11 results about "Propiolic acid" patented technology

The invention relates to a repeatable and environment-friendly process for preparing phenylpropiolic acid and derivatives thereof by a one-step method, in particular to a preparation method of phenylpropiolic acid and derivatives thereof. Specifically, the invention provides a method for preparing phenylpropiolic acid and derivatives thereof by taking CO2 as a carboxyl source under mild reaction conditions, the method has the advantages of greenness, high efficiency and good selectivity, the application range of a substrate is wide, the compatibility of functional groups of a product is good, raw materials are easy to obtain, the operation is simple and convenient, and the method has a potential synthesis application prospect.

The invention discloses a method for preparing a polyfluoroalkyl coumarin derivative, and belongs to the field of organic synthesis. According to the method, cheap and easily available polyfluorocarboxylic acid anhydride is used as a polyfluoroalkylating reagent, and in-situ activation of NHPI is combined to prepare the C3-site polyfluoroalkyl substituted coumarin derivative. Under the condition of visible light catalysis, polyfluoroalkyl carboxylic acid anhydride is used as a polyfluoroalkylating reagent, polyfluoroalkyl free radicals are generated through in-situ activation of NHPI, the free radicals and aromatic propiolate are subjected to a free radical cyclization rearrangement reaction, and finally preparation of the C3-site polyfluoroalkyl substituted coumarin derivative is achieved. The polyfluoroalkyl carboxylic acid anhydride used in the method is stable in property, low in price and easy to obtain, and the synthesis cost is reduced. The method is wide in applicable substrate range and applicable to various polyfluoroalkyl carboxylic acid anhydrides, and the tolerance of reaction functional groups is good.

The invention discloses an adsorbent material for perfluorinated compounds in water and a preparation method and application thereof, and belongs to the technical field of water treatment materials, 1, 3-diamino-2-hydroxypropane, m-tribenzoic acid and 3, 3 '-(1, 4-phenylene) bis [2-propiolic acid] are used as raw materials to react to obtain a polyamide polymer, and finally the polyamide polymer is hydrolyzed to remove the m-tribenzoic acid to obtain the perfluorinated compounds in the water. The polymer adsorbent material is prepared; the adsorbent material for the perfluorinated compounds in the water, prepared by the invention, has a relatively large specific surface area and adsorption capacity, can be used for adsorbing the perfluorinated compounds in the water, has relatively strong mechanical stability, long service life and regeneration capacity, and has a good application prospect in the aspect of removing the perfluorinated compounds in the water.

The application discloses a preparation method of 4-bromothieno[2,3-c]pyridine-2-carboxylic acid ethyl ester, which comprises the following steps: 5-bromo-4-iodopyridine-3-thiol and propargyl acid ethyl ester are subjected to a Sonogashira coupling and a ring-closing series reaction under the action of a catalyst and an alkali to obtain 4-bromothieno[2,3-c]pyridine-2-carboxylic acid ethyl ester. The raw material adopted by the method is cheap and easy to obtain, the synthesis method is simple to operate, the reaction condition is mild, the requirement for equipment is low, and the method is suitable for the needs of industrial large-scale production.

Disclosed is a novel method for preparing a crosslinked film without the use of a catalyst. The propiolic acid ester is obtained by grafting propiolic acid with glycidyl or epoxy under mild conditions by using a phosphonium catalyst. The propiolic acid ester can be thermally crosslinked at temperatures as low as 120 DEG C (such that the polymer film is insoluble), while some embodiments can be photoinduced crosslinked upon exposure to DUV light. The resulting cross-linked membrane is equivalent to or better than an acid-catalyzed epoxide cross-linked membrane in stability, and can be used in a variety of different applications.

This invention belongs to the field of herbicide technology and aims to solve the problems of complex preparation processes for dichloroisoxaflubenzuron, high equipment requirements, and environmental disadvantages. To this end, this invention provides a green synthetic method for preparing dichloroisoxaflubenzuron and the application of the prepared product in herbicides. The method includes reacting 5-hydroxymethylfurfural with hydroxylamine hydrochloride to generate an oxime product, followed by the direct addition of a propynic acid derivative, and cyclization under a first bifunctional catalyst and a hydrogen atmosphere to generate intermediate I; dissolving or dispersing intermediate I in a chloride-containing electrolyte and anolyzing it to generate a dichloro intermediate II; reacting dichloro intermediate II with an acrylate compound under light conditions and a catalyst in a one-pot conversion reaction to directly obtain crude dichloroisoxaflubenzuron; and finally, introducing the crude product into a continuous crystallization and separation device to obtain a high-purity dichloroisoxaflubenzuron product. This invention features a simple process, reduces equipment requirements, and is environmentally friendly.

The application belongs to the field of compound organic synthesis, and particularly relates to a synthesis method of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid. The application provides a new method for synthesizing 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, wherein inexpensive propargylic acid is selected as a reaction material in a reaction process, and the synthesis method is simple. In the application, the 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is synthesized by using more inexpensive difluoromonochloromethane and carbon monoxide for the first time, the 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is low in price, high in reaction selectivity, low in generation of three wastes, high in economic value and environmental protection value, and more suitable for industrialized production.

The invention discloses acenaphthene resin, a preparation method thereof and a copper-clad plate prepared from the acenaphthene resin, and belongs to the field of high polymer materials. The acenaphthylene resin is prepared from the following raw materials in parts by weight: 45 to 60 parts of acenaphthylene-diallyl bisphenol A prepolymer, 4 to 9 parts of single benzene ring acrylate, 0.3 to 1 part of initiator and 40 to 50 parts of toughening coating filler. The preparation method comprises the following steps: stirring, mixing and heating the acenaphthylene-diallyl bisphenol A prepolymer, the single-benzene-ring acrylate, the toughening coating filler and the solvent, adding the initiator for reaction to obtain an acenaphthylene resin glue solution after the reaction is finished, and drying the acenaphthylene resin glue solution to obtain the acenaphthylene resin. The acenaphthene resin has the effect of improving the damp-heat resistance of the acenaphthene resin for preparing the copper-clad plate.

The invention relates to a Cu-based catalyst and application of the Cu-based catalyst in tandem preparation of adipic acid (ester) or hexanediol from propiolic acid (ester) or propargyl alcohol. According to the method, by constructing the copper-based catalysts in different dispersed states, the structure of the copper active species is effectively regulated and controlled, the copper active species are suitable for different reaction steps such as oxidative coupling reaction and hydrogenation reaction, and therefore the efficiency of the whole cascade reaction is improved. In the reaction process, the fully-exposed copper cluster catalyst is beneficial to promoting the oxidative coupling reaction of propiolic acid or propiolic acid ester, and the copper nanoparticle catalyst shows good hydrogenation activity and selectivity in the subsequent hydrogenation reaction. Compared with the prior art, the method has the advantages that a noble metal catalyst does not need to be used, efficient conversion from propiolic acid (ester) or propargyl alcohol to adipic acid (ester) or hexanediol can be achieved under mild conditions by reasonably regulating and controlling the dispersion state of copper species and reaction conditions, and the method has the advantages of being high in reaction selectivity, good in catalyst stability, high in environmental friendliness and the like. The method provides a green and efficient technical approach for synthesizing C6 dicarboxylic acid with high additional value and ester compounds thereof by taking acetylene and C1 raw materials as starting points, and has a good application prospect.

The application discloses a method for preparing coumarin derivatives by photocatalysis of three components and application, which comprises the following steps: adding propynoate compounds shown in formula (I), 2-bromo-2,2-difluoro-N-aryl / alkyl acetamides shown in formula (II) and DABSO shown in formula (III) into a reaction solvent, stirring and reacting under the protection of nitrogen and light, and obtaining target compounds, i.e., difluoroaminosulfonylated / bicyclic coumarin derivatives shown in formula (IV) with antitumor activity after post-treatment of the reaction liquid, wherein the reaction equation is as follows: the DABSO is bis(dioxidosulfur)-1,4-diazabicyclo[2.2.2]octane adduct; R is selected from H, C1-C4 alkyl, a halogen group, methoxy or trifluoromethyl; R 1 is selected from C1-C6 alkyl or aryl; and R 2 is selected from aryl or C1-C6 alkyl. The application has the advantages of simple operation, cheap and easily available raw materials, mild reaction conditions, green environmental protection, high atom economy and yield, and difluoroaminosulfonylated coumarin derivatives with antitumor activity.

The invention discloses a synthesis method of an N-aryl amide compound, which comprises the following steps: dissolving a carboxylic acid compound, a propiolic acid ester compound and an organic base catalyst in an organic solvent, reacting at 80-130 DEG C for 5-60 minutes to obtain an active intermediate, adding an aromatic amine compound into the organic solvent, and continuously reacting at 80-130 DEG C for 0.5-12 hours to obtain the N-aryl amide compound. The invention provides a method for synthesizing the N-aryl amide compound by directly mediating carboxylic acid and aromatic amine to perform one-pot reaction by utilizing propiolic acid ester by utilizing a propiolic acid ester mediating strategy, and the synthesis method is efficient, simple and convenient to operate, strong in substrate universality and mild in reaction condition, and can be used for preparing intermediates.