195 results about "Injectable hydrogels" patented technology

The invention relates to the technical field of material physical property detection, and discloses an injectable hydrogel wound dressing water absorbability detection method, which comprises: constructing a main measurement and reference dual channel, and synchronously monitoring a mixed conductivity signal and an interference signal generated only by gel self ion leakage; according to the method, the interference is deducted through real-time differential operation, a pure target signal is obtained, and then the water absorption volume of the hydrogel is calculated through inversion based on the law of conservation of mass, a measured object is transferred to an external solution from a gel body, and the interference of a sample is stripped through an endogenous dynamic correction mechanism, so that the accuracy of the water absorption volume of the hydrogel is improved. The determinacy of a measurement result is derived from a physical law instead of model hypothesis, so that double restrictions caused by irregular sample forms and complexity of a chemical environment are avoided, and reliable quantification of the water absorption performance of the in-situ dynamic forming hydrogel is realized.

The invention relates to the technical field of material physical property testing, and discloses an injectable hydrogel wound dressing tensile strength testing method, which comprises: establishing a correlation model of the mass and the maximum fracture load of a standard sample at different temperatures, and the correlation model of the initial rigidity and the temperature; measuring the mass and the actual maximum fracture load of the to-be-measured sample, and determining the actual initial rigidity of the to-be-measured sample; according to the method, the actual initial stiffness is calculated, the equivalent temperature of the test is converted by utilizing the actual initial stiffness, the standard theoretical maximum fracture load is calculated in combination with the sample mass and the corresponding model, and the performance is judged by comparing the two, so that the measurement of the geometric dimension of an irregular sample is avoided by constructing the correlation between the mass and the mechanical performance; the quality control problem of an in-situ forming material is solved, and the reliability of a judgment result in an industrial environment is further ensured by utilizing mechanical response data of the same test through an integrated temperature self-adaptive calibration mechanism.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention belongs to the technical field of biomedical anti-inflammatory gels, and discloses a renewable boundary lubrication natural polyphenol anti-inflammatory hydrogel and a preparation method and application thereof.The hydrogel is of a hydrophilic viscoelastic sea island structure, gallic acid grafted gelatin blended with hyaluronic acid serves as a base material, celecoxib lipidosome is entrapped in the hydrogel, and the hydrogel is prepared from natural polyphenols, an articular cavity is injected through an enzyme crosslinking technology to form gel, hyaluronic acid and lipidosome form a hydrated lubricating layer on a cartilage-gel interface, and after the interface is abraded, internal lipidosome and hyaluronic acid are exposed to supplement lubrication so as to form sustainable lubrication; the liposome responds to friction shear crushing to release celecoxib and cooperates with gallic acid at an interface to resist inflammation progress and repair cartilage, the injectable hydrogel is developed based on gallic acid, hyaluronic acid, gelatin and celecoxib liposome to treat early osteoarthritis, mechanical lubrication and inflammation resistance are combined, and the preparation method has the advantages that the preparation method is simple, the preparation cost is low, and the application prospect is wide. The problems of large-dose toxicity, short lubrication period and the like caused by independent treatment are effectively solved, and the preparation has important clinical application significance.

The invention relates to antibacterial hydrogel, in particular to injectable hydrogel which is antioxidant, responds to hydrogen peroxide and glucose and is antibacterial, a preparation method of the injectable hydrogel and application of the injectable hydrogel to preparation of antibacterial hydrogel dressing for repairing diabetic infectious wounds. The injectable hydrogel capable of resisting oxidation, responding to hydrogen peroxide and glucose and resisting bacteria has a porous three-dimensional network structure and mainly comprises gelatin modified by 4-carboxyphenylboronic acid, tannic acid, zinc chloride and water. The porous three-dimensional network structure is obtained by chemical crosslinking of gelatin modified by 4-carboxyphenylboronic acid and tannic acid, and zinc chloride is loaded in the hydrogel by complexing with the tannic acid. The hydrogel disclosed by the invention has good self-healing ability, injectable ability, oxidation resistance, hydrogen peroxide and glucose response property, good biocompatibility and excellent antibacterial property.

The invention discloses a zinc-selenium doped white calcium stone injectable hydrogel for treating melanoma and a preparation method of the zinc-selenium doped white calcium stone injectable hydrogel. The preparation method comprises the following steps: 1, preparing hydrophilic zinc-selenium doped white calcium stone; 2, preparing oxidized sodium alginate; and (3) dispersing the hydrophilic zinc-selenium-doped white phosphorus calcium stone into the oxidized sodium alginate solution, adding the carboxymethyl chitosan solution, and uniformly mixing to obtain the zinc-selenium-doped white phosphorus calcium stone injectable hydrogel for treating melanoma. The injectable hydrogel prepared by the invention has good injectability, self-healing property and biocompatibility, and is suitable for tumor wound models with any shape and depth; the composition has good effects of promoting normal cell proliferation and inhibiting tumor cell growth, and can be used for tumor postoperative treatment to inhibit tumor recurrence and promote surgical defective tissue repair.

Systems, compositions, and methods related to injectable hydrogels are generally described. In some embodiments, a composition comprises a first polymer and a plurality of particles comprising a second polymer capable of forming a hydrogel at elevated temperatures, such as body temperature. The plurality of particles (e.g., hydrogel particles) may comprise an active substance, such as a biological material and / or a therapeutic agent. Together, the first polymer and the second polymer may interact with each other (e.g., the first polymer may interpenetrate the second polymer, and / or the first polymer may cross-link with the second polymer) at elevated temperatures to form a hydrogel. Interactions between the first and second polymer, and / or between hydrophobic domains thereof, may facilitate the relatively slow and / or controlled release of the active substance. In some embodiments, the plurality of particles may have advantageously high loadings of biological materials (e.g., antibodies, proteins, peptides).

The invention discloses a gelatin-hyaluronic acid injectable hydrogel drug-carrying nanoparticle composite material as well as a preparation method and application thereof, relates to the technical field of biomedicine, and solves the problems that in the prior art, existing drugs for treating cartilage related diseases are difficult to deliver; the chronic inflammatory response in the articular cavity cannot be effectively controlled and cartilage cells cannot be protected at the same time, so that the application effect of the medicine is limited. The preparation method disclosed by the invention comprises the following steps: S1, obtaining a carnosine modified hyaluronic acid derivative Car-HA; s2, preparing nano particles (FNPs) loaded with fenofibrate; and S3, mixing the gelatin solution containing the FNPs with a Car-HA solution, adding transglutaminase into the mixed system, and carrying out an enzymatic cross-linking reaction to form the hydrogel FNPs-GelHA with a stable network structure. The CarHA and FNPs synergistic hydrogel strategy provided by the invention has good structural adjustability and drug adaptability, is suitable for delivery of various anti-inflammatory, anti-oxidation and cartilage repair drugs, and can be widely applied to local precise treatment of cartilage related diseases.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention belongs to the technical field of biomedical materials, and discloses pH-responsive injectable hydrogel as well as a preparation method and application thereof. Comprising the following steps: (1) dissolving sodium alginate in water to form a uniform solution; (2) adding a fat-soluble small molecule drug and Fe3O4 nanoparticles into the solution, carrying out high-speed shearing dispersion under an ice-water bath condition to form a drug / nano composite system, and standing; and (3) sequentially adding a calcium carbonate suspension and glucolactone into the drug / nano composite system, uniformly stirring, and incubating until the mixture is completely cured to obtain the pH-responsive injectable hydrogel. The hydrogel obtained by the invention not only has excellent injectability and pH response release performance, but also can remarkably improve the loading efficiency of fat-soluble drugs, and provides a new technical approach for realizing local anti-tumor treatment.

The invention provides application of injectable hydrogel in preparation of a medicine for treating myocardial infarction. The injectable hydrogel is obtained by mixing aniline tetramer grafted gelatin, adipic dihydrazide modified hyaluronic acid and an aldehyde group-containing metal polyphenol complex. The injectable hydrogel has antioxidant activity, conductivity and angiogenesis promoting activity performance, and myocardial repair is promoted through synergistic regulation and control.

The invention discloses a dual-network injectable hydrogel as well as a preparation method and application thereof. The hydrogel is methacrylated gelatin / oxidized hyaluronic acid loaded with metal polyphenol nano-particles, and the metal polyphenol nano-particles are copper-gallic acid nano-particles which contain quaternized chitosan coatings and are loaded with antibacterial peptide HHC36. After the hydrogel is injected into a periodontal pocket, the hydrogel can adapt to different defect shapes, and the CuGA-coated HHC36-coated QCS nanoparticles are released by responding to a periodontitis microenvironment, so that the effects of resisting periodontal pathogenic bacteria, removing local excessive ROS (reactive oxygen species), effectively promoting fibroblast proliferation, collagen deposition, extracellular matrix accumulation and angiogenesis and further promoting periodontal bone regeneration are achieved. The preparation process is simple, the injectable hydrogel is low in price and easy to obtain, the injectable hydrogel can be prepared through simple steps, and a new thought is provided for treatment of periodontitis.

Provided herein are methods of preparing an engineered heart valve for implantation into a subject in need (e.g., a pediatric patient). For example, a porcine pulmonary valve can be decellularized and then recellularized with cells from the subject. Hydrogels can be used to facilitate cell delivery and growth within the sub-endothelial layer (e.g., spongiosa) of a heart valve, which is essential for long-term success of the implantation.

The invention provides hydrogel, preparation of the hydrogel and medical dressing containing the hydrogel, CMC-PBA and HA-DA are used as hydrogel matrixes and are connected through boric acid ester bonds, and copper nano-enzyme (Cu NCs) chelated by EGCG is added into the hydrogel matrixes, so that the hydrogel (EGCG-Cu NPs) loaded with the copper nano-enzyme (injectable) is obtained. Wherein the CMC-PBA is a product obtained by reacting carboxymethyl chitosan (CMC) with carboxyl activated 4-carboxyphenylboronic acid (PBA), and the HA-DA is a product obtained by reacting carboxyl activated hyaluronic acid (HA) with dopamine hydrochloride (DA). The hydrogel can deeply promote wound recovery through in-vivo use, has good antioxidant activity and antibacterial activity, has extremely high active oxygen removal performance on necrotic cells of the wound, greatly accelerates the healing speed of the wound, brings clinical welfare to the wound, especially a chronic disease wound, and promotes the development of chronic wound diseases.

This invention relates to an injectable hydrogel, its preparation method, and its applications. It solves the technical problems of short half-life, rapid degradation, and inability to directly form bone by direct systemic injection of disulfiram in existing technologies. The hydrogel contains catecholized calcium alginate, disulfiram, and water. The catecholized calcium alginate contains calcium alginate, a catechol group, and calcium ions. The catechol group is coupled to the side chain of the calcium alginate. The mass percentage content of the catecholized calcium alginate is 0.5-5%; the mass percentage content of the disulfiram is 0.25-2%; and the balance is water. This invention can be used to prepare materials that promote alveolar bone repair and regeneration.

The invention relates to nervonic acid-loaded near-infrared light response type injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological engineering. According to the invention, P (NIPAM-co-NHMAM) and a modified natural polymer material are combined to prepare a temperature-responsive hydrogel capable of realizing reversible volume shrinkage / expansion at a specific temperature, near-infrared light physiotherapy and irradiation are combined to damage local skin, and the hydrogel is stimulated to realize reversible volume deformation by controlling tissue temperature, so that the temperature-responsive hydrogel can be used for preparing the hydrogel with the reversible volume shrinkage / expansion at the specific temperature. Therefore, accurate and wireless space-time regulation and control of nervonic acid release behaviors are realized. Therefore, the nervonic acid loaded near-infrared light response type injectable hydrogel disclosed by the invention can realize efficient carrying and light response controllable release of nervonic acid, promotes functional recovery after spinal cord injury, and has a relatively good application prospect and research significance.

In some aspects, the present disclosure pertains to a hydrogel agitation and injection assembly, the assembly comprising a delivery device providing a barrel configured as a reservoir for an injectable hydrogel; and a shuttle disposed in the reservoir, where the shuttle is configured at least to translate along a longitudinal axis of the delivery device responsive to an application of a magnetic field to the shuttle, and where the shuttle includes an aperture extending entirely through the shuttle along the longitudinal axis of the delivery device.

The invention belongs to the technical field of biological medicine, and discloses an injectable hydrogel combined reagent, self-curing conductive hydrogel and application thereof. The injectable hydrogel combined reagent provided by the invention comprises a solution A and a solution B, the solution A is a first precursor solution formed by dissolving modified poloxamer PFUDAm and ammonium persulfate in deionized water; the solution B is a second precursor solution formed by dissolving N-isopropylacrylamide NIPAM, ferrous gluconate and PEDOT: PSS in deionized water, after the injectable hydrogel combined reagent is mixed in a duplex injection mode, PFUDAm, poly (N-isopropylacrylamide) and PEDOT: PSS are subjected to an oxidation-reduction reaction of ammonium sulfate and ferrous gluconate to initiate polymerization, and the self-curing conductive hydrogel is constructed. The self-curing conductive hydrogel has controllable curing time, and the self-curing conductive hydrogel has excellent swelling resistance, conductivity and good elasticity and toughness, and is expected to be combined with a cardiac pacemaker to be applied to treatment of arrhythmia.

This invention relates to a locally injectable hydrogel for treating pancreatic cancer, its preparation method, and its application. The hydrogel is prepared from raw materials comprising hyaluronic acid-dopamine and a radionuclide. Through extensive research and optimization, this invention has discovered that reacting hyaluronic acid-dopamine and a radionuclide in a suitable temperature and solvent, followed by mixing the resulting reaction solution with an alkaline sodium periodate solution and rapid stirring, successfully prepares a locally injectable hydrogel highly suitable for treating pancreatic cancer. The hydrogel is prepared under mild conditions, has a simple composition, and high safety. It effectively addresses the core bottlenecks in local radiotherapy for pancreatic cancer, such as poor stability of radionuclide carriers, short retention time, and uncontrollable release. Furthermore, it can reshape the body's immune microenvironment and enhance anti-tumor immune responses, significantly improving therapeutic efficacy. This has significant clinical implications for overcoming the current limitations in the treatment of locally advanced unresectable pancreatic cancer.

Provided are an injectable joint cavity hydrogel pharmaceutical composition and a method for preparing same. The hydrogel pharmaceutical composition comprises a gel particle and a drug loaded in the gel particle. The gel particle is formed by cross-linking hyaluronic acid or a salt thereof with fibroin via a cross-linking agent. The drug comprises an anti-inflammatory agent and / or a growth factor. The hydrogel pharmaceutical composition can treat a bone and joint-related disease by means of intra-articular injection.

The invention relates to the technical field of medical material performance testing, in particular to a performance testing system for injectable hydrogel, which is characterized in that an external testing environment characteristic parameter, a rheological characteristic parameter of a testing sample and a core temperature are acquired through a data acquisition module; calculating the viscous modulus and the elastic modulus of the test sample based on the rheological characteristic parameters through a data analysis module so as to judge whether the sample conforms to gelation dynamic characteristics or not; a standard evaluation module is used for extracting corresponding time points conforming to gelation dynamic characteristics so as to judge whether the performance test system conforms to the standard or not; analyzing the characteristic characterization value of the test environment through a compensation control module so as to judge whether the reason that the performance test system does not meet the standard is an environment reason or not; and determining a main interference reason based on the correlation coefficient of the test environment characteristic parameter and the sample core temperature, and starting compensation adjustment. According to the invention, the accuracy of the performance test system for injectable hydrogel is obviously improved.

This invention relates to the field of medical biopolymer materials technology, specifically to an injectable hydrogel for kidney stone removal, its preparation method, and its application. The preparation materials include at least a precursor solution 1 and a precursor solution 2. Precursor solution 1 contains at least a polyethylene glycol derivative and a thickener, while precursor solution 2 contains at least a polyamino polymer. By optimizing the formulation ratio of the two-component precursor solutions, a hydrogel with strong conformability, good toughness, and viscosity is formed in situ in the kidney stone area. This encapsulates the kidney stone, facilitating its removal from the body and avoiding the safety hazards associated with small kidney stone fragments or conventional drug treatment.

The invention relates to a preparation method and application of macroporous alanine modified nanocellulose-based dynamic hydrogel, and the preparation method comprises the following steps: S1, by taking alanine and nanocellulose as raw materials, synthesizing alanine modified nanocellulose through esterification reaction; s2, phenylboronic acid and beta-cyclodextrin are used as raw materials, and phenylboronic acid modified cyclodextrin is synthesized through a substitution reaction; and S3, introducing the Ala-CNFs into a polyvinyl alcohol and PBCD system, so as to obtain the macroporous alanine modified nano cellulose based dynamic hydrogel. The synthesis and preparation method of the hydrogel has the characteristics of being green and environment-friendly, alanine can be grafted on nano cellulose in an aqueous solution environment, and the problem that tissue regeneration is hindered due to the fact that an existing injectable hydrogel adhesive occupies the space of angiogenesis and tissue regeneration in the wound healing process can be effectively solved. The hydrogel has the characteristics of injectability, self-healing, shape adaptability, biological tissue adhesion, biodegradability, biocompatibility, hemostasis, and promotion of tissue regeneration and angiogenesis.

The application discloses an antibacterial hollow mesoporous silica ball injectable hydrogel dressing and a preparation method thereof, and belongs to the technical field of hydrogel dressing preparation. The antibacterial hollow mesoporous silica ball injectable hydrogel dressing provided by the application is obtained by self-crosslinking of a four-arm polyethylene glycol modified by o-phthaldehyde as a crosslinking agent and a hollow mesoporous silica ball loaded with tannic acid in a solvent. Compared with the prior art, the antibacterial hollow mesoporous silica ball injectable hydrogel dressing provided by the application can be gelled without the participation of catalase, has a better gelation time, and can be injected and in-situ formed, so that deep wounds can be treated (the existing hydrogel is too fast or too slow in gelation, and can only be directly made into a gel for use in shallow wounds); moreover, the mechanical strength of the gel can be improved; and the hydrogel dressing has good biocompatibility, degradability, antibacterial property and good repair promoting capacity.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The invention discloses injectable hydrogel and a preparation method and application thereof in nerve repair, the hydrogel is medical hydrogel of poly-beta amino ester loaded with indole-3-propionic acid, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate (PEGDA) as a scaffold material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with polyethylene glycol diacrylate (PEGDA) via an acrylate bond; and indole-3-propionic acid (IPA) as an active ingredient. The injectable hydrogel is adjustable in mechanical property and excellent in biocompatibility, can slowly release IPA, and is used for filling nerve injury areas, inhibiting oxidative stress and promoting neuron regeneration and functional recovery.

The invention relates to the field of biological materials, and provides an injectable hydrogel pre-gelatinizing solution based on ligand regulation and control and a preparation method and application of the injectable hydrogel pre-gelatinizing solution. A multivalent metal ion; a small molecule ligand; wherein the alginic acid compound comprises alginic acid or alginate and a derivative thereof; the molar ratio of the micromolecule ligand to the multivalent metal ions is marked as L / M; defining the minimum L / M for keeping the system in a sol state at the set temperature and ion strength as a critical ligand ratio, and recording the critical ligand ratio as CLR; in the pre-gelatinizing solution, L / M is greater than or equal to CLR. The pre-gelatinizing solution can be smoothly injected through a fine needle, can quickly form a gel shell at an interface to prevent leakage after being injected to a water-containing environment, has continuous self-enhancement performance, and is wide in application range.

This application discloses a preparation method and application of injectable hydrogel microspheres. By integrating the hydrogel drug delivery system with liposome microparticles obtained by microfluidic technology, NMN is encapsulated by liposome material, and the mitochondrial targeting peptide SS-31 is introduced into the liposome to achieve a more sustained and stable release, thereby enabling NMN to selectively target cell mitochondria and improve the application effect.

The invention discloses injectable hydrogel as well as a preparation method and application thereof. The injectable hydrogel is formed by self-assembling a natural plant active component, a framework material and an inorganic nano material, the natural plant active component comprises any one of puerarin, resveratrol, curcumin and quercetin; the framework material comprises any one of chitosan, gelatin, sodium alginate, hyaluronic acid and a polylactic acid-glycolic acid copolymer; the inorganic nano material comprises any one of mesoporous silica, calcium phosphate nano particles, zinc oxide nano particles and hydroxyapatite. The injectable hydrogel composed of puerarin, chitosan and mesoporous silica realizes the synergy of local immune regulation and tissue regeneration functions, and can be used for skeletal muscle defect repair.

This invention relates to an injectable hydrogel, its preparation method, and its applications. The composite gel comprises biodegradable polyester microspheres containing milk exosomes that provide nutrients. A cross-linked hyaluronic acid gel is prepared by cross-linking hyaluronic acid, DMTMM, and L-lysine ethyl ester dihydrochloride. PLLA microspheres containing milk exosomes are then added and mixed to form the injectable hydrogel. This composite gel possesses ideal mechanical properties, and its degradation rate meets the requirements for injectable fillers. The PLLA microspheres are loaded with active nutrients, providing a slow, long-term release, while the gel provides short-term release and injection performance, achieving a short-term plus long-term repair effect. The bioactive function of milk exosomes, the collagen regeneration function of PLLA microspheres, and the immediate filling function of hyaluronic acid gel are organically integrated into the same system, enabling immediate filling, long-term regeneration, and bioactive regulation.