109 results about "Drug control" patented technology

The invention discloses a sewage treatment drug delivery control method based on reinforcement learning and particle swarm optimization, and the method achieves the precise control of turbidity and the optimization of drug cost through the dynamic adjustment of particle swarm parameters and the fusion of a reinforcement learning strategy. According to the technical scheme, the method comprises the following steps: combining a PSO algorithm with a DDPG algorithm to construct a drug control model; designing a reward function; the empirical data with the state coverage rate higher than a first preset threshold value are stored in a full-reservation empirical pool, the empirical data with the current policy access larger than a second preset threshold value are reserved in a first-in first-out mode through a policy empirical pool, and mixed sampling is carried out according to a preset proportion; training a drug control model; and inputting the current turbidity value, the drug delivery amount of the last time step, the water inlet flow, the parameters of the water quality detection camera and the future turbidity value into a trained drug control model, and outputting the current drug delivery amount. Through prediction-control closed-loop integration, a raw water turbidity prediction result is fed back to the optimizer, and the method is suitable for real-time adaptive control of a sewage treatment system.

The invention discloses an exosome engineered targeted drug delivery system and a preparation method and application thereof, and belongs to the field of biomedices.The exosome engineered targeted drug delivery system is prepared by mixing and reacting surface modified exosome and pH response type drug controlled release nanoparticles; the pH response type drug controlled release nanoparticles react with the surface modified exosome through a click chemical reaction; the surface of the membrane of which the surface is modified with the exosome is modified with a maleimide group and an azide group; the novel nano-drug has pH responsiveness; the click chemical reaction is thiol-ene click reaction. Bifunctional groups (MAL and N3) are directionally grafted on the surface of an exosome membrane, uniform drug particles are prepared in combination with a micro-fluidic technology, an efficient bimodal targeting drug delivery system is successfully constructed, and remarkable technical advantages are shown in the aspects of improving targeting precision, enhancing antitumor activity, controlling drug release, inhibiting tumor metastasis and the like; and a new technical approach is provided for precise treatment of adenoid cystic carcinoma.

The invention belongs to the technical field of hydrogel preparation, and relates to a cartilage-imitating multifunctional drug release hydrogel material and a preparation method thereof. According to the invention, biocompatible high polymer materials such as polyvinyl alcohol, chitosan, grape seed protein, acyl chloride, sulphobetaine methacrylate and lecithin are used as raw materials, a cartilage structure is simulated to prepare the multilayer hydrogel, gelatin and plant polyphenol are mixed as an adhesive to improve the binding capacity with subosseous bones, and a drug is loaded to improve the biological activity. The preparation method of the hydrogel material comprises the five steps of preparation of high-strength anti-swelling precursor hydrogel, introduction of double bonds through surface modification, introduction of a poly SBMA molecular brush through interfacial polymerization, drug loading and preparation of an adhesion layer. The hydrogel has excellent anti-swelling ability, lubricating property, anti-pollution ability, free radical scavenging ability, self-adhesion characteristic, drug controlled release ability and biocompatibility, and has important significance for widening the application of the hydrogel in the field of artificial cartilage.

The invention belongs to the field of biomedical materials, and discloses a preparation method and application of a mesoporous polydopamine nano preparation loaded with ultra-small nano enzyme. The nano preparation takes mesoporous polydopamine nanoparticles as a carrier skeleton and is combined with ultra-small nano enzyme through an in-situ reaction: the mesoporous polydopamine nanoparticles can efficiently carry drugs and accurately deliver the drugs to inflammatory tissues such as psoriasis, gout, colitis and the like by virtue of a modified targeting ligand by virtue of high specific surface area, biocompatibility and modifiability; the ultra-small nano enzyme has catalytic activity of catalase and the like, and can remove active oxygen and relieve oxidative stress. The two components are combined to achieve a synergistic effect, so that the catalytic efficiency of the enzyme is improved by virtue of the characteristics of the carrier, the high activity of the enzyme under different conditions is maintained by virtue of the stability of the carrier, and the platform can synchronously realize targeted delivery, enzymatic treatment and drug controlled release, and has a wide application prospect in the fields of inflammatory disease intervention and wound repair. And an efficient, accurate and low-toxicity universal treatment strategy is provided for chronic inflammatory diseases.

The invention discloses a preparation method and application of oxidative stress microenvironment response intelligent semi-conversion hydrogel, and belongs to the technical field of biological medicine. According to the preparation method disclosed by the invention, a therapeutic drug can be wrapped in the drug and placed in a local injury part, and a large amount of ROS released by oxidative stress in the early stage of spinal cord injury (SCI) is responded, so that conversion from a gel state to a semi-gel sol state is realized, and explosive release of the drug is caused while the ROS is consumed; the medicine treatment concentration is quickly reached in the acute stage of SCI; after the SCI oxidative stress period, ROS release is reduced, and under the action of in-vivo reducing substances, the hydrogel can be recovered from a semi-sol-gel state to a gel state, so that long-term slow release of to-be-released drugs is realized, and later-stage neural restoration of SCI is promoted; through the conversion from the gel state to the semi-sol gel state to the gel state, intelligent drug controlled release responding to oxidative stress can be achieved, and therefore the optimal SCI treatment effect is achieved.

The invention relates to the technical field of dental intelligent adjuvant therapy, and discloses an adjuvant therapy system and method for difficult-to-inverse suppurative periapical periodontitis, and the system comprises a multi-modal image fusion module which fuses CT / OCT images to generate a three-dimensional diagram, segments an infected region through a lightweight CNN, and outputs a probability diagram; the reinforcement learning debridement navigation module is used for optimizing the dentin injury risk by combining a biological membrane thickness dynamic planning path on the basis of a DDPG algorithm; the intelligent medicine control module is used for positioning a catheter according to an infection map, triggering medicine release by a pH / enzyme sensor and adjusting delivery pressure by PID; the biosensor monitoring module is used for detecting inflammatory factors, predicting the recurrence risk through LSTM, and triggering image rescanning and path updating when a threshold value is exceeded. Through multi-modal image fusion, reinforcement learning dynamic debridement navigation, microenvironment response type drug control and time sequence prediction closed-loop feedback, accurate elimination and relapse active inhibition of periapical periodontitis focuses are realized.

The invention provides a nano-drug delivery system for treating fatty liver based on liposome, exosome and metal organic framework synergistic targeting and a preparation method of the nano-drug delivery system, and relates to the technical field of novel nano-material preparation, the nano-drug delivery system comprises liposome, mesenchymal stem cell exosome and metal organic framework nanoparticles; the liposome is used as a carrier and entraps the metal organic framework nano-particles, the mesenchymal stem cell exosome and the miR-204-3p which have a slow release characteristic. By integrating the advantages of the liposome, the exosome and the metal organic framework, the synergistic treatment of the MASLD is realized. According to the system, lipidosome is adopted as an intelligent carrier, MOF nanoparticles and mesenchymal stem cell exosomes with slow release characteristics are entrapped, and therapeutic miR-204-3p is loaded at the same time. The MOF material has functions of drug controlled release and active oxygen removal, and synergistically exerts anti-oxidation, anti-inflammatory and anti-fibrosis effects with the exosome and miRNA. The system has a pH response characteristic, and can intelligently release drugs in an acidic microenvironment of an MASLD focus to realize targeted treatment of the liver.

The invention discloses a clean coal flotation reagent regulation and control method and a reagent regulation and control system thereof.The method comprises the steps that in the clean coal flotation process, an image sample file is recorded by a visual module; the central processing module processes the sample file to obtain a flotation state judgment reference set; performing size calculation on a plurality of foam objects in the flotation state judgment reference set, and drawing a foam size distribution proportion diagram of the generated sample unit; then comprehensively judging the flotation effect in a sampling time period according to the uniformity change trend of a foam layer, the thickness change trend of the foam layer, the relative proportion condition of foam objects in an ideal foam size range in each sample unit and the foam stability in a plurality of continuous sample units, and calculating to obtain an agent adjustment addition amount; and the medicine adding adjusting module adjusts and controls the medicine adding amount in real time according to the obtained medicine adjusting adding amount. The agent adding amount can be regulated and controlled according to the real-time dynamic change of the foam layer, so that the flotation effect and stability are improved.

The invention relates to the technical field of hydrogel microspheres, and particularly discloses hydrogel microspheres as well as a preparation method and application thereof. Sodium alginate and acrylamide are used for constructing a stable hydrogel skeleton structure with a certain mechanical property, and in a specific oil phase-hydrogel solution system, the release time and the release rate of Fe ions from an EDTA-Fe complex are accurately controlled by adjusting the pH value, so that the stability and the stability of the hydrogel are improved. The iron ions are released at proper time and rate and participate in the crosslinking reaction of the hydrogel, so that the hydrogel microspheres which are uniform in crosslinking, stable in performance and capable of accurately regulating and controlling the metal ions are prepared; besides, the lithium chloride can enhance the structural stability of a hydrogel network and adjust the plasticity of the hydrogel, so that the hydrogel is more flexible, and a uniform microsphere structure is favorably formed in the stirring and dispersing processes. The hydrogel microspheres prepared by the method have wide application prospects in the fields of drug controlled release, biosensing, environmental restoration and the like.

Intelligent control of patient-controlled drug delivery is disclosed. An infusion control device detects a patient-controlled drug request device in operable communication with the infusion control device. The infusion control apparatus identifies a sensor apparatus in operable communication with the infusion control apparatus and a drug delivery device separate from the infusion control apparatus. The infusion control device selects a drug control algorithm for approving a drug request received by a patient-controlled drug request device. The infusion control device identifies a patient using a patient-controlled drug request device and receives patient physiological data from a sensor device. The infusion control apparatus receives a request for a medicament to be delivered to a patient by a medicament delivery device. The infusion control device determines whether the patient is authorized to perform the medication request. And based on a determination that the patient is authorized, the infusion control device causes delivery of the medicament to the patient.

The invention discloses a preparation method and application of a myofibrillar protein emulsion based on enzymatic modification. According to the technology, a myofibrillar protein aqueous suspension is subjected to enzymatic deamidation and glycosylation reaction through protein glutaminase and glucan, a protein-polysaccharide compound with good emulsifying performance is constructed, soybean oil serves as an oil phase, and emulsion systems with different oil phase volume fractions are constructed through a controllable homogenizing technology. The obtained emulsion has the characteristics of natural degradability, excellent rheological property, uniform particle size distribution, long-term physical stability and the like. Compared with a traditional chemical modification technology, the technology adopts a whole bio-based raw material combined enzyme method green technology, the problems of organic solvent residues and the like are effectively solved, and the production cost is reduced while the product safety is ensured. The emulsion has remarkable application advantages in the fields of functional food active ingredient delivery, drug controlled release carriers, cosmetic transdermal absorption systems and the like, and a new thought is provided for development of a biomacromolecule-based delivery system.

The invention relates to the field of macromolecules, and discloses a polymer as well as a preparation method and application thereof. The polymer has a chemical structural unit as shown in a formula 1. Compared with polyester, the polymer disclosed by the invention has the characteristics of higher degradation rate in a water environment, large molecular weight and good heat resistance or mechanical property, and can be applied to the fields of degradable packaging materials, drug controlled release carriers and the like.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention discloses application of loganin and / or hydroxygenkwanin in preparation of an EGFR (epidermal growth factor receptor) inhibitor for treating inflammatory bowel diseases. Molecular docking experiments find that loganin and hydroxygenkwanin can be specifically bound with EGFR protein, the binding energy is lower than-5kcal / mol, and the loganin and hydroxygenkwanin can inhibit EGFR protein expression, block downstream RAS / ERK signal channels, relieve intestinal inflammation and repair mucosal barriers. Animal experiments show that in a DSS-induced UC mouse model, the pathological manifestation of a mouse can be remarkably improved by administration of loganin, and the effect of a 100mg / kg dose group is remarkably superior to that of a positive drug control. The two natural small molecule compounds are used for preparing the EGFR inhibitor for treating the inflammatory bowel disease for the first time, a low-toxicity and high-efficiency brand-new scheme is provided for IBD treatment, the problems of drug resistance and toxic and side effects of existing drugs are hopefully solved, and wide clinical application prospects are achieved.

The application discloses a preparation method of a temperature-ultraviolet light double response type functional polymer, specifically comprising the following steps: preparing a macromolecular initiator PEG2-ABCPA; preparing a p-styrylmethyl diethanolamine borate monomer VMAB; and performing a free radical polymerization reaction on the macromolecular initiator PEG2-ABCPA, the p-styrylmethyl diethanolamine borate monomer VMAB and 7-(4-vinylbenzyloxy)-4-methyl coumarin VBC to obtain a block copolymer, i.e. the temperature-ultraviolet light double response type functional polymer. The polymer not only has unique amphiphilic properties, but also exhibits double response to temperature and ultraviolet light, thereby showing wide application prospects in the fields of drug controlled release, intelligent materials, photoelectric devices and the like.

The application provides an antibacterial and anti-inflammatory drug controllable release hydrogel and a preparation method and application thereof, solves the problems of complex preparation process of photo-induced imine crosslinking hydrogel and lack of antibacterial and anti-inflammatory functions, and provides an effective way for treating chronic refractory wounds. The photo-crosslinking hydrogel designed in the application uses an amino-modified polymer derivative as a crosslinking matrix, and uses a double-branched small molecule compound as a crosslinking agent. The crosslinking system is simple to prepare, and can be quickly gelled under 395nm ultraviolet light. By further introducing a double-branched photo-crosslinking agent-antibacterial drug co-carrier and an anti-inflammatory drug slow-release particle into the above crosslinking system, the photo-crosslinking hydrogel of the application exhibits two drug release mechanisms of burst release of antibacterial drugs and slow release of anti-inflammatory drugs, thereby effectively solving the problems of bacterial infection in the early stage and chronic inflammation in the middle stage in the treatment process of chronic refractory wounds.

The invention belongs to the technical field of bioengineering, and provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, a preparation method and an application, aiming at the technical problem that complications are easily caused by the existing treatment means of endometriosis, so that the invention provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, and a preparation method and application of the drug-loaded targeted nano platform. According to the invention, the ZIF-8 nano-particles and the drugs aiming at the energy metabolism level are combined to be used as the carrier, so that endometriosis cells with acidic cell microenvironment can be targeted, drug controlled release can be realized in the acidic environment of lesions, and the effective uptake of the endometriosis cells to the drugs is enhanced, thereby effectively increasing the uptake rate and the drug concentration at the target position, and improving the curative effect of the drug on the endometriosis cells. Meanwhile, the distribution of the medicine in normal tissues or cells is reduced, and the toxic and side effects of the medicine are reduced; and through the design of combining the macrophages with the ZIF-8 nano-particle carrier, the drug targeting property of the ZIF-8 nano-particle carrier can be obviously improved.

The invention discloses a B-CGT hydrogel as well as a preparation method and application thereof. The B-CGT hydrogel is prepared from a rhizoma bletillae 2-isobutyl malic acid glucose oxybenzyl ester extract serving as a main raw material, carbomer-940 serving as a gel matrix, glycerol serving as a cross-linking agent (also can be used as a humectant) and triethanolamine serving as a pH regulator. The prepared B-CGT hydrogel has good oxidation resistance, remarkable free radical scavenging capacity, good blood compatibility and cell proliferation promoting effect, the wound healing speed is remarkably increased, new epithelial tissue and collagen are formed more perfectly, and the B-CGT hydrogel is a promising wound dressing candidate product and has wide application prospects. The hydrogel has excellent physicochemical characteristics and drug controlled release capability, can effectively promote the wound healing process, and especially has a remarkable curative effect on healing of diabetic wounds.

The invention provides a preparation method of zinc ion polysaccharide spray hydrogel for treating psoriasis, which comprises the following steps: preparing a cationic polysaccharide solution, dissolving zinc ions into the cationic polysaccharide solution, and then filling into a spray bottle to form a solution A; preparing an anionic polysaccharide solution, and filling the anionic polysaccharide solution into another spray bottle to form a solution B; the solution A and the solution B are alternately sprayed on an affected part for multiple times, polysaccharide molecules in the solution A and the solution B are rapidly combined and cured through electrostatic interaction to form hydrogel to be adhered to the surface of skin, and a film is formed after moisture is volatilized to cover the affected part. The alternate spraying mode is adopted, and operation is easy and convenient; zinc ions and chitosan have synergistic anti-inflammatory and immunoregulation effects, the formed hydrogel has efficient drug controlled release and good skin adhesion, and the preparation method is mild and controllable.

The invention relates to preparation and application of a malignant tumor targeting gambogic acid preparation. An inner core-middle layer-shell three-layer structure is adopted, wherein the inner core is a gambogic acid-black phosphorus quantum dot compound and has chemical treatment and photo-thermal treatment functions; the middle layer is nano vesicles derived from frozen NK92 MI cells and provides natural immune targeting and killing ability; a shell is a hyaluronic acid chelate, and active targeting and pH / photo-thermal response type drug controlled release are achieved. The core of the preparation method is that a coaxial electrojet technology is adopted, three layers of materials are formed in one step, the process is efficient, and the preparation stability is good. The preparation can realize photo-thermal-chemical-immune triple synergistic treatment, has near-infrared fluorescence and photo-acoustic multimode imaging functions, effectively solves the problems of poor targeting property, large toxic and side effects and lack of real-time monitoring of traditional chemotherapy, and shows significant advantages and application potential in precise treatment and diagnosis of solid tumors.

This invention belongs to the field of biomedical technology, specifically relating to a drug control system based on the KFERQ sequence, its construction method, and its application. This drug control system is composed of a KFERQ sequence, an HCV-NS3 sequence, and a protein-targeting sequence recombined together. During recombination, the protein-targeting sequence is located at the N-terminus or C-terminus of the recombinant sequence. This invention provides a novel strategy for endogenous protein degradation by recombinating the KFERQ sequence with the HCV-NS3 sequence and the endogenous protein-targeting sequence, and utilizing the self-cleavage property of the HCV-NS3 protease to regulate the degradation of endogenous proteins.

The invention discloses a physiological index monitoring and drug delivery integrated system and an application thereof in wearable equipment, through integration of a microneedle array, a fluid chamber area, a piezoelectric sensing module, a drug controlled release module and a signal processing module, real-time monitoring of physiological indexes and automatic drug delivery are realized by using a double-chamber structure. The fluid chamber area is composed of a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber guide the flowing direction of a body fluid sample and medicine in a one-way mode through a microfluid channel and a one-way valve, and the first chamber is used for receiving and guiding the body fluid sample to the piezoelectric sensing module for physiological detection. The second chamber guides the medicine to the microneedle array for accurate delivery to realize real-time monitoring of physiological indexes and automatic medicine delivery, the piezoelectric sensing module guides a body fluid sample to the sensing unit and detects physiological parameters based on the acoustic surface wave effect, and the signal processing module controls the dosage of the medicine according to the detection result. And precise drug release is realized through the drug controlled release module.

The invention discloses a viscous tussah silk gland protein gel dressing with microenvironment response and antibacterial property and a preparation method thereof, N-isopropylacrylamide is polymerized to form poly-N-isopropylacrylamide through in-situ free radical polymerization, and meanwhile, the poly-N-isopropylacrylamide, tussah silk gland protein and sodium alginate form gel in a stable form through intermolecular interaction; on one hand, the gel dressing has good temperature-sensitive response performance and realizes intelligent drug controlled release, and on the other hand, the hydrogel can be well adhered to the skin surface, can promote growth and reproduction of human skin fibroblasts, shows good biocompatibility and mechanical properties, has better adhesion stress than commercial wound dressings, and has good application prospects. An application basis is provided for the application of the sodium alginate group in the intelligent medicine controlled release medical wound dressing; finally, the gel dressing is loaded with a natural antibacterial agent and Chinese herbal medicines, and has the effects of resisting bacteria, diminishing inflammation and the like at the affected part; therefore, the gel dressing disclosed by the invention has great application potential in the medical field.

The invention provides a porous tissue engineering scaffold with a drug controlled release function as well as preparation and application of the porous tissue engineering scaffold. The preparation method of the porous tissue engineering scaffold comprises the following steps: S1) preparing double-layer nanoparticles by PLGA-PEG; and S2) preparing a composite scaffold by a low-temperature 3D printing technology. The stent prepared by the method has efficient drug controlled release capability, excellent mechanical properties, good biocompatibility and controllable degradation. The optimized porous structure promotes cell proliferation and tissue regeneration, meanwhile, low-temperature printing keeps the stability and activity of materials and drugs, and the material is widely applied to the fields of bone tissue engineering, local drug delivery and the like and shows remarkable clinical application value and market potential.

The application discloses a targeted magnetic nano-composite of palygorskite, a preparation method and application thereof in preparation of an in-vitro drug controlled release medicine. In the application, an anti-tumor drug DOX is loaded through an acid-cleavable acylhydrazone bond, and the drug release rate is lower in a normal physiological environment and higher in a tumor acid environment compared with electrostatic adsorption and pore storage of the DOX with HPal, so that the drug controlled release performance is obviously improved. In addition, loading of magnetic Fe3O4 nanoparticles and grafting of FA enrich the means of transporting the DOX to a designated area by the carrier, that is, the tumor cells can be positioned by external magnetic field control or receptor-ligand interaction targeting. MTT analysis and cell uptake research prove the targeting effect of the FA, and the therapeutic effect of the DOX can be effectively improved.

The utility model relates to a full-automatic sludge medicine control system of a desliming system. The full-automatic sludge medicine control system comprises a PLC, a stepping motor, a medicine adding device, a dissolving box, a medicine adding pump, a sludge pump, a flow meter, a mixing tank and a desliming machine. Wherein the PLC is electrically connected with the stepping motor and the flow meter; the stepping motor is connected with the dosing device and drives the dosing device to put a desliming agent into the dissolving tank under the control of the PLC; the dissolving tank is used for dissolving the desliming agent in the dissolving tank, and the dissolved desliming agent is conveyed to the dosing pump; the dosing pump conveys the dissolved desliming agent to the mixing tank through a dosing pipeline; the sludge pump conveys sludge to the mixing tank through a sludge pipeline; the mixing tank is used for mixing the desliming agent and the sludge and conveying the mixed sludge to the desliming machine; the desliming machine is used for desliming the mixed sludge; the flowmeter is arranged in the sludge pipeline and used for detecting sludge flow data in the sludge pipeline and sending the sludge flow data to the PLC.

The utility model belongs to the technical field of medical devices, specifically a respiratory medicine spraying device, including a spraying connecting pipe, one end of the spraying connecting pipe is connected to a spraying head control component, and the other end of the spraying connecting pipe is threadedly connected to an atomized medicine control component, and the bottom of the spraying connecting pipe is fixedly connected to a spraying positioning component; the spraying head control component includes a fixed seat, a spring, an elastic plate, a convex point, a rotating shaft, a protective cover, a detachable spraying head, and a groove, a spring is installed inside the fixed seat, and one end of the spring is fixedly connected to the elastic plate, and the side of the elastic plate is connected with a convex point, the outer wall of the fixed seat is installed with a rotating shaft, and the outer wall of the rotating shaft is connected to the protective cover; the utility model is convenient for disassembling the spraying head for cleaning or replacement, and can control the amount of medicine entering the human body, and can locate the position of the spraying to prevent the medicine from spraying into the eyes of people.

The invention relates to the field of medicine informatization management, and discloses an informatization medicine accurate regulation and control method and system for hemodialysis anemia patients, and the method comprises the steps: randomly dividing the collected patient information into a research group and a control group, comparing and analyzing the treatment effect difference caused by the anemia index change of the two groups of patients, and determining the accuracy of the treatment effect. The anemia improvement effect is evaluated by analyzing the relationship between the anemia index level change before and after the adjustment of the drug dose and injection frequency of a research group patient, whether the drug regulation direction is correct or not is judged, and the drug dose and injection frequency are adjusted according to the anemia index level change in the body of the patient. According to the method, the drug dosage and the injection frequency are dynamically optimized, and the difference of patients in a research group and patients in a control group in the aspect of anemia index level improvement is analyzed based on a model prediction result, so that drug regulation is further tracked and monitored, the drug use process is accurately regulated, the treatment quality is improved, and the treatment cost is reduced. And the workload of medical staff is reduced.

The present invention discloses the application of Gliocladium roseum in the biological control of Plutella xylostella. The strain is Gliocladium roseum SWFUYHL02-01. Through exploration, it is known that the Gliocladium roseum SWFUYHL02-01 provided by the present invention has toxicity and control effect on the larvae of Plutella xylostella. Its median lethal concentration (LC 50 ) for controlling the larvae of Plutella xylostella is 4.1×10 4 spores / mL, and the median lethal time (LT 50 ) is 32.4 h, providing a certain experimental and theoretical basis for the biological control of the larvae of Plutella xylostella, avoiding residues in the process of chemical drug control, reducing environmental impact and harm to human health, etc., providing new microbial resources for the biological control of Plutella xylostella, and having significant research significance and application value.