Production technology for synthesis of ethyl 2-bromopropionate

A technology of ethyl bromopropionate and production process, which is applied in the field of production technology for synthesizing ethyl 2-bromopropionate, can solve problems such as low yield, complex production process, low purity and pollution, etc., and achieves high purity and raw materials. Easy-to-obtain, easy-to-prepare effects

Inactive Publication Date: 2014-05-21
ANHUI HUARUN PAINTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is used for organic synthesis intermediates and solvents, but the current method of industrial production of ethyl 2-bromopropionate is still a relatively traditional way. There are problems such as low yield, low purity and serious pollution in this traditional production method, and the production The process is more complicated, and it is difficult to meet the needs of human beings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of production technology that ethyl 2-bromopropionate is synthesized, comprises following processing steps,

[0023] (1) Acid chloride

[0024] a. Select freshly steamed thionyl chloride and heat it to boiling, then stop heating, then add propionic acid to the inside for reflux reaction.

[0025] b. After the reflux reaction in the above step a for 25 minutes, start cooling, add red phosphorus to the inside after cooling, and start heating until the temperature is 85°C.

[0026] c. Add dry bromine to the heated reaction solution in the above step b, and continue heating to reflux for 6.5 h to obtain 2-bromopropionyl chloride.

[0027] (2) Esterification

[0028] a. Select a 1000L bromination enamel reaction kettle equipped with a stirrer and jacket, add 170kg of absolute ethanol to the reaction kettle, start stirring, and then weigh 550kg of 2-bromopropionyl chloride prepared in the above step (1) Add to the reaction kettle.

[0029] b. Heating the reaction f...

Embodiment 2

[0035] A kind of production technology that ethyl 2-bromopropionate is synthesized, comprises following processing steps,

[0036] (1) Acid chloride

[0037] a. Select freshly steamed thionyl chloride and heat it to boiling, then stop heating, then add propionic acid to the inside for reflux reaction.

[0038] b. After the reflux reaction in the above step a for 30 minutes, start cooling, add red phosphorus to the inside after cooling, and start heating until the temperature is 90°C.

[0039] c. Add dry bromine to the heated reaction solution in the above step b, and continue heating to reflux for 6.5-7.5 hours to obtain 2-bromopropionyl chloride.

[0040] (2) Esterification

[0041] a. Select a 1000L bromination enamel reaction kettle equipped with a stirrer and jacket, add 180kg of absolute ethanol to the reaction kettle, start stirring, and then weigh 550 kg of 2-bromopropionyl chloride prepared in the above step (1). -650kg is put into the reaction kettle, and the disch...

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Abstract

The invention discloses a production technology for synthesis of ethyl 2-bromopropionate and relates to the technical field of chemical engineering. The 2-bromopropionyl chloride is prepared by steps of carrying out the acylating chlorination reaction for sulfoxide chloride, propionic acid, red phosphorus and dry bromine, and then carrying out esterification reaction between the 2-bromopropionyl chloride serving as a raw material and anhydrous ethanol to obtain the ethyl 2-bromopropionate, filtering and distilling. The production technology disclosed by the invention has the beneficial effects that the preparation is convenient and easy, and environment-friendly without pollution, the raw materials are easily available, the equipment investment is small, the purity is high, the operation is convenient, and the prepared ethyl 2-bromopropionate is good in using effect, safe and reliable.

Description

technical field [0001] The invention relates to the technical field of chemical industry, in particular to a production process for the synthesis of ethyl 2-bromopropionate. Background technique [0002] Ethyl 2-bromopropionate is a colorless liquid that turns yellow when exposed to light, has a strong pungent odor, density 1.4135, boiling point 159-161, flash point 125, miscible with ethanol, ether, chloroform, insoluble in water , is the herbicide quizalofop, fenoxaprop, thiazoprop, chlorprop, fluazifop, lactofen, metolachlor, napropamide and fungicides Intermediates of metalaxyl, benalaxyl, procymidone, etc. It is used for organic synthesis intermediates and solvents, but the current method of industrial production of ethyl 2-bromopropionate is still a relatively traditional way. There are problems such as low yield, low purity and serious pollution in this traditional production method, and the production The process is more complicated, and it is difficult to meet the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/63C07C67/14
CPCC07C67/14C07C51/60C07C51/62C07C69/63C07C53/50C07C53/42
Inventor 张学永陆建新靳民张广生
Owner ANHUI HUARUN PAINTS
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