4results about How to "Retain biocompatibility" patented technology

This invention relates to the field of sensing materials technology, specifically disclosing a cellulose-based conductive hydrogel material for ascorbic acid detection, its preparation method, and its applications. This hydrogel uses TEMPO oxidized cellulose nanofibers (TOCNF) as a biocompatible matrix. By introducing Cu-BTC / CNT composite nanoparticles, a three-dimensional conductive network with both high electrochemical activity and structural stability is constructed. While retaining the biocompatibility and flexibility of cellulose, it exhibits particularly high sensitivity and selectivity in detecting small biomolecules such as ascorbic acid, with short response time and good stability. This method achieves synergistic optimization of the composite material's structural uniformity and functionality without relying on complex molding processes. Experimental results show that the conductive hydrogel prepared by this invention possesses good mechanical properties and biocompatibility, exhibiting high sensitivity and stability in biosensing fields such as ascorbic acid detection, providing a novel high-performance material basis for flexible biosensors.

This invention belongs to the field of biological engineering technology, specifically relating to an MXene-based photothermal coupling composite film for bone repair and its preparation method; comprising MXene, type I collagen, and gelatin solution, obtained by sequential bridging and cross-linking with FeCl3 solution; wherein the mass ratio of MXene to type I collagen is (3-9):(1-7), and gelatin accounts for 3.6%-10.4% of the final composite material mass; the preparation method includes: ultrasonically dispersing MXene and mixing it with gelatin solution, then compounding it with type I collagen solution, vacuum filtering and drying to form a matrix film, and finally cross-linking it by impregnation with FeCl3 solution; this film has mechanical properties matching natural bone tissue, good biocompatibility, and high-efficiency photothermal conversion capability under near-infrared light irradiation, and is suitable for bone defect repair and photothermal synergistic therapy.

The application discloses a production method of high-strength water-resistant polyvinyl alcohol film and relates to the technical field of high polymer materials. When the high-strength water-resistant polyvinyl alcohol film is prepared, first, quaternary phosphonium salt is prepared by reacting 4-bromobutyric acid and tris(4-fluorophenyl) phosphine, then the quaternary phosphonium salt is subjected to esterification with polyvinyl alcohol to prepare modified polyvinyl alcohol; then, functionalized carbon dots are prepared by taking clove extract, branched polyethyleneimine and cysteine as raw materials, and then the functionalized carbon dots are reacted with 4-formaldehyde benzene boronic acid to prepare boronic acid functionalized carbon dots; the modified polyvinyl alcohol, the boronic acid functionalized carbon dots and sodium carboxymethyl cellulose are mixed and reacted, and after being cast into a film, the high-strength water-resistant polyvinyl alcohol film is prepared by a two-way stretching process. The high-strength water-resistant polyvinyl alcohol film prepared by the application has excellent comprehensive performance, and has good mechanical strength, water resistance and functionality.

The invention discloses a preparation method and application of a functionalized konjac glucomannan / silsesquioxane composite sponge dressing, and belongs to the field of biomedical materials. The preparation method comprises the following steps: oxidizing konjac glucomannan by sodium periodate to prepare formylation modified konjac glucomannan; the preparation method comprises the following steps of: mixing an aqueous solution of the compound with an aqueous solution of polyamino silsesquioxane (POSS) and salts thereof, controlling the molar ratio of aldehyde groups to amino groups, carrying out chemical crosslinking by utilizing a Schiff base reaction, and homogenizing and freeze-drying to obtain the composite sponge dressing. The konjac glucomannan skeleton in the dressing has good biocompatibility, liquid absorption and healing promotion potential, and the covalent cross-linked POSS nano unit can efficiently adsorb endotoxin (LPS) in wound exudate by virtue of dense positive charge clusters on the surface of the covalent cross-linked POSS nano unit, so that the inflammation microenvironment is cooperatively regulated and controlled. The method can be used for preparing wound repair products.