130 results about "Injectable hydrogels" patented technology

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

Systems, compositions, and methods related to injectable hydrogels are generally described. In some embodiments, a composition comprises a first polymer and a plurality of particles comprising a second polymer capable of forming a hydrogel at elevated temperatures, such as body temperature. The plurality of particles (e.g., hydrogel particles) may comprise an active substance, such as a biological material and / or a therapeutic agent. Together, the first polymer and the second polymer may interact with each other (e.g., the first polymer may interpenetrate the second polymer, and / or the first polymer may cross-link with the second polymer) at elevated temperatures to form a hydrogel. Interactions between the first and second polymer, and / or between hydrophobic domains thereof, may facilitate the relatively slow and / or controlled release of the active substance. In some embodiments, the plurality of particles may have advantageously high loadings of biological materials (e.g., antibodies, proteins, peptides).

The invention belongs to the technical field of biomedical materials, and discloses pH-responsive injectable hydrogel as well as a preparation method and application thereof. Comprising the following steps: (1) dissolving sodium alginate in water to form a uniform solution; (2) adding a fat-soluble small molecule drug and Fe3O4 nanoparticles into the solution, carrying out high-speed shearing dispersion under an ice-water bath condition to form a drug / nano composite system, and standing; and (3) sequentially adding a calcium carbonate suspension and glucolactone into the drug / nano composite system, uniformly stirring, and incubating until the mixture is completely cured to obtain the pH-responsive injectable hydrogel. The hydrogel obtained by the invention not only has excellent injectability and pH response release performance, but also can remarkably improve the loading efficiency of fat-soluble drugs, and provides a new technical approach for realizing local anti-tumor treatment.

This invention relates to a locally injectable hydrogel for treating pancreatic cancer, its preparation method, and its application. The hydrogel is prepared from raw materials comprising hyaluronic acid-dopamine and a radionuclide. Through extensive research and optimization, this invention has discovered that reacting hyaluronic acid-dopamine and a radionuclide in a suitable temperature and solvent, followed by mixing the resulting reaction solution with an alkaline sodium periodate solution and rapid stirring, successfully prepares a locally injectable hydrogel highly suitable for treating pancreatic cancer. The hydrogel is prepared under mild conditions, has a simple composition, and high safety. It effectively addresses the core bottlenecks in local radiotherapy for pancreatic cancer, such as poor stability of radionuclide carriers, short retention time, and uncontrollable release. Furthermore, it can reshape the body's immune microenvironment and enhance anti-tumor immune responses, significantly improving therapeutic efficacy. This has significant clinical implications for overcoming the current limitations in the treatment of locally advanced unresectable pancreatic cancer.

Provided are an injectable joint cavity hydrogel pharmaceutical composition and a method for preparing same. The hydrogel pharmaceutical composition comprises a gel particle and a drug loaded in the gel particle. The gel particle is formed by cross-linking hyaluronic acid or a salt thereof with fibroin via a cross-linking agent. The drug comprises an anti-inflammatory agent and / or a growth factor. The hydrogel pharmaceutical composition can treat a bone and joint-related disease by means of intra-articular injection.

The invention relates to the technical field of medical material performance testing, in particular to a performance testing system for injectable hydrogel, which is characterized in that an external testing environment characteristic parameter, a rheological characteristic parameter of a testing sample and a core temperature are acquired through a data acquisition module; calculating the viscous modulus and the elastic modulus of the test sample based on the rheological characteristic parameters through a data analysis module so as to judge whether the sample conforms to gelation dynamic characteristics or not; a standard evaluation module is used for extracting corresponding time points conforming to gelation dynamic characteristics so as to judge whether the performance test system conforms to the standard or not; analyzing the characteristic characterization value of the test environment through a compensation control module so as to judge whether the reason that the performance test system does not meet the standard is an environment reason or not; and determining a main interference reason based on the correlation coefficient of the test environment characteristic parameter and the sample core temperature, and starting compensation adjustment. According to the invention, the accuracy of the performance test system for injectable hydrogel is obviously improved.

This invention relates to the field of medical biopolymer materials technology, specifically to an injectable hydrogel for kidney stone removal, its preparation method, and its application. The preparation materials include at least a precursor solution 1 and a precursor solution 2. Precursor solution 1 contains at least a polyethylene glycol derivative and a thickener, while precursor solution 2 contains at least a polyamino polymer. By optimizing the formulation ratio of the two-component precursor solutions, a hydrogel with strong conformability, good toughness, and viscosity is formed in situ in the kidney stone area. This encapsulates the kidney stone, facilitating its removal from the body and avoiding the safety hazards associated with small kidney stone fragments or conventional drug treatment.

The application discloses an antibacterial hollow mesoporous silica ball injectable hydrogel dressing and a preparation method thereof, and belongs to the technical field of hydrogel dressing preparation. The antibacterial hollow mesoporous silica ball injectable hydrogel dressing provided by the application is obtained by self-crosslinking of a four-arm polyethylene glycol modified by o-phthaldehyde as a crosslinking agent and a hollow mesoporous silica ball loaded with tannic acid in a solvent. Compared with the prior art, the antibacterial hollow mesoporous silica ball injectable hydrogel dressing provided by the application can be gelled without the participation of catalase, has a better gelation time, and can be injected and in-situ formed, so that deep wounds can be treated (the existing hydrogel is too fast or too slow in gelation, and can only be directly made into a gel for use in shallow wounds); moreover, the mechanical strength of the gel can be improved; and the hydrogel dressing has good biocompatibility, degradability, antibacterial property and good repair promoting capacity.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

This invention relates to an injectable hydrogel, its preparation method, and its applications. The composite gel comprises biodegradable polyester microspheres containing milk exosomes that provide nutrients. A cross-linked hyaluronic acid gel is prepared by cross-linking hyaluronic acid, DMTMM, and L-lysine ethyl ester dihydrochloride. PLLA microspheres containing milk exosomes are then added and mixed to form the injectable hydrogel. This composite gel possesses ideal mechanical properties, and its degradation rate meets the requirements for injectable fillers. The PLLA microspheres are loaded with active nutrients, providing a slow, long-term release, while the gel provides short-term release and injection performance, achieving a short-term plus long-term repair effect. The bioactive function of milk exosomes, the collagen regeneration function of PLLA microspheres, and the immediate filling function of hyaluronic acid gel are organically integrated into the same system, enabling immediate filling, long-term regeneration, and bioactive regulation.

The application belongs to the technical field of medicine, and specifically discloses a glycyrrhetinic acid injectable hydrogel as well as a preparation method and application thereof. The preparation method of the glycyrrhetinic acid injectable hydrogel comprises the following steps: glycyrrhetinic acid and choline hydroxide are added into pure water, heated and stirred to fully react, and a mixed solution is obtained; the mixed solution is first spin-evaporated and then vacuum-dried to obtain glycyrrhetinic acid-choline; the glycyrrhetinic acid-choline is added into pure water, heated to completely dissolve and cooled at room temperature to form an injectable hydrogel. The hydrogel is used for preparing an antitumor drug in an injectable dosage form. In the application, the glycyrrhetinic acid and the choline hydroxide are self-assembled into a hydrogel with a three-dimensional network microstructure by losing one molecule of water without adding any cross-linking agent and organic solvent. The hydrogel can quickly recover to the original gel state after injection, and the problems of low drug loading, low bioavailability and difficult degradation existing in the prior art are solved.

This invention discloses a photothermal synergistic tumor stem cell inhibition system, its preparation method, and its applications. Addressing the current lack of effective treatments for large / unresectable GBM and its strongly immunosuppressive microenvironment, this invention constructs an injectable hydrogel platform (MIN-PPIC@iGel) integrating multiple key functions. This platform achieves a synergistic therapeutic model involving photothermal ablation for local tumor reduction, inhibition of residual GBM stem cells (GSCs), and activation of dendritic cells (DCs)-mediated anti-tumor immunity. Cellular experiments show that this invention can synergistically kill GL261 cells, significantly inhibit tumor stem cells and malignant phenotypes, induce significant ICD, and enhance DC maturation and activation effects. In a large-volume orthotopic GBM mouse model, a single intratumoral injection of MIN-PPIC@iGel combined with short-term near-infrared light irradiation doubled survival; further combination with antibody therapy unexpectedly achieved long-term tumor-free survival in 50% of mice, providing a new strategy for the local treatment of unresectable GBM.

The application discloses a mussel-mimic bacterial-responsive injectable hydrogel and a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel is composed of a mussel-mimic viscous hydrogel support and a bacterial response agent; the viscous hydrogel support is QCS-EC, which is formed by non-covalent combination of quaternary ammonium chitosan QCS and epigallocatechin gallate EGCG; and the bacterial response agent is a supramolecular nanometer cross-linking compound TEBox-B 12， which is self-assembled by hydrogen bonds and electrostatic interactions. 12 H 12 2‑ The hydrogel of the application has NIR-II photothermal and photodynamic antibacterial treatment functions, can realize efficient killing of bacteria in deep tissues, has high adhesion, good biocompatibility and injectability, is convenient and applicable, can provide a good healing environment for a wound, promotes fibroblast proliferation and migration, accelerates wound tissue regeneration and healing process, and reduces scar formation.

A method for delivering stem cells for cartilage regeneration comprising substantially simultaneously administering a first composition comprising a chitosan-hydrogel precursor and a second composition comprising a hyaluronic acid-hydrogel precursor to a site in need of cartilage regeneration to provide an in situ stem cell-containing chitosan / hyaluronic acid hydrogel at the site.

The application discloses a preparation method of a fluorescent self-healing injectable hydrogel and application thereof. A biocompatible fluorescent small molecule is anchored on a polysaccharide macromolecular chain through an EDC / NHS coupling reaction, and then in-situ cross-linking is carried out through a dynamic imine bond under physiological conditions to prepare a fluorescent self-healing injectable hydrogel. The fluorescent self-healing injectable hydrogel has self-healing, injectability, shape adaptability, biodegradability, cell compatibility, tissue compatibility and outstanding fluorescence effect, and can be used for non-destructive, in-situ and real-time detection, thereby providing a new strategy for synthesizing a polysaccharide-based fluorescent self-healing injectable hydrogel under mild conditions, and simultaneously providing a new idea for establishing a system model of an in-situ real-time monitoring biomedical platform of minimally invasive interventional treatment technology.

An injectable hydrogel for inhibiting osteosarcoma growth and its component preparation method are disclosed. The hydrogel is composed of curcumin nanoparticles, nano-hydroxyapatite, and methacryloxychitosan. This injectable hydrogel for inhibiting osteosarcoma growth combines the antitumor properties of curcumin nanoparticles, the osteogenic ability and good mechanical strength of nano-hydroxyapatite, and the porous structure and injectability of methacryloxychitosan. This injectable hydrogel for inhibiting osteosarcoma growth exhibits a significant killing effect on osteosarcoma cells and simultaneously promotes the proliferation of mouse embryonic pre-osteoblasts. Through its synergistic antitumor and osteogenic dual functions, this hydrogel shows promising application prospects in postoperative treatment of osteosarcoma.

The invention belongs to the technical field of biological materials, and relates to injectable hydrogel for tissue engineering and regenerative medicine, in particular to GelMA-HA-CGF composite hydrogel used in the fields of cell culture, tissue repair and regeneration and the like as well as a preparation method and application of the GelMA-HA-CGF composite hydrogel. The hydrogel provided by the invention presents a mutually communicated honeycomb porous structure, compared with GelMA-HA hydrogel, the aperture of the GelMA-HA-CGF composite hydrogel is in a decreasing trend, the density of a matrix between pores is more uniform, and finally a three-dimensional network structure with stronger stability is formed. An observation result under a high-power microscope shows that the freeze-dried CGF is uniformly dispersed in a net-shaped structure of the hydrogel, and the distribution characteristic is beneficial to slow release of growth factors in subsequent application. The prepared composite hydrogel has proper rheological property, swelling and degradability, mechanical property, CGF growth factor slow release property and PH responsiveness (acidic degradation), the degradation rate of the composite hydrogel and release of growth factors can be accelerated under the acidic condition, and the composite hydrogel has the characteristic of acidic degradation.

The invention discloses low-temperature injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. Hydrogel is prepared from high-molecular-weight hyaluronic acid grafted with vitamin E and poly (N-isopropylacrylamide), the hydrogel is in an injectable liquid state at 4 DEG C, and a drug capsaicin (CPZ) wrapped by micelle is loaded and injected into the brain from the brain in a stereotactic mode. The pharmaceutical composition can temporarily maintain local low temperature of brain tissue and release capsaicin, reduce local metabolic activity of ischemic brain tissue, temporarily inhibit biogenesis, reduce NADH, FADH2 and other reducing equivalents and ADP accumulation, reduce the possibility of electron leakage in an electron transport chain, and improve the bioavailability of ischemic brain tissue. Vitamin E is added to reduce superoxide anions (O2 <.->) generated by reduction reaction of oxygen and leaked electrons in the reperfusion process, and vitamin E can promote ROS removal, synergistically alleviate oxidative stress and subsequent inflammation, and comprehensively improve cerebral ischemia reperfusion injury.

The application provides an injectable hydrogel for endometrial repair and / or prevention of adhesion of uterine cavity and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The injectable hydrogel is composed of a base gel and a decellularized matrix distributed in the base gel; the base gel is composed of a cross-linked carboxymethyl chitosan gel and a carbomer gel; the base gel has an interpenetrating or semi-interpenetrating double network structure; and the cross-linked carboxymethyl chitosan gel is a chemical cross-linked carboxymethyl chitosan gel. In the application, the injectable hydrogel forms a base gel with an interpenetrating or semi-interpenetrating double network structure by using a cross-linked carboxymethyl chitosan gel and a carbomer gel, and is compounded with a decellularized matrix, so that the injectable hydrogel has high elasticity and high adhesion, can effectively prevent adhesion and repair damaged tissues, has a long action time, and has good biocompatibility.

The invention discloses triptolide hydrogel, a preparation method thereof and application of the triptolide hydrogel in preparation of a medicine for treating hepatocellular carcinoma, and belongs to the field of biological medicine. The stable injectable hydrogel drug is prepared by utilizing the self-assembly capability of glycyrrhizic acid saponins and loading triptolide, and while the anti-tumor effect of triptolide is played, the toxic and side effects are reduced by virtue of the targeting and anti-inflammatory effects of glycyrrhizic acid, and accurate treatment of liver cancer is realized.

The invention relates to injectable hydrogel as well as a preparation method and application thereof, and solves the technical problems that an existing suture hiding needle is longer in degradation time and easy to cause inflammatory response, and the injectable hydrogel is prepared from the following components in percentage by mass: 3-10% of oxidized dextran, 2-10% of carboxymethyl chitosan, 0.5-1% of quaternized chitosan, 0.5-1% of chitosan oligosaccharide and the balance of water. The material can be used as an acupoint catgut embedding material.

This invention discloses an injectable hydrogel for long-term sustained release of NGF and CNTF, its preparation method, and its application in visual system diseases. The bioactive factor sustained-release hydrogel of this invention comprises a hydrogel matrix and bioactive factor microspheres loaded on the matrix; the raw materials for preparing the hydrogel matrix include chitosan, type II collagen, and hyaluronic acid; the bioactive factor microspheres comprise an inner core and a capsule wall, the inner core being a bioactive factor selected from one or both of ciliary neurotrophic factor and nerve growth factor, and the capsule wall being a polylactic acid-glycolic acid copolymer. This hydrogel can achieve long-term stable release of NTF, activating endogenous neural stem cells in the retina to generate new retinal ganglion cells. It exhibits high safety, good injectability, and a long sustained-release period, and can be used to prepare drugs for treating visual system diseases such as glaucoma, optic nerve damage, and macular degeneration.

A starch-based injectable hydrogel system for localized cancer treatment. The pre-formed hydrogel delivers chemotherapeutic drugs (such as doxorubicin) and / or medical radionuclides directly to tumor sites while minimizing systemic exposure. The composition uses dimethyl sulfoxide as a solvent and can be stored in pre-filled syringes for clinical use. Key advantages include >90% drug retention, sustained local delivery, and compatibility with image-guided injection techniques. The system is particularly suitable for pediatric brain tumors and other solid tumors requiring localized high-dose therapy.

The invention discloses photo-thermal controlled-release injectable hydrogel for promoting wound healing through nerve and blood vessel synergistic regeneration as well as a preparation method and application of the photo-thermal controlled-release injectable hydrogel. The preparation method comprises the following steps: preparing an ovalbumin electrostatic spinning fiber membrane; the preparation method comprises the following steps: modifying an ovalbumin electrostatic spinning fiber membrane with dopamine, grafting deferoxamine, and shearing and grinding to obtain the drug-loaded short fiber capable of providing a topological structure to guide cell growth; the preparation method comprises the following steps: mixing drug-loaded short fibers with a multi-walled carbon nanotube dispersion liquid, preparing micro-droplets through a microfluidic device, and carrying out cross-linking curing to obtain photothermal responsive drug-loaded short fiber microspheres; the preparation method comprises the following steps: blending an ovalbumin hydrogel precursor solution with photo-thermal responsive drug-loaded short fiber microspheres, and carrying out catalytic molding through a cross-linking agent under a heating condition. According to the invention, the photo-thermal response microspheres are combined with the hydrogel, so that the regeneration microenvironment is synergistically regulated and controlled by multiple factors, and a new thought is provided for tissue engineering nerve grafts. The method has the characteristics of no toxicity, harmlessness, environmental protection, simplicity, feasibility and easiness in operation.

An injectable hydrogel including oxidized nanocrystalline cellulose, and gelatine peptide chains. The oxidized nanocrystalline cellulose and the gelatine peptide chains are cross-linked. The oxidized nanocrystalline cellulose and the gelatine peptide chains are crosslinked by imine moieties. The injectable hydrogel may be used to cure or relieve the symptoms of osteoarthritis. A syringe may contain the injectable hydrogel.

This invention discloses an injectable hydrogel-MOF nanozyme composite formulation (G@ZnFe-Gel), its preparation method, and its application in pancreatic cancer immunotherapy. Specifically, the system is constructed from a Zn / Fe bimetallic MOF nanozyme loaded with glucose oxidase (GOD) and a Pluronic F127 / sodium alginate thermosensitive hydrogel. It exists as an injectable sol at 4°C and rapidly gels in situ at 37°C, achieving long-term retention and controlled release of the nanozyme. This system amplifies reactive oxygen species through a GOD-Fenton-like cascade catalysis, inducing ferroptosis in pancreatic cancer cells; the mitochondrial DNA released during ferroptosis is then absorbed into the ZnFe nanozyme. 2+ This invention synergistically activates the cGAS-STING pathway, promoting immune activation and transforming immune-cold pancreatic cancer into immune-hot tumors. In vitro and in vivo experiments have demonstrated that this system significantly inhibits pancreatic cancer growth, reshapes the immune microenvironment, and exhibits high biosafety and ease of preparation. This invention provides a novel, safe, and highly effective immunotherapy strategy for pancreatic cancer, featuring in situ delivery and multi-mechanism synergy, and holds promising clinical translational potential.

The invention belongs to the field of biological materials, and particularly relates to injectable hydrogel and application thereof. The injectable hydrogel is prepared by mixing the following components in one step: blood plasma rich in platelets, nano clay, dimethyl oxidized glutathione and calcium chloride. A specific preparation method of the injectable hydrogel comprises the following steps: mixing blood plasma rich in platelets with a calcium chloride solution at room temperature; adding a nano clay solution, and stirring to form a milk white mixture solution; and adding the dimethyl oxidized glutathione, and uniformly stirring. The hydrogel has the advantages of excellent bone defect repair capability, angiogenesis promotion effect, good injectability and slow release characteristic, simple preparation, and suitableness for clinical application and large-scale production.

The invention discloses injectable hydrogel for treating periodontitis as well as a preparation method and application of the injectable hydrogel. The injectable hydrogel is prepared from the following raw materials: chitosan and derivatives thereof, oxidative modified natural polysaccharide and modified hydroxyapatite, the modified hydroxyapatite comprises hydroxyapatite, and the surface of the hydroxyapatite is modified with a metal polyphenol network. The modified hydroxyapatite has multiple functions of oxidation resistance, immunoregulation, osteogenesis promotion, migration promotion, tube formation promotion, antibiosis and the like, and can be combined with the injectable hydrogel with biological adhesion and self-healing performance to realize better in-vivo tissue healing. The injectable hydrogel of the composite functional hydroxyapatite nanoparticles synthesized by the invention has biocompatibility, oxidation resistance, immunoregulation performance, osteogenesis promotion performance and antibacterial performance, and can realize better alveolar bone regeneration and repair in a rat periodontitis model, and the effect of the injectable hydrogel is superior to that of clinically common minocycline.

The invention discloses an inner ear local release hydrogel and a preparation method thereof, and belongs to the field of biomedical materials and drug delivery. PLGA microspheres are used as model particles, after the PLGA microspheres are wrapped by polydopamine, a diol structure is introduced to the surface, and the PLGA microspheres and a phenylboronic acid grafted hyaluronic acid main chain form a stable borate bond under a neutral condition, so that a three-dimensional injectable hydrogel network is constructed under the condition that no extra small molecule cross-linking agent is needed. The drug-release hydrogel provided by the invention has good biocompatibility, adhesion and slow release ability, can prolong local drug residence time, improves the drug concentration of inner ears, and significantly improves the treatment effect.

This invention relates to the field of materials science and technology, and discloses the application of zwitterionic polymer injectable hydrogels as vitreous substitutes. Zwitterionic monomers selected from CBUIA, CBUTA, CBOH, CBMA, or MPC are dissolved in an aqueous phase, and polymerization is initiated by an initiator to obtain a hydrogel. After swelling equilibrium, the zwitterionic polymer injectable hydrogel is obtained. This invention uses initiator-initiated free radical polymerization of monomers and prepares physically cross-linked pure zwitterionic hydrogels through multi-hydrogen bond interactions or chain entanglement. The pure zwitterionic hydrogel with injectable properties is prepared through swelling equilibrium. It exhibits good biocompatibility, which is beneficial for improving the affinity of this zwitterionic polymer-based hydrogel vitreous substitute to the vitreous cavity, reducing adverse reactions after implantation. Furthermore, the preparation method is simple and the conditions are mild, making it more suitable for large-scale promotion and use as a vitreous substitute in ocular surgery, and it exhibits excellent biofouling resistance.