9 results about "Propynoic acid" patented technology

The invention belongs to the technical field of metal organic framework materials, and provides an Ag-based organic framework material and a preparation method and application thereof.The specific preparation method comprises the steps that silver-based cyclic trinuclear pyrazole aldehyde, 2, 4, 6-tris (4-aminophenyl)-1, 3, 5-triazine and 1H-pyrazole-4-formaldehyde serve as building monomers, benzyl alcohol and 1, 2-dichlorobenzene serve as solvents, and the Ag-based organic framework material is prepared through a hydrothermal method; the preparation method comprises the following steps of: mixing the raw materials with trifluoroacetic acid as a catalyst, freezing, degassing and sealing the obtained mixture, heating to room temperature, uniformly mixing and dispersing, and heating the obtained mixture at 60-70 DEG C to react for 6-10 hours; and after the reaction is finished, carrying out post-treatment to obtain the Ag-based organic framework material. The Ag-based organic framework material is used as a catalyst for synthesis of propiolic acid compounds through a CO2 carboxylation reaction and shows excellent catalytic activity, and the catalyst is high in structural stability, easy to recycle and capable of being recycled and has a wide development prospect.

The invention provides a method for producing propionic acid and calcium salt thereof through fermentation, and belongs to the technical field of agricultural microbial fermentation. The method for producing propionic acid by fermentation comprises the following steps: (1) activating acid-producing propionibacterium with the preservation number of CGMCC1.2230, inoculating the acid-producing propionibacterium to a special seed culture medium for propionic acid, and standing and culturing for 48-72 hours under the anaerobic condition at the temperature of 37 + / -0.5 DEG C; and (2) inoculating the obtained bacterial liquid into a fermentation medium according to an inoculation ratio of 2.8-3.2%, fermenting under an anaerobic condition at 37 + / -0.5 DEG C and a stirring speed of 80-100rpm until the content of propionic acid is not obviously changed, and adjusting the pH value by using a calcium hydroxide suspension with a solid-to-liquid ratio of 15-20% during fermentation. According to the method, the yield of propionic acid produced by fermentation of the propionibacterium propionate is increased by adjusting the proportion of fermentation substrates and controlling the fermentation pH in a segmented mode, the yield of propionic acid produced by fermentation of the propionibacterium propionate can reach 16.23 g / L, and the production intensity is 0.225 gL <-1 > h <-1 >. The mixed fermentation ensures the realization of high-titer propionic acid production, and provides a theoretical basis for increasing the yield of propionic acid produced by industrial fermentation to a certain extent.

The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either:X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; orX3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; orX4 is 5,5-dimethylproline (dmPro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; orX6 is Nap and X1, X3 and X4 are any amino acid.The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.

Disclosed is a novel method for preparing a crosslinked film without the use of a catalyst. The propiolic acid ester is obtained by grafting propiolic acid with glycidyl or epoxy under mild conditions by using a phosphonium catalyst. The propiolic acid ester can be thermally crosslinked at temperatures as low as 120 DEG C (such that the polymer film is insoluble), while some embodiments can be photoinduced crosslinked upon exposure to DUV light. The resulting cross-linked membrane is equivalent to or better than an acid-catalyzed epoxide cross-linked membrane in stability, and can be used in a variety of different applications.

The invention discloses a method for determining organic acids in main stream smoke of cigarettes, which is used for determining 16 organic acids in the main stream smoke of the cigarettes. The 16 organic acids are respectively crotonic acid, tiglic acid, trans-2-methyl-crotonic acid, levulinic acid, benzoic acid, furoic acid, lauric acid, tetradecanoic acid, cinnamic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, nonadecanoic acid, linolenic acid and arachidic acid; the method comprises the following steps: capturing flue gas, oscillating and extracting, preparing a standard solution, preparing a solution to be detected, qualitatively analyzing and quantitatively analyzing. By adopting the method, the 16 organic acids in the mainstream smoke of the cigarette can be accurately determined.

The invention discloses a preparation method of a gadotetrol isomer, which comprises the following steps: by taking cycleanine as an initial raw material, firstly reacting with halogenated acetate to obtain a tri-substituted intermediate, and then reacting with 2-halogenated tert-butyl propionate to construct a tetra-substituted intermediate containing two different ester protecting groups; selectively removing tert-butyl ester by using an acidic reagent to obtain a monocarboxylic acid intermediate, and reducing carboxyl by using a borane reducing agent to obtain an alcohol intermediate containing a hydroxypropyl side chain; and finally, removing residual protecting groups through alkaline hydrolysis, and carrying out chelation reaction with a gadolinium source to obtain the gadotetrol isomer. According to the preparation method, two different protecting groups are selected and matched with a step-by-step deprotection and reduction process, so that the preparation of the gadotetrol isomer is realized.

The application belongs to the technical field of fine chemical synthesis, and particularly relates to a preparation method of a key intermediate of Naomaining, i.e. p-methylphenylacetone. A reaction solution is prepared by mixing p-methylbenzoic acid and propionic acid according to a mass ratio, the reaction solution is continuously introduced into a fixed bed reactor under nitrogen protection by means of a constant flow pump, and a decarboxylation coupling reaction is carried out under the action of a Ce / gamma-Al2O3, Fe / gamma-Al2O3 or Ce-Fe / gamma-Al2O3 supported catalyst at 220-290 DEG C under normal pressure, and high-purity p-methylphenylacetone is obtained after post-treatment. The application adopts a fixed bed continuous synthesis process, overcomes the disadvantages of a traditional kettle type synthesis process, such as complicated operation, poor product selectivity and unstable product purity, and has the advantages of mild overall reaction conditions, no need of high-pressure equipment, high raw material conversion rate and high target product selectivity; the main reaction by-products are 3-pentanone and carbon dioxide, no strong-pollution waste such as aluminum-containing wastewater is discharged, and the application is green and environmentally friendly; the purity of the obtained product can reach more than 98.5 %, and the product can be directly used for Naomaining drug synthesis, and the process has high stability.

The invention relates to the technical field of hoops, and provides a corrosion-resistant hoop and a preparation method thereof. The preparation method of the corrosion-resistant hoop comprises the following steps that flat steel is sequentially subjected to alkali washing, water washing, acid pickling, water washing, drying, plating assisting, drying, zinc plating, cooling, passivating and assembling, a plating assisting agent adopted for plating assisting comprises zinc chloride, ammonium chloride, a surfactant, a synergist and water, and the synergist comprises beta-(acryloyloxy) propionic acid. According to the technical scheme, the problem that the corrosion resistance of the hoop is insufficient due to the fact that the quality of a zinc coating formed on the surface of the hoop through a hot galvanizing process in the related technology is poor is solved.

The application discloses a kind of water-based environmental protection inks and preparation method and application in printing, it is related to ink field.The application is when preparing water-based environmental protection ink, it is mixed and reacted to obtain modified nanometer titanium dioxide by grafting 3-butene-1-alcohol after nanometer titanium dioxide, methyl acrylate trifluoroethyl ester and maleic anhydride are mixed evenly;It is reacted after dimethyl diethoxysilane, 1,1,3,3-tetramethyl disiloxane and hydroxypropyl pentamethyl disiloxane, and grafting 2-(2'-hydroxy-3'-methyl allyl-5'-methyl phenyl) benzotriazole to obtain modified siloxane;It is reacted to obtain modified polyurethane emulsion by grafting 2,2-dimethylol propionic acid and 1,4-butanediol after isophorone diisocyanate, modified siloxane, polyhexanedioic acid neopentyl glycol ester diol;Then modified polyurethane emulsion, modified nanometer titanium dioxide and each component are mixed evenly to obtain water-based environmental protection ink.The water-based environmental protection ink prepared by the application has excellent adhesion, water resistance, anti-aging and antifouling property.