Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application

A water-soluble chitosan and sponge technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of prolonging the degradation time of carboxymethyl chitosan sponge, uncomfortable wound application, etc., achieving non-immunogenicity, sticking Good application performance and good safety performance

Inactive Publication Date: 2007-10-17
OCEAN UNIV OF CHINA
View PDF1 Cites 26 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the added chitosan powder or chitin powder prolongs the degradation time of the carboxymethyl chitosan sponge in vivo due to its own characteristics, so it is not suitable for in vivo trauma applications.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application
  • Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application
  • Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 5 g of carboxymethyl chitosan powder, place it in a 500 ml beaker, add 195 g of distilled water and stir until completely dissolved to obtain carboxymethyl chitosan colloidal solution. Pour the colloid solution into a 50mm×50mm×5mm stainless steel mold, put it into a vacuum freeze dryer and freeze it at -45°C for 2 hours, turn on the vacuum pump, sublimate the water, and vacuum freeze-dry for 36 hours to obtain a size of 50mm×50mm ×5mm flake porous sponge, packaged, 60 Co sterilization is the water-soluble chitosan-based hemostatic guaiac sponge of the present invention. The sponge is soft, loose and porous, and white in color.

Embodiment 2

[0015] Weigh 5g of carboxymethyl chitin powder, place it in a 500ml beaker, add 196g of distilled water and stir until completely dissolved, add 4g of fibrinogen aqueous solution with a concentration of 5% by weight as a hemostatic agent, carboxymethyl The weight ratio of chitosan powder and hemostatic agent is 100:4, and the mixture is stirred evenly to obtain carboxymethyl chitosan colloidal solution. Pour the colloid solution into a 50mm×50mm×5mm stainless steel mold, put it into a vacuum freeze dryer at -45°C for 2 hours, turn on the vacuum pump, sublimate the water, and vacuum freeze-dry for 24 to 36 hours to obtain a size of 50mm× 50mm * 5mm sheet-shaped porous sponge, packaged, is the water-soluble chitosan-based hemostatic guaiac sponge of the present invention. The sponge is soft, loose and porous, and its color is off-white.

Embodiment 3

[0017] Weigh 6g of hydroxypropyl chitosan powder, place it in a 500ml beaker, add 197g of distilled water and stir until completely dissolved, then add 3g of thrombin aqueous solution with a concentration of 1% by weight as a hemostatic agent, hydroxypropyl chitosan The weight ratio of powdered sugar and hemostatic agent is 100:0.5, and they are stirred evenly to obtain a colloidal solution of hydroxypropyl chitosan. Pour the colloid solution into a 50mm×50mm×5mm stainless steel mold, put it in a vacuum freeze dryer at -45°C for 2 hours, turn on the vacuum pump, sublimate the water, and vacuum freeze-dry for 36-48 hours to obtain a size of 50mm× 50mm * 5mm sheet-shaped porous sponge, packaged, is the water-soluble chitosan-based hemostatic guaiac sponge of the present invention. The sponge is soft, loose and porous, and its color is off-white.

[0018] In above-mentioned embodiment, described carboxymethyl chitosan, carboxymethyl chitin, hydroxypropyl chitosan all can be refe...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
degree of substitutionaaaaaaaaaa
Login to view more

Abstract

A preparation method of water soluble chitosan group stanch wound sponge, which is characterized in dissolving water soluble chitosan derivatives in water, preparing 1%-10% weight percentage concentration of uniform colloid solution; subpackaging the colloid solution in mould, freezing in vacuum freeze drier at -20--60 DEG C, vacuum freeze drying 24-60 hours. The water soluble chitosan group stanch wound sponge of the invention is used for stanching and boosting wound healing of clinical operation, has advantages of convenient using, great mount of absorption solution, firm adhesion, better exerting function locally; selected material absorb water gradually to form gel in physiology pH condition during preparation, products have good local pasting property, exert stanching and boosting wound healing function so much the better; and products without immunogenicity in body, short degradation time, good compatibility with living body, better safety performance of clinic.

Description

technical field [0001] The invention relates to a hemostatic guaiac medical material, in particular to a water-soluble chitosan-based hemostatic guaiac sponge and its preparation method and application. Background technique [0002] Controlling bleeding, hemostasis, and promoting incision healing during and after clinical operations are very important for shortening operation time, improving operation effect, and reducing postoperative complications. Conventional hemostasis methods such as ligation, suture, and electrocoagulation are commonly used in clinical operation and trauma hemostasis, but these hemostatic methods are not always effective in controlling bleeding. Therefore, according to clinical needs, various local hemostatic materials have been applied, and these hemostatic materials mainly include products such as gelatin sponge, collagen protein sponge, and fibrin glue. Gelatin sponge has been used clinically for many years, but its hydrophilicity is poor, and its...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
CPCC08L5/08
Inventor 韩宝芹刘万顺杨艳彭燕飞位晓娟
Owner OCEAN UNIV OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap