732 results about "Water soluble chitosan" patented technology

The invention discloses a preparation method of multiple cross-linked polysaccharide injectable hydrogel. Modified water-soluble chitosan with carboxyl or hydroxyl groups as a first component and a hydroformylation-modified polysaccharide polymer or polysaccharide polymer mixer as a second component produce electrostatic action with each other and undergo a Schiff-base reaction to produce the hydrogel with a multiple cross-linked net structure. The multiple cross-linked polysaccharide injectable hydrogel has gelling time of 5-200s and has good mechanical properties. Through change of a chitosan and polysaccharide modification rate, a mole ratio of two components and solid content of hydrogel, gelling time, mechanical strength, microscopic morphology and water content are adjusted and controlled. The gel network contains a large amount of amino, carboxyl and aldehyde groups as active groups, the active groups can be bonded to drugs and proteins by covalent bonds, the multiple cross-linked polysaccharide injectable hydrogel as a novel medical material with excellent biocompatibility has a good application prospect in the fields of regeneration medical science, tissue engineering and drug controlled release.

The present invention relates to a water soluble chitosan nanoparticle (WSC-NP) for delivering an anticancer agent and a preparing method thereof, more precisely, a water soluble chitosan nanoparticle for delivering an anticancer agent which has function of targeting on a wanted area by introducing a functional group in the location of highly reactive amine group and becomes an excellent gene carrier with the use of water soluble chitosan since the water soluble chitosan itself can combined with DNA having a negative electric charge(−) owing to the very strong positive electric charge(+) of its amine group, and a preparing method thereof. Therefore, a water-soluble chitosan nanoparticle for delivering an anticancer agent of the present invention can effectively envelope paclitaxel by introducing hydrophilic and hydrophobic groups in the position of highly reactive amine group of the water-soluble chitosan. A water soluble chitosan nanopaclitaxel prepared as the above has an excellent re-dispersion force, after freeze-drying, in distilled water and has an outstanding anticancer effect with its accumulation in tumor cells greater than that of the other anticancer agent carriers.

The present invention relates to one kind of amphiphilic chitosan quaternary ammonium salt with long alkane radical and its preparation process. The amphiphilic chitosan quaternary ammonium salt with long alkane radical is prepared with water soluble chitosan derivative as modified target and through epoxy long chain alkyl quaternary ammonium salination, and has high solubility. Compared with available technology, the present invention has the features of simple preparation process suitable for industrial production, capacity of using the product as gene medicine carrier, emulsifier and antiseptic, and wide application of the product in medicine, daily chemical, etc.

The invention relates to a water-soluble chitosan quaternary ammonium salt antibiotic finishing agent. The invention is characterized in that the antibiotic finishing agent is names as O-methacrylamide-N-hydroxypropyl alkyl dimethyl ammonium chloride chitosan and the concrete structural formula is as follows. The preparation thereof includes that: alkyl dimethyl tertiary amide and epichlorohydrin are taken as raw materials to synthesize 2, 3-epoxy alkyl dimethyl ammonium chloride, then the 2, 3-epoxy alkyl dimethyl ammonium chloride is introduce onto the ammonium group of chitosan, so as to obtain N-hydroxypropyl alkyl dimethyl ammonium chloride chitosan HDCC, and then crosslinking is carried out on the HDCC and hydroxymethyl acrylamide is carried out, thus obtaining NMA-HDCC. The quaternary ammonium salt antibiotic finishing agent contains water-soluble group and fibrous reactivity group and has good water solubility, the bacterial inhibition rate of finished cotton fabrics is close to 100%, and the finishing agent can be combined with cellulose fiber by covalent bond and is wash-resistant; and cost is low, raw material is environmental friendly, environmental pollution is less, thus having industrialization application prospect.

Water-soluble chitosan having a low concentration of endotoxin is disclosed. Products containing the water-soluble chitosan are also disclosed. Methods of making and using water-soluble chitosan having a low concentration of endotoxin are further disclosed.

The invention relates to a water-soluble plant growth nutrient solution and a preparation method. In the plant growth nutrient solution, the content of small molecular weight water-soluble chitosan accounts for 8-120g / L, the sum of the content of nitrogen, phosphorus and potassium is larger than or equal to 60g / L, the sum of the content of medium trace elements accounts for 3-30g / L, the content of organic matter accounts for 30-200g / L, the content of plant growth regulator accounts for 0.01-5g / L, and the content of spread penetrating agents is larger than or equal to 0.2g / L; the small molecular weight water-soluble chitosan is obtained through the preparation steps that chitosan is firstly subjected to alkalization of strong base, then subjected to carboxyl chemical modification, degraded through strong oxidant after carboxyl chemical modification and finally neutralized through acid. The water-soluble plant growth nutrient solution integrates the effects of nutritional complement, growth promotion, antibiosis, virus resistance, stress tolerance and the like and has multiple functions and effects of improving soil, preventing hardening, increasing ground temperature, resisting to disease, being tolerant to stress, resisting to continuous cropping, supplementing nutrition rapidly, raising the yield and improving fruit quality and the like.

The invention discloses a preparation method of water-soluble chitosan / polyvinyl alcohol composite films capable of being used as biological package materials. Water-soluble chitosan and polyvinyl alcohol are respectively dissolved in deionized water, the solution is subjected to mixing casting for forming films, then, the films are soaked into one kind of solution or several kinds of mixed solution from glutaraldehyde solution, borax solution, epichlorohydrin, glyoxal and sodium tripolyphosphate to be subjected to crosslinking for 40 to 60 minutes, peeling and natural drying or baking are carried out, and the water-soluble chitosan / polyvinyl alcohol composite films are obtained. The composite films have good antibacterial activity, biocompatibility and biodegradability, in addition, special gas blocking performance and excellent mechanical performance are realized, and the composite films have the advantages of chitosan and the polyvinyl alcohol. In addition, the production cost is low, the preparation process is simple, the production efficiency is high, and the environment is friendly.

The invention relates to a medical wound surface hemostatic and wound healing agent, which is characterized in that the invention consists of two parts of water solution, one part is the oxidative polysaccharide water solution containing dialdehyde, and the other part is the water-soluable chitosan water solution. The medical wound surface hemostatic and wound healing agent can be applied in the preparation of drugs or medical devices for wound surface sealing and wound surface hemostasis, and the invention can also be applied in the preparation of drugs or medical devices for the promotion of wound surface healing and the prevention of postoperative tissue adhesion. The medical wound surface hemostatic and wound healing agent of the invention has significant effects on wound surface sealing, hemostasis, promotion of wound surface healing, prevention of postoperative tissue adhesion and other aspects, at the same time, the biocompatibility is good, which can not cause the tissue immune response, and the polysaccharides can not generate side effects on organisms after the in vivo degradation, so the safety is good.

A chitin-nano selenium compound for regulating immunity, delaying sanility and preventing cancer and cardiovascular disease is prepared from chitin (chitosan, water-soluble chitosan, or chitoligose) and Se compound through reaction.

The invention relates to an alginate antibacterial dressing and its preparation method. The preparation method comprises the following steps of: preparing a spinning stock solution from soluble alginate, a water-soluble chitosan derivative or water-soluble chitin derivative and simultaneously adding a silver-based antibacterial agent into a coagulation bath, carrying out wet spinning to obtain a blend fiber product and further obtain the alginate antibacterial dressing, which can be used as a wound dressing, a hemostatic material and the like. The antibacterial dressing obtained in the invention has good biocompatibility, permeability and water absorption, can be used to rapidly stop bleeding, ease pain and promote wound healing, continuously acts on regenerative bacteria, and has a lasting and high-efficient sterilizing characteristic.

The invention discloses a method for separating high purity phycocyanin from spirulina, comprising the following steps: adopting 0.05-0.5M of phosphate buffer to elute a spirulina powder raw material by an elution method, enabling the phycocyanin to be effused from spirulina cells, adding soluble chitosan to phycocyanin crude extract, controlling the mass concentration of chitosan in the phycocyanin solution to be 0.1-1%, and collecting supernate by centrifuging; adding activated carbon to the supernate, centrifuging and collecting supernate, adopting ammonium sulfate precipitation with the mass concentration of 30-60% to precipitate the phycocyanin in the solution, adopting ion-exchange chromatography, and performing gradient elution by phosphate buffer containing sodium chloride to obtain the high purity phycocyanin solution. The invention has the advantages of low cost, short elapsed time, convenient and rapid operation, low energy consumption, and easy massive preparation, is an efficient method for massively preparing phycocyanin with high purity and high activity and is favor of scaled development and utilization of the phycocyanin in our country.

The invention discloses a composite biological antistaling agent for a minced fillet product. The composite biological antistaling agent consists of the following components by mass percentage: 0.001 to 7 of water-soluble chitosan, 0.001 to 0.3 of tea polyphenol, 0.001 to 0.5 of nisin and the balance of water. The biological antistaling agent is prepared by compounding the water-soluble chitosan, the tea polyphenol and the nisin, is added into the minced fillet product, obviously improves the antibacterial and fresh-keeping functions and can prolong the shelf life of the minced fillet product more than two times under the refrigerating condition. The biological antistaling agent is nontoxic and safe, and does not generate influence on the flavor of the minced fillet product when being added into the minced fillet product. The invention also provides a method for using the composite biological antistaling agent.

The invention provides a shrimp preservative prepared from water-soluble chitosan and ginger extract, and a using method thereof. The shrimp preservative is a composite preservative which is formed by taking water-soluble chitosan and ginger extract as main raw materials and compounding the main raw materials with antioxidant, phytic acid, sodium citrate and dextrin. Fresh shrimps or shrimp meat with no head and shell are soaked in seawater or clear water in which the shrimp preservative is dissolved at a temperature of between 0 and 10 DEG C, and then the aims of preventing decay, stopping shrimp heads from blackening, preventing fishy smell from increasing and the like can be achieved. The shrimp preservative has broad application prospects. As the shrimps subjected to freshness-keeping treatment seldom change color or decay in a processing course, are bright in body, pure in taste, strong and elastic in meat, the sensory quality of the shrimps is remarkably improved. The shrimp preservative has the advantages that the shrimp preservative is simple in production method, convenient to use, capable of applying to various types of food processing taking the shrimps as raw materials, remarkable in freshness-keeping effects and capable of keeping the moisture of the shrimps, raising product yield, improving product quality and increasing economic benefit.

The process of preparing water soluble chitosan includes adding chitosan into 2-8 wt% concentration acetic acid aqua to compound acetic acid solution of chitosan of 2-10 wt% concentration, adding enzyme or oxidant to degrade chitosan to polymerization degree below 1000, cooling the solution to 0-10 deg.c, adding ethanol or methanol solution of acetic anhydride, stirring first at normal temperature for 2-24 hr and then at 20-40 deg.c for another 20-40 deg.c, adding alkali to regulate pH to over 8 under stirring, adding ethanol to deposit, centrifugation to obtain solid product, soaking in alcohol solution of KOH, centrifugation, alcohol washing, and drying to obtain water soluble chitosan of acetyl degree of 45-55%. The present invention has simple preparation process, and the product is used as material for tumor resisting and immunity raising medicine and health product and as additive for cosmetics and food.

The invention belongs to a method for preparing small molecular weight or water-solubility chitosan by using radiation process. It is characterized by that a refined high molecular weight chitosan solid or solution can be irradiated by using 60 Co gamma-rays and degraded, and the degradation product is undergone the after-treatment steps of dissolution and decolouration, etc. so as to obtain the invented small molecular weight or water-solubility chitosan. Said chitosan has several purposes, can be used as agricultural production-increasing agent, food drying agent, natural anti-bacterial material and bio-medicine material, etc.

The composite flocculant for treating printing and dyeing effluent consists of natural high molecular water soluble chitosan and polyaluminium chloride. The usage of the composite flocculant in treating printing and dyeing effluent includes regulating effluent to pH 6-8, and throwing composite flocculant in the amount of chitosan in 1-2 ppm and polyaluminium chloride in 100-250 ppm to result in printing and dyeing effluent decolorizing rate up to 91 %. The composite flocculant of the present invention has simple compounding process, easy use, low cost, small thrown amount, excellent decolorizing performance, fast deposition, small sludge amount, easy biodegradation, less secondary pollution of water and thus wide application foreground.

The invention discloses a novel chitosan hemostatic sponge and a preparation method thereof. The preparation method comprises the following steps of: stirring 5-20 percent of water-soluble chitosan carboxylate or carboxymethyl chitosan and 0.1-5 percent of 407 or 188 poloxamer in water at a low speed to fully dissolving state; adding 0-10 percent of glycerol, stirring at a high speed, foaming for 30 minutes to one hour, and performing injection molding; rapidly refrigerating at the temperature 40 DEG C below zero; demolding; refrigerating and drying till the water content is below 3 percent; and cutting, sterilizing and packing to obtain the novel chitosan hemostatic sponge.

A preparation method of water soluble chitosan group stanch wound sponge, which is characterized in dissolving water soluble chitosan derivatives in water, preparing 1%-10% weight percentage concentration of uniform colloid solution; subpackaging the colloid solution in mould, freezing in vacuum freeze drier at -20--60 DEG C, vacuum freeze drying 24-60 hours. The water soluble chitosan group stanch wound sponge of the invention is used for stanching and boosting wound healing of clinical operation, has advantages of convenient using, great mount of absorption solution, firm adhesion, better exerting function locally; selected material absorb water gradually to form gel in physiology pH condition during preparation, products have good local pasting property, exert stanching and boosting wound healing function so much the better; and products without immunogenicity in body, short degradation time, good compatibility with living body, better safety performance of clinic.

The invention relates to a freshness-keeping and water-retaining agent for prawns, belonging to the technical field of processing of aquatic products processing. The freshness-keeping and water-retaining agent is prepared from the following ingredients in percentage by weight: 5-10% of water-soluble chitosan, 10-20% of carboxymethyl chitosan, 10-20% of mycose, 5-10% of an antioxidant, 10-20% of konjac polysaccharide degradation product, and the balance of dextrin. For the freshness-keeping and water-retaining agent, konjac polysaccharide with strong hygroscopic property is degraded into oligosaccharide, which serves as a main auxiliary material of the water-retaining agent, the water-soluble chitosan is taken as a main auxiliary material for a bacteriostatic agent, and the carboxymethyl chitosan is taken as a film-forming agent, so as to prepare the freshness-keeping and water-retaining agent for prawns. After the freshness-keeping and water-retaining agent for prawns is applied to prawn processing, the freshness-keeping time of the prawns can be prolonged, blackening of the prawns is prevented, during refrigeration storage process of the prawns, water can be kept, and loss caused by drying loss is prevented. A processing technology of the freshness-keeping and water-retaining agent is simple, and easy to operate, and expected use effect can be achieved.

This invention discloses a stable water soluble shell polysaccharide derivant fluorescence quanta point and its preparation method. The template is the shell polysaccharide derivant, its production method is home position grown in molecular grid form nm micro-crystal, particle diameter is between 2-6nm. The preparation method is that the derivant is dissolved in pure water, metal salt solution is added under agitation condition at house temperature to form complex, chalcogen predecessor solution is high speed agitated added the formed nm semiconductor micro-crystal, it is quanta point, finally high fluorescence efficiency quanta point solution is got after heat reflow and dialysis. The fluorescence point made in neutral water solution can effectively avoid poisonous side effect of organic solvent, the energy needed is large less than ordinary method, and it is specially to combination of bio-molecular. It has great application prospect in cell recognition, organism mark and disease diagnosis fields.

The invention provides a preparation method of carbon nanotube-chitosan-phycocyanin nanoparticles, which comprises the following steps: modifying carboxylated carbon nanotubes with water-soluble chitosan in a non-covalent mode to obtain a water-soluble multiwall carbon nanotube-chitosan (MWCNT-CS) compound; and coupling the MWCNT-CS compound with high-purity spirulina phycocyanin to obtain the biomedical material carbon nanotube-chitosan-phycocyanin nanoparticles (MWCNT-CS-PC). The method has the advantage of simple preparation technique; and the obtained biomedical material has the advantages of favorable water solubility and biocompatibility, has favorable absorption characteristic in both visible light and near-infrared light regions, and is expected to be applied to photodynamic therapy and photo-thermal therapy on cancer cells.

The invention discloses a humic acid solid fertilizer, which comprises (by weight ratio based on 100 parts) nitrogen 4-40 parts, phosphor 3-35 parts, potassium 3-40 parts, secondary elements 0-6.5 parts, trace element 0-1.5 parts, reactive humic acid 15-30 parts, water-soluble chitosan 0-1.0 parts, wherein the reactive humic acid is provided by reactive weathered coal containing the reactive humic acid. The invention also discloses the preparation of reactive weathered coal.

The preparation process of water soluble chitosan includes the following steps: a) stoving and crushing clean crab shell and soaking in acid solution; b) washing, boiling in alkali solution and washing to neutrality; c) dissolving chitin in alkali and heating to obtain chitosan; d) washing and stoving chitosan, dissolving in acetic acid solution, and hydrolyzing with excessive hydrogen peroxide; and e) vacuum concentration, suction filtering, and neutralizing with alkali solution to obtain water soluble chitosan. The present invention has the advantages of simple technological process, low production cost, safe product without side effect, and excellent physiological activity and health care effect of the product.

The invention discloses gynecological chitosan gel. The gynecological chitosan gel comprises the following components: 0.5-10 percent of water-soluble chitin derivative, 0.01-0.5 percent of guanidine bacteriostatic agent, 0.5-10 percent of lubricating agent, 0.05-0.5 percent of thickening agent and the balance of water. The preparation method of the gynecological chitosan gel comprises the following steps: (1) preparing the thickening agent into gel; (2) preparing the water-soluble chitin derivative, the guanidine bacteriostatic agent and the lubricating agent into a mixed solution; (3) mixing and stirring the solution prepared in the steps (1) and (2); (4) filling and sterilizing. The process is simple, the needed equipment is simple and readily available, and the gynecological chitosan gel has a good curative effect on gynecological diseases such as vaginitis and cervical erosion.

The invention provides a multi-resistant nutrient for plant growth and a preparation method of the multi-resistant nutrient for plant growth. The multi-resistant nutrient comprises the components in parts by weight as follows: 6-10 parts of compound amino acids, 0.5-1.5 parts of mushroom protein polysaccharide, 0.5-1.5 parts of water soluble chitosan, 2-4 parts of zinc sulfate, 1-3 parts of boric acid and 90-180 parts of water. The preparation method comprises the steps of: heating part of water and dissolving zinc sulfate and boric acid; then heating the residual water and dissolving compound amino acids, mushroom protein polysaccharide and water soluble chitosan; then heating while agitating, and uniformly mixing with zinc sulfate and boric acid; and cooling after insulating so as to obtain the multi-resistant nutrient for plant. The multi-resistant nutrient for plant is rich in various amino acid trace elements which prompt growth of the plant, has remarkable effects of enhancing the immunologic function of the plant and preventing diseases and insect pests, has various biological adjusting functions, and is stress resistant, cold resistant, draught resistance and prevents diseases and insect pests.

The present invention discloses an antiblocking hernia patch and a preparation method thereof. A polypropylene net is combined with an absorptive material chitosan antiblocking piece to prepare a partial absorptive composite mesh. The invention is characterized in that the absorptive material chitosan antiblocking piece is prepared from water-soluble chitosan by a tap casting method. The chitosan phlegm is arranged between the polypropylene net and the absorptive material chitosan antiblocking piece. The preparation method comprises the steps of preparing the chitosan antiblocking piece, uniformly coating one layer of chitosan on the polypropylene woven mesh, then placing the chitosan antiblocking piece on the polypropylene woven mesh, placing the polypropylene woven mesh between the moulds after compressing, and obtaining the antiblocking hernia patch after drying by a film isolation method in the environment at a temperature of between 15 DEG C below zero and 150 DEG C and pressure of 0 to 0.6MPa. The antiblocking hernia patch of the invention has the advantages of effectively preventing the blocking after surgery, increasing the anti-inflection effect, sustaining the excellent repairing strength, reducing the recurrence rate and complication after surgery, reducing the probability of adverse effect caused by the unthorough elimination of acid, simply controlling preparation process and eliminating the adverse effect which may be caused by the chemical process.

The invention relates to a medical material, especially to a hemostatic and wound-healing water-soluble chitosan-based fiber material. The water-soluble chitosan-based fiber material comprises carboxymethyl chitosan fiber, hydroxypropyl chitosan fiber, hydroxyethyl chitosan fiber, carboxymethyl hydroxyethyl chitosan fiber or mixtures thereof.

The invention discloses granular material for a cigarette filter stick and a preparation method of the granular material, relates to the cigarette filter stick and particularly relates to adsorption granular material added to tows of the cigarette filter stick and the preparation method of the adsorption granular material. The invention is characterized in that the granular material is prepared by unglued jute fiber powder, microcrystalline cellulose, nanometer calcium carbonate, water-soluble chitosan and tobacco extract through the procedures of material mixing, granule forming, drying, preparing tobacco extract and granule scenting. The granular material for the cigarette filter stick and the preparation method have the advantages that the adsorption performance is high, the retention rate is high, the safety high, the bonding force is high, and selective adsorption is realized.