Poly(N-isopropyl acrylamide)-polyurethane-polypeptide block-graft copolymer and preparation method thereof

A technology of isopropylacrylamide and graft copolymer, which is applied in the field of biopolymer material preparation, and achieves the effect of simple preparation method and precise control of relative content

Inactive Publication Date: 2012-02-01
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this block-graft copolymer has not been reported in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment one, preparation steps are:

[0021] 1) Synthesis of polyurethane containing side carboxyl groups and terminal double bond groups: 5.89 gram of toluene diisocyanate, 22 gram of molecular weight are 2000 polypropylene glycol, 3 gram of molecular weight are 1000 polyethylene glycol in dry reaction bottle, another Add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, then add 200 grams of dimethylformamide to dissolve, and stir and react at 55°C for 55 minutes under an inert atmosphere; then add dibutyltin dilaurate dissolved in dimethylformamide 1.64 grams of methylol propionic acid was reacted for 10 minutes; then 0.5 gram of butanediol was added and reacted for 10 minutes; then 0.8 gram of hydroxypropyl acrylate was added and reacted for 10 minutes to terminate the reaction and obtain the target object.

[0022] 2) Synthesis of poly-N-isopropylacrylamide-polyurethane block copolymer: add 15 grams of polyurethane containing side ...

Embodiment 2

[0025] Embodiment two, preparation steps are:

[0026] 1) Synthesis of polyurethane containing side carboxyl groups and terminal double bond groups: add 143.2 grams of hexamethylene diisocyanate, 212.5 grams of molecular weight polypropylene glycol of 2000, 27.5 grams of polyethylene glycol with a molecular weight of 1000 in a dry reaction flask, and add Dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, then add 1000 grams of dimethylformamide to dissolve, and stir and react at 60°C for 60 minutes under an inert atmosphere; then add dihydroxyl tin dilaurate dissolved in dimethylformamide 87.5 grams of methacrylic acid was reacted for 15 minutes; then 5 grams of butanediol was added and reacted for 10 minutes; then 11 grams of hydroxypropyl acrylate was added and reacted for 10 minutes to terminate the reaction and obtain the target object.

[0027] 2) Synthesis of poly-N-isopropylacrylamide-polyurethane block copolymer: add 15 grams of polyuretha...

Embodiment 3

[0030] Embodiment three, preparation steps are:

[0031] 1) Synthesis of polyurethane containing side carboxyl groups and terminal double bond groups: 115 gram diphenylmethane diisocyanate, 220 gram molecular weight are 2000 polypropylene glycol, 30 gram molecular weight are 1000 polyethylene glycols in dry reaction bottle Alcohol, add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, add 1000 grams of dimethylformamide to dissolve, and stir and react at 65°C for 65 minutes under an inert atmosphere; then add dibutyltin dilaurate dissolved in dimethylformamide 32 grams of dimethylol propionic acid in the mixture, reacted for 15 minutes; then added 5 grams of butanediol, reacted for 15 minutes; then added 8 grams of hydroxypropyl acrylate and reacted for 10 minutes, terminated the reaction, and obtained the target object.

[0032] 2) Synthesis of poly-N-isopropylacrylamide-polyurethane block copolymer: add 19 grams of polyurethane containing side ...

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PUM

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Abstract

The invention relates to a poly(N-isopropyl acrylamide)-polyurethane-polypeptide block-graft copolymer and a preparation method thereof. In the copolymer, the molecular weight of polyurethane is 10000-60000; the molecular weight of poly(N-isopropyl acrylamide) is 3000-10000; and the molecular weight of polypeptide is 500-4000. The preparation method comprises the steps: 1) synthesis of polyurethane containing side carboxyl group and terminal double-bond group: adding diisocyanate, polypropylene glycol, polyethylene glycol, a catalyst and a solvent to a reaction bottle and reacting, then sequentially adding bis(hydroxymethyl) propanoic acid, butylene glycol and hydroxypropyl acrylate and reacting; 2) synthesis of poly(N-isopropyl acrylamide)-polyurethane block copolymer: adding polyurethane containing side carboxyl group and terminal double-bond group, a solvent and an initiator, and isopropyl acrylamide to a reactor and reacting; and 3) adding poly(N-isopropyl acrylamide)-polyurethane block copolymer, a solvent, a condensing agent, and a polypeptide homopolymer to a reactor and reacting to obtain a target product with temperature and pH dual responsibility.

Description

technical field [0001] The invention relates to a poly-N-isopropylacrylamide-polyurethane-polypeptide block-graft copolymer and a preparation method thereof, belonging to the technical field of biopolymer material preparation. Background technique [0002] Polyurethane is usually a multi-block copolymer composed of soft segments and hard segments alternately. The urethane group (-NHCOO) contained in the molecular chain can cause strong hydrogen bond interaction between the molecule and the molecule. By selecting appropriate soft and hard segment structures and their proportions, polymer materials with good physical and mechanical properties, such as good flexibility and elasticity, can be obtained. At the same time, polyurethane also has excellent anticoagulant properties, biocompatibility, and no allergic reactions, so it has been widely used in the field of biomedicine and is the first choice for making artificial hearts, artificial blood vessels, and artificial catheters....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08F293/00C08G18/83C08G18/66C08G18/48
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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