29 results about "Ethyl propiolate" patented technology

The present invention relates to a method of adding an isocitrate lyase specific inhibitor to a lactic acid fermentation process to block the production of succinic acid as a byproduct of fermentation. The specific inhibitor includes a combination of one or more of glycolic acid methyl ester, malonic acid dimethyl ester, hydroxymalonic acid diethyl ester, 3-nitropropionic acid ethyl ester, mercuric chloride, or 5,5'-dithiobis(2-nitrobenzoic acid) to effectively reduce the amount of succinic acid in the lactic acid.

The invention relates to a battery cell and a rechargeable lithium battery including the same. The battery cell includes: a wound electrode assembly including a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode; and an electrolyte immersed in the wound electrode assembly. The wound electrode assembly includes a pair of curved portions on opposite sides of the wound electrode assembly and a flat portion between the pair of curved portions. The electrolyte can include a non-aqueous organic solvent, a lithium salt, and an additive. The non-aqueous organic solvent comprises ethylene carbonate and ethyl propionate. The additive includes a compound represented by Chemical Formula 1. The ratio of the area of the negative electrode active material layer in the pair of curved portions to the total area of the negative electrode active material layer is 18%-50%. The volume ratio of the ethylene carbonate to the non-aqueous organic solvent is 20-50% by volume. The volume ratio of the ethyl propionate to the non-aqueous organic solvent is 50-80% by volume. Based on 100 parts by weight of the electrolyte, the amount of the additive is 1-10 parts by weight. Chemical formula 1

A battery cell and a rechargeable lithium battery including the battery cell are disclosed. The battery cell may include a wound electrode assembly including a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode, and an electrolyte impregnated in / with the wound electrode assembly. The wound electrode assembly may include a pair of curved sections on two opposite (e.g., opposite facing) sides of the wound electrode assembly and a flat section between the pair of curved sections. The electrolyte may include a non-aqueous (e.g., water-insoluble) organic solvent, a lithium salt, and an additive. The non-aqueous (e.g., water-insoluble) organic solvent may include ethylene carbonate and ethyl propionate. The additive may include a compound represented by Chemical Formula 1.

This invention relates to the field of energy storage electronic components, specifically to a lithium-ion battery. The lithium-ion battery includes a positive electrode, a negative electrode, and a separator. The negative electrode includes a negative electrode current collector and a negative electrode active material layer disposed on the surface of the current collector. The non-aqueous electrolyte includes a lithium salt, an organic solvent, and a first additive. The organic solvent includes dimethyl carbonate and a low-viscosity solvent, wherein the low-viscosity solvent is composed of at least one of methyl acetate, ethyl acetate, and ethyl propionate. The lithium-ion battery satisfies the following conditions: 0.05 ≤ 4, 0.01 ≤ a ≤ 2, 25 ≤ b ≤ 55, 4 ≤ c ≤ 30, 10 ≤ d ≤ 30. The lithium-ion battery of this invention can fully utilize the advantages of carboxylic acid ester solvents in increasing battery power, while greatly suppressing their degradation of high-temperature performance and thermal runaway, achieving a balance between high power performance and high safety performance.

The application discloses a processing technology of ethyl dicyanopropionate, and comprises the following specific steps: S1, preparing raw materials, storing liquid raw materials uniformly for standby, and placing solid raw material ethyl cyanoacetate in a humid environment with certain humidity to make it lump; S2, pre-treating the lumped ethyl cyanoacetate by using a pre-treatment device, and then crushing the lumped ethyl cyanoacetate after component separation; S3, mixing the ethyl cyanoacetate with a potassium cyanide solution, and then slowly adding a formaldehyde solution into the mixture for reaction; S4, separating the organic layer from the reaction liquid, extracting the water layer by using a solvent dimethyl sulfoxide, mixing the organic layers, and finally obtaining ethyl dicyanopropionate finished products after drying and desolventizing; in the step S2, the pre-treatment device comprises a storage mechanism, a high-frequency vibration device and an ejection mechanism; the processing technology of ethyl dicyanopropionate disclosed by the application has the effect of reducing the exposure amount of dust, thereby providing effective protection for the personal safety of workers.

The invention relates to a method for efficiently preparing flurbiprofen based on a Suzuki-Miyaura coupling reaction. The preparation method comprises the following steps: taking ethyl cyanoacetate as a raw material, and carrying out methylation reaction on the ethyl cyanoacetate and methyl iodide or dimethyl sulfate to prepare racemic ethyl 2-cyanopropionate; the racemic ethyl 2-cyanopropionate and 4-bromine-2-fluorobiphenyl are subjected to a similar Suzuki-Miyaura reaction under the combined action of a zero-valent palladium metal catalyst, a metal stabilizer phosphine ligand and alkali, and the racemic ethyl 2-cyano-2-(2-fluoro4-biphenyl) propionate is obtained; and carrying out hydrolysis and decarboxylation on the racemic 2-cyano-2-(2-fluoro-4-biphenyl) ethyl propionate to obtain racemic 2-(2-fluoro-4-biphenyl) propionic acid, namely, the flurbiprofen. The process route comprises three steps of reaction, materials are cheap and easy to obtain, operation is simple, aftertreatment is convenient, and the obtained product is high in purity.

The invention relates to the technical field of perfume synthesis, in particular to an efficient hydrolysis process in perfume synthesis, which comprises the following steps: mixing ethyl lactate, ethyl 3-chloropropionate and ethanol, and reacting under the conditions of metal sodium and heating reflux; after the reaction is finished, distilling off the ethanol under reduced pressure, neutralizing the residual reaction liquid with dilute sulphuric acid, extracting with an organic solvent, separating the liquid to obtain an organic phase, and concentrating the organic phase under reduced pressure to obtain a 2-methyl-4-methyl ester tetrahydrofuran-3-ketone crude product; the method comprises the following steps: heating a 2-methyl-4-methyl ester tetrahydrofuran-3-ketone crude product under the catalysis of cationic resin to hydrolyze, filtering out the cationic resin, extracting with an organic solvent, separating liquid to obtain an organic phase, concentrating under reduced pressure, and rectifying to obtain breadone. According to the method for synthesizing breadone, use of a large amount of acid water is avoided, output of a large amount of waste acid is avoided, the process is more environmentally friendly, meanwhile, the yield is high, the steps are simple, and the industrial production prospect is wide.

A secondary battery includes: a positive electrode containing a lithium-nickel composite oxide; a negative electrode containing a lithium-titanium composite oxide; and an electrolyte containing a carboxylic acid ester containing at least one of ethyl acetate, propyl acetate, ethyl propionate, and propyl propionate. In surface analysis of the positive electrode using X-ray photoelectron spectroscopy, a first oxygen spectrum having a peak in a range of a binding energy of 528 eV or more and 531 eV or less, and a second oxygen spectrum having a peak in a range of a binding energy of more than 531 eV and 535 eV or less are detected, and a ratio of an intensity of the first oxygen spectrum to an intensity of the second oxygen spectrum is 0.30 or more and 0.80 or less. In surface analysis of the negative electrode using X-ray photoelectron spectroscopy, a third oxygen spectrum having a peak in a range of a binding energy of 528 eV or more and 531 eV or less, and a fourth oxygen spectrum having a peak in a range of a binding energy of more than 531 eV and 535 eV or less are detected, and a ratio of an intensity of the third oxygen spectrum to an intensity of the fourth oxygen spectrum is 0.82 or more and 1.35 or less.

The application belongs to the technical field of drug chemical synthesis, and particularly relates to a preparation method of an FGFR2 inhibitor Lirafugratinib (RLY-4008). The reaction steps of the synthetic method are as follows: 2-bromo-p-nitroacetophenone is reacted with 3-amidinopropionic acid ethyl ester hydrochloride, then is ring-closed with formamide (formamidine) to obtain a key intermediate 4-hydroxy-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine, halogenation, aminolysis, methylation, suzuki coupling reaction, reduction, and finally reaction with methacryloyl chloride to obtain Lirafugratinib (RLY-4008).

The application relates to a preparation method and application of a low-temperature-resistant ester-based electrolyte. The method comprises the following steps: firstly, dissolving lithium bistrifluoromethylsulfonylimide into a mixed solution of difluoropropionic acid ethyl ester and fluorinated ethylene carbonate to obtain solution A; secondly, dissolving lithium nitrate into ethylene glycol dimethyl ether to obtain solution B; and thirdly, adding solution B into solution A to obtain the low-temperature-resistant ester-based electrolyte. The weak-solvent electrolyte is composed of three solvents and two lithium salts, the carboxylic acid ester has a low melting point and a strong salt-dissolving capacity, the freezing point of the electrolyte can be significantly reduced, the electrolyte still has strong fluidity at low temperature, the migration rate of lithium ions at low temperature is improved, and the low-temperature performance of the battery is improved. The low-temperature-resistant ester-based electrolyte prepared by the application provides valuable insights for the next-generation electrolyte of lithium ion batteries operated under extreme conditions.

A rechargeable lithium battery includes a battery cell, wherein the battery cell may include: a wound electrode assembly, wherein the wound electrode assembly includes a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode; and an electrolyte solution impregnated in the wound electrode assembly. The wound electrode assembly may include a pair of curved parts on opposite sides thereof, and a flat part between the pair of curved parts. The electrolyte solution may include a non-aqueous organic solvent, a lithium salt, an impregnation improver, and an additive, and the non-aqueous organic solvent may include ethylene carbonate and ethyl propionate.

The application relates to the technical field of lithium ion batteries, in particular to an electrolyte and a lithium ion battery. The electrolyte comprises an organic solvent, a lithium salt, a silane compound, a ring compound and lithium difluoro(oxalato)borate. The electrolyte effectively improves the performance and safety of the battery cell through the synergistic effect between the additives, and meanwhile, the long cycle and low swelling performance are considered. In the electrolyte, ethyl propionate and lithium bis(trifluoromethylsulfonyl)imide which is easier to dissociate are added, the solvent viscosity is reduced, the electrolyte wettability and ion conductivity are greatly improved, the low-temperature disadvantage caused by the thick SEI film with large impedance generated by the combination of the silane compound and the ring compound is improved, and the low-temperature performance of the battery cell is improved. Through the synergistic effect between the electrolyte and the negative electrode material, the lithium ion battery prepared by using the silicon-doped negative electrode material can effectively improve the safety performance of the battery cell, and meanwhile, the long cycle and low-temperature performance of the battery cell are considered.

A secondary battery and an electronic device. The secondary battery comprises a positive electrode, a negative electrode and an electrolyte. The positive electrode comprises lithium cobalt oxide, a binder and an inorganic additive. The electrolyte comprises: (I) lithium difluorophosphate; (II) a boron-containing lithium salt; and (III) ethyl propionate, wherein on the basis of the mass of the electrolyte, the total content of (I) and (II) is 0.03% by mass or more, but 1.5% by mass or less, and the content of (III) is 12% by mass or more, but 37% by mass or less. By means of a combination of the specific positive electrode composition and the electrolyte, not only can the through-plane resistance and peel strength of the positive electrode be improved, but the low-temperature output characteristic and the low-temperature rate capability of the secondary battery can also be improved.

The invention relates to the technical field of organic chemistry, in particular to triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate as well as a preparation method and application of the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate. The structural formula of the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate is as shown in formula (I), and the preparation method of the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate as shown in formula (I) comprises the following steps: taking ethyl 3-bromo-2, 2-difluoropropionate and 1, 3-adamantanediol as initial reaction raw materials, and carrying out a reaction at the temperature of 60-80 DEG C for 1-2 hours; the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate shown in the formula (I) is obtained through ester exchange reaction, substitution reaction, oxidation reaction and coordination reaction. The preparation method is simple, the reaction system is green and environment-friendly, the selectivity is good, the preparation cost is low, the product yield is high, and the method is suitable for industrial production.

The present application relates to the technical field of thickening agent, in particular to a kind of salt-resistant and temperature-resistant water thickening agent for fracturing fluid and preparation method thereof, for solving the problem of insufficient salt resistance and temperature resistance of existing thickening agent, the salt-resistant and temperature-resistant water thickening agent for fracturing fluid is obtained by sulfonic acid base-phenyl ether fluorenyl hyperbranched polyacrylamide, synthesis tetrahydroxy phenyl ether fluorene, with dihydroxyethyl amino propionic acid ethyl ester to obtain intermediate product 1 containing phenyl ether fluorenyl, intermediate product 1 and maleic anhydride synthesis intermediate product 2, intermediate product 2 and acrylic acid, acrylamide, 2-acrylamido-2-methylpropane sulfonic acid polymerization obtain sulfonic acid base-phenyl ether fluorenyl hyperbranched polyacrylamide, phenyl ether has good thermal stability, cooperates with fluorenyl to improve the temperature resistance of polymer, sulfonic acid group can effectively shield sodium ion, calcium ion and other cations Compression effect on polymer chain, improve the salt resistance of polymer, enhance the stability and strength of thickening agent.

The application provides a wide-temperature lithium ion battery electrolyte and a lithium ion battery thereof, wherein the lithium ion battery electrolyte comprises a lithium salt, a nonaqueous organic solvent and an additive; the nonaqueous organic solvent comprises a first carbonate, a second carbonate, a third carbonate, a fourth carbonate and a carboxylic acid ester; the first carbonate is dimethyl carbonate and the volume percentage is 39-51%; the second carbonate is propylene carbonate and the volume percentage is 10-15%; the third carbonate is ethylene carbonate and the volume percentage is 8-15%; the fourth carbonate is methyl ethyl carbonate and / or diethyl carbonate and the volume percentage is 8-10%; and the carboxylic acid ester is one or more of propyl acetate, propyl propionate and ethyl propionate and the volume percentage is 19-26%. On the basis of the synergistic effect of dimethyl carbonate and propylene carbonate, the addition of ethylene carbonate, the fourth carbonate and the linear carboxylic acid ester can make the lithium ion battery have better high and low temperature performance.

The invention relates to a battery cell and a rechargeable lithium battery including the same. The battery cell includes: a wound electrode assembly including a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode; and an electrolyte immersed in the wound electrode assembly. The wound electrode assembly includes, on opposite sides thereof, a pair of curved portions and a flat portion between the pair of curved portions. The electrolyte comprises a non-aqueous organic solvent, a lithium salt, an impregnation improver and an additive. The non-aqueous organic solvent comprises ethylene carbonate and ethyl propionate. A ratio of an area of the negative electrode active material layer to a total area of the negative electrode active material layer in the pair of curved portions is about 18% to about 50%, a ratio of a volume of ethylene carbonate to a total volume of the non-aqueous organic solvent is about 20% to about 50% by volume, and a ratio of a volume of ethyl propionate to a total volume of the non-aqueous organic solvent is about 50% to about 80% by volume. The impregnation modifier is in an amount of about 1 part by weight to about 10 parts by weight based on 100 parts by weight of the electrolyte.

The invention provides a battery and electric equipment, the battery comprises an electrolyte, an organic solvent in the electrolyte comprises ethyl propionate and propyl propionate, a positive plate is provided with at least two positive tabs, and a negative plate comprises a negative current collector and a negative active layer arranged on the negative current collector. Part of the negative electrode current collector is exposed out of the negative electrode active layer and forms a negative electrode lug groove, a negative electrode lug is welded in the negative electrode lug groove, the battery meets the condition that A / B is larger than or equal to 2, and when the amount of the carboxylic ester solvent added into the electrolyte is adjusted and meets the relation of the ratio of the total welding printing area of the negative electrode lug to the area of the negative electrode lug groove, the total welding printing area of the negative electrode lug is larger than or equal to 2. And lithium precipitation at a negative electrode lug position can be improved.

The present invention relates to a composition comprising: (a) 0.0001 to 5 wt.-% of a lactam; (b) 1 to 80 wt.-% of a solvent selected from the group consisting of 2-methyltetrahydrofuran, ethyl levulinate and ethyl levulinate glycerol ketal (LGK); or mixtures thereof; to a non-therapeutic method of surface treatment to increase the resistance of said surface against bacterial soiling; and to the use of a solvent selected from the group consisting of 2-methyltetrahydrofuran, ethyl levulinate and ethyl levulinate glycerol ketal (LGK); or mixtures thereof to improve the solubility of a lactam.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing 4-acetylpyridine from isonicotinic acid, which comprises the following steps: carrying out esterification reaction on isonicotinic acid and ethanol as raw materials to obtain ethyl isonicotinate, carrying out Claisen ester condensation reaction on ethyl isonicotinate and ethyl acetate to obtain ethyl 3-oxo-3-(4-pyridyl) propionate, and carrying out condensation reaction on ethyl 3-oxo-3-(4-pyridyl) propionate to obtain 4-acetylpyridine. And then carrying out hydrolysis decarboxylation to obtain a target product 4-acetylpyridine. The method for preparing the 4-acetylpyridine is high in yield, easy to amplify and simple and convenient to operate, the product quality is good, and the method has good industrial application value.

The invention belongs to the field of medicinal chemistry, and particularly relates to a synthetic method of an atrasentan intermediate. The preparation method comprises the following steps: taking 4-bromo-1, 2-methylenedioxybenzene as a raw material, sequentially carrying out substitution reaction on the 4-bromo-1, 2-methylenedioxybenzene and N-BOC-glycine-N '-methoxyl-N'-methyl amide, carrying out cyclization reaction on the 4-bromo-1, 2-methylenedioxybenzene and 3-(4-methoxyphenyl)-3-oxo ethyl propionate, and finally carrying out reduction and chiral resolution to obtain the atrasentan intermediate. The main route is short, and compared with an existing route, raw materials are easy to obtain, the yield is higher, cost is low, and industrial production is facilitated.

The invention belongs to the technical field of fine chemical engineering, and discloses a preparation method of ethyl levulinate. The method comprises the following steps: by taking levulinic acid as a raw material, absolute ethyl alcohol as a solvent and an ammonia water hydrothermal modified HY type zeolite molecular sieve as a catalyst, carrying out esterification reaction at 60-140 DEG C in a normal-pressure N2 protection environment to generate ethyl levulinate. The HY type zeolite molecular sieve catalyst is subjected to hydrothermal modification by using ammonia water, so that the selectivity of ethyl levulinate in a final reaction product exceeds 90%. The reaction temperature is low, and the levulinic acid reaction speed is high. The HY type zeolite molecular sieve catalyst provided by the invention has good reusability in batch kettle reaction. According to the preparation method provided by the invention, the product is single, the reaction temperature is 120 DEG C, the reaction lasts for 4 hours, levulinic acid is completely converted, and the selectivity of ethyl levulinate is 92.1%.

The invention relates to the technical field of lithium ion batteries, and provides a propyl propionate-free electrolyte and a battery containing the same. The electrolyte comprises ethyl propionate, a sulfur-containing compound, a nitrile compound and a compound A; based on the total mass of the electrolyte, the mass ratio of the ethyl propionate is 20-60%; the structural formula of the compound A is as shown in formula I; wherein R1, R2 and R5 are respectively and independently one or more of H, halogen substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl and substituted or unsubstituted C2-C6 alkynyl, and if the substituent is substituted, the substituent is halogen; r < 3 >, R < 4 >, R < 6 > and R < 7 > are independently H and C1-C6 alkyl substituted or unsubstituted by halogen, and if substituted, the substituent is halogen. Through the synergistic effect of multiple components, the dynamic performance, the cycling stability and the safety performance of the battery under high-temperature and high-voltage scenes are considered.

This application relates to the field of lithium-ion battery technology and discloses a lithium iron phosphate battery with improved low-temperature performance and its preparation method. The battery includes a positive electrode, a pre-lithiated negative electrode, a separator, and a low-temperature electrolyte. The positive electrode comprises lithium iron phosphate coated with nano-carbon; the negative electrode comprises modified artificial graphite doped with soft carbon and treated with a dual-load pre-lithiation reagent containing lithium 1-methylnaphthalene and lithium biphenyl; the low-temperature electrolyte comprises a base solvent such as 2-methyltetrahydrofuran and ethyl propionate, a main lithium salt composed of lithium hexafluorophosphate and lithium difluorosulfonylimide, and film-forming additives such as lithium difluorooxalate borate, vinyl sulfate, and tris(trimethylsilane) phosphate. This invention reduces the low-temperature impedance of the battery and improves the discharge capacity under low-temperature conditions through the synergistic effect of modified positive and negative electrode materials, dual-load pre-lithiation supplementing active lithium, and a specific low-temperature electrolyte, while also considering the battery's room-temperature cycle stability and high-temperature storage performance.

Disclosed is a pouch-type rechargeable lithium battery. The pouch-type rechargeable lithium battery includes: an electrode assembly including a first electrode plate, a second electrode plate, and a separator interposed between the first electrode plate and the second electrode plate; and an electrolyte into which the electrode assembly is impregnated, in which the separator includes a porous substrate and a coating layer disposed on at least one surface of the porous substrate. The coating comprises a binder and a filler. The binder includes a (meth) acrylic binder including a first structural unit derived from (meth) acrylic acid, a (meth) acrylate, or a salt thereof, a second structural unit derived from a hydroxyalkyl (meth) acrylate, and a third structural unit derived from a (meth) acrylamide sulfonic acid or a salt thereof. The electrolyte has an ethyl propionate content in the non-aqueous organic solvent ranging from about 10% by volume to about 40% by volume.

The invention discloses a synthesis method of 4-(diacetoxyphosphoryl)-2-methyl-2-ethyl crotonate and application of the 4-(diacetoxyphosphoryl)-2-methyl-2-ethyl crotonate, and relates to the technical field of fine chemical engineering. The synthesis method comprises the following steps: carrying out condensation reaction on halogenated acetaldehyde dimethyl acetal and ethyl propionate to form a first compound; removing methanol from the first compound to form a second compound; and carrying out a reaction on the second compound and triethyl phosphite to obtain the ethyl 4-(diacetoxyphosphoryl)-2-methyl-2-butenoate. According to the present invention, the new 4-(diacetoxyphosphoryl)-2-methyl-2-ethyl crotonate synthesis route is provided, the halogenated acetaldehyde dimethyl acetal is adopted as the starting material, the synthesis route is simple, the raw material is simple and easy to obtain, the 4-(diacetoxyphosphoryl)-2-methyl-2-ethyl crotonate yield is high, and the product yield can achieve more than 88%.

The invention discloses a method for preparing ethyl levulinate through a microwave-assisted two-phase solvent system, and belongs to the technical field of ethyl levulinate preparation. The method comprises the following steps: putting a biomass raw material into a two-phase solvent system, and preparing ethyl levulinate by using a microwave-assisted catalyst, the catalyst is any one of Ti (SO4) 2 or a mixture of Ti (SO4) 2 and H2SO4; the solvent is a mixture of ethanol and gamma-valerolactone. Titanium sulfate is selected as a catalyst and is used for converting a biomass raw material solvent and successfully synthesizing ethyl levulinate. The esterification reaction path is not recorded in literatures so far, and the unique application potential of titanium sulfate in the field is shown.

The application discloses a continuous synthesis method of 2,3-dicyano-2-(pyridine-3-yl diazenyl) propionic acid ethyl ester, and belongs to the technical field of medicine intermediate preparation, which comprises the following steps: precooling 3-amino pyridine, strong acid and diazotization reagent in a pipeline, then pumping into a first mixer for mixing, and finally delivering into a first stage connecting reactor for reaction to obtain a 3-amino pyridine diazonium salt intermediate; precooling an ethyl alcohol solution of 2,3-dicyano propionic acid ethyl ester in a pipeline, then mixing with the 3-amino pyridine diazonium salt intermediate in a second mixer, and then delivering into a second stage connecting reactor for reaction to obtain a reaction product mixture; and separating and purifying the reaction product mixture to obtain a target product. The application can solve the problem of unstable process amplification caused by intermediate decomposition, and improve the production scale.