23 results about "Hydroxybenzoate Ethers" patented technology

The invention discloses a method for synthesizing p-hydroxyanisole by catalyzing oxidation of anisole with a TS-1 titanium silicalite molecular sieve, which comprises the following steps: 1) adding anisole, acetonitrile, tert-butyl alcohol and the TS-1 titanium silicalite molecular sieve into a reaction container, controlling the temperature at 45-55 DEG C, and stirring for reaction; 2) filtering the TS-1 titanium silicalite molecular sieve; controlling the temperature to be 0-10 DEG C, and adding a reducing agent to quench oxidability; concentrating dry tert-butyl alcohol and acetonitrile; extracting by using an organic solvent; washing is performed; concentrating the dry organic phase; and 3) carrying out vacuum reduced pressure distillation, and collecting fractions to obtain the product. According to the method, the anisole which is relatively low in price is used as a raw material, the TS-1 titanium silicalite molecular sieve catalyst is used as a core, so that no black oil exists in the reaction for producing the p-hydroxyanisole, the yield of the p-hydroxyanisole is increased to 93% and the selectivity is as high as 97% due to the acetonitrile and tert-butyl alcohol solvents, the selectivity and conversion rate of the reaction are greatly improved, and the method is suitable for industrial production. The method has the characteristics of simple process, high yield, good quality and the like.

The invention relates to a titanium complex catalyst, a preparation method of the titanium complex catalyst and application of the titanium complex catalyst in hydroxylation of anisole. Anisole and hydrogen peroxide react under catalysis of the titanium complex catalyst to obtain o-hydroxyanisole and p-hydroxyanisole. The invention provides a novel catalyst, active titanium and reactants are in full contact, and higher reaction activity is achieved; the catalyst has a certain space effect, can achieve a shape-selective catalysis effect, can generate more para-products, and improves the para-ortho ratio of hydroxyanisole.

The invention discloses a preparation method of super-weather-resistant polyester modified hydantoin epoxy acrylate, which comprises the following steps: reacting pentaerythritol triacrylate, hexahydrophthalic anhydride and cyclohexene oxide serving as main raw materials in the presence of triphenylphosphine serving as a catalyst, p-hydroxyanisole serving as a polymerization inhibitor and hypophosphorous acid serving as an antioxidant to obtain polyester resin containing monocarboxylic acid; and modifying hydantoin epoxy resin by using the prepared polyester resin to obtain the six-functionality polyester modified hydantoin epoxy acrylate. The main body structure of the resin is a saturated six-membered ring structure, a five-membered ring structure and a polyester structure, the phenomena of yellowing, pulverization and the like are not prone to occurring outdoors, and the resin has the outstanding advantages of being high in UV curing efficiency, resistant to abrasion and good in adhesion.

The invention belongs to the technical field of electrolysis, and discloses a method for preparing p-hydroxyanisole through electrolytic oxidation of anisole. The method comprises the following steps: S1, adding anisole, an acylation reagent, an organic alkali proton trapping agent and an alkaline amine group-containing solvent into a single-chamber electrolytic bath together, starting electrification, carrying out electrolysis, and obtaining a product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the single-chamber electrolytic bath after electrolysis is finished; the organic base proton trapping agent is at least one of N, N-diisopropylethylamine, tributylamine and tripropylamine; and S2, adding a saturated sodium bicarbonate aqueous solution into the product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the step S1 to hydrolyze p-methoxytrifluoroacetic acid phenyl ester, and extracting to obtain p-hydroxyanisole. The selectivity of para-position and ortho-position products of methoxyl on anisole is regulated and controlled, so that the selectivity of p-hydroxyanisole prepared by the method is higher.

The invention relates to a synthesis process for co-production of p-hydroxyanisole and o-hydroxyanisole, anisole and hydrogen peroxide are used as raw materials, and under the action of a catalyst and an auxiliary agent, the content of p-hydroxyanisole and o-hydroxyanisole can be adjusted. The additive is prepared by taking benzothiophene as a raw material through alkyl ether, ethynylation and ring closing reaction, has certain solvent effect and limiting effect, and can change the proportion of p-hydroxyanisole to o-hydroxyanisole in a product.

The present invention provides a method for gas-phase synthesis of p-hydroxyanisole. The method uses a graphite-supported P-Ru-Gd catalyst to catalyze the synthesis of p-hydroxyanisole by hydroquinone and methanol under gas-phase conditions. The process uses a fixed-bed continuous reactor, wherein the reactor includes a gasification section, a reaction section and a heat preservation section. The raw materials are first fully gasified in the gasification section and then enter the reaction section containing the catalyst to react. Thereafter, the raw materials enter the storage tank through the heat preservation section and are condensed to obtain a reaction solution. The preparation method in the present invention ensures that the activity and stability of the catalyst in the reaction section are not affected, and the catalyst has the advantages of strong activity and long life.

This invention relates to the field of hydrophobic anti-icing coating technology, specifically to a high-durability isooctyl / acryloyloxy mixed siloxane modified PMMA superhydrophobic anti-icing coating and its preparation method, comprising the following steps: S1. Mixing a silane modifier, anhydrous ethanol, and deionized water, adjusting the pH to obtain a cocondensate; S2. Mixing the cocondensate, functional monomer modifier, and solvent, then adding p-hydroxyanisole, precipitating, filtering, and drying to obtain a modified PMMA prepolymer resin; S3. Mixing the modified PMMA prepolymer resin, methyl methacrylate, and solvent, purging with nitrogen to remove oxygen, then adding nano-silica, a substrate wetting agent, and a dispersant, dispersing, grinding, and sieving, and finally adding benzoyl peroxide to obtain the modified PMMA superhydrophobic anti-icing coating. This invention effectively avoids phase separation through chemical grafting, ensuring that hydrophobic segments are uniformly distributed on the coating surface and within the coating, significantly improving the hydrophobic stability and durability of the coating, breaking through the technical bottleneck of traditional PMMA coatings where hydrophobicity, hardness, and durability are difficult to balance.

The present invention discloses a method for synthesizing tert-butyl (meth)acrylate by using a composite metal oxide catalyst, belonging to the technical field of organic synthesis. In the present invention, a catalyst, an inhibitor, (meth)acrylic acid and isobutene are mixed in a reaction kettle to synthesize tert-butyl (meth)acrylate. The catalyst is a composite oxide WO 3 / Ce x Fe y M z O 2 , wherein M is one or more of Zr, Nb, Sn, Ga, Re, Y, La, Nd, Sm, Er. The inhibitor is a combination of tert-butanol, phenothiazine, p-methoxyphenol, and tert-butylcatechol, and is used in combination with air. The present invention significantly reduces the production cost of tert-butyl acrylate, improves the esterification rate, and effectively prevents the polymerization of raw materials and products during the reaction process. It has the advantages of a simple process route, mild reaction conditions, and easy separation of the catalyst from the raw materials and products.

The invention discloses a method for co-producing p-hydroxyanisole and o-hydroxyanisole through hydroxylation reaction of anisole, which comprises the following steps: carrying out hydroxylation reaction on anisole and hydrogen peroxide under the action of a catalyst, and feeding the obtained anisole hydroxylation reaction liquid into a desolventizing tower for desolventizing; a mixture extracted from the top of the desolventizing tower is fed into a reactor for recycling, a material discharged from the bottom of the desolventizing tower is fed into an anisole tower for normal-pressure azeotropic rectification, a mixture extracted from the top of the desolventizing tower is fed into a liquid-liquid two-phase separator, a material discharged from the bottom of the anisole tower is fed into an o-hydroxyanisole tower for extracting an o-hydroxyanisole product, and a material at the bottom of the desolventizing tower is fed into a p-hydroxyanisole tower; and extracting a p-hydroxyanisole product from the p-hydroxyanisole tower. The method realizes co-production of p-hydroxyanisole and o-hydroxyanisole, has the advantages of simple and efficient technological process, convenient and stable operation in the technological process, high product purity, low operation temperature in the separation process, small deterioration loss and the like, and is especially suitable for industrial application.

The present invention provides a phosphine ligand catalyst, a preparation method thereof, and an application in the synthesis of p-hydroxyanisole. The structural formula of the phosphine ligand catalyst is as follows, wherein R represents a C1-C6 alkyl group. Benzofuran is sequentially subjected to a coupling reaction with phosphorus trichloride and an alkylamine, and then complexed with a metal ion to obtain the catalyst. The catalyst can improve the reactivity and selectivity of hydroquinone etherification, reduce the reaction temperature, and effectively reduce the loss of phosphorus.

The application belongs to the technical field of supported catalyst preparation, and relates to a preparation method and application of a CeO2@P2O5@SBA15 catalyst. The CeO2@P2O5@SBA15 catalyst is obtained by loading CeO2 and P2O5 in SBA15 as a carrier in situ through a tartaric acid sol-gel method, and is used for preparing o-hydroxybenzyl anisole by single etherification of o-diphenol and methyl alcohol. The catalyst has the characteristics of high reaction activity, few by-products, low selectivity to by-products and high stability.

The present invention relates to a preparation method of 2-tert-butyl-4-hydroxyanisole, hydroquinone and tert-butyl alcohol are used as starting raw materials to synthesize 2-tert-butyl-4-hydroxyanisole, 4-position hydroxyl with less steric hindrance is protected by tert-butyldimethylchlorosilane (TBSCl), iodomethane is preferentially reacted with 1-position hydroxyl with greater steric hindrance, and finally protecting group is removed under mild conditions to obtain 2-tert-butyl-4-hydroxyanisole (2-BHA) with high yield. Preparation method of the present invention is not prone to side reaction, and reaction conditions are mild, the generation of harmful substances is reduced, and the obtained products have good purity and high yield. Simultaneously, production cost is low, and it is suitable for industrialized large-scale production.

The present invention relates to a preparation method of butylated hydroxyanisole, and belongs to the field of pharmaceutical chemistry. The preparation method comprises taking 2-tert-butylphenol as a raw material, reacting with sodium methoxide solution under the conditions of a catalyst and / or a co-catalyst by bromination reaction, and preparing butylated hydroxyanisole. The preparation method provided by the present invention does not need to use a large amount of toxic reagents, is safe and environmentally friendly, is not easy to cause harm to production personnel and the environment, has high reaction selectivity, and is conducive to industrial implementation.

The invention discloses a method for separating hydroxyanisole from an anisole hydroxylation reaction liquid, which comprises the following steps: the anisole hydroxylation reaction liquid sequentially enters a desolventizing tower, an anisole tower, a decoking tower, a melt crystallization separation tower and an o-hydroxyanisole tower for separation and refining to obtain a hydroxyanisole product and an o-hydroxyanisole product. The method realizes effective separation of p-hydroxyanisole and o-hydroxyanisole, has the advantages of simple and efficient technological process, convenient and stable operation in the technological process, high product purity, low operation temperature in the separation process, small loss and the like, and is especially suitable for industrial application.

The application provides a bisisoquinoline-based iron complex with the structure shown in formula (I), and also provides a preparation method of the bisisoquinoline-based iron complex and application of the bisisoquinoline-based iron complex as a catalyst for hydroxylation reaction of anisole, and further provides a method for preparing p-hydroxyanisole and co-producing o-hydroxyanisole. When the bisisoquinoline-based iron complex provided by the application is used for catalyzing the hydroxylation reaction of anisole, excellent reaction activity and p-hydroxy product selectivity can be achieved, a new process idea is provided for industrialized production of p-hydroxyanisole, and the bisisoquinoline-based iron complex has very important economic value and social value.

The invention belongs to the technical field of drug intermediates, and discloses a method for preparing p-hydroxyanisole with high selectivity. The method comprises the following steps: heating anisole and a TS-1 molecular sieve to a first temperature, and then adding first hydrogen peroxide to carry out a first-stage reaction; raising the temperature to a second temperature after the first-stage reaction is finished, adding second hydrogen peroxide to carry out a second-stage reaction, and carrying out post-treatment after the reaction is finished. The p-hydroxyanisole is synthesized with high selectivity by taking anisole as a raw material, a TS-1 molecular sieve as a catalyst, hydrogen peroxide as an oxidizing agent and water as a solvent in a manner of changing temperature gradient and feeding in batches, and the unconverted raw material anisole and the catalyst are recycled through a separation process and are reused.

The application discloses a preparation method of a hydrogenated rosin derivative and belongs to the technical field of rosin derivative preparation. The method comprises the following steps: taking a rosin solution and performing hydrogenation reaction under the catalysis of a catalyst to obtain hydrogenated rosin; taking the hydrogenated rosin, crushing and treating, mixing with glycidyl methacrylate, p-hydroxyanisole and triethylamine in a nitrogen atmosphere, and performing heat preservation reaction to obtain the hydrogenated rosin derivative; the catalyst comprises a nickel-based active component and a hydrophilic-lipophilic carrier; the hydrophilic-lipophilic carrier comprises a hydrophilic mesoporous silica shell layer and a lipophilic molecular sieve core cavity; the conversion rate of rosin hydrogenation reaction is improved by introducing the hydrophilic-lipophilic catalyst; and the coating prepared by using the hydrogenated rosin-based acrylate derivative prepared from the hydrogenated rosin as a coating monomer has good hardness, bonding strength and wear resistance.

The invention belongs to the technical field of chemical production, and particularly relates to a preparation method of hydroxyanisole. A vertical segmented fixed bed reactor is adopted for reaction, the vertical segmented fixed bed reactor is divided into n reaction sections in the axial direction, and each reaction section independently controls the reaction temperature and is provided with a hydrogen peroxide feeding port; the method comprises the following steps: filling a catalyst in a reactor in a gradient manner, introducing an anisole solution from an anisole feed port of a first reaction section, introducing hydrogen peroxide from hydrogen peroxide feed ports of all reaction sections, decreasing the mass percent of the hydrogen peroxide introduced into all the reaction sections from the first reaction section to the nth reaction section, increasing the reaction temperature gradient of all the reaction sections, a hydroxyanisole product is obtained. According to the method provided by the invention, the utilization efficiency of the oxidant can be improved, side reactions are reduced, the controllability of the reaction process is enhanced, and the production efficiency and the product yield of the hydroxyanisole are optimized.

The invention discloses a preparation method of a hydrogenated rosin derivative, and belongs to the technical field of rosin derivative preparation. Comprising the following steps: carrying out hydrogenation reaction on a rosin solution under the catalytic action of a catalyst to obtain hydrogenated rosin; and crushing the hydrogenated rosin, mixing the crushed hydrogenated rosin with glycidyl methacrylate, p-hydroxyanisole and triethylamine in a nitrogen atmosphere, and carrying out a heat preservation reaction to obtain the hydrogenated rosin derivative. The catalyst comprises a nickel-based active component and a hydrophilic and oleophylic carrier, the hydrophilic and lipophilic carrier comprises a hydrophilic mesoporous silica shell layer and a lipophilic molecular sieve core cavity; the conversion rate of rosin hydrogenation reaction is improved by introducing a hydrophilic and oleophylic catalyst; the coating prepared by using the hydrogenated rosin-based acrylate derivative prepared from hydrogenated rosin as a coating monomer has good hardness, bonding strength and wear resistance.

To provide a novel ophthalmologic composition that can reduce the elastic modulus of a soft contact lens.SOLUTION: An ophthalmologic composition contains (A) at least one selected from the group consisting of retinol and derivatives thereof, tocopherol and derivatives thereof, azulene sulfonate and salts thereof, chlorpheniramine and salts thereof, and terpenoids and (B) polyoxyethylene polyoxypropylene glycol, while being free of dibutylhydroxytoluene and butylhydroxyanisol.SELECTED DRAWING: None

Methods of providing pain relief to animals, for example cats, by administering a formulation comprising buprenorphine or salt thereof are described. A formulation comprising buprenorphine or salt thereof and an additive selected from butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and combinations thereof and methods of storage and using such formulations are also provided.

The invention belongs to the technical field of hydroxyanisole synthesis, and provides a preparation method of p-hydroxyanisole and o-hydroxyanisole. According to the preparation method, anisole and hydrogen peroxide are subjected to a hydroxylation reaction in an organic solvent containing carboxylic acid in the presence of a catalyst, and the catalyst is a metal phthalocyanine complex / titanium silicalite molecular sieve composite catalyst. According to the invention, p-hydroxyanisole and o-hydroxyanisole are prepared through hydroxylation reaction of anisole, and low-carbon-chain carboxylic acid is added, so that the conversion rate of anisole is increased; in the metal phthalocyanine complex / titanium silicalite molecular sieve composite catalyst, metal phthalocyanine is uniformly distributed in a pore channel of a titanium silicalite molecular sieve in a complex form, the metal phthalocyanine modified titanium silicalite molecular sieve is loaded with active components containing alkaline earth metal oxide and alkali metal chloride through an equivalent-volume impregnation method, and the metal phthalocyanine modified titanium silicalite molecular sieve and the active components have a synergistic effect; the catalytic activity of the composite catalyst and the selectivity of hydroxylation reaction of a target product can be improved at the same time.

To provide a composition for promoting growth of leguminous plant contained in beans housed in a container and a container housing the same.SOLUTION: A growth promoting composition of legumes contained in legumes consisting of a combination of (A) a first agent containing ascorbic acid or a salt thereof, (B) an antioxidant and (C) a second agent containing an organic solvent, where (B) the antioxidant is at least one selected from tocopherol, dibutylhydroxytoluene and butylhydroxyanisole, and (C) the organic solvent is one or more selected from alcohols and dimethyl sulfoxides having 5 or fewer carbon atoms, and (A) a ratio (mass ratio) of ascorbic acid or its salts is 10-3,000,000 when component (B) is 1, or (C) the ratio (mass ratio) of the organic solvent is 4-100,000 when component (B) is 1, and the first and second agents are housed in one of the two-headed bottle bodies connected by connecting members, respectively.SELECTED DRAWING: Figure 22