2-aminobenzimidazole sterilization microsphere, and synthetic method and application thereof

A technology of ‐aminobenzimidazole and synthesis method, applied in the field of 2‐aminobenzimidazole bactericidal microspheres and its synthesis, can solve the problem of bacterial scale, slime stripping and poor washing effect, high transportation and storage costs, and toxic by-products etc. to achieve the effects of easy mass production and automatic control, high physical stability and high mechanical strength

Active Publication Date: 2017-10-27
ZHEJIANG GONGSHANG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional fungicides also have insurmountable shortcomings: when the content of organic matter in the water source is slightly high, oxidative fungicides such as chlorine gas sterilization will produce chlorinated organic matter, which can cause cancer; poor stability, easy to decompose, high transportation and storage costs, and Potential threats such as explosion; in industrial water treatment, the stripping and washing effect on bacterial scale and slime is poor
Because water-soluble fungicides will cause certain hazards in residual water and liquid food after use, oxidizing fungicides will produce toxic by-products, and non-oxidizing fungicides are residual toxicity problems, and there is a risk of "secondary pollution"

Method used

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  • 2-aminobenzimidazole sterilization microsphere, and synthetic method and application thereof
  • 2-aminobenzimidazole sterilization microsphere, and synthetic method and application thereof
  • 2-aminobenzimidazole sterilization microsphere, and synthetic method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0031] Measure 40 mL of reaction solvent into a three-necked flask with a volume of 100 mL, and add 60.0 mg of precursor (chlorine balls) to soak overnight. After the parent body is fully swollen, add 2-aminobenzimidazole with a molar ratio of 1:3 to 5 and catalyst metal sodium accounting for 3 to 7% of the added amount of the parent body into the three-necked flask. The reaction was stirred at 70° C. to 90° C., and nitrogen was protected throughout the reaction. After reacting for 10-12 hours, filter out the microspheres in the three-necked flask, then soak and wash them with the reaction solvent until the washing liquid is colorless or there is no obvious attachment on the surface of the microspheres, wash with distilled water, then soak with NaOH aqueous solution, wash with water, and then After repeated washing several times with absolute ethanol, acetone, and ether in sequence, the filtered microspheres were vacuum-dried at 50°C for later use.

[0032] Quaternization of ...

Embodiment 2

[0037] The synthetic method of the 2-aminobenzimidazole bactericidal microsphere of the present embodiment, comprises the following steps:

[0038] (1) Using chlorine balls as the matrix, soak the chlorine balls in the solvent toluene to make them fully swell, add 2-aminobenzimidazole as the ligand, the molar ratio of the matrix to the ligand is 1:4, and add catalyst sodium metal , the amount added is 5% of the amount added to the matrix; under the protection of nitrogen, stir the reaction at 80°C at a speed of 200rpm for 11 hours, first soak and wash with the reaction solvent toluene until the washing liquid is colorless or there is no obvious attachment on the surface of the microspheres, then wash with distilled water After that, soak in NaOH aqueous solution, wash with water, and then wash repeatedly with absolute ethanol, acetone, and ether for 3 to 5 times. After washing, vacuum dry at 50°C for later use;

[0039] (2) Place the product obtained in step (1) in a reaction...

Embodiment 3

[0052] The synthetic method of the 2-aminobenzimidazole bactericidal microsphere of the present embodiment, comprises the following steps:

[0053] (1) Taking chlorine balls as the matrix, soaking the chlorine balls in a solvent to make them fully swell, adding 2‐aminobenzimidazole as a ligand, the molar ratio of the matrix to the ligand is 1:3, adding catalyst metal sodium, The addition amount is 3% of the addition amount of the matrix; under the protection of nitrogen, stir and react at 70°C at a speed of 200rpm for 12 hours, first soak and wash with the reaction solvent until the washing liquid is colorless or there is no obvious attachment on the surface of the microspheres, after washing with distilled water, Then soak in NaOH aqueous solution, wash with water, and then wash with absolute ethanol, acetone, and ether repeatedly for 3 to 5 times. After washing, vacuum dry at 50°C for later use;

[0054] (2) Place the product obtained in step (1) in a reaction vessel, add p...

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Abstract

The invention discloses a 2-aminobenzimidazole sterilization microsphere, and a synthetic method and application thereof. The synthetic method comprises the following steps: (1), a chloromethylated bead is used as a parent compound, 2-aminobenzimidazole is used as a ligand, a catalyst of metal sodium is added, and under the protection of nitrogen gas, stirring is performed for 10-12h at a rotation speed of 200rpm at a temperature of 70-90 DEG C, washing is finished, and vacuum drying is performed at a temperature of 50 DEG C; and (2), the material obtained in the step (1) is placed in a reaction vessel, propylene oxide is added under the atmosphere of nitrogen gas, stirring is performed for 5-7h at a temperature of 15-25 DEG C, benzyl chloride is added to the reaction vessel, reaction is performed for 5-7h at room temperature with stirring, then filtration is performed, and washing is repeatedly performed by using ethanol and distilled water in a filtration process, and the filtered microsphere is subjected to vacuum drying at a temperature of 50 DEG C, so that the water-insoluble immobilized sterilization microsphere is obtained. The raw material of the obtained sterilization microsphere is the chloromethylated bead, and the chloromethylated bead has relatively high mechanical strength and physical stability, the source is wide, the price is low, and the economic benefits are remarkable. The synthetic method of the composite sterilization microsphere provided in the invention is convenient in operation, green and economic, and has good application prospect.

Description

technical field [0001] The invention belongs to the field of bactericides, and in particular relates to 2-aminobenzimidazole bactericidal microspheres and a synthesis method and application thereof. Background technique [0002] In recent years, the pollution of fresh water resources has been serious, and the safety problems of canned water and liquid food have occurred frequently. Commonly used indicator bacteria or other indicator microorganisms in drinking water are: total coliforms, fecal coliforms, faecal streptococci, coli phages, enteroviruses, Staphylococcus, Bifidobacterium, Clostridium perfringens , Salmonella, aeruginosa, Pseudomonas, Shigella, Vibrio parahaemolyticus, etc. 80% of human diseases come from polluted water. According to the World Health Organization's survey results, 500,000 people die each year due to drinking unhealthy water, and the direct or indirect losses have exceeded 1% of GDP in that year. The pollution of pathogenic microorganisms not onl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/52A01N25/10A01P1/00B01J13/02C02F1/50A23L2/44
CPCA01N25/10A01N43/52A23L2/44B01J13/02C02F1/50
Inventor 熊春华阎亚利何若铭勇括
Owner ZHEJIANG GONGSHANG UNIVERSITY
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