50 results about "Water soluble chitosan" patented technology

The invention relates to the technical field of lithium batteries, and relates to a carbon-coated lithium iron phosphate precursor and a preparation method thereof, and carbon-coated lithium iron phosphate and a preparation method thereof, and the preparation method comprises the following steps: preparing a phosphorus source solution and a mixed solution A containing a lithium source and an iron source; mixing the phosphorus source solution, the mixed solution A and polyol to obtain a mixed solution B; adjusting the pH value of the mixed solution B to be weakly acidic, neutral or alkaline, and performing heat treatment to obtain a mixed solution C; and mixing the mixed solution C with water-soluble chitosan, and adjusting the pH value to be neutral or alkaline to obtain the carbon-coated lithium iron phosphate precursor. According to the method, the nanoscale lithium iron phosphate precursor with the uniform size can be synthesized in a liquid phase, lithium iron phosphate with the small particle size and the higher crystallinity can be rapidly synthesized at low cost, and the electrochemical performance of the carbon-coated lithium iron phosphate material can be improved.

The invention relates to the technical field of medical cosmetology, and particularly discloses a dialdehyde group-containing oxidized polysaccharide-water-soluble chitosan hydrogel for cosmetic injection, which comprises the following raw materials: a water-soluble chitosan aqueous solution and a dialdehyde group-containing oxidized polysaccharide aqueous solution, the water-soluble chitosan comprises one of carboxyl alkyl chitosan, hydroxyalkyl chitosan, carboxyl alkyl chitosan sodium salt and hydroxyalkyl chitosan sodium salt. The used raw materials do not contain cross-linking agents, safety risks caused by the fact that the cross-linking agents remain in the body are avoided, and the hydrogel is used for filling wrinkles, improving facial contours and promoting regeneration and repair of skin, so that the skin looks young and smooth.

The invention relates to a selective nanofiltration membrane as well as a preparation method and application thereof. The selective nanofiltration membrane comprises a support layer and a separation layer, the separation layer is obtained through interfacial polymerization of an oil-phase reactant and a water-phase reactant; the water-phase reactant comprises a negatively charged monomer and a positively charged monomer; the positively charged monomer comprises any one or a combination of at least two of polyvinylamine, polyethyleneimine, diethylenetriamine, water-soluble chitosan, quaternized polyethyleneimine, polyallylamine or triethylene tetramine. According to the method, monomers with different charges are added into a water phase, so that the nanofiltration membrane is wholly charged and neutral, the interception of sodium sulfate can be effectively reduced, the interception of antibiotics is increased, and the separation of the antibiotics and inorganic salts can be efficiently promoted.

The invention provides a water-soluble chitosan fiber mask and a production process thereof, and mainly relates to the technical field of mask production, and the production process comprises the following steps: mixing and dispersing chitosan and a surfactant solution, and carrying out plasma treatment on a fiber material; carrying out gradient mixing on the pretreated chitosan and a fiber material in the presence of a dispersing agent; preparing a fiber base material through needling, spunlace and hot melting bonding processes; immersing the mixed fiber base material in a mixed solution of acid containing chitosan and ethanol under a negative pressure condition, wherein the mass ratio of the chitosan to the mixed solution is 1: 0.2-1: 2; and removing ethanol through reduced pressure distillation, recovering, and drying to obtain the water-soluble chitosan mask. By optimizing chitosan dispersion, fiber activation, a gradient structure and negative pressure permeation design, the technical problems that chitosan is poor in dispersity, molecules are easy to degrade and load is uneven in a mask base material are systematically solved, and meanwhile collaborative optimization of the instant solubility of the mask and slow release of active ingredients is achieved.

The utility model relates to the field of chitosan production, in particular to a filtering device for water-soluble chitosan production, which comprises a filter cartridge, a heating column is mounted in the filter cartridge through a partition plate, a fine mesh filter cartridge is mounted on the outer side far away from the heating column in a sleeving manner, and an electric sealing door is arranged below the fine mesh filter cartridge obliquely. A filter screen is arranged below the electric sealing door, a guide slope is obliquely arranged below the filter screen, and a discharging port is formed in one side of the guide slope. According to the utility model, through the arrangement of the heater assembly, the heating column and the fine-mesh filter cartridge, chitosan can be preliminarily heated to improve the filtering speed of the chitosan, the chitosan is preliminarily filtered through the filter cartridge, and meanwhile, the electric sealing door is opened to continuously lead the chitosan into the filter screen at the bottom to be filtered.

The invention provides a preparation method and application of an antibacterial water-soluble chitosan derivative, chitosan is used as a raw material, the chitosan has active sites of two aldehyde groups through a chemical reaction mode, lysine is grafted to a chitosan carbon skeleton, and the antibacterial water-soluble chitosan derivative is prepared. The chitosan derivative has good antibacterial activity and has no obvious cytotoxicity, and the application range of chitosan in food preservation is widened.

The present invention discloses a nanofiber-based multifunctional hydrogel and a preparation method thereof and application in drug delivery. The hydrogel is prepared by introducing high-density amino groups on a carboxylated nanocellulose fiber matrix and then introducing phenolic hydroxyl groups to selectively detect Fe 3+ The phenolic hydroxyl-rich nanofiber-based detection material is used to detect Fe 3+ At the same time, enrichment of Fe 3+ On the surface of the phenolic hydroxyl-rich nanofiber-based detection material, a recursive nanofiber-based detection material that can further detect butyrylcholinesterase is prepared in situ, and in the process of detecting butyrylcholinesterase activity, Prussian blue nanoparticles are generated in situ on the material surface to prepare a nanofiber-based photothermal effect material with near-infrared response, which is then mixed with tumor therapeutic drugs, water-soluble chitosan and sodium alginate to form a nanofiber-based multifunctional hydrogel. The hydrogel combines detection, tumor drug delivery and multi-modal tumor treatment.

The application provides a transparent fire-retardant fireproof paint and a preparation method and application thereof, and particularly relates to the technical field of fire-retardant fireproof paint. The transparent fire-retardant fireproof paint comprises, by weight fraction, 1-8 parts of water-soluble chitosan, 0.5-5 parts of gelatin, 3-10 parts of phytic acid solution, 0.1-0.8 parts of hydrophilic fumed nano-silicon dioxide, 0.1-3.0 parts of a stabilizer and 30-80 parts of water; wherein the stabilizer is a water-soluble amine compound. By introducing the water-soluble amine stabilizer into the chitosan / gelatin / phytic acid water-based transparent fire-retardant system, the low-temperature stability, compatibility and long-term storage stability of the paint system are significantly improved.

The invention belongs to the technical field of sunscreen cosmetics, and particularly relates to a sunscreen agent based on hydroxyapatite microspheres and a preparation method of the sunscreen agent. The sun-screening agent based on the hydroxyapatite microspheres is prepared from the following components in percentage by mass: 13 percent to 26 percent of water-soluble chitosan, 40 percent to 43 percent of the hydroxyapatite microspheres and 34 percent to 44 percent of a freeze-drying protective agent. The sun-screening agent can act on the skin epidermis through introduction, is different from a traditional sun-screening agent which is only simply smeared to maintain the sun-screening effect of one day or several days, and the long-acting sun-screening agent based on the hydroxyapatite microspheres can stay on the skin epidermis for a long time to achieve the effects of absorbing and reflecting UVB, so that the sun-screening effect is achieved until the sun-screening agent is completely degraded.

The present invention relates to an anti-transpiration agent for reducing plant transpiration and a preparation method thereof, which includes an agent A and an agent B, wherein the agent A is composed of a water-soluble chitosan solution, a metal organic framework MIL-125 (Ti) and a phosphate buffer, and the agent B is composed of glycerol, ferric chloride and water. In sunny weather, the agent A is first sprayed on the plant leaf surface using a sprayer, and 1.5 to 2 hours after the spraying is completed, the agent B is sprayed on the plant leaf surface using a sprayer, and after the leaf surface is dried, a layer of anti-transpiration agent is attached to the leaf surface. The anti-transpiration agent for reducing plant transpiration of the present invention is sprayed on the leaves of the plant, which can significantly reduce the plant transpiration, and has a significant inhibitory effect on the transpiration rate of the plant leaves. At the same time, the leaf surface is less damaged and is not prone to poisoning symptoms. The anti-transpiration effect is more lasting, and after a single use for 9 days, there is still a certain anti-transpiration effect. The anti-transpiration agent of the present invention has good stability after film formation and good resistance to rainwater impact.

The invention discloses kiwi fruit extracellular vesicle supported injectable hydrogel with active oxygen scavenging capacity as well as a preparation method and application of the kiwi fruit extracellular vesicle supported injectable hydrogel, and belongs to the cross technical field of biomedical materials and clinical medicine. Comprising the following raw materials: water-soluble chitosan (CS), polyvinyl alcohol (PVA), an active oxygen responsive chain segment construction macromonomer (Linker), a cross-linking agent and a drug-containing kiwi fruit extracellular vesicle. The injectable hydrogel is prepared by preparing the raw materials into an aqueous solution and carrying out a cross-linking reaction, and aims to optimize the postoperative recovery process and prevent the occurrence of abdominal adhesion by integrating a multi-effect treatment strategy of wound healing, inflammatory reaction control and tissue regeneration promotion.

The present invention relates to a strongly absorbable water-soluble carotenoid and a preparation method thereof, specifically including the following steps: (1) preparation of water-soluble chitosan; (2) preparation of carotenoid-fatty acid mixture; (3) preparation of alkaline electrolyte water; (4) preparation of carotenoid-protein complex by electrolyzed water coupling ultrasonic technology; (5) preparation of chitosan-protein-fatty acid-carotenoid complex; (6) obtaining of water-soluble carotenoid. The present invention innovatively combines the alkaline electrolyzed water coupling ultrasonic technology and the non-covalent self-assembly technology to prepare a strongly absorbable water-soluble carotenoid. Compared with the untreated carotenoid, the carotenoid has good water solubility and stability, and the intestinal absorption efficiency is increased by 5 to 10 times. The preparation process of the present invention is simple, has a high embedding rate, good safety, and the product has good stability and high absorption rate, and can be widely used as a nutritional fortifier in the food system and is suitable for industrial production.

The invention provides an open type tissue culture method of bamboo reed, which comprises the following tissue culture steps: S1, preparation of a gradient antibacterial culture medium: (1) preparation of the gradient antibacterial culture medium: an MS culture medium, 0.5 mg / L 6-BA and 0.1 mg / L NAA are added, 0.1% of tea polyphenol aqueous extract is added, and 0.03% of water-soluble chitosan oligosaccharide is added. Traditional chemical disinfection is replaced with a natural gradient antibacterial system, the dual functions of pollution prevention and control and root protection are achieved by combining a symbiotic bacterium slow release technology, and the stress resistance and lignification characteristics of plants are synchronously improved through the synergistic effect of salinity gradient stimulation and environmental signal molecules; a light-gas intelligent regulation and control system is developed to simulate the optimal growth condition, and a transplanting survival guarantee system is constructed in cooperation with a mycorrhiza pre-activation technology; the dependence of traditional tissue culture on a sterile environment is broken through, and the seedling culture efficiency, the ecological compatibility and the resource utilization level are comprehensively improved under an open condition.

The present invention relates to a water-soluble fucoxanthin and a preparation method thereof. The water-soluble fucoxanthin is a water-soluble particle formed by self-assembly of fucoxanthin, fatty acids, bovine serum albumin, and water-soluble chitosan. The preparation method comprises the following steps: (1) preparing water-soluble chitosan; (2) preparing a fucoxanthin-fatty acid mixture; (3) preparing alkaline electrolyte water; (4) preparing a fucoxanthin-protein complex by electrolysis water coupling ultrasound technology; (5) preparing a chitosan-protein-fatty acid-fucoxanthin complex; and (6) obtaining water-soluble fucoxanthin. The present invention adopts alkaline electrolysis water coupling ultrasound technology and non-covalent self-assembly technology to prepare water-soluble fucoxanthin with good stability and high absorption rate. The preparation process is simple, the embedding rate is high, the safety is good, the production cost is low, the fucoxanthin is suitable for industrial production, and the fucoxanthin can be widely used in food systems as a nutritional enhancer.

The invention discloses a novel water-soluble chitosan fluorescent probe and application of the novel water-soluble chitosan fluorescent probe in ClO <-> and NO2 <-> ion detection. The structural formula of the water-soluble chitosan fluorescent probe is as follows: # imgabs0 #. The water-soluble chitosan fluorescent probe disclosed by the invention can realize qualitative and quantitative detection of ClO <-> and / or NO2 <-> ions through fluorescence spectrometry, and has good anti-interference performance, high selectivity and sensitivity in the presence of other analytes; meanwhile, the probe can be applied to test paper detection and shows huge potential in the aspect of detecting ClO <-> and NO2 <-> ions.

The invention discloses a vaginal temperature-sensitive antibacterial gel and a preparation method thereof, the gel is composed of water-soluble chitosan, poloxamer 407, hydroxy propyl cellulose, nano silver, plant polyphenol, a transdermal absorption enhancer, propylene glycol and deionized water, the poloxamer 407 is used as an only thermally induced hydrogel forming agent, and the nano silver, the plant polyphenol, the transdermal absorption enhancer, the propylene glycol and the deionized water are added into the gel; a solvation temperature-sensitive adjusting system is constructed through propylene glycol, and the sol-gel transition temperature is accurately regulated and controlled to 28-32 DEG C. The gel is a low-viscosity fluid (500-1000 mPa.s) at the normal temperature of 15-25 DEG C, and is easy to push and inject; and after contacting with the body temperature of 36 DEG C, the gel is instantly subjected to phase change within 30 seconds to form high-strength gel, and the gel is stably anchored on the vagina wrinkling wall for more than 8 hours by utilizing the synergistic effect of physical chimerism and electrostatic adsorption. The problems that an existing temperature-sensitive preparation is difficult in normal-temperature administration, slow in-vivo solidification and prone to loss are solved, a split-phase sterilization method is adopted in the preparation process, and the preparation method is suitable for industrial production.

The invention discloses vitamin B12 micro-capsule powder applied to soft sweets and a preparation method of the vitamin B12 micro-capsule powder, and the vitamin B12 micro-capsule powder is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of a vitamin B12 core material, 4-7 parts of protein, 2.25-4 parts of water-soluble chitosan, 40-45 parts of Arabic gum and 40-50 parts of cyclodextrin. The mass ratio of the Arabic gum to the water-soluble chitosan is 10: (0.5-1). Arabic gum is used as a main wall material, water-soluble chitosan is compounded, cyclodextrin is used as a filling agent, protein is used as an emulsifier and a film-forming agent, and the vitamin B12 microcapsule is prepared through a spray drying method. According to the vitamin B12 soft sweets, multiple protections of protein, protein-polysaccharide, the mixed wall material and cyclodextrin are formed outside the vitamin B12 core material, degradation of the vitamin B12 in the soft sweets can be effectively delayed, the problem of content loss in the preparation process of the vitamin B12 soft sweets is solved, and the vitamin B12 soft sweets have the advantages of being simple in process, high in production efficiency, good in stability and the like.

The invention discloses injectable hydrogel for inhibiting adhesion after an abdominal cavity operation and a preparation method of the injectable hydrogel, and belongs to the cross technical field of biomedical materials and clinical medicine. The honeysuckle plant exosome is prepared from the following raw materials: water-soluble chitosan (CS), hyaluronic acid (HA), an active oxygen responsive chain segment construction macromonomer (Linker), a medicine-loaded honeysuckle plant exosome solution and a cross-linking agent. The raw materials are mixed and subjected to a cross-linking reaction, and the injectable hydrogel is prepared. According to the preparation method, water-soluble chitosan, hyaluronic acid and active oxygen responsive chain segments are used for constructing a macromonomer, genipin is used as a biological cross-linking agent, and the honeysuckle plant exosome containing drugs is loaded into injectable hydrogel, so that the purposes of eliminating postoperative abdominal inflammation and repairing and treating wounds are achieved, and the preparation method is simple and convenient. Therefore, postoperative abdominal cavity tissue adhesion can be synergistically treated and / or prevented.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a nifedipine tablet and a preparation method thereof. The nifedipine tablet comprises nifedipine, a composite sustained-release material, a filler, an adhesive and a lubricant, the composite sustained-release material comprises a polylactic acid-glycolic acid copolymer, a polyethylene glycol-polylactic acid copolymer, chitosan, alginate and calcium salt. PLGA ensures that the in-vivo degradation period is matched with the requirement of 24-hour release of nifedipine, and the dispersibility and water solubility of nifedipine are improved by utilizing the amphipathy of PEG-PLA; the chitosan and nifedipine form a complex due to the positive charge characteristic, so that the crystal form transformation of the medicine is inhibited; alginate is rapidly gelated under the action of calcium ions, and cooperates with PEG-PLA to regulate and control the initial release rate, so that burst release is avoided. A novel composite sustained-release material is adopted and is matched with a specific preparation process, so that the comprehensive effects of 24-hour constant-speed release, high bioavailability and excellent stability can be realized.

The invention discloses a pH stimuli-responsive controlled-release nano-pesticide and a preparation method thereof, and belongs to the technical field of controlled-release nano-pesticides, a complex formed by ellagic acid and aluminum ions is adsorbed on the surface of an MXene material under a weakly alkaline condition through a pi-pi accumulation effect to prepare modified MXene powder, and the modified MXene powder is used for preparing the pH stimuli-responsive controlled-release nano-pesticide. The preparation method comprises the following steps: preparing modified MXene powder, coating a water-soluble chitosan material on the surface of the modified MXene powder through hydrogen-bond interaction to prepare nano-carrier powder, and loading an original drug on the nano-carrier powder to obtain the pH stimulation response controlled-release nano-pesticide. The nano-pesticide can reduce leakage of raw pesticide under a weak alkaline condition and promote release of the raw pesticide under a weak acidic condition, and compared with an MXene-based nano-carrier which improves the pesticide release rate in both acidic and alkaline environments, the nano-carrier powder has more accurate weak acidic pH response controlled release performance.

The invention provides a collagen composite material for joint injury repair and a preparation method and application thereof.The collagen composite material comprises collagen and chitosan, the chitosan is water-soluble chitosan subjected to one or two or more combined treatment of carboxylation, hydroxylation, phosphatization and quaternization, and the chitosan is water-soluble chitosan subjected to one or two or more combined treatment of carboxylation, hydroxylation, phosphatization and quaternization. The weight ratio of the collagen to the water-soluble chitosan is (1: 15)-(1: 3). The composition and proportion of the collagen and the water-soluble chitosan are scientifically screened, the collagen composite material which is closer to natural synovial fluid in composition is formed, the water-soluble chitosan provides physical blocking inflammatory factors and a lubricating effect between cartilages, and the collagen has a pore structure, so that the cartilages have a good anti-inflammatory effect on the cartilages, and the cartilages have a good anti-inflammatory effect on the cartilages. Adhesion of cartilage cells is facilitated, nutrition is obtained, proliferation of the cartilage cells is promoted, and repair of damaged cartilage is achieved.

The application relates to the packaging box processing field and particularly discloses a packaging box printing process. The packaging box printing process comprises the following steps: S1: a pretreatment liquid is brushed on the surface of a packaging box to be printed for 10-15 minutes and then heated and dried, wherein the pretreatment liquid is prepared by mixing the following raw materials in parts by weight: 80-100 parts of water and 5-7 parts of water-soluble chitosan; S2: 50-70 parts of a connecting agent, 8-12 parts of pigment, 40-55 parts of water, 1-3 parts of polyether modified silicon defoaming agent, 1-3 parts of oleic acid amide and 10-15 parts of nano titanium dioxide are uniformly mixed to prepare water-based ink; and S3: the water-based ink is sprayed on a paper packaging box to be printed and dried. In addition, the printing process has the advantages that the water-based ink printed has good adhesion.

The application discloses a kind of double-network crosslinked hydrogel and its preparation method and application, belong to the field of biomedical materials.The double-network crosslinked hydrogel is composed of two aqueous solutions, one of which is an aqueous solution containing 1-15% carboxylated hydroxybutyl chitosan or carboxylated hydroxybutyl chitosan and other water-soluble chitosan by mass volume ratio, the other aqueous solution is an aqueous solution containing 1-15% dialdehyde-based oxidized polysaccharide by mass volume ratio, and the two aqueous solutions are mixed to form a double-network crosslinked hydrogel.The hydrogel of the present application undergoes temperature-sensitive physical crosslinking and Schiff base chemical crosslinking at body temperature to form a double-network hydrogel, which has better gel strength than single temperature-sensitive physical crosslinking hydrogel or single Schiff base chemical crosslinking hydrogel, prolongs the in vivo degradation time of the hydrogel, improves the cell compatibility of the hydrogel, is easy to use and operate, and can be used to prepare in vivo or in vitro absorbable medical devices or medical materials or drugs.

The invention relates to the technical field of cloth preparation, and provides a front and back same-color densified blackout cloth preparation method, which comprises: 1, preparing a same-color fabric surface layer and a same-color fabric bottom layer, selecting polyester fiber yarns with a fineness of 450 d + / -5%, weaving through a precision spinning device, pre-finishing the woven fabric surface layer and the woven fabric bottom layer, and removing surface impurities; and 2, mixing the titanium-zinc composite nano-powder with benzophenone tetracarboxylic dianhydride and a water-soluble chitosan derivative by adopting composite polymer fibers, and putting the mixed material into a supercritical reaction kettle. Through a double-sided compounding technology, the obverse side and the reverse side of the black-out cloth are in the same color, and the attractive requirement is met. And the shading core layer structure realizes high shading and anti-ultraviolet effects. And the structure is firm and durable through adhesive bonding and double-roller hot pressing. Sectional type cooling shaping ensures fabric flatness, and the process is controllable and suitable for industrial production.

The invention discloses an application containing an acne-removing traditional Chinese medicine composition and a preparation method of the application, and belongs to the technical field of traditional Chinese medicine acne-removing patches. The application sequentially comprises a non-woven fabric layer, an ointment layer and a polyethylene layer from top to bottom. The ointment layer comprises a first ointment layer and a second ointment layer; the first ointment layer is prepared from the following components in parts by mass: 6 to 12 parts of fructus forsythiae extract, 2 to 4 parts of cortex phellodendri extract, 3 to 6 parts of honeysuckle flower extract, 2 to 5 parts of herba taraxaci extract, 0.5 to 1.5 parts of radix gentianae extract, 0.5 to 1 part of radix ginseng extract and 1 to 4 parts of herba centellae extract; the second ointment layer is prepared from the following components in parts by mass: 0.5 to 2.5 parts of borneol, 6 to 8 parts of water-soluble chitosan and 3 to 6 parts of modified nano silicon dioxide. According to the application, grease generated by acnes can be adsorbed, redness and swelling can be eliminated, skin barriers can be repaired, relapse can be prevented, and both symptoms and root causes of the acnes can be treated.

The application relates to a film-coating process of sheet-shaped materials and a film-coated sheet-shaped material produced by the process, and belongs to the field of sheet-shaped medical materials, which comprises the following steps: S1, preparing glue solution: uniformly dissolving and mixing film-forming agent, plasticizer and organic solvent to prepare glue solution; S2, glue solution coating: coating the glue solution on a film coating platform by using a coating machine to form a glue film; S3, glue film drying: feeding the film coating platform and the glue film into a front drying box to dry to obtain a film body; S4, solvent spraying: spraying the dried film body with organic solvent and placing for timing; S5, film-coating and bonding: a film-coating mechanism coats sheet-shaped materials on the film body sprayed with organic solvent to obtain a film-coated sheet-shaped material after bonding; and S6, film-coating drying: placing the bonded film-coated sheet-shaped material into a rear drying box for drying. The application improves the inconvenient use of water-soluble chitosan non-woven fabric in clinical application and the conditions that the oral cavity application scene is prone to rapid dissolution and poor positioning.

The application discloses a novel water-soluble chitosan fluorescent probe and application of the probe in ClO ‑ and NO2 ‑ ion detection. The water-soluble chitosan fluorescent probe has the structural formula as shown in the following. The water-soluble chitosan fluorescent probe can realize qualitative and quantitative detection of ClO ‑ and / or NO2 ‑ ions by a fluorescence spectrum method, and has good anti-interference, high selectivity and sensitivity in the presence of other analytes; meanwhile, the probe can be applied to test paper detection, and has great potential in the detection of ClO ‑ and NO2 ‑ ions.

The invention discloses a preparation method of a composite plant extract slow-release preservative for targeted inhibition of putrefying bacteria of aquatic products, which comprises the following steps: selecting plant extract, tea polyphenol, vitamin E and water-soluble chitosan, compounding, adding sodium hyaluronate, homogenizing, finally adjusting the pH value, adding a stabilizer to form a preservative solution, and freeze-drying to obtain the preservative. Plant extracts of origanum vulgare, clove and the like can damage a microbial film structure and a metabolic function in a targeted manner and cover gram positive / negative bacteria and fungi; the tea polyphenol and the vitamin E scavenge free radicals and inhibit the activity of lipoxygenase through redox cycle, and block the oxidation chain reaction of lipid and protein; the water-soluble chitosan and the plant polyphenol can form a pH-responsive slow-release film, so that the invasion of oxygen and microorganisms is physically blocked, and active ingredients are intelligently released in a putrefying microenvironment (the pH is reduced), so that'on-demand bacteriostasis' is realized; the preservative disclosed by the invention can effectively protect the color, luster and texture quality of aquatic products through multi-mechanism synergistic antibiosis.

The invention relates to the technical field of soluble microneedles, in particular to an exosome soluble microneedle based on water-soluble chitosan and a manufacturing method thereof.The exosome soluble microneedle comprises a base plate and microneedles, the multiple microneedles are arranged at intervals, and the microneedles are fixed to the surface of the same side of the base plate; the microneedle is prepared from the following components in parts by weight: a pure chitosan substrate, crystal water, a fusion agent, a photocatalytic curing agent and exosome, the substrate comprises the following components in parts by weight: a pure chitosan substrate, crystal water and a photocatalytic curing agent; according to the exosome soluble microneedle and the manufacturing method thereof, the fusion agent can assist in rapid fusion of the exosome and the photocatalytic curing agent in the stock solution, the exosome can be distributed in all corners in the microneedle, the photocatalytic curing agent can be rapidly cured under the special illumination condition, the curing time of the product is greatly shortened, and the production efficiency is improved. The method is suitable for large-scale rapid production and is very worthy of popularization and application in the market.

The present invention belongs to the technical field of adhesives, and discloses an aqueous neoprene adhesive and a preparation method thereof. The aqueous neoprene adhesive is prepared from the following components in parts by weight: 30-60 parts of neoprene latex, 5-20 parts of methyl methacrylate, 1-10 parts of lithium silicate, 0.2-1.5 parts of water-soluble chitosan, 1-5 parts of redox initiator, 1-10 parts of emulsifier and deionized water; the solid content of the aqueous neoprene adhesive is 10-40%. When used as an adhesive, the aqueous neoprene adhesive of the present invention has excellent heat resistance and T-peel strength, and has high product value and good market application prospects.