21 results about "Propynoic acid" patented technology

The invention belongs to the technical field of metal organic framework materials, and provides an Ag-based organic framework material and a preparation method and application thereof.The specific preparation method comprises the steps that silver-based cyclic trinuclear pyrazole aldehyde, 2, 4, 6-tris (4-aminophenyl)-1, 3, 5-triazine and 1H-pyrazole-4-formaldehyde serve as building monomers, benzyl alcohol and 1, 2-dichlorobenzene serve as solvents, and the Ag-based organic framework material is prepared through a hydrothermal method; the preparation method comprises the following steps of: mixing the raw materials with trifluoroacetic acid as a catalyst, freezing, degassing and sealing the obtained mixture, heating to room temperature, uniformly mixing and dispersing, and heating the obtained mixture at 60-70 DEG C to react for 6-10 hours; and after the reaction is finished, carrying out post-treatment to obtain the Ag-based organic framework material. The Ag-based organic framework material is used as a catalyst for synthesis of propiolic acid compounds through a CO2 carboxylation reaction and shows excellent catalytic activity, and the catalyst is high in structural stability, easy to recycle and capable of being recycled and has a wide development prospect.

The invention provides a method for producing propionic acid and calcium salt thereof through fermentation, and belongs to the technical field of agricultural microbial fermentation. The method for producing propionic acid by fermentation comprises the following steps: (1) activating acid-producing propionibacterium with the preservation number of CGMCC1.2230, inoculating the acid-producing propionibacterium to a special seed culture medium for propionic acid, and standing and culturing for 48-72 hours under the anaerobic condition at the temperature of 37 + / -0.5 DEG C; and (2) inoculating the obtained bacterial liquid into a fermentation medium according to an inoculation ratio of 2.8-3.2%, fermenting under an anaerobic condition at 37 + / -0.5 DEG C and a stirring speed of 80-100rpm until the content of propionic acid is not obviously changed, and adjusting the pH value by using a calcium hydroxide suspension with a solid-to-liquid ratio of 15-20% during fermentation. According to the method, the yield of propionic acid produced by fermentation of the propionibacterium propionate is increased by adjusting the proportion of fermentation substrates and controlling the fermentation pH in a segmented mode, the yield of propionic acid produced by fermentation of the propionibacterium propionate can reach 16.23 g / L, and the production intensity is 0.225 gL <-1 > h <-1 >. The mixed fermentation ensures the realization of high-titer propionic acid production, and provides a theoretical basis for increasing the yield of propionic acid produced by industrial fermentation to a certain extent.

The invention relates to a steel ball valve which comprises a ball valve main body, and the surface of the ball valve main body is treated by an antirust agent comprising the following components: pyridine-3-carboxylic acid acyl chloride, n-butylamine thiocyanate, p-formylbenzoic acid, 4-hexylbenzaldehyde, pyrrole, p-toluene sulfonic acid, propionic acid, absolute ethyl alcohol, polyethylene glycol and dichloromethane. The application has the following advantages and effects: an acyl chloride group in pyridine-3-carboxylic acid acyl chloride reacts with n-butylamine thiocyanate, and a-N = C = S group is introduced to improve the corrosion inhibition performance; p-methylbenzenesulfonic acid catalyzes p-formylbenzoic acid, 4-hexylbenzaldehyde and pyrrole to react to obtain a porphyrin compound, the porphyrin compound has hydrophilic carboxyl and a hydrophobic long carbon chain, and the overall amphoteric balance of the antirust agent is improved; the acyl isothiocyanate compound and the porphyrin compound have a synergistic effect to enhance the rust prevention and corrosion inhibition performance of the ball valve main body, so that the corrosion generated when the steel ball valve is exposed in a humid environment for a long time is reduced, and the service life is prolonged.

The invention provides a metal surface polar group reinforcing agent, a preparation method and application thereof and a metal surface treatment method, and the metal surface polar group reinforcing agent comprises the following components in percentage by mass: 2-5% of phosphomolybdic acid, 1-3% of potassium fluotitanate, 0.5-2% of 3-mercaptopropionic acid, 2-4% of trisodium citrate and the balance of water. The metal surface polar group enhancer can increase the number of polar functional groups such as carboxyl on the metal surface, so that when the metal surface is coated with a coupling agent to bond metal and silicone rubber, the bonding capacity of the coupling agent and the polar groups on the metal surface is enhanced, and the bonding performance between the metal and the silicone rubber is improved.

The invention relates to the field of fabrics, in particular to a wear-resistant easy-to-clean fabric, a preparation method thereof and a tool prepared from the fabric. A preparation method of the wear-resistant easy-to-clean fabric comprises the following steps: preparing modified nano aluminum oxide; preparing an outer-layer fabric; preparing a chitosan-based antibacterial agent; preparing an inner layer fabric; and preparing the wear-resistant easy-to-clean fabric. The preparation method comprises the following steps: reacting acryloyl chloride with 1, 4-butanediamine to generate a difunctional cross-linking agent with acrylamide double bonds at two ends, then preparing a prepolymer emulsion from the difunctional cross-linking agent, polytetrahydrofuran glycol, 2, 2-dimethylolpropionic acid and the like, and reacting with an organic silicon emulsion under the initiation of ammonium persulfate to prepare a modified waterborne polyurethane emulsion. The surface of the nylon fabric is coated with the coating to form the wear-resistant and easy-to-clean coating, so that the washing resistance of the coating can be remarkably improved, the long-term wear-resistant and easy-to-clean properties of the outer-layer fabric are maintained, the risk that the coating is stripped from the surface of the fabric during friction is reduced, and the wear resistance of the outer-layer fabric is improved.

The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either:X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; orX3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; orX4 is 5,5-dimethylproline (dmPro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; orX6 is Nap and X1, X3 and X4 are any amino acid.The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.

The invention relates to the technical field of mortar pumps, and discloses a fluid medium impact damage resistant mortar pump impeller and a preparation method thereof, the fluid medium impact damage resistant mortar pump impeller is prepared from the following components: a copolymer, grafted chlorinated polyethylene resin, nano silicon dioxide, polystyrene, glass fiber, stearic acid, trimethylolpropane trimethacrylate, ABS resin, tetra [beta-(3, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, the preparation method comprises the following steps: adding 2, 3, 5-di-tert-butyl-4-hydroxyphenyl) propionic acid] pentaerythritol ester and poly (butylene succinate); the mortar pump impeller prepared by the invention has excellent mechanical properties, particularly the impact resistance is greatly improved, and the fluid medium impact resistance of the mortar pump impeller can be remarkably improved by improving the impact resistance of the mortar pump impeller, so that the occurrence of fluid medium impact damage can be effectively reduced, and the service life of the mortar pump impeller is prolonged. Therefore, the service life of the impeller of the mortar pump is greatly prolonged.

The invention provides a flotation inhibitor for separating chalcopyrite and molybdenite and a beneficiation method for the chalcopyrite and the molybdenite, and particularly relates to the technical field of beneficiation. The flotation inhibitor comprises sodium thioglycolate, hydroxycarboxylic acid homologues and a reducing agent according to the mass ratio of (20-60): (1-5): (1-5). The hydroxy carboxylic acid homologues comprise at least one of 3-mercaptopropionic acid, beta-mercaptopropionic acid, thiopropanolic acid, mercaptopropionic acid and thiolactic acid. The flotation inhibitor provided by the invention is economical in dosage and simple and convenient to add, and efficient separation of molybdenite and chalcopyrite can be effectively realized. In addition, the flotation inhibitor successfully solves the problem that copper impurities in molybdenum concentrate exceed the standard when only sodium thioglycollate is used, and therefore the overall use cost of the inhibitor in the flotation process is reduced. The flotation inhibitor is efficient, clean and safe, and the problem in the separation process of chalcopyrite and molybdenite is effectively solved.

Disclosed is a novel method for preparing a crosslinked film without the use of a catalyst. The propiolic acid ester is obtained by grafting propiolic acid with glycidyl or epoxy under mild conditions by using a phosphonium catalyst. The propiolic acid ester can be thermally crosslinked at temperatures as low as 120 DEG C (such that the polymer film is insoluble), while some embodiments can be photoinduced crosslinked upon exposure to DUV light. The resulting cross-linked membrane is equivalent to or better than an acid-catalyzed epoxide cross-linked membrane in stability, and can be used in a variety of different applications.

The invention discloses a method for determining organic acids in main stream smoke of cigarettes, which is used for determining 16 organic acids in the main stream smoke of the cigarettes. The 16 organic acids are respectively crotonic acid, tiglic acid, trans-2-methyl-crotonic acid, levulinic acid, benzoic acid, furoic acid, lauric acid, tetradecanoic acid, cinnamic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, nonadecanoic acid, linolenic acid and arachidic acid; the method comprises the following steps: capturing flue gas, oscillating and extracting, preparing a standard solution, preparing a solution to be detected, qualitatively analyzing and quantitatively analyzing. By adopting the method, the 16 organic acids in the mainstream smoke of the cigarette can be accurately determined.

The application discloses a synchronous green extraction method of salvianolic acid B, tanshinone I, cryptotanshinone and tanshinone IIA in Danshen, which comprises the following steps: crushing Danshen into powder, and adding a bio-based solvent to the Danshen powder for ultrasonic-assisted extraction. When the extraction solvent is glycerol formal / acetic propionic acid (57.8 / 42.2, v / v), the liquid-solid ratio is 15 mL / g, the ultrasonic extraction temperature is 35 DEG C, the ultrasonic extraction time is 30 min, and the ultrasonic power is 360 W, the extraction rate of salvianolic acid B, tanshinone I, cryptotanshinone and tanshinone IIA in Danshen is 85.18 (mg / g), 0.347 (mg / g), 1.120 (mg / g) and 0.931 (mg / g) respectively, which is significantly higher than that of traditional methanol and ethanol. Therefore, the method provided by the application can effectively improve the extraction efficiency of salvianolic acid B, tanshinone I, cryptotanshinone and tanshinone IIA in Danshen, avoid the use of organic solvents such as methanol and ethanol, and is more green and environment-friendly.

The invention discloses non-natural 1, 4-pentanediol biosynthetic pathway construction and application thereof, starting from beta-ketoadipic acid, beta-ketoacid decarboxylase KDC catalyzes beta-ketoadipic acid to generate levulinic acid, then levulinic acid generates 4-hydroxyvaleric acid under the action of alcohol dehydrogenase ADH, and the 1, 4-pentanediol biosynthetic pathway construction is realized. Then, 4-hydroxyvalerate generates 4-hydroxyvaleraldehyde under the catalytic action of carboxylic acid reductase CAR, and finally, 4-hydroxyvaleraldehyde generates 1, 4-pentanediol under the action of alcohol dehydrogenase BDH. The invention provides a non-natural synthesis way for biosynthesis of 1, 4-pentanediol.

The present invention discloses an aqueous environmentally friendly high-temperature resistant polyester resin and a preparation method thereof. It is made from raw materials such as neopentyl glycol, methylpropanediol, pentaerythritol, trimethylolethane, trimethylolpropane, glycidyl versatate, phthalic anhydride, trimellitic anhydride, hexahydrophthalic anhydride, benzoic acid, 1,4-cyclohexanedicarboxylic acid, isophthalic acid, 2,2-dimethylolpropionic acid, dibutyltin dilaurate, monobutyltin oxide, γ-butyrolactone, ethylene glycol monobutyl ether, methylpropanediol monobutyl ether, ethylene glycol monomethyl ether, propylene glycol methyl ether acetate, deionized water, ammonia water, dimethylethanolamine, etc. Through a large number of experimental screenings, the present invention adopts a positive pressure high-temperature melt polymerization process to preferably adjust a system with an optimal hydroxyl and carboxyl ratio, and the conversion rate of the present invention is as high as 96.86%. The prepared polyester resin has comprehensive properties such as high temperature resistance, high weather resistance, high chemical resistance, high adhesion, high gloss, and good impact performance.

The invention discloses a preparation method of a gadotetrol isomer, which comprises the following steps: by taking cycleanine as an initial raw material, firstly reacting with halogenated acetate to obtain a tri-substituted intermediate, and then reacting with 2-halogenated tert-butyl propionate to construct a tetra-substituted intermediate containing two different ester protecting groups; selectively removing tert-butyl ester by using an acidic reagent to obtain a monocarboxylic acid intermediate, and reducing carboxyl by using a borane reducing agent to obtain an alcohol intermediate containing a hydroxypropyl side chain; and finally, removing residual protecting groups through alkaline hydrolysis, and carrying out chelation reaction with a gadolinium source to obtain the gadotetrol isomer. According to the preparation method, two different protecting groups are selected and matched with a step-by-step deprotection and reduction process, so that the preparation of the gadotetrol isomer is realized.

The application belongs to the technical field of fine chemical synthesis, and particularly relates to a preparation method of a key intermediate of Naomaining, i.e. p-methylphenylacetone. A reaction solution is prepared by mixing p-methylbenzoic acid and propionic acid according to a mass ratio, the reaction solution is continuously introduced into a fixed bed reactor under nitrogen protection by means of a constant flow pump, and a decarboxylation coupling reaction is carried out under the action of a Ce / gamma-Al2O3, Fe / gamma-Al2O3 or Ce-Fe / gamma-Al2O3 supported catalyst at 220-290 DEG C under normal pressure, and high-purity p-methylphenylacetone is obtained after post-treatment. The application adopts a fixed bed continuous synthesis process, overcomes the disadvantages of a traditional kettle type synthesis process, such as complicated operation, poor product selectivity and unstable product purity, and has the advantages of mild overall reaction conditions, no need of high-pressure equipment, high raw material conversion rate and high target product selectivity; the main reaction by-products are 3-pentanone and carbon dioxide, no strong-pollution waste such as aluminum-containing wastewater is discharged, and the application is green and environmentally friendly; the purity of the obtained product can reach more than 98.5 %, and the product can be directly used for Naomaining drug synthesis, and the process has high stability.

The invention relates to the technical field of hoops, and provides a corrosion-resistant hoop and a preparation method thereof. The preparation method of the corrosion-resistant hoop comprises the following steps that flat steel is sequentially subjected to alkali washing, water washing, acid pickling, water washing, drying, plating assisting, drying, zinc plating, cooling, passivating and assembling, a plating assisting agent adopted for plating assisting comprises zinc chloride, ammonium chloride, a surfactant, a synergist and water, and the synergist comprises beta-(acryloyloxy) propionic acid. According to the technical scheme, the problem that the corrosion resistance of the hoop is insufficient due to the fact that the quality of a zinc coating formed on the surface of the hoop through a hot galvanizing process in the related technology is poor is solved.

The application discloses a kind of water-based environmental protection inks and preparation method and application in printing, it is related to ink field.The application is when preparing water-based environmental protection ink, it is mixed and reacted to obtain modified nanometer titanium dioxide by grafting 3-butene-1-alcohol after nanometer titanium dioxide, methyl acrylate trifluoroethyl ester and maleic anhydride are mixed evenly;It is reacted after dimethyl diethoxysilane, 1,1,3,3-tetramethyl disiloxane and hydroxypropyl pentamethyl disiloxane, and grafting 2-(2'-hydroxy-3'-methyl allyl-5'-methyl phenyl) benzotriazole to obtain modified siloxane;It is reacted to obtain modified polyurethane emulsion by grafting 2,2-dimethylol propionic acid and 1,4-butanediol after isophorone diisocyanate, modified siloxane, polyhexanedioic acid neopentyl glycol ester diol;Then modified polyurethane emulsion, modified nanometer titanium dioxide and each component are mixed evenly to obtain water-based environmental protection ink.The water-based environmental protection ink prepared by the application has excellent adhesion, water resistance, anti-aging and antifouling property.

The invention discloses a sour and sweet composition, atomized liquid and an electronic atomization device.The sour and sweet composition comprises a first sour component, a second sour component, a first sweet component and a second sweet component, the first sour component comprises at least one of acetic acid and propionic acid, and the second sour component comprises at least one of lactic acid, citric acid and malic acid; the first sweet component comprises at least one of neotame and sucralose, and the second sweet component comprises at least one of perilla lepidium and damascenone B; wherein the sour and sweet composition is prepared from the following components in parts by mass: 12 to 18 parts of a first sour component, 4.5 to 10 parts of a second sour component, 1.5 to 2 parts of a first sweet component and 0.13 to 0.6 part of a second sweet component. The sour and sweet composition provided by the invention can enrich the sour taste and increase the sweet feeling and the juice feeling of the oral cavity at the same time, so that the user experience can be improved.

The application relates to the technical field of antiskid materials, and discloses a preparation method of an antiskid material for outdoor floor, wherein a carboxyl hyperbranched epoxy resin is synthesized by taking (3-glycidyloxypropyl) triethoxysilane and 2,2-dimethylol propionic acid as raw materials, the carboxyl group of the carboxyl hyperbranched epoxy resin is used to modify boehmite antiskid particles, and a SAN-ASA skin material is prepared; silicon carbide, boron nitride whisker, glass fiber and indium tin oxide are used as inorganic filler to reinforce the core layer material; the skin-core combination process is used for in-mold co-extrusion flow channel co-extrusion; and the product post-process can contain traditional physical slotting and embossing, so that the friction and the pattern style are further provided.

The invention provides a transparent water-based strippable film decontamination material as well as a preparation method and application thereof. According to the invention, water is taken as a solvent, waterborne polyurethane with environmental stability is taken as a film-forming matrix, 2, 2-bis (hydroxymethyl) propionic acid is taken as a hydrophilic chain extender, and a cross-linked network can be formed under the action of a cross-linking agent, so that the cross-linking degree of a polymer is improved. In the normal-temperature curing process, polymer chains can be gradually close to each other along with moisture volatilization, so that a stable cross-linked network structure is further formed, and finally the film is cured. The strippable decontamination material can be completely stripped on substrates with different surface roughness and surface energy, such as glass, stainless steel, cement and the like, and has a relatively high decontamination rate. The decontamination material is relatively high in stability and can meet the requirement of long-term storage; film forming conditions of normal-temperature curing have low requirements on curing equipment, and energy conservation and consumption reduction can be realized; and the transparent film body can also be used for temporary protection of devices and instruments. The preparation method is simple in preparation, low in cost, environment-friendly, wide in application range, excellent and stable in performance and high in application value.

The invention discloses high-weather-resistance polyester resin as well as a preparation method and application thereof. The high-weather-resistance polyester resin is prepared from the following raw materials: polycarboxylic acid consisting of hexahydrophthalic anhydride and 1, 4-cyclohexanedicarboxylic acid; the polyhydric alcohol is prepared from neopentyl glycol, ethylene glycol, 2, 2-dimethyl-3-hydroxypropionic acid neopentyl glycol ester, 1, 6-hexanediol and trimethylolpropane. According to the technical scheme of the invention, the problem that the high-weather-resistance polyester finish paint is difficult to have good weather resistance, T-bend, constructability, appearance (high gloss retention rate and the like) at the same time when being used for pre-coating the metal coiled material is solved.