500results about How to "Increased susceptibility" patented technology

Breed-specific dog food formulations that comprise chicken meat as the major ingredient, rice as the predominant (or sole) grain source, fruit and / or vegetable fiber as the primary or sole fiber source, unique fat and antioxidant blend, vitamins, herbs and spices, carotenoids, and no corn or artificial colors, preservatives, flavors or sugars are provided.

A dietary supplement blend composition is disclosed, the basic formulation of the composition containing vitamins, minerals, and carotenoids. The composition can also contain bioflavonoids, cartilage protectors such as glucosamine or chondroitin, alpha-lipoic acid, coenzyme Q10, and a source of omega-3 fatty acids such as flax seed oil. The composition is beneficial for improving health and preventing disease, particularly for degenerative conditions. A method for supplementing the diet is also disclosed, wherein the quantity of daily rations of the dietary supplement blend composition is determined based on the person's age, body weight, and quality of diet.

A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.

An intracranial, light-emitting implant for providing therapy to a patient having Alzheimer's Disease.

The invention relates to a therapeutic device to promote the healing of a wound, comprising a porous paid which is permeable for fluids to place on the wound, a bandage to cover the wound and to provide an essentially airtight seal around the wound, a drainage line connecting the pad with a suction pump so that suction can be applied to the wound to draw the fluids away from it, whereby the line is connected to the suction pump via a canister to collect fluid sucked from the wound, a connector to connect the pad to the drainage line, means to determine a prevailing wound pressure basically comprising the wound and this surrounding skin area, as well as a control unit to control the wound pressure. In order to generally improve metrology with the goal of making possible a more reliable and more secure dressing of the wound, and also to design metrology in an especially simple and error-free way, it is proposed that the pad interconnect the suction pump solely via the drainage line.

A composition for treating a biofilm comprises a first anchor enzyme component to degrade biofilm structures and a second anchor enzyme component having the capability to act directly upon the bacteria for a bactericidal effect.

Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a silyl ether chemistry that facilitates degradation of the polymer. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.

The present invention restores the normal low-dose flushing of the lower airways with air from the upper airways, containing nitric oxide (NO) and possible other biologically active agents by aspiration of air from the upper airways and introducing said air in the inspiratory airflow of a ventilator. The inventive apparatus and method is free from the risks associated with traditional administration of exogenous NO.

Contemplated compositions and methods are directed to the use of microvesicles from an optionally recombinant donor cell to impart a desirable effect to a recipient cell. In certain preferred aspects, RNA of the microvesicles is employed to achieve the desirable effect. For example, microvesicles are used in vitro to increase the number of passages of a cell growing in a medium, reduce serum and / or growth factor requirements of a cell growing in a medium, and / or delay differentiation of a cell growing in a medium. Further preferred aspects include use of the microvesicles as therapeutic agents in which RNA, a membrane protein, and / or a cytosolic protein encapsulated in or coupled to the microvesicle provide a therapeutic effect. Additionally, diagnostic methods are contemplated in which RNA of a microvesicle isolated from a mammal is associated with a condition of the mammal.

The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.

A significant problem in PEM fuel cell durability is in premature failure of the ion-exchange membrane and in particular by the degradation of the ion-exchange membrane by reactive hydrogen peroxide species. Such degradation can be reduced or eliminated by the presence of an additive in the anode, cathode or ion-exchange membrane. The additive may be a radical scavenger, a membrane cross-linker, a hydrogen peroxide decomposition catalyst and / or a hydrogen peroxide stabilizer. The presence of the additive in the membrane electrode assembly (MEA) may however result in reduced performance of the PEM fuel cell. Accordingly, it may be desirable to restrict the location of the additive to locations of increased susceptibility to membrane degradation such as the inlet and / or outlet regions of the MEA.

The present invention comprises systems and methods for cellular, PCS, GPS and / or Bluetooth mobile communication (e.g., a mobile telephone). The systems and methods employ a fully integrated dual band IFA / loop CDMA antenna for cellular and PCS communication. Fully integrating the CDMA antenna within a PWB provides for mitigation of lumped elements to establish dual banding, and can provide for reduced antenna size, device size, cost and interference form a user's hand. The IFA antenna is configured to transmit and receive within the cellular frequency band via a capacitive tap, and the loop antenna is configured to transmit and receive within the PCS frequency band via an impedance matching stub and ground location. The system and methods further employ a firewall to mitigate antenna coupling, and a metal reflector to reduce the electromagnetic reflection, and improve antenna gain and efficiency.

A method of developing a brain state advisory system including the following steps: deriving a brain state advisory algorithm; applying the brain state advisory algorithm to patient EEG data to identify occurrences of the target patient brain state (such as, e.g., a pro-ictal state or a contra-ictal state) in the patient EEG data; determining if a performance measure of the advisory algorithm for the target brain state exceeds the performance measure of a chance predictor for the target brain state; and if the performance measure of the advisory algorithm for the target brain state exceeds the performance measure of a chance predictor for the target brain state, storing the advisory algorithm in memory of the brain state advisory system. The invention also includes seizure advisory systems.

The present invention is directed to a method of pre-treating a lignocellulosic feedstock. The lignocellulosic feedstock comprises cereal straw, stover, or grass. One or more than one bale of lignocellulosic feedstock is conveyed into a pre-treatment reactor. Steam and acid are added to the bales and are maintained at a temperature, acid concentration, and for a time sufficient to hydrolyze hemicellulose to xylose and increase susceptibility of cellulose to digestion by cellulase enzymes, thus producing a pre-treated feedstock. The pre-treated feedstock is then removed from the pre-treatment reactor.

Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.

Methods for stabilizing unstable proteins or for restoring functionality to non-functional or poorly functioning (semi-functional) proteins using exon skipping technology are provided. The methods involve the administration of antisense oligonucleotides to cause exon skipping, thereby removing one or more exons responsible for protein instability or lack of functionality. For example, exons encoding protease recognition sites may be removed. The method is useful for treating diseases caused by protein instability, such as Becker Muscular Dystrophy, or for treating Duchenne Muscular Distrophy patients with semi-functional dystrophin due to treatment with other exon skipping or stop codon readthrough therapies.

In response to the need for highly-sensitive antibiotic susceptibility assays and identification assays that do not require extensive incubation times, the present invention provides automated assay methods and systems that permit the determination of antibiotic susceptibilities and / or microorganism identification in a timeframe that is substantially shorter than has previously been attainable using a hybrid system that combines turbimetric and fluorescence determinations using a single, clear-plastic assay platform. Related devices, kits, and components thereof are also disclosed.

The present invention relates to methods for treating inflammation in body tissues. More specifically, certain disclosed methods relate to selectively inducing apoptosis in inflammatory immune cells. The methods are particularly suitable for treating inflamed atherosclerotic plaques. The techniques generally involve heating the cells with a catheter that is equipped to produce infrared radiation. The cells are heated for a sufficient time and at a sufficient temperature to induce programmed cell death.

A method for manufacturing a semiconductor device including a semiconductor substrate composed of silicon carbide, an upper surface electrode which contacts an upper surface of the substrate, and a lower surface electrode which contacts a lower surface of the substrate, the method including steps of: (a) forming an upper surface structure on the upper surface side of the substrate, and (b) forming a lower surface structure on the lower surface side of the substrate. The step (a) comprises steps of: (a1) depositing an upper surface electrode material layer on the upper surface of the substrate, the upper surface electrode material layer being a raw material layer of the upper surface electrode, and (a2) annealing the upper surface electrode material layer. The step (b) comprises steps of: (b1) depositing a lower surface electrode material layer on the lower surface of the substrate, the lower surface electrode material layer being a raw material layer of the lower surface electrode, and (b2) annealing the lower surface electrode material layer with a laser to make an ohmic contact between the lower surface electrode and the substrate.

In a method for dynamically optimizing resource utilization in a system over time according to one or more objectives, data including information indicative of current environmental conditions, upcoming environmental conditions, a current state of a system configuration, and current system operating conditions is dynamically updated. Automatic analysis of the data using a probabilistic model based on conditional relationships is performed periodically. For each periodically generated set of possible system control actions, a probabilistic model is used to automatically analyze each possible system control action and an optimal system control action is selected based on a set of current utility functions. For each periodically generated set of possible system control actions, control of the system according to the optimal system control action selected from the possible system control actions. Resource optimization couples condition-based and environmental monitoring with automated reasoning and decision making technologies, to develop real time optimal control and decision strategies.

The invention discloses a method for the production of packaging made from borosilicate glass for pharmaceutical products and medical products comprising the steps of: providing a glass tube made from a borosilicate base glass, generating a temporary interface layer on an inner surface of the glass tube, hot-forming the glass tube at a temperature above Tg, and cooling down the glass tube to room temperature.

The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.

A digital printer is equipped with a built-in color measurement device (6) in the form of a colorimeter or spectral photometer, as well as with color management support. The built-in color measurement device (6) is used for control and optimization of the print output, especially for the simplification, optimization and automation of the work processes and for the verification of the output results.

The invention relates to methods and compositions for reducing exosome mediated tumor resistance against a therapeutic binding molecule and for increasing the efficacy of a therapeutic binding molecule suitable in the treatment of a disease. The methods include administering an effective amount of at least one agent inhibiting exosome formation and administering the therapeutic binding molecule.

A chip on film according to an exemplary embodiment includes: a driving film, a wire layer formed on a first surface of the driving film, a driving chip connected to the wire layer, and an electromagnetic wave blocking layer formed on a second surface of the driving film, in which a mesh portion may be formed on a portion of the electromagnetic wave blocking layer.

A monolithically formed laser and photodiode. The monolithically formed laser and photodiode includes a Vertical Cavity Surface Emitting Laser (VCSEL) that includes a first PN junction. The first PN junction includes a first p layer and a first n layer. A tunnel diode is connected to the VCSEL both physically and electronically through a wafer fabrication process. A photodiode is connected to the tunnel diode. The photodiode is connected to the tunnel diode by physical and electronic connections. The tunnel diode and photodiode may share some common layers. The tunnel diode includes a second PN junction. The monolithically formed laser and photodiode allow for an integrated structure with diode biasing flexibility including the use of a single supply to bias both the laser and photodiodes.

The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as an genetic modification in a biosynthetic pathway gene such as the purI gene. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and / or reduction in volume of solid tumors.

A compression ignition engine is supplied with a first fuel in a flow of air and a second fuel is injected into the combustion chamber. The first fuel comprises a more volatile fuel than diesel such as ethanol, LPG or other combustible gas; the second fuel comprises diesel or biodiesel; and the second fuel is injected in multiple pulses in each ignition cycle with the first pulse acting as a pilot pulse to trigger ignition, and the timing of the second pulse being such as to modify the temperature through evaporation of the second fuel and thereby reduce the combustion temperature and mitigate knock susceptibility. Preferably the pilot pulse is followed by a single further pulse of the second fuel in the ignition cycle. The engine may be controlled to operate in two different modes, one mode for light and medium load conditions when there is only a pilot pulse injection of the second fuel which reduces NOx and soot emissions, and the other mode for higher load conditions when there is a pilot pulse injection followed by a main pulse injection of the second fuel. The first fuel may comprise bioethanol and or one or more of the following: ethanol, butanol, propanol, lpg, natural gas, hydrogen.

A micromechanical acceleration sensor is described which includes a substrate and a seismic mass which is movably situated with respect to the substrate in a detection direction. The micromechanical sensor includes at least one damping device for damping motions of the seismic mass perpendicular to the detection direction.