHANGHAI JIAO TONG UNIV
Methylphenyl silicon aryl ether aryne resin and composite material and preparation method thereof
The invention discloses methylphenyl silicon aryl ether aryne resin and a composite material and preparation method thereof. The resin has a structural formula defined in the description, wherein m =0-4, n = 1-6, and m and n are integers. The methylphenylsilyl silicon aryl ether aryne resin is yellow solid, has stability and easy storage at normal temperature, and polymerized crosslinking curingcan be performed at 180-260 DEG C; a wide processing range is achieved, the cured product of the resin has excellent processability, mechanical properties and heat resistance, and the cast body curedproduct of the resin has excellent mechanical properties; and the composite material prepared from the resin has high bending strength, high flexural modulus and high shear strength, for example, thebending strength of the carbon fiber-reinforced composite material can reach 766.1 MPa, and a wide application prospect is achieved in aerospace and other high-tech fields.
Owner:EAST CHINA UNIV OF SCI & TECH
Method for synthesizing multi-substituted chromone compound
The invention relates to a method for synthesizing multi-substituted chromone compounds, which includes a step for generating a series of multi-substituted chromone compounds, namely, enabling 2,3-allenoic acid and benzyne generated on the spot to give an insertion / 1,2-addition / ring opening / 1,4-addition reaction in tetrahydrofuran. The method for synthesizing the multi-substituted chromone compounds is simple in operation, easily obtainable in raw materials and reagent, higher in reaction yield, capable of avoiding the shortcoming of difficulty in preparation and severe conditions of a traditional method precursor, easily separable and purificatory in products, and suitable for synthesizing the multi-substituted chromone compounds.
Owner:ZHEJIANG UNIV
Benzofuran or naphthofuran derivative and preparation method thereof
The invention relates to a benzofuran or naphthofuran derivative and a preparation method thereof. A structural formula of the derivative is shown in the specification, wherein R1 is OCH3, OC2H5 or CH3, and R2 is CH3 or C6 H5, or R1 and R2 are the same and are (CH2)3, CH2C(CH3)2CH2. The reaction is a typical [3+2] cycloaddition, aryne is produced to participate in the reaction to synthesize the benzofuran or naphthofuran derivative, the requirement of the atomic economic reaction can be met, a completely novel through is provided for establishing a skeleton of benzofuran or naphthofuran, the synthesis method of organic heterocyclic compound is enriched, and the research of the synthesis method of the benzofuran or naphthofuran derivative is not reported in any literature.
Owner:SHANGHAI UNIV
Novel method for preparing triaryl sulfonium salt
The invention discloses a new method for preparing triarylsulfonium salts, specifically: in the presence of a fluorine-containing accelerator, diarylsulfoxide and aryne precursors are reacted in a solvent to synthesize triarylsulfonium salts. The raw materials used in the method are cheap and easy to obtain, and the shortcomings of too strong alkalinity, strict requirements on reaction conditions and limited reaction substrates in the traditional method are avoided. The method has mild reaction conditions, good selectivity, high yield, easy separation of products and simple operation.
Owner:ZHEJIANG NORMAL UNIVERSITY
Bearing and ablative thermal protection integrated composite missile wing and rudder for hypersonic missile, and preparation method of bearing and ablative thermal protection integrated composite missile wing and rudder
ActiveCN111707145AOvercoming performance deficienciesTemperature controlWeight reductionProjectilesEpoxyFiber
The invention discloses a bearing and ablative thermal protection integrated composite missile wing and rudder for a hypersonic missile, and a preparation method of the bearing and ablative thermal protection integrated composite missile wing and rudder. The preparation method comprises the following steps: (1) according to the situation that different hypersonic missile models have different requirements for the air flow temperature borne by the missile wing and rudder, the ablation time and the wing tip displacement under an aerodynamic load, the overall overlay structure of the missile wingand rudder is designed into two parts, namely a missile wing and rudder bearing layer and a missile wing and rudder ablation-resisting layer; and (2) one of a woven carbon / high-temperature epoxy prepreg cloth, a woven carbon / polyimide prepreg cloth and a woven carbon / bismaleimide prepreg cloth is selected as the missile wing and rudder bearing layer, and one of a carbon / phenol prepreg cloth, a carbon / benzoxazine prepreg cloth and a carbon / aryne resin prepreg cloth is adopted as the missile wing and rudder ablation-resisting layer, wherein the fiber mass content is controlled to be 65-75%. A carbon fiber prepreg cloth overlay one-time die-pressing process is adopted, and the performance defect caused by the fact that structural / functional layer matrix resin interpenetrates due to the excessively-high resin content, the early pressure applying moment and the excessively-large pressure, and consequently too much glue liquid of the missile wing and rudder ablation-resisting layer overflows is avoided.
Owner:NINGBO SHUXIANG NEW MATERIAL
Borazine aryne resin and preparation method thereof
InactiveCN103524746AImprove heat resistanceLow dielectric constantGroup 3/13 element organic compoundsPolymer scienceResin-Based Composite
The invention discloses a borazine aryne resin and a preparation method thereof. The borazine aryne resin is structurally characterized in that the polymer molecular chain contains borazine and aryl alkynyl structures. The preparation method of the resin comprises the following steps: on the basis of taking diacetylene-benzene, boron trihalide and ammonium chloride or organic primary amine as raw materials, reacting in three steps in the presence of an inert gas so as to synthesize the borazine aryne resin. The preparation method is simple in process, convenient to operate and short in reaction time, the process condition is easy to control, and the aftertreatment process is simple; the borazine aryne resin is reddish brown viscous fluid or faint yellow solid, and can be solidified in a light and thermal polymerization mode; the borazine aryne resin has excellent thermal resistance and low dielectric property, can be used for preparing an advanced resin-based composite material, can be also used as a low dielectric material, and can be widely applied to the fields of aerospace and electronic information.
Owner:EAST CHINA UNIV OF SCI & TECH
Synthetic method of diaryl sultam compounds
The invention discloses a synthetic method of diaryl sultam compounds. According to the method, transition metal palladium is taken as a catalyst, N-methoxybenzenesulfonamide compounds and aryne precursors are subjected to a cyclization reaction based on functionalization of a C-H bond in an ortho-position of -SO2NHOMe in N-methoxybenzenesulfonamide in presence of fluoride, and a series of diarylsultam compounds are synthesized efficiently and conveniently. The method has the advantages of simple and easily available raw materials, simple reaction operation, high substrate applicability, highatom utilization ratio and the like.
Owner:SHAANXI NORMAL UNIV
Diethynylphenylaminosilane modified silicon-containing aryne resin and preparation method thereof
The present invention relates to a diethynylphenylaminosilane modified silicon-containing aryne resin, wherein 10-40 parts by weight of diethynylphenylaminosilane SZ and 60-90 parts by weight of a silicon-containing aryne resin PSA react for 0.5-4 h at a temperature of 100-150 DEG C under a stirring reaction under the protection of an inert gas to prepare the diethynylphenylaminosilane modified silicon-containing aryne resin. According to the present invention, the diethynylphenylaminosilane modified silicon-containing aryne resin has excellent forming process characteristics such as low melt viscosity, good solubility, low curing temperature, no small molecular gas release during curing, and the like, the cured product has excellent high temperature resistance and provides excellent adhesion with fibers, the quartz fiber-reinforced composite material has excellent mechanical property and dielectric property, and the resin of the present invention can be used in rge high-tech fields of aviation, aerospace and the like.
Owner:EAST CHINA UNIV OF SCI & TECH
Sesquialter siloxane polyaryne hybrid resin and preparation method and use thereof
InactiveCN101134816AImprove mechanical propertiesImprove heat resistanceOligomerResin-Based Composite
The present invention discloses one kind of sesquisiloxane-multiaryne hybrid resin in the structure as shown, its preparation process with octo(dimethyl silicone) sesquisiloxane (Q8M811) and silicon-containing aryne oligomer, and its application in high temperature composite material, such as wave transmitting material, radiation resisting material, etc. The sesquisiloxane-multiaryne hybrid resin has broad application foreground in aviation, space flight, electronics, automobile industry and other fields.
Owner:EAST CHINA UNIV OF SCI & TECH +1
Synthesis method of conjugated alkenyl amidine compound
ActiveCN113135840AReduce use costReduce pollutionOrganic compound preparationOrganic chemistry methodsCombinatorial chemistryPerylene derivatives
The invention discloses a synthetic method of a conjugated alkenyl amidine compound, which comprises the following step: carrying out one-pot reaction on a Kobayashi aryne precursor derivative, N,N-dimethylformamide and an isonitrile compound under the action of fluorine ions to obtain the conjugated alkenyl amidine compound. According to the method, transition metal or noble metal catalysts are not needed, the reaction conditions are mild, the steps are simple, the substrate universality is good, the yield is good, and an intermediate raw material source is provided for drug synthesis.
Owner:JIANGXI NORMAL UNIV
Isoindolinone compound containing eneyne structure and synthetic method thereof
The invention relates to an isoindolinone compound containing an eneyne structure and a synthetic method thereof. The compound has the structural formula that: a specific preparation method of the compound comprises the following steps: the isoindolinone and substituted aryne are dissolved in triethylamine according to the molar ratio of 1: (1.0-2.0), dichloro (triphenylphosphine) palladium and cuprous iodide are added in catalyst amount and mixed for reaction till the raw materials are disappeared, and the isoindolinone compound containing the eneyne structure is obtained through filtration, solvent removal and purification after the reaction. The isoindolinone compound containing the eneyne structure is a significant active skeleton of drug molecules and an organic synthetic intermediate, plays an important role in pharmaceutical chemistry and has potential physiological activity. The method has easy availability of raw materials, high reaction yield and wide application range of substrates. The conventional solvent is used in reaction, the operation is simple, the condition is mild, the reaction is environment-friendly, the reaction yield can reach up to 93%, and the method is particularly applicable to industrial production.
Owner:SHANGHAI UNIV
Preparation method of terminal arylacetylenes
ActiveCN104177209AAvoid decompositionShort reaction timeSilicon organic compoundsAmino preparation from aminesArylAlcohol
The invention discloses a preparation method of terminal arylacetylenes. The method comprises the following steps: obtaining an aryne component 4-aryl-2-methyl-3-butyne-2-alcohol with 2-hydroxy-2-popyl protection groups from ayl halide and 2-methyl-3-butyne-2-alcohol by Sonogashira cross coupling reaction, and then removing the protection groups to obtain terminal arylacetylenes products, wherein the deprotection reaction is carried out by taking methylbenzene as a solvent in the presence of NaOH and diethylene glycol ethyl ether. According to the preparation method of the terminal arylacetylenes disclosed by the invention, the reaction temperature can be greatly reduced, the reaction time is shortened, and the terminal arylacetylenes can be prepared with high yield and a controlled speed at a low temperature.
Owner:TAIYUAN UNIV OF TECH
New method of synthesizing 2,4-di-substituted benzothiazole
A new method of synthesizing 2,4-di-substituted benzothiazole is disclosed, wherein R and R' both can be aryl groups, alkyl groups and heterocyclic ring groups. The method includes the steps of mixing a substituted thioamide substrate and a fluorine-containing alkali with a reaction solvent 1,4-dioxane, adding a known benzyne precursor slowly into the reaction solution to prepare 2,4-di-substituted benzothiazole, and performing column chromatographic purification to obtain a finish product of which the yield is 75%. The new method is low in raw material cost and the raw material is easy to obtain. The new method is simple in operation, is less in synthetic steps, is high in yield and has important application value in the fields of pharmaceutical chemistry and organic synthesis.
Owner:CHONGQING UNIV
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