Preparation method of reactive type water-solubility chitosan derivative

Abstract

The invention relates to a preparation method of a reactive type water-solubility chitosan derivative, which comprises the steps of adding chitosan into the aqueous solution of 2-acrylamido-2-methylpropanesulfonic acid, stirring for 0.5 hour at room temperature, preparing the chitosan aqueous solution to 2 wt% with the mole number of the 2-acrylamido-2-methylpropanesulfonic acid being 0.5-4 timesof that of amido of the chitosan, adding p-Hydroxyanisole accounting for 1-3 percent of the mole number of the 2-acrylamido-2-methylpropanesulfonic acid in the above solution, keeping stirring for 0.5hour to lead the chitosan to be fully dissolved in the aqueous solution, heating up to 30-60 DEG C fast, and reacting for 2-6 hours, thus obtaining the reactive type water-solubility chitosan derivative. The method has mild reaction condition, easy control, simple procedures, easy control of substitution degree, environment-protecting subsequent treatment and economical reaction process.

Description

technical field [0001] The invention relates to a preparation method of reactive water-soluble chitosan derivatives. Background technique [0002] Chitin is the second largest natural biopolymer in the storage capacity after cellulose in nature. Chitosan is the product of chitin after deacetylation treatment. It is a natural alkaline polysaccharide existing in nature. It is a kind of Environmentally friendly natural polymers widely exist in the shells of shrimps, crabs, insects, maggots, flies and other animals, and are an inexhaustible renewable resource. Chitosan not only has the advantages of non-toxic, harmless, good biocompatibility, biodegradability, etc., but also has many excellent physiological properties such as anticancer, antibacterial, hemostatic, and enhancing human immunity. Therefore, chitosan has great application value in food, cosmetics, environmental protection, textile, printing and dyeing, papermaking and other industries, especially in the fields of b...

AI Technical Summary

Problems solved by technology

The disadvantage of these methods is that the degree of substitution of the water-soluble chitosan derivative obtained is relatively low, the reaction time is longer, and the degree of substitution of the prepared chitosan derivative is not easy to control, because the introduced group is not very hydrophilic. , making the water solubility of the derivatives poor

[0006] 1. The preparation method is complex and requires a catalyst, and the post-processing is troublesome, which increases the cost;

[0007] 2. The use of organic solvents not only increases the cost, but also introduces toxic substances, which reduces the biomedical application value of chitosan derivatives;

[0008] 3. The reaction conditions are violent and harsh, and it is not easy to control;

[0009] 4. The prepared water-soluble chitosan derivatives have a low degree of substitution and poor water solubility;

[0010] 5. The preparation process consumes a lot of energy, and the post-processing causes secondary pollution, which does not conform to the concept of environmental protection

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