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Gynecological chitosan gel and preparation method thereof

A chitosan and gel technology, applied in the field of medical materials, can solve the problems of poor bacteriostatic performance of gynecological suppositories, vaginal irritation, complicated equipment, etc., and achieve the effects of good patient compliance, good contact time, and good contact area.

Inactive Publication Date: 2014-04-09
王东宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

ZL00253842 discloses a disposable cleaning sponge for women, but the polyester sponge is not biodegradable, has no biocompatibility, and has certain irritation to the vagina
The patent application of 03112762 discloses a biological sponge for treating gynecological diseases and its production method, but the biological sponge contains many components, and its production method is also very complicated, so both the cost and the production cost are relatively high
200510035046.8 discloses a chitosan gynecological suppository and its preparation method, but the gynecological suppository has poor antibacterial performance, the suppository absorbs water during use and causes vaginal dryness, and the required equipment is complicated

Method used

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Examples

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preparation example Construction

[0012] A chitosan gynecological gel of the present invention is made of the following raw materials in weight ratio: 0.5% to 10% of water-soluble chitin derivatives, 0.01% to 0.5% of guanidine antibacterial agents, and 0.0% of lubricants. . 5% to 10%, thickener 1% to 20%, and the balance is water. The gel preparation method has the following steps:

[0013] (1) Make a gel with a thickener;

[0014] (2) Water-soluble chitosan derivatives, guanidine antibacterial agents, and lubricants are made into a mixed solution;

[0015] (3) Mix and stir the solutions prepared in (1) and (2);

[0016] (4) Filling and sterilization.

[0017] The suitable weight ratio of the present invention is: 2%-8% of water-soluble chitin derivatives, 0.05%-0.3% of guanidine antibacterial agents, 2%-8% of lubricants, 2%-10% of thickeners, and the remaining The amount is water.

[0018] The water-soluble chitin derivatives of the present invention are carboxymethyl chitin sodium or potassium salt, ...

Embodiment 1

[0020] A chitosan gynecological gel, which includes water-soluble chitin derivatives, guanidine antibacterial agents, lubricants, thickeners and purified water; the ratio between the components is chitosan hydrochloride 1 %, polyhexamethyleneguanidine 0.02%, propylene glycol 3%, hydroxyethyl cellulose 2%, and the balance is water.

[0021] A method for preparing above-mentioned chitosan gynecological gel, it comprises the steps:

[0022] (1) Make a gel with a thickener;

[0023] (2) Make a mixture of water-soluble chitosan derivatives and guanidine antibacterial agent lubricant;

[0024] (3) Mix and stir the solutions prepared in (1) and (2);

[0025] (4) Filling and sterilization.

Embodiment 2

[0027] A chitosan gynecological gel, which includes water-soluble chitin derivatives, guanidine antibacterial agents, lubricants, thickeners and purified water; the ratio between the components is chitosan acetate 3 %, polyhexamethylene biguanide hydrochloride 0.1%, polyethylene glycol-200 5%, hydroxyethyl cellulose 3%, and the balance is water.

[0028] A method for preparing above-mentioned chitosan gynecological gel, it comprises the steps:

[0029] (1) Make a gel with a thickener;

[0030] (2) Make a mixture of water-soluble chitosan derivatives and guanidine antibacterial agent lubricant;

[0031] (3) Mix and stir the solutions prepared in (1) and (2);

[0032] (4) Filling and sterilization.

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PUM

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Abstract

The invention discloses gynecological chitosan gel. The gynecological chitosan gel comprises the following components: 0.5-10 percent of water-soluble chitin derivative, 0.01-0.5 percent of guanidine bacteriostatic agent, 0.5-10 percent of lubricating agent, 0.05-0.5 percent of thickening agent and the balance of water. The preparation method of the gynecological chitosan gel comprises the following steps: (1) preparing the thickening agent into gel; (2) preparing the water-soluble chitin derivative, the guanidine bacteriostatic agent and the lubricating agent into a mixed solution; (3) mixing and stirring the solution prepared in the steps (1) and (2); (4) filling and sterilizing. The process is simple, the needed equipment is simple and readily available, and the gynecological chitosan gel has a good curative effect on gynecological diseases such as vaginitis and cervical erosion.

Description

technical field [0001] The invention relates to a medical material, in particular to a chitosan gynecological gel and a preparation method thereof. Background technique [0002] Bacterial vaginosis, candida vaginosis, trichomonas vaginosis, and cervical erosion are common and frequently occurring diseases in gynecology. At present, most of the drugs used in the treatment of chronic cervicitis and vaginitis are antibiotics. Long-term use will not only cause certain damage to the body, but also the body will develop drug resistance, which will affect the efficacy of the drug and the therapeutic effect. . At present, physical therapy is often used in the treatment of cervical erosion, such as microwave, freezing, laser, etc., but this physical method requires a long time for patients to repair and adjust. ZL00253842 discloses a disposable cleaning sponge for women, but the polyester sponge cannot be biodegraded, has no biocompatibility, and has certain stimulation to the ...

Claims

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Application Information

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IPC IPC(8): A61K31/785A61K9/06A61P15/02A61P15/00A61P31/04A61P31/10A61K31/722
Inventor 王东宇
Owner 王东宇
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