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501results about "Algae/lichens peptides" patented technology
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Identification and engineering of antibodies with variant Fc regions and methods of using same
ActiveUS20050037000A1High affinityAltered affinityAntibacterial agentsSenses disorderTherapeutic antibodyWild type
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcgammaRIIA and / or FcgammaRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcgammaR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
Owner:MARCOGENICS INC +1
Identification and engineering of antibodies with variant Fc regions and methods of using same
ActiveUS7355008B2Function increaseGood curative effectAntibacterial agentsSenses disorderTherapeutic antibodyEffector cell
Owner:MARCOGENICS INC +1
Light-Sensitive Ion-Passing Molecules
ActiveUS20130019325A1Dissuade depolarizationIncrease probabilityNervous disorderPeptide/protein ingredientsOptical stimulationLight activated
Disclosed are polynucleotides and methods for expressing light activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The disclosure also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Pufa polyketide synthase systems and uses thereof
Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
Owner:DSM IP ASSETS BV
Use of Light Sensitive Genes
InactiveUS20090088399A1Prevent and show degenerationImprove eyesightOrganic active ingredientsSenses disorderCell specificLight-gated ion channel
The invention relates to the use of a light-gated ion channel for the manufacture of a medicament for the treatment of blindness and a method for expressing said cell specific fashion, e.g. in ON-bipolar cells, ON-ganglion cells, or AII amacrine cells.
Owner:NOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INST FOR BIOMEDICAL RES FMI
Light-activated chimeric opsins and methods of using the same
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
PUFA polyketide synthase systems and uses thereof
Owner:DSM IP ASSETS BV
Pufa polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
Owner:DSM IP ASSETS BV
Technique for extracting phycocyanin, chlorophyll and spirulina polysaccharide in spirulina
InactiveCN101607988AEfficient use ofAvoid wastingPeptide preparation methodsAlgae/lichens peptidesFreeze and thawPhycocyanin
Owner:威海格瑞安生物工程有限公司
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
Owner:DSM IP ASSETS BV
Modulation of sulfate permease for photosynthetic hydrogen production
InactiveUS20050014239A1Closely alignedContinuous productionSugar derivativesBacteriaAlgaenanWild type
Sustained hydrogen production is obtained by the culturing of a genetically-modified algae, where the ability of the chloroplasts to intake sulfate is reduced or eliminated compared to wild-type algae. The alga is cultured in a sealed environment in a liquid or solid medium that contains sulfur, and hydrogen is generated continuously. Alternatively, the algae may be cultured in the presence of bacteria that also produce hydrogen gas. The hydrogen produced can be collected and used as a clean energy source.
Owner:RGT UNIV OF CALIFORNIA
Signal processing devices comprising biological and bio-mimetic components
This invention provides modified phycobilisomes and phycobilisome complexes that are supramolecular complexes with diverse spectral properties, and which may optionally be immobilized on a manufactured solid support. The invention provides a versatile set of highly sensitive signal-generating systems and conjugates that may be used as highly detectable tracers and labels, or in biotransducers comprising phycobilisomes or phycobilisome complexes, and also provides methods for performing specific binding assays using signal-generating systems comprising phycobilisomes as detectable labels. The embodiments of the invention provide the art with an extremely sensitive, nonisotopic detection means for assaying analytes and for sensing molecular events and environmental conditions.
Owner:CUBICCIOTTI ROGER S
Comprehensive method and system for utilizing carbon-contained organic matter
The invention relates to a comprehensive method for utilizing a carbon-contained organic matter, comprising a high-pressure hot water / supercritical water gasifying sub-method and a poly-generation sub-method, wherein the high-pressure hot water / supercritical water gasifying sub-method is continuously carried out by the decompression continuous discharge of a reaction product. The decompression continuous discharge is realized by adopting at least two buffer tanks which are operated in parallel connection or at least one decompressing valve. The invention converts the carbon-contained organic matter into a clean energy chemical product, such as methane, and the like and / or clean electricity by coupling the high-pressure hot water / supercritical water gasifying sub-method, the poly-generation sub-method, an alga carbon absorbing sub-method and / or a composite energy source hydrogen preparation sub-method to form an ecological cycle mode for the development and utilization of carbon-contained organic matter resources. The invention also provides a comprehensive system for implementing the comprehensive method.
Owner:ENN SCI & TECH DEV
Light-Sensitive Ion-Passing Molecules
ActiveUS20130089503A1Dissuade depolarizationIncrease probabilityNervous disorderPeptide/protein ingredientsHuman animalNucleotide
The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Method for separating high purity phycocyanin from spirulina
InactiveCN101899102AEasy pretreatmentReduce energy consumptionPeptide preparation methodsAlgae/lichens peptidesPhosphateIon exchange
The invention discloses a method for separating high purity phycocyanin from spirulina, comprising the following steps: adopting 0.05-0.5M of phosphate buffer to elute a spirulina powder raw material by an elution method, enabling the phycocyanin to be effused from spirulina cells, adding soluble chitosan to phycocyanin crude extract, controlling the mass concentration of chitosan in the phycocyanin solution to be 0.1-1%, and collecting supernate by centrifuging; adding activated carbon to the supernate, centrifuging and collecting supernate, adopting ammonium sulfate precipitation with the mass concentration of 30-60% to precipitate the phycocyanin in the solution, adopting ion-exchange chromatography, and performing gradient elution by phosphate buffer containing sodium chloride to obtain the high purity phycocyanin solution. The invention has the advantages of low cost, short elapsed time, convenient and rapid operation, low energy consumption, and easy massive preparation, is an efficient method for massively preparing phycocyanin with high purity and high activity and is favor of scaled development and utilization of the phycocyanin in our country.
Owner:SOUTH CHINA UNIV OF TECH
System and method for identifying complex patterns of amino acids
InactiveUS7774144B2SsRNA viruses negative-sensePeptide/protein ingredientsProtein DatabasesHistidine residue
A method and system are disclosed for identifying and / or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
Owner:BOGOCH SAMUEL +3
Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR)
ActiveUS8236934B2Improve efficiencyImmobilised enzymesAntibacterial agentsDendritic cellAsialoglycoprotein receptor
Owner:BAYLOR RES INST
Antibody of fucosylated Golgi protein GP73 and use thereof
InactiveCN101555282AFast detection methodReduce testing costsTissue cultureImmunoglobulins against fungi/algae/lichensCDNA libraryDisease
The invention relates to an antibody against fucosylated protein GP73, a method for preparing the antibody against the fucosylated protein GP73, a reagent for diagnosing liver cancers, a kit for diagnosing the liver cancers, application of the reagent and / or the kit to preparing products for diagnosing liver diseases and a method for preparing purified fucosylated protein GP73. Occurrence, development and metastasis of liver cancers are diagnosed by detecting the fucosylated protein GP73 or the antibody. The antibody against the fucosylated protein GP73 can be more widely used for affinity chromatography, cDNA library screening, immunologic diagnosis or pharmaceutical preparation.
Owner:THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
Optically-Based Stimulation of Target Cells and Modifications Thereto
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in vivo or in vitro environments).
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Regulatory elements and uses thereof
InactiveUS20140363892A1Increase nutritionHigh protein yieldSugar derivativesUnicellular algaeMicroorganismDNA construct
The present application provides novel regulatory elements including promoter sequences from marine microorganisms. The application further discloses DNA constructs containing these novel regulatory elements; transgenic cells, transgenic non-human organisms, and progeny containing these novel regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory elements disclosed herein are particularly suited for use in Nannochloropsis and other microalgae.
Owner:SYNTHETIC GENOMICS INC
Comprehensive utilization method and system for coal
ActiveCN101792680AIncrease contentOvercoming the Difficulty of Single Catalytic GasificationElectrolysis componentsBiofuelsProcess engineeringClean energy
The invention provides a comprehensive utilization method for coal. The coal is transformed into methane and other clean energy chemical products and / or clean power by integrating a multi-region coal gasification sub-method, a coal-based poly-generation sub-method, a composite power source hydrogen production sub-method and / or an algae carbon absorption sub-method, and an ecological cycle mode for development and utilization of coal resources is formed, wherein in the multi-region coal gasification sub-method, methane-containing gas flow is produced in the presence of a catalyst and a gasification agent by putting coal powder into a gasification furnace comprising a partial pyrolysis region, a catalytic gasification region and a residue gasification region. The invention also provides a system for implementing the comprehensive utilization method for coal.
Owner:ENN SCI & TECH DEV
Regulatory Factors Controlling Oil Biosynthesis In Microalgae And Their Use
The production of transgenic plant oils is described by transfecting plant host cells with heterologous transcription inducers. Such inducers are specific for endogenous biosynthetic plant oil genes, such that the inducers induce an overexpression of the plant oil genes. The overexpressed gene product (i.e., for example, diacylglycerol transferase) thereby results in a increased intracellular production of a plant oil (i.e., for example, triacylglycerol). In one embodiment, the transfected plant host cell can be a plant algae species (i.e., for example, Chlamydomonas reinhardtii).
Owner:BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIV
A kind of production method of comprehensively utilizing oleaginous microalgae
InactiveCN102295983ALess investmentEasy to operateClimate change adaptationBioloigcal waste fertilisersOil phaseHigh pressure
A production method for comprehensively utilizing oil-containing microalgae, comprising: using a high-pressure homogenizer to homogenize and break the wall of the microalgae at room temperature and high pressure. Transfer to the extraction tank, extract the microalgae oil under agitation, separate the liquid phase and the solid phase after centrifugation, wash the solid phase with water three times, add it to a spray dryer for drying to obtain microalgae powder. The liquid phase and the three times of washing liquid are added to the oil-water separator to separate into an oil phase and a water phase, and the oil phase is microalgae oil. The separated water phase is separated and purified to extract bioactive substances such as microalgae protein, microalgae polysaccharide, and microalgae liquid fertilizer. The invention has the advantages of low investment, simple operation, large-scale utilization of microalgae production method, and can produce microalgae oil, EPA, DHA, microalgae powder, microalgae protein, microalgae polysaccharide, microalgae liquid fertilizer and other high added value Semi-finished products.
Owner:上海辰浩生物技术有限公司
Light-receiving channel rhodopsin having improved expression efficiency
Disclosed is a Volvox carteri-derived light-receiving channel rhodopsin with an improved expression efficiency on a cell membrane. Specifically disclosed is a modified Volvox carteri-derived light-receiving channel rhodopsin protein. The protein is modified to contain an N-terminal region of Chlamydomonas reinhardtii-derived channel rhodopsin-1 at the N-terminal of the Volvox carteri-derived light-receiving channel rhodopsin protein, wherein the N-terminal region is involved in cell membrane-localized expression and contains no transmembrane domain of the Chlamydomonas reinhardtii-derived channel rhodopsin-1.
Owner:TOHOKU UNIV
Light-Sensitive Ion-Passing Molecules
ActiveUS20130090454A1Dissuade depolarizationIncrease probabilityNervous disorderPeptide/protein ingredientsNucleotideOptical stimulation
The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Enrichment and separation method of blue green algae phycocyanin
ActiveCN101560254AImprove adsorption capacityReduce manufacturing costDepsipeptidesPeptide preparation methodsChromatographic separationFreeze-drying
An enrichment and separation method of blue green algae phycocyanin belongs to the technical field of biochemical separation engineering. The invention comprises the following steps: blue green algae disrupted solution is prepared; JDN-3 type resin enriches phycocyanin in the blue green algae disrupted solution; phycocyanin is eluted and separated; chromatographic separation is carried out on the JDN-3 type resin; freeze drying is carried out on eluent after desalination to obtain phycocyanin with certain purity; the recovery rate of albumen is up to 85.5%. The method is simple, directly uses the JDN-3 type resin to enrich the blue green algae disrupted solution without using usual ammonium sulfate salt precipitation, organic solvents, isoelectric points and other similar methods, reduces the dosage of chemical agents in the preparation process, simplifies the steps of the purification process, avoids the loss of products; the phycocyanin obtained by the chromatography of the JDN-3 type resin has higher purity which is up to A620 / A280>2.0. The raw material uses fresh algae or dried algae powder, or even field blue-green algae in Taihu Lake, thereby providing a technical method for solving scale use of algal resource.
Owner:DONGTAI CITY SPIRULINA BIO ENG CO LTD
Nanoscale particles synthesized within an assembled virion
Virion-constrained nanoparticles comprising a shell of virion coat protein(s) surrounding an organic, inorganic and / or organo-metallic non-viral nanoparticle and methods of making and using.
Owner:MONTANA STATE UNIVERSITY
Scfvs in photosynthetic microbes
Expression of functionally active recombinant single chain antibodies in prokaryotic and eukaryotic heterotrophic algae for pathogen treatment or control in aquaculture and agriculture applications is disclosed; and subsequent modification of the strains to generate transgenic algae propagated under defined conditions.
Owner:THE HONG KONG UNIV OF SCI & TECH
Method for preparing phycocyanin from blue algae in water bloom
InactiveCN1563083AAvoid cloggingAvoid decompositionAlgae/lichens peptidesHollow fibreFreeze and thaw
The invention discloses a method for preparing phycocyanin by using bloom cyanophyte. Said invention uses the fresh bloom cyanophyte as raw material, and adopts the following steps: first step, extracting crude filtrate; dehydrating fresh bloom cyanophyte, adding buffer solutio, mixing them uniformly, frezing, takingout and thawing at room temperature, freezing and thawing for 3-5 times and filtering by using plate and frame; second step, ultrafiltering and purification; using hollow fibre ultrafiltration device whose trapping molecular weight is 1000-200000 daltons to remove various substances with smaller molecular weight from crude extract passed through microfiltration by using ultrafiltering membrane; third step, settling-clearing purification; removing most of small molecules from phycocyanin portion purified by means of ultrafiltration, at the same time making concentration and storing the concentrated phycocyanin portion at a certain temperature; and fourth step; hydroxyapatite column chromatography to make purification.
Owner:INST OF AQUATIC LIFE ACAD SINICA
Food grade phycocyanin and preparation method thereof
ActiveCN101942014AHigh purityHigh activityPeptide preparation methodsAlgae/lichens peptidesFood gradePhycoerythrin
The invention discloses a preparation method of food grade phycocyanin protein, comprising the following steps: breaking the wall of the spirulina power; adding weak acid salt buffer solution in the wall broken spirulina power for digestion; carrying out solid-liquid separation on the spirulina power leach liquor; extracting supernatant; filtering the supernatant to obtain the crude extract; and purifying the crude extract to obtain the concentrated solution; and spraying and drying the concentrated solution. The invention also discloses a food grade phycocyanin protein prepared by the method, wherein the purity (OD620 / OD280) is larger than 1.0; the content of the phycocyanin protein is larger than 50%; the content of allophycocyanin is larger than 10%; the content of phycoerythrin is larger than 2%; and the content of other proteins is smaller than 2%. The method has low production cost, is simple and effective, and is suitable for preparing mass food grade phycocyanin proteins.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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