The invention belongs to the technical field of bioactive peptides, and particularly relates to a
phycocyanin peptide and application thereof in preparation of a product with functions of inhibiting PTGS2 expression and regulating an Akt / GSK3beta
signal channel. According to the invention,
phycocyanin is taken as a
raw material, active polypeptides with specific sequences are obtained through an enzymolysis
separation technology, and the
amino acid sequences of the active polypeptides are respectively Leuu-Ala-Ser and Leuu-Gly-Leu. Experiments prove that the
phycocyanin peptide prepared by the invention can significantly inhibit the expression of PTGS2, and can play a related regulation role by activating an Akt / GSK3beta
signal channel, so that the technical blank of
plant active
peptide targeting PTGS2 and Akt / GSK3beta
signal channels is filled, and the phycocyanin peptide can be widely applied to the development of related products for regulating the
abnormal expression of PTGS2 and Akt / GSK3beta signal channels.