203results about "Ether preparation by ester reactions" patented technology

The invention belongs to the technical field of organic synthesis of ethers, and particularly relates to a method for continuously synthesizing ethylene glycol dimethyl ether. The method comprises the following steps that ethylene glycol, sodium hydroxide and methane chloride serve as raw materials, multi-stage continuous reaction is carried out in liquid membrane reactors to synthesize ethylene glycol dimethyl ether, ethylene glycol, sodium hydroxide and methane chloride are introduced into the first-stage liquid membrane reactor, sodium hydroxide and methane chloride are introduced into the subsequent stages of liquid membrane reactors, and the first-stage liquid membrane reactor and the second-stage liquid membrane reactor are connected with the second-stage liquid membrane reactor. A byproduct sodium chloride is separated from a reaction product in the previous-stage liquid membrane reactor and then enters the next-stage liquid membrane reactor, a byproduct sodium chloride is separated from a reaction product in the last-stage liquid membrane reactor and then clear liquid is obtained, and ethylene glycol dimethyl ether is obtained through rectification treatment. The invention develops a novel process mode for continuously synthesizing an ethylene glycol dimethyl ether product, and provides a new idea for large-scale continuous production of ethylene glycol dimethyl ether.

The invention relates to a preparation method of fluoro-ether, which comprises the following steps: providing a first reaction system which comprises paratoluensulfonyl chloride, fluorine-containing alcohol, an alkali metal hydroxide aqueous solution, a phase transfer catalyst and an organic solvent which is insoluble in water; performing a first reaction on the first reaction system to generate p-toluenesulfonate, then standing for layering, and taking an organic phase; providing a second reaction system, wherein the second reaction system comprises the organic phase, fluorine-containing alcohol and an alkali metal hydroxide aqueous solution; and carrying out a second reaction on the second reaction system to generate fluoroether. The preparation method is simple in operation steps, does not need or reduces the steps of extraction, separation and the like, and has the advantage of saving reagent cost.

The invention discloses a film-embedded conjugated oligomeric electrolyte based on a natural product, and the structure of the film-embedded conjugated oligomeric electrolyte takes a natural polyphenol compound as a conjugated skeleton part, so that the overall biocompatibility of molecules is improved, and the toxicity is reduced; alkyl chains with different lengths or numbers are used as side chain parts to adjust the compatibility with a cell membrane and promote the membrane embedding and retention of molecules, and the alkyl chains can disturb the phospholipid arrangement of the cell membrane and increase the membrane permeability after the molecules are embedded into the membrane; a positively charged group is used as an end group part, and a negatively charged cell membrane is anchored through electrostatic attraction, so that the local molecular concentration is improved. The cell membrane is modified by the embedded membrane conjugated oligomeric electrolyte derived from the natural product, so that the permeability of the cell membrane is improved, the cytotoxicity is reduced, and the catalytic efficiency of cells is improved. The cell membrane is modified by the embedded membrane conjugated oligomeric electrolyte derived from the natural product, so that the permeability of the cell membrane is improved, the cytotoxicity is reduced, and the catalytic efficiency of cells is improved.

The application belongs to the technical field of electrolyte solvent synthesis and application, and discloses a fluorosulfone ether compound, a preparation method thereof and a sodium ion battery electrolyte. The structural general formula of the fluorosulfone ether compound is R'-O-L-SO2-R; wherein R' and R are respectively selected from C1-C6 alkyl; and L is a fluorinated alkylene group with a carbon atom number greater than or equal to 2. The fluorosulfone ether compound of the application can be applied to the sodium ion battery electrolyte, so that the high-voltage stability, low-temperature stability and interface stability of the electrolyte can be significantly improved.

The invention discloses a method for preparing anisole by taking dimethyl carbonate as a methylation reagent, a ternary concerted catalytic system is created for the first time to break through temperature limitation, phenol is efficiently activated by [BMIM] OH to generate high-activity phenoxy anions through a composite catalytic design of an alkaline ionic liquid / quaternary ammonium salt / nano metal oxide, the quaternary ammonium salt executes phase transfer and reaction path switching, and the anisole is prepared by taking dimethyl carbonate as a methylation reagent. The nano metal oxide has the effects of balance regulation and structural protection, and the conversion rate of phenol is gt according to the mass ratio of phenol to dimethyl carbonate to basic ionic liquid to quaternary ammonium salt compound to nano metal oxide being 94: (99-117): (2.82-7.52): (0.94-4.7): (0.47-3.76); the selectivity of anisole is gt; the method has the advantages that the concentration is 99%, decomposition of DMC and generation of by-products such as o-cresol are inhibited from the source, a self-settling separation-circulation method subverts a catalyst recovery mode, the by-products are directionally inhibited, the separation process is simplified, and the product can reach gt through single washing and reduced pressure distillation; and high-energy-consumption multi-tower rectification for substances with approximate boiling points in the traditional method is omitted, so that the economic benefit is greatly improved.

The application discloses a titanium-doped sheet-layer FER molecular sieve and application of the titanium-doped sheet-layer FER molecular sieve in an electrochemical sensing detector for rutin, and belongs to the technical field of molecular sieve synthesis and electrochemical sensor detection. n -O-(p-C6H4)2-O-(CH2) n -NH-C2H4-NH2; wherein n is 10-16. The titanium-doped sheet-layer FER molecular sieve is immobilized with chitosan to obtain a composite material, an electrode is modified by using the obtained composite material to construct an electrochemical sensor, and the obtained electrochemical sensor is used for detecting and analyzing rutin. The concentration linear range of the electrochemical sensor for detecting rutin reaches 0.1-10 micromoles per liter, the concentration detection range is wide, the detection sensitivity, accuracy, repeatability and selectivity are high, the detection lower limit is low, and the stability is good.

Provided herein are halogenated ether compounds of Formula (I), Formula (II), or Formula (III): Formula (I)Formula (II)Formula (III) Also provided are electrolytes comprising one or more compounds of Formula (I), Formula (II), or Formula (III) and electrochemical cells comprising electrolytes comprising one or more compounds of Formula (I), Formula (II), or Formula (III).

This invention provides novel fluorine-containing diether compounds. [Solution] Formula (1) below: JPEG2026065628000011.jpg30128 (In formula (1), R1 represents a fluorine atom or a perfluoroalkyl group having 1 to 10 carbon atoms, R2 may be the same or different, consisting of a methyl group, an ethyl group, -CH2CF3, or -CH2(C2F4). n Showing H n represents an integer between 1 and 10 (inclusive). A fluorine-containing diether compound represented by the following:

The application provides a kind of plane chiral boronic acid compound based on cycloaralkane skeleton and its synthesis method and application, the plane chiral compound has the structure shown in formula I;R 1 It is selected from one of C1-C8 alkyl, C1-C8 alkoxy, C1-C20 aryloxy.R 2 It is selected from one of hydrogen, fluorine, methyl, ethyl, methoxy, ester group, nitro group, phenyl, benzyl, tert-butyl, isopropyl.The application can effectively synthesize plane chiral boronic acid catalyst based on cycloaralkane skeleton, and the plane chiral boronic acid catalyst based on cycloaralkane skeleton can realize diol desymmetrization reaction.

The invention relates to a process for preparing an alkoxylated product. The aim of the invention is to provide aromatic polyols for preparing polyurethane-based and polyisocyanurate-based polymers, which ensure good miscibility with the isocyanate component and other components, have a good storage stability and render the end product flameproof. For this purpose, the invention devises a process for preparing an alkoxylated product by reacting bisphenol F with propylene carbonate and / or propylene oxide as propoxylation agent and ethylene carbonate and / or ethylene oxide as ethoxylation agent, the propoxylation agent and the ethoxylation agent being used in a molar ration of 70:30 to 45:55.

The present invention relates to halogenated alkenylalkoxymethyl ether compounds of the following general formula (1): R 1 CH2OCH2OCH2CH2CH=CH(CH2) a X 1 (1), wherein R 1 represents a hydrogen atom, a n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, X 1 represents a halogen atom, and a represents an integer of 3 to 14. The present invention also relates to a method for producing terminal conjugated alkadien-1-yl acetate compounds of the following general formula (5): CH2=CHCH=CH(CH2) a OAc (5), wherein a is defined as above, and Ac represents an acetyl group, and a method for producing terminal conjugated alkadien-1-ol compounds of the following general formula (6): CH2=CHCH=CH(CH2) a OH (6), wherein a is defined as above.

The present invention relates to the technical field of chemical synthesis, and provides a method for synthesizing 5-chloro-2-(2-chloroethoxy)benzenesulfonamide. The method comprises: performing an amination reaction on 5-chloro-2-(2-chloroethoxy)benzenesulfonyl chloride and aqueous ammonia to obtain 5-chloro-2-(2-chloroethoxy)benzenesulfonamide. The above technical solution solves the problems of incomplete amination, unstable product quality, and subsequent deactivation of a hydrogenation catalyst in the production process of 5-chloro-2-(2-chloroethoxy)benzenesulfonamide in the related art, while also solving the problems of low product yield and high production and processing costs.

The invention provides a cholesteric luminescent liquid crystal material with a high asymmetric factor, a film and a preparation method, and belongs to the technical field of photoluminescent materials. The cholesteric luminescent liquid crystal material prepared by the invention is obtained by taking 9, 9-dioctylfluorene as a central group through Suzuki reaction and Williamson synthesis. According to the material, supermolecule co-assembly can be realized in a thermal annealing process under the action of a chiral binaphthalene inducer by regulating and controlling an alkyl chain and an effective conjugate length, so that a relatively high CPL signal is obtained. The chiral liquid crystal co-assembly thin film and the polymer network thin film have the advantages that the chiral liquid crystal co-assembly thin film and the polymer network thin film prepared by the aid of the method are ingenious in design and low in cost, and the chiral liquid crystal co-assembly thin film and the polymer network thin film can be applied to advanced photon applications such as 3D (three-dimensional) imaging and anti-counterfeiting encryption.

The invention provides a norbornene derivative and a preparation method thereof, a polydicyclopentadiene material and a preparation method thereof, and plastic, the structural general formula of the norbornene derivative is as shown in a formula a: in the formula a, X is selected from halogen, Y is selected from halogen, and R1-R10 are respectively and independently selected from substituted or unsubstituted saturated groups. The norbornene derivative can be subjected to polymerization reaction with dicyclopentadiene to generate the flame-retardant polydicyclopentadiene material, and the flame-retardant polydicyclopentadiene material has excellent strength, toughness, flame retardance and interface performance.

A solid catalyst component for the polymerization of olefins made from or containing a magnesium halide, a titanium compound having at least a Ti-halogen bond, and at least an electron donor compound selected from 1,3-diethers.

The application belongs to the field of medicine synthesis, and specifically provides a daunorubicin intermediate compound. The daunorubicin can be synthesized by pure chemical synthesis by using the intermediate compound. The daunorubicin is synthesized by taking 2,5-dihydroxybenzyl alcohol as a raw material. The route has low raw material cost, mild reaction condition, convenient post-treatment, high total yield, and good industrial application prospect.

The invention relates to a preparation method of a KRAS G12D intermediate. Specifically, the method for preparing the compound as shown in the formula (V-1) is simple in preparation process route, and the cost can be remarkably reduced.

Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((−)-trans-Δ9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

The application is suitable for the field of fine chemical technology, and provides a production device and process of fine chemicals, which comprises a raw material mixing tank, a reaction rectifying tower, a light-removing tower and a heavy-removing tower, the inlet material of the raw material mixing tank is a mixture of phenol, ethylene carbonate and catalyst, the material outlet of the raw material mixing tank is connected with the inlet of the reaction rectifying tower through a reaction preheater, the tower kettle material outlet of the reaction rectifying tower is connected with the material inlet of the light-removing tower, the tower kettle material outlet of the light-removing tower is connected with the material inlet of the heavy-removing tower, and the tower kettle material outlet of the heavy-removing tower is the catalyst concentrate outlet.The process is simple and efficient, the conversion rate of ethylene carbonate is 100%, and the selectivity of phenoxy ethanol is > 95%; the device structure is simple, the operation is convenient, the product quality is stable and reliable, the device investment of phenoxy ethanol can be effectively reduced, and the market competitiveness of the product can be improved.

Provided are: 1,1,1,5,5,5-hexafluoro-3-(2,2,2-trifluoroethoxy)-2-pentene which is a new compound; and a use application and a production method for the new compound.　The present invention provides 1,1,1,5,5,5-hexafluoro-3-(2,2,2-trifluoroethoxy)-2-pentene. This new compound can be produced by, for example, reacting 1,1,1,5,5,5-hexafluoro-3-chloro-2-pentene and 2,2,2-trifluoro ethanol in the presence of a base. Further, the new compound is useful as an additive in a nonaqueous electrolytic solution of a secondary battery.

The research aims to optimize the synthesis process of oxyfluorfen, improve the product yield and purity, and turn byproducts into wealth. According to an original process route, resorcinol is used as a starting raw material, and oxyfluorfen is synthesized through double etherification, nitration and ether exchange. After optimization, the total yield reaches 94.1%, and the purity reaches 98.4%. In order to improve the utilization rate of the raw materials, an acidic water phase obtained after quenching of an oxyfluorfen reaction solution is subjected to reduced pressure distillation, the byproduct 3-chloro-4-hydroxy-trifluorotoluene is recovered, and the yield can reach 93.7%. Further serving as a raw material of a new process, and synthesizing a target product through nucleophilic substitution. In the route, 2, 4-dichloronitrobenzene with moderate reaction activity and better selectivity is innovatively used for replacing 2, 4-difluoronitrobenzene, so that side reaction is effectively inhibited, and a target product with the content of 98.7% is obtained at the total yield of 94.8%. According to the new and old combination strategy, through integration of two process routes, high-valued conversion of by-products is realized, limitation of a traditional synthesis method is broken through, and atom economy is remarkably improved.

The invention discloses a simple synthesis method of 2, 2, 2-trifluoroethyl ether, and belongs to the field of organic synthesis. According to the synthesis method, the easily available 2, 2, 2-trifluoroethanol, trifluoromethanesulfonic anhydride / trifluoromethanesulfonyl chloride and the like are directly adopted to synthesize the 2, 2, 2-trifluoroethyl ether in one step under the action of organic alkali and under the conditions of normal temperature and normal pressure, dangerous metal / high temperature and high pressure / gas delivery is not involved, the preparation cost of the 2, 2, 2-trifluoroethyl ether is greatly reduced, and the synthesis method is suitable for an industrial production route.

The present invention provides a method for synthesizing pentaerythritol triallyl ether. This method uses pentaerythritol and allyl chloride as starting materials, water as the reaction solvent, and reacts in two stages under strong alkaline conditions. Two kinds of phase transfer catalysts with hydrophilicity and lipophilicity are respectively used in the two-stage reaction. That is, a hydrophilic phase transfer catalyst is used in the initial stage of the reaction to ensure the catalytic efficiency and reaction efficiency, and an organic layer mainly composed of pentaerythritol monoallyl ether and pentaerythritol diallyl ether is obtained. Since the lipophilicity in the organic layer is enhanced, at this time, a lipophilic phase transfer catalyst is added, and then allyl chloride is continuously added for reaction, so as to obtain a crude product mainly composed of pentaerythritol monoallyl ether. The synthesis method of the present invention is simple in operation, uses water as the solvent, and the yield and selectivity of the obtained pentaerythritol triallyl ether product are relatively high. Moreover, the contents of other monoethers, diethers, and tetraethers can be respectively controlled below 0.05%, below 5%, and below 10%. At present, pilot-scale production has been carried out.

The present invention relates to a process for preparing a haloalkyl alkoxymethyl ether compound (1B), wherein X1 represents a halogen atom, and R1 represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, the process comprising the steps of converting a haloalkyl alkoxymethyl ether compound of the following general formula (1A), wherein X1 and R1 are as defined above, into a nucleophilic reagent, 4-alkoxymethoxy-1-methylbutyl, of the following general formula (2A), wherein M1A represents Li, MgZ1A, CuZ1A, or CuLiZ1A, Z1A represents a halogen atom or a 4-alkoxymethoxy-1-methylbutyl group, and R1 is as defined above, and subsequently subjecting the nucleophilic reagent, 4-alkoxymethoxy-1-methylbutyl (2A), to a nucleophilic addition reaction with propylene oxide of the following formula (3) to obtain 6-hydroxy-4-methylheptyl alkoxymethyl ether compound of the following general formula (4), wherein R1 is as defined above, and subjecting the 6-hydroxy-4-methylheptyl alkoxymethyl ether compound (4) to a halogenation reaction to form the aforesaid haloalkyl alkoxymethyl ether compound (1B).

The invention belongs to the technical field of power equipment fault diagnosis, and particularly relates to a preparation method of a fault diagnosis agent for transformer insulating oil. The preparation method comprises the following steps: mixing a phenolic compound, a halogenated hydrocarbon compound, alkali and a solvent, carrying out a stirring reaction, and carrying out optional cooling, optional filtering, optional filtrate concentration and optional purification to obtain the fault diagnosis agent. The preparation method of the fault diagnosis agent provided by the invention is simple in reaction steps, does not need complex equipment and is easy to industrialize; cheap and easily available raw materials are used, no catalyst is used, and the cost is low; the reaction conditions are mild, the safety is high, and the method is environment-friendly; and the product has high purity and good compatibility with insulating oil.

The utility model discloses a feeding device for producing pentaerythritol triallyl ether, and relates to the technical field of chemical production. The device comprises a bottom plate, a material box is arranged above an electric push rod, a conveying pipe is fixed to the bottom of the material box, a conveying motor is fixed to the left end of the conveying pipe, and a spiral blade is fixed to the outer portion of a rotating rod; a stirring motor is fixed in the middle of the upper wall of the stirring barrel; a fan is fixed on the upper side of the peripheral wall of the stirring barrel. The conveying pipe is inserted into the stirring barrel, raw materials are conveyed through rotation of the spiral blade, and the raw materials falling into the stirring barrel are dispersed under the action of airflow generated by the fan; the problems that in the prior art, vibration is generated during raw material conveying, part of raw materials drift away when the raw materials are separated from a feeding mechanism and move into a feeding hopper, the raw materials are wasted, the operation environment is polluted, the falling point is fixed after the raw materials enter a body, and the stirring efficiency during raw material stirring is reduced are solved.

The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to a method for preparing a honokiol derivative and an intermediate thereof. The preparation method comprises: reacting compound M2 with ethyltriphenylphosphonium bromide under alkaline conditions to prepare a compound of formula I; allylating the compound of formula I to prepare compound M3; demethylating compound M3 under acidic conditions to prepare compound M4; and rearranging compound M4 to prepare a compound of formula II. This method utilizes readily available, inexpensive raw materials, is low cost, has simple steps, mild reaction conditions, low purification requirements, high purity, high yield, is environmentally friendly, safe, and suitable for industrial production, thus possessing significant application value.

Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((−)-trans-Δ9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

The application belongs to the field of medicine synthesis, and particularly relates to a chemical synthesis method of an epirubicin intermediate, daunorubicin. The daunorubicin is synthesized by taking 2,5-dihydroxybenzyl alcohol as raw material, the route has low raw material cost, mild reaction condition, convenient post-treatment, high total yield, and has a good industrial application prospect.