A kind of synthetic method of carbendazim hapten

A synthetic method and hapten technology, applied in the direction of chemical instruments and methods, material inspection products, instruments, etc., to achieve highly specific effects

Active Publication Date: 2016-06-22
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, the analogue 2-aminobenzimidazole of carbendazim is synthesized as a raw material, and the hapten of carbendazim is obtained through three steps of chemical reactions. This hapten has no literature reports at present

Method used

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  • A kind of synthetic method of carbendazim hapten
  • A kind of synthetic method of carbendazim hapten
  • A kind of synthetic method of carbendazim hapten

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Embodiment 1

[0026] The preparation of embodiment 1 carbendazim hapten

[0027] (1) Synthesis of active ester 348: tert-butyloxycarbonyl (Boc)-protected aminocaproic acid, 1.155 g, 5 mmol, was dissolved in 20 mL of dichloromethane-tetrahydrofuran mixed solvent, the mixing volume ratio was 1:1, followed by Add the condensing agent 1-hydroxybenzotriazole monohydrate (HOBT) and 1-(3-dimethylaminopropyl)-3-ethyl carbon in an equimolar amount to the aminocaproic acid protected by tert-butyloxycarbonyl Diimine (EDCI), stirred at room temperature for 2h, set aside;

[0028] (2) Synthesis of precursor 346: 2-aminobenzimidazole (0.665 g) dissolved in a small amount of DMF was added to the active ester 348 solution prepared in step (1), and stirred at room temperature overnight; the reaction solution was rotary evaporated to remove dichloro Methane-tetrahydrofuran, the residue was dissolved in 20 mL of dichloromethane, washed three times with water, 20 mL each time; then washed three times with sat...

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Abstract

The invention relates to a synthetic method for carbendazim hapten, and belongs to the technical field of biochemical engineering. According to the synthetic method, 2-aminobenzimidazole is used as a raw material; the carbendazim hapten is obtained by three steps of chemical reactions; and liquid chromatography-mass spectrometry technology and nuclear magnetic resonance technology are used to identify and analyze important intermediate products and a target product. With the method, the carbendazim hapten is synthesized successfully, and synthetic steps are safe and effective, thereby providing favorable conditions for establishing an enzyme-linked immunoassay method of carbendazim and meeting requirements of domestic studies.

Description

technical field [0001] The invention relates to a method for synthesizing carbendazim hapten, which belongs to the technical field of biochemical industry. Background technique [0002] Carbendazim is a broad-spectrum, high-efficiency, low-toxic systemic benzimidazole fungicide. Its chemical structural formula is as follows: [0003] [0004] Its mechanism of action is that it interferes with cell division by interfering with the formation of the cell spindle, and has good protective and therapeutic effects on plants. It is widely used in various agricultural products, and has the effect of preventing and controlling the diseases of various crops caused by fungi (such as Deuteromycetes, polyascomycetes). Can be used for foliar spray, seed treatment and soil treatment etc. Carbendazim has potential damage to animal liver, kidney and reproductive system. [0005] At present, the methods for detecting carbendazim are mainly gas chromatography (GC), liquid chromatography ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D235/30C07K16/44G01N33/531G01N33/53
CPCC07D235/30C07K16/44G01N33/53G01N33/531G01N33/577G01N2430/00
Inventor 徐丽广胥传来严会娟匡华马伟刘丽强宋珊珊吴晓玲
Owner JIANGNAN UNIV
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