Method for synthesizing multi-substituted chromone compound

A chromone compound, multi-substitution technology, applied in the direction of organic chemistry, etc., can solve the problems of restricting the synthesis and development of multi-substitution chromone compounds, difficult to prepare, etc.
CN102382091AActive Publication Date: 2012-03-21ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2012-03-21

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Abstract

The invention relates to a method for synthesizing multi-substituted chromone compounds, which includes a step for generating a series of multi-substituted chromone compounds, namely, enabling 2,3-allenoic acid and benzyne generated on the spot to give an insertion / 1,2-addition / ring opening / 1,4-addition reaction in tetrahydrofuran. The method for synthesizing the multi-substituted chromone compounds is simple in operation, easily obtainable in raw materials and reagent, higher in reaction yield, capable of avoiding the shortcoming of difficulty in preparation and severe conditions of a traditional method precursor, easily separable and purificatory in products, and suitable for synthesizing the multi-substituted chromone compounds.
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Description

technical field

[0001] The present invention relates to a method for synthesizing various substituted chromones, that is, a series of various substituted chromones are generated in one step through the series reaction of 2,3-alkenoic acid and benzyne generated on the spot in tetrahydrofuran compound.

[0002] Background technique

[0003] Chromone compounds are a class of compounds with benzo-γ-pyrone as the skeleton, which widely exist in nature in various forms. There are many reports on its physiological and pharmaceutical activities, and it has many uses such as anti-inflammatory, antibacterial, anti-cancer, anti-oxidation, anti-AIDS, anti-allergic, and hypolipidemic, so it has always been a hot spot in medicinal chemistry research. In the literature, such compounds are mainly prepared by the acid-catalyzed intramolecular condensation reaction of 1,3-diketone compounds, but the precursors of this method are not easy to prepare, and harsh conditions such as strong acid ...

Claims

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