32 results about "2-aminobenzimidazole" patented technology

The invention relates to polyimide containing a benzimidazole unit and a preparation method thereof. The polyimide has the following structural formula. The preparation method comprises the following steps of: firstly, performing the reaction on 2,6-disubstituted aniline and aldehyde under the acidic condition to generate a diamine compound 3,3',5,5'-tetra-substituted aromatic diamine; and then, after mixing the synthesized aromatic diamine and a heterocyclic diamine monomer 6-aminophenyl-2-aminobenzimidazole according to a certain ratio, performing the reaction on the mixture and a dianhydride monomer in an organic solvent to obtain the polyimide. The polyimide provided by the invention has excellent solubility property, can be dissolved in conventional solvents such as NMP (N-methyl-2-pyrrolidone) and DMAc (dimethyl acetamide), has excellent heat resistance and mechanical property and has excellent thermal properties of glass-transition temperature of over 410 DEG C, decomposition temperature of over 500 DEG C and the like.

The invention discloses a zeolite imidazate framework / polyamide composite membrane and a preparation method thereof. The preparation method comprises the following steps: dissolving sodium formate, 2-aminobenzimidazole and 2-methylimidazole into deionized water so as to obtain a mixed solution; dissolving zinc salt into N,N-dimethyl formamide so as to obtain a zinc salt solution; performing mixing reaction on the mixed solution and the zinc salt solution, and performing centrifugation, washing and drying so as to obtain an NH2-ZIF-8 nano material; and soaking a substrate membrane into an organic phase solution, pouring off an organic phase solution on the substrate membrane, naturally drying in air, soaking the substrate membrane into a water-phase solution, pouring off the water-phase solution on the substrate membrane, cleaning the surface of the substrate membrane with deionized water, and drying in air at room temperature, thereby obtaining an NH2-ZIF-8 / polyamide composite membrane. The prepared NH2-ZIF-8 / polyamide composite membrane is used for separating gases such as CO2, N2, H2, CH4 and NOx, and the permeability and the selectivity of the membrane can be improved.

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

A chromatography media such as silica controlled pore glass or agarose containing an affinity ligand such as 2-Aminobenzimidazole (ABI) or aminomethylbenzimidazole (AMBI). The ligand is present in density of from about 30 to about 80 μmole / ml.

The present invention provides forms of curcumin and the pharmaceutical compositions thereof. The forms of curcumin disclosed herein are curcumin polymorph Form III, curcumin-2-aminobenzimidazole co-crystal, and curcumin-L-lysine co-crystal. Further, the invention provides methods inhibiting cancer cells and HSV-1 using these curcumin novel solid forms.

The invention discloses a time resolution fluorescent immunochromatographic test strip for detecting carbendazim, and a preparation method and application thereof. The time resolution fluorescent immunochromatographic test strip comprises a bottom plate and further comprises a sample absorbent pad, a combination releasing pad, a nitrocellulose membrane and a water absorbent pad which are lapped and pasted on the bottom plate in sequence. A carbendazim monoclonal antibody labelled by fluorescent microspheres is embedded into the combination releasing pad, and a detecting area and a quality control area are fixed to the nitrocellulose membrane. A carbendazim hapten-carrier protein conjugate is sprayed in the detecting area, and an anti-sheep and anti-mouse antibody is sprayed in the qualitycontrol area. A carbendazim hapten is obtained in the mode of reacting of 2-aminobenzimidazole with butanedioic anhydride. The invention further provides the preparation method of the test strip and amethod for detecting the carbendazim in samples by applying the test strip. The time resolution fluorescent immunochromatographic test strip and the detecting method provided by the invention have the advantages that operation is easy, sensitivity is high, the detecting speed is high, and the cost is low, and the carbendazim in the large-batch samples can be detected quickly and monitored on site.

The invention discloses amidation modified graphene oxide and a preparation method and application thereof. The preparation method comprises the following steps: dissolving graphene oxide in an organic solvent, and carrying out ultrasonic treatment for 1 hour to enable the graphene oxide to be dispersed fully; weighing 2-aminobenzimidazole, slowly adding the 2-aminobenzimidazole in suspension liquid of the graphene oxide, and reacting for 36-48 hours under magnetic stirring and heating; cooling to a room temperature and then carrying out suction filtration, and washing repeatedly; placing an obtained filter cake in a vacuum drying box, and drying for 24 hours under vacuum to obtain the amidation modified graphene oxide. In a preparation process of the amidation modified graphene oxide, over-high requirements to equipment do not exist, technological conditions are conventional, the process is simple and convenient to operate, the amidation modified graphene oxide is suitable for a composite filling material of an anti-corrosion coating, and the corrosion resistance of the coating can be improved remarkably.

The invention discloses a preparation method and application of a carbendazim hapten and antigen. The method is characterized in that the carbendazim hapten is prepared from 2-aminobenzimidazole and butanedioic anhydride which are reacted; the carbendazim antigen is obtained by coupling the carbendazim hapten and carrier protein. The antigen prepared through the method presents a specific carbendazim antigenic determinantantigen epitope, so that screening out a high-specificity carbendazim monoclonal antibody becomes possible; the generated antibody is high in specificity and high in sensitivity, and can be used for building an enzyme-linked immunosorbent assay method and a colloidal gold test strip rapid determination method, so that carbendazim in tobacco and food is fast detected.

The invention discloses a preparation method of an antistatic silica gel protective film. The preparation method comprises following steps: 1, a substrate layer is prepared; 2, methyl vinyl silicone rubber, polyisoprene rubber, silicone resin, vinyl silicone oil, hydrogen-containing silicone oil, 3-thiocyanopropyltriethoxysilane, 2-aminobenzimidazole, nanometer graphite powder, lauryl alcohol phosphoric acid ester potassium, toluene, and ethyl acetate are uniformly mixed and stirred, methylbutynol, platinum catalyst, and cyclohexanone peroxide are stirred uniformly to prepare an organic silicagel adhesive; 3, the surface of the substrate layer is uniformly coated with the organic silica gel adhesive, and curing is carried out so as to form an organic silica gel layer and obtain a semi-finished protective film; and 4, the semi-finished protective film is cut into strips based on need so as to obtain the antistatic silica gel protective film. The antistatic silica gel protective film islow in surface resistivity; and in using process of the antistatic silica gel protective film, no static discharging is caused, so that a problem in the prior art that automatic continuous product isinfluenced by static discharging is solved.

The invention relates to the technical field of metal surface treatment chemicals, in particular to a coarse micro-etching agent used in a circuit board and a preparation method of the coarse micro-etching agent. The coarse micro-etching agent is composed of, by weight, 5%-10% of sulfuric acid, 0.01%-0.1% of copper sulfate pentahydrate, 0.05%-1% of piperidine or 4-Cloperastine or 4-Hydroxypiperidine or 4-aminopiperidine, 0.1%-1% of 2-aminobenzimidazole or 2-mercapto benzimidazole or benzimidazole-2-methanal or 2-alkylbenzimidazole or 2-phenylbenzimidazole or 2-(4-pyridine) benzimidazole or 2-(4-benzyl) benzimidazole, 0.1%-1% of benzenesulfonic acid or p-chlorobenzenesulfonic acid or sulfanilic acid or p-methyl benzene sulfonic acid, 0.05%-1% of tetrazole or 5-amino-1H-tetrazole hydrate or 5-methyl tetrazole or 5-phenyl-tetrazole and the balance being deionized water. The coarse micro-etching agent used in the circuit board is stable in component, long in service life, capable of effectively removing oxides on the surface of metal and enabling the surface of the metal to be in proper coarse degree after micro-etching and especially suitable for increasing the binding force of a dry film and the copper surface in the process of pressing the dry film; in addition, through control over the coarse degree, the dry film is firm during pressing, and the exposed dry film can be removed more easily.

The invention relates to the field of medicinal chemistry and particularly relates to 2-aminobenzimidazoles, preparation methods thereof, medicinal compositions with the 2-aminobenzimidazoles and medical applications of the 2-aminobenzimidazoles.

The invention discloses a benzimidazole Schiff base and a synthesis method thereof. The structure formula of the compound is as follows: FORMULA, wherein R is hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen or nitryl. The synthesis method comprises the following steps of: dissolving 2-aminobenzimidazole and substituted benzaldehyde in the molar ratio of 1: (1-1.5) by organic solvent; adding catalyst; heating to 105-115 degrees centigrade by 100-400W microwave irradiation; reacting for 5-20min; cooling; filtering; washing; and re-crystallizing to obtain series of derivatives of benzimidazole Schiff base. The invention has the advantages of short reaction time, high yield and easy industrialization.

The invention discloses a 2,3-disubstituted benzimidazo[1,2-alpha]pyrimidine compound and a preparation method and the application thereof. The compound adopts a structural formula as shown in the specification, wherein R represents any one of phenyl, C1-C4 alkyl-substituted phenyl, C1-C4 alkoxy-substituted phenyl, halogenated phenyl, cyano-substituted phenyl, thienyl and naphthyl. The compound isprepared from aromatic aldehyde, 2-aminobenzimidazole and propiolic acid as raw materials by a one-pot method under the coaction of a copper catalyst and an alkaline additive. A synthesis method is simple, intermediate separation is not required, operating steps are simplified, and the application range of a substrate is relatively wide. The compound has fluorescence performance and can be applied to selective fluorescent detection of low-concentrations of Fe<3+>.

The invention discloses a method for detecting carbendazim content in edible fungi by using carbendazim-specific antibody. The method includes: stirring and dissolving 2-aminobenzimidazole in acetonitrile, adding succinic anhydride, stirring and reacting at 40 for 4 h, filtering a reaction solution to obtain residue, washing the residue twice with acetonitrile at 40 DEG C to obtain a crude product, subjecting the crude product further to column chromatography purification, and identifying via thin-layer chromatography and mass spectrometry to obtain the product 2-succinyl benzimidazole. A 4-carbon spacer arm is then coupled to 2-amino group of the 2-succinyl benzimidazole to serve as a hapten, and coupling carrier proteins by activated ether method to obtain an artificial antigen; then, a specific polyclonal antibody is acquired by animal immunization and antiserum purification; finally, simple, quick and sensitive direct competitive ELISA (enzyme-linked immuno sorbent assay) method established via the antibody is utilized to quantify carbendazim in edible fungi, and important technical means is provided for monitoring carbendazim content in edible fungi.

The invention discloses a CO2 gathering agent for soil. The CO2 gathering agent is prepared from, in parts by weight, 30-40 parts of peat soil, 8-12 parts of L-arginine and 10-30 parts of expanded vermiculite. The CO2 gathering agent for the soil takes the peat soil, L-arginine and the expanded vermiculite as main raw materials, has better gathering performance on CO2 gas and produces no side products during adsorption; 3-butenamine hydrochloride, a zeolite molecular sieve, an imidazole framework material, sodium humate, photosynthetic bacteria, ethylindole-3-carboxylate, cocoanut fiber, 2-aminobenzimidazole and polyethylene polyamine are added to host materials in a corresponding proportion, the gathering efficiency of the CO2 gathering agent is further increased, the CO2 gathering agenthas remarkable effects on the physical property of the soil, the photosynthetic gathering and controlled release capability of plants is notably improved, and the physical structure of the soil is activated.

The invention discloses a defective-glue-prevention silica gel protection membrane for processing. The defective-glue-prevention silica gel protection membrane comprises a base material layer and an organic silica gel layer coating the surface of the base material layer. The organic silica gel layer is prepared from 200-350 parts of methyl vinyl silicone rubber, 10-40 parts of polyisoprene rubber,10-25 parts of silicone resin, 2-6 parts of vinyl silicone oil, 0.5-5 parts of hydrogen-containing silicone oil, 0.3-4 parts of 3-3-thiocyanatopropyltriethoxysilane, 0.3-2 parts of 2-aminobenzimidazole, 0.5-3 parts of methylbutynol, 0.5-2 parts of a platinum catalyst, 0.3-1 part of cyclohexanone peroxide, 0.2-3.8 parts of nano-graphite powder, 1-3 parts of lauryl alcohol phosphoric acid ester potassium, 400-600 parts of methylbenzene and 250-400 parts of ethyl acetate. The protection membrane is moderate in viscosity, the problems of edge warping and even shedding in the using process do noteasily occur, defective glue is easily removed completely, and the technology requirement for temporary fixing during mobile phone processing can be met.

The invention discloses a method for preparing a 2-aminobenzimidazole derivative. The method comprises the following steps that: in the presence of a copper catalyst and an alkaline compound, 2-halogen phenylamine and carbodiimide are reacted to form the 2-aminobenzimidazole derivative. In the method, the copper catalyst is any of CuI, CuBr and CuCI; and the alkaline compound is tBuONa. The method for preparing the 2-aminobenzimidazole derivative, which is provided by the invention, is scientific and reasonable, the 2-aminobenzimidazole derivative with various substituent groups, which cannot be synthesized by the other method, can be synthesized and obtained, and the method also has the characteristics that synthesis yield is high and a product is easy to purify.

The invention relates to an antibacterial high-toughness polyhexylenediamine adipate / polyphenylene oxide composite material and preparation method thereof. The composite material is prepared from: PA66, PPO, toluene diisocynate, silver methacrylate, 2-aminobenzimidazole, an initiator and an antioxidant. The composite material has excellent processability and anti-impact toughness and durable and great antibacterial effect, and can be applied to the fields, such as electronic and electrical, automobile interiors and exteriors, etc.

The invention discloses a catalyst, a system and a method for achieving simple and convenient catalytic preparation of a benzimidazo [2, 1-b] quinolin-6-one derivative, and belongs to the technical field of preparation of chemical materials. The system comprises a reaction container, a microwave reactor, a suction filtration device, a washing device and a drying device. Aromatic aldehyde, 1, 3-cyclohexanedione and 2-aminobenzimidazole are used as reactive raw materials, and through selection of specific functionalized ionic liquid as a catalyst and in a microwave-assisted heating reaction way, the utilization rate of the raw materials and the yield rate of the obtained product can be effectively increased; the catalyst is relatively small in using amount, good in recycling performance and low in preparation cost and is conveniently produced industrially on a large scale.

The invention discloses a 2-aminobenzimidazole sterilization microsphere, and a synthetic method and application thereof. The synthetic method comprises the following steps: (1), a chloromethylated bead is used as a parent compound, 2-aminobenzimidazole is used as a ligand, a catalyst of metal sodium is added, and under the protection of nitrogen gas, stirring is performed for 10-12h at a rotation speed of 200rpm at a temperature of 70-90 DEG C, washing is finished, and vacuum drying is performed at a temperature of 50 DEG C; and (2), the material obtained in the step (1) is placed in a reaction vessel, propylene oxide is added under the atmosphere of nitrogen gas, stirring is performed for 5-7h at a temperature of 15-25 DEG C, benzyl chloride is added to the reaction vessel, reaction is performed for 5-7h at room temperature with stirring, then filtration is performed, and washing is repeatedly performed by using ethanol and distilled water in a filtration process, and the filtered microsphere is subjected to vacuum drying at a temperature of 50 DEG C, so that the water-insoluble immobilized sterilization microsphere is obtained. The raw material of the obtained sterilization microsphere is the chloromethylated bead, and the chloromethylated bead has relatively high mechanical strength and physical stability, the source is wide, the price is low, and the economic benefits are remarkable. The synthetic method of the composite sterilization microsphere provided in the invention is convenient in operation, green and economic, and has good application prospect.

The invention provides a compound type carbon steel pickling corrosion inhibitor and application thereof and belongs to the technical field of corrosion inhibitors. The corrosion inhibitor comprises thiotriazinone-sulfonate-containing type surfactant, a heterocyclic compound and Tween, wherein the heterocyclic compound comprises at least one in 2-mercaptobenzothiazole and 2-aminobenzimidazole, andthe structure of the thiotriazinone-sulfonate-containing type surfactant is shown as the general formula (I), wherein n=5-11. The compound type carbon steel pickling corrosion inhibitor is mainly applied to carbon steel pickling, all the components which are the thiotriazinone-sulfonate-containing type surfactant, the small molecule heterocyclic compound and the Tween interact synergistically, thus a compact adsorption layer is formed on the surface of carbon steel, and the corrosion inhibition effect of the corrosion inhibitor on the carbon steel is improved.

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

The invention discloses a triphenylamine derivative with AIE characteristics, which is prepared by reacting 4-formyl triphenylamine with 2-aminobenzimidazole in the presence of a solvent and a catalyst by stirring and refluxing the reactants at 60-80 DEG C for 18-24 hours. The invention also discloses a preparation method and applications of the derivative. The triphenylamine derivative can be used as a pH probe to detect volatile organic acid and alkali. In addition, the triphenylamine derivative probe responds to mercury ions under neutral and alkaline conditions, and has potential application in detection of heavy metal, mercury ions.

The invention discloses a carbendazim-degrading bacterium MBC‑6F, which was preserved in the China Center for Type Culture Collection on December 31, 2014, with the preservation number CCTCC NO: M 2014680. The carbendazim-degrading bacteria MBC‑6F was isolated and screened in the soil. It was identified as Microbacterium sp.MBC‑6F by 16S rDNA, which can directly produce specific degradation effect on carbendazim. According to HPLC analysis, MBC‑6F can degrade carbendazim within 72 hours. Completely degrade 40µM carbendazim, the optimum degradation temperature is 37℃, and the optimum degradation acidity is pH 7.0. The main degradation products determined by HPLC-MS are 2-aminobenzimidazole and 2-hydroxybenzimidazole. The 16S rDNA sequence of the strain was disclosed for the first time, as well as the degradation efficiency and product analysis of carbendazim.