90 results about "Drug control" patented technology

The invention discloses a sewage treatment drug delivery control method based on reinforcement learning and particle swarm optimization, and the method achieves the precise control of turbidity and the optimization of drug cost through the dynamic adjustment of particle swarm parameters and the fusion of a reinforcement learning strategy. According to the technical scheme, the method comprises the following steps: combining a PSO algorithm with a DDPG algorithm to construct a drug control model; designing a reward function; the empirical data with the state coverage rate higher than a first preset threshold value are stored in a full-reservation empirical pool, the empirical data with the current policy access larger than a second preset threshold value are reserved in a first-in first-out mode through a policy empirical pool, and mixed sampling is carried out according to a preset proportion; training a drug control model; and inputting the current turbidity value, the drug delivery amount of the last time step, the water inlet flow, the parameters of the water quality detection camera and the future turbidity value into a trained drug control model, and outputting the current drug delivery amount. Through prediction-control closed-loop integration, a raw water turbidity prediction result is fed back to the optimizer, and the method is suitable for real-time adaptive control of a sewage treatment system.

The invention belongs to the field of biomedical materials, and discloses a preparation method and application of a mesoporous polydopamine nano preparation loaded with ultra-small nano enzyme. The nano preparation takes mesoporous polydopamine nanoparticles as a carrier skeleton and is combined with ultra-small nano enzyme through an in-situ reaction: the mesoporous polydopamine nanoparticles can efficiently carry drugs and accurately deliver the drugs to inflammatory tissues such as psoriasis, gout, colitis and the like by virtue of a modified targeting ligand by virtue of high specific surface area, biocompatibility and modifiability; the ultra-small nano enzyme has catalytic activity of catalase and the like, and can remove active oxygen and relieve oxidative stress. The two components are combined to achieve a synergistic effect, so that the catalytic efficiency of the enzyme is improved by virtue of the characteristics of the carrier, the high activity of the enzyme under different conditions is maintained by virtue of the stability of the carrier, and the platform can synchronously realize targeted delivery, enzymatic treatment and drug controlled release, and has a wide application prospect in the fields of inflammatory disease intervention and wound repair. And an efficient, accurate and low-toxicity universal treatment strategy is provided for chronic inflammatory diseases.

The invention relates to the technical field of dental intelligent adjuvant therapy, and discloses an adjuvant therapy system and method for difficult-to-inverse suppurative periapical periodontitis, and the system comprises a multi-modal image fusion module which fuses CT / OCT images to generate a three-dimensional diagram, segments an infected region through a lightweight CNN, and outputs a probability diagram; the reinforcement learning debridement navigation module is used for optimizing the dentin injury risk by combining a biological membrane thickness dynamic planning path on the basis of a DDPG algorithm; the intelligent medicine control module is used for positioning a catheter according to an infection map, triggering medicine release by a pH / enzyme sensor and adjusting delivery pressure by PID; the biosensor monitoring module is used for detecting inflammatory factors, predicting the recurrence risk through LSTM, and triggering image rescanning and path updating when a threshold value is exceeded. Through multi-modal image fusion, reinforcement learning dynamic debridement navigation, microenvironment response type drug control and time sequence prediction closed-loop feedback, accurate elimination and relapse active inhibition of periapical periodontitis focuses are realized.

The invention provides a nano-drug delivery system for treating fatty liver based on liposome, exosome and metal organic framework synergistic targeting and a preparation method of the nano-drug delivery system, and relates to the technical field of novel nano-material preparation, the nano-drug delivery system comprises liposome, mesenchymal stem cell exosome and metal organic framework nanoparticles; the liposome is used as a carrier and entraps the metal organic framework nano-particles, the mesenchymal stem cell exosome and the miR-204-3p which have a slow release characteristic. By integrating the advantages of the liposome, the exosome and the metal organic framework, the synergistic treatment of the MASLD is realized. According to the system, lipidosome is adopted as an intelligent carrier, MOF nanoparticles and mesenchymal stem cell exosomes with slow release characteristics are entrapped, and therapeutic miR-204-3p is loaded at the same time. The MOF material has functions of drug controlled release and active oxygen removal, and synergistically exerts anti-oxidation, anti-inflammatory and anti-fibrosis effects with the exosome and miRNA. The system has a pH response characteristic, and can intelligently release drugs in an acidic microenvironment of an MASLD focus to realize targeted treatment of the liver.

The invention relates to the technical field of hydrogel microspheres, and particularly discloses hydrogel microspheres as well as a preparation method and application thereof. Sodium alginate and acrylamide are used for constructing a stable hydrogel skeleton structure with a certain mechanical property, and in a specific oil phase-hydrogel solution system, the release time and the release rate of Fe ions from an EDTA-Fe complex are accurately controlled by adjusting the pH value, so that the stability and the stability of the hydrogel are improved. The iron ions are released at proper time and rate and participate in the crosslinking reaction of the hydrogel, so that the hydrogel microspheres which are uniform in crosslinking, stable in performance and capable of accurately regulating and controlling the metal ions are prepared; besides, the lithium chloride can enhance the structural stability of a hydrogel network and adjust the plasticity of the hydrogel, so that the hydrogel is more flexible, and a uniform microsphere structure is favorably formed in the stirring and dispersing processes. The hydrogel microspheres prepared by the method have wide application prospects in the fields of drug controlled release, biosensing, environmental restoration and the like.

The invention discloses a preparation method and application of a myofibrillar protein emulsion based on enzymatic modification. According to the technology, a myofibrillar protein aqueous suspension is subjected to enzymatic deamidation and glycosylation reaction through protein glutaminase and glucan, a protein-polysaccharide compound with good emulsifying performance is constructed, soybean oil serves as an oil phase, and emulsion systems with different oil phase volume fractions are constructed through a controllable homogenizing technology. The obtained emulsion has the characteristics of natural degradability, excellent rheological property, uniform particle size distribution, long-term physical stability and the like. Compared with a traditional chemical modification technology, the technology adopts a whole bio-based raw material combined enzyme method green technology, the problems of organic solvent residues and the like are effectively solved, and the production cost is reduced while the product safety is ensured. The emulsion has remarkable application advantages in the fields of functional food active ingredient delivery, drug controlled release carriers, cosmetic transdermal absorption systems and the like, and a new thought is provided for development of a biomacromolecule-based delivery system.

The invention relates to the field of macromolecules, and discloses a polymer as well as a preparation method and application thereof. The polymer has a chemical structural unit as shown in a formula 1. Compared with polyester, the polymer disclosed by the invention has the characteristics of higher degradation rate in a water environment, large molecular weight and good heat resistance or mechanical property, and can be applied to the fields of degradable packaging materials, drug controlled release carriers and the like.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention discloses application of loganin and / or hydroxygenkwanin in preparation of an EGFR (epidermal growth factor receptor) inhibitor for treating inflammatory bowel diseases. Molecular docking experiments find that loganin and hydroxygenkwanin can be specifically bound with EGFR protein, the binding energy is lower than-5kcal / mol, and the loganin and hydroxygenkwanin can inhibit EGFR protein expression, block downstream RAS / ERK signal channels, relieve intestinal inflammation and repair mucosal barriers. Animal experiments show that in a DSS-induced UC mouse model, the pathological manifestation of a mouse can be remarkably improved by administration of loganin, and the effect of a 100mg / kg dose group is remarkably superior to that of a positive drug control. The two natural small molecule compounds are used for preparing the EGFR inhibitor for treating the inflammatory bowel disease for the first time, a low-toxicity and high-efficiency brand-new scheme is provided for IBD treatment, the problems of drug resistance and toxic and side effects of existing drugs are hopefully solved, and wide clinical application prospects are achieved.

The application discloses a preparation method of a temperature-ultraviolet light double response type functional polymer, specifically comprising the following steps: preparing a macromolecular initiator PEG2-ABCPA; preparing a p-styrylmethyl diethanolamine borate monomer VMAB; and performing a free radical polymerization reaction on the macromolecular initiator PEG2-ABCPA, the p-styrylmethyl diethanolamine borate monomer VMAB and 7-(4-vinylbenzyloxy)-4-methyl coumarin VBC to obtain a block copolymer, i.e. the temperature-ultraviolet light double response type functional polymer. The polymer not only has unique amphiphilic properties, but also exhibits double response to temperature and ultraviolet light, thereby showing wide application prospects in the fields of drug controlled release, intelligent materials, photoelectric devices and the like.

The application provides an antibacterial and anti-inflammatory drug controllable release hydrogel and a preparation method and application thereof, solves the problems of complex preparation process of photo-induced imine crosslinking hydrogel and lack of antibacterial and anti-inflammatory functions, and provides an effective way for treating chronic refractory wounds. The photo-crosslinking hydrogel designed in the application uses an amino-modified polymer derivative as a crosslinking matrix, and uses a double-branched small molecule compound as a crosslinking agent. The crosslinking system is simple to prepare, and can be quickly gelled under 395nm ultraviolet light. By further introducing a double-branched photo-crosslinking agent-antibacterial drug co-carrier and an anti-inflammatory drug slow-release particle into the above crosslinking system, the photo-crosslinking hydrogel of the application exhibits two drug release mechanisms of burst release of antibacterial drugs and slow release of anti-inflammatory drugs, thereby effectively solving the problems of bacterial infection in the early stage and chronic inflammation in the middle stage in the treatment process of chronic refractory wounds.

The invention belongs to the technical field of bioengineering, and provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, a preparation method and an application, aiming at the technical problem that complications are easily caused by the existing treatment means of endometriosis, so that the invention provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, and a preparation method and application of the drug-loaded targeted nano platform. According to the invention, the ZIF-8 nano-particles and the drugs aiming at the energy metabolism level are combined to be used as the carrier, so that endometriosis cells with acidic cell microenvironment can be targeted, drug controlled release can be realized in the acidic environment of lesions, and the effective uptake of the endometriosis cells to the drugs is enhanced, thereby effectively increasing the uptake rate and the drug concentration at the target position, and improving the curative effect of the drug on the endometriosis cells. Meanwhile, the distribution of the medicine in normal tissues or cells is reduced, and the toxic and side effects of the medicine are reduced; and through the design of combining the macrophages with the ZIF-8 nano-particle carrier, the drug targeting property of the ZIF-8 nano-particle carrier can be obviously improved.

The invention provides a preparation method of zinc ion polysaccharide spray hydrogel for treating psoriasis, which comprises the following steps: preparing a cationic polysaccharide solution, dissolving zinc ions into the cationic polysaccharide solution, and then filling into a spray bottle to form a solution A; preparing an anionic polysaccharide solution, and filling the anionic polysaccharide solution into another spray bottle to form a solution B; the solution A and the solution B are alternately sprayed on an affected part for multiple times, polysaccharide molecules in the solution A and the solution B are rapidly combined and cured through electrostatic interaction to form hydrogel to be adhered to the surface of skin, and a film is formed after moisture is volatilized to cover the affected part. The alternate spraying mode is adopted, and operation is easy and convenient; zinc ions and chitosan have synergistic anti-inflammatory and immunoregulation effects, the formed hydrogel has efficient drug controlled release and good skin adhesion, and the preparation method is mild and controllable.

The invention relates to preparation and application of a malignant tumor targeting gambogic acid preparation. An inner core-middle layer-shell three-layer structure is adopted, wherein the inner core is a gambogic acid-black phosphorus quantum dot compound and has chemical treatment and photo-thermal treatment functions; the middle layer is nano vesicles derived from frozen NK92 MI cells and provides natural immune targeting and killing ability; a shell is a hyaluronic acid chelate, and active targeting and pH / photo-thermal response type drug controlled release are achieved. The core of the preparation method is that a coaxial electrojet technology is adopted, three layers of materials are formed in one step, the process is efficient, and the preparation stability is good. The preparation can realize photo-thermal-chemical-immune triple synergistic treatment, has near-infrared fluorescence and photo-acoustic multimode imaging functions, effectively solves the problems of poor targeting property, large toxic and side effects and lack of real-time monitoring of traditional chemotherapy, and shows significant advantages and application potential in precise treatment and diagnosis of solid tumors.

This invention belongs to the field of biomedical technology, specifically relating to a drug control system based on the KFERQ sequence, its construction method, and its application. This drug control system is composed of a KFERQ sequence, an HCV-NS3 sequence, and a protein-targeting sequence recombined together. During recombination, the protein-targeting sequence is located at the N-terminus or C-terminus of the recombinant sequence. This invention provides a novel strategy for endogenous protein degradation by recombinating the KFERQ sequence with the HCV-NS3 sequence and the endogenous protein-targeting sequence, and utilizing the self-cleavage property of the HCV-NS3 protease to regulate the degradation of endogenous proteins.

The invention discloses a physiological index monitoring and drug delivery integrated system and an application thereof in wearable equipment, through integration of a microneedle array, a fluid chamber area, a piezoelectric sensing module, a drug controlled release module and a signal processing module, real-time monitoring of physiological indexes and automatic drug delivery are realized by using a double-chamber structure. The fluid chamber area is composed of a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber guide the flowing direction of a body fluid sample and medicine in a one-way mode through a microfluid channel and a one-way valve, and the first chamber is used for receiving and guiding the body fluid sample to the piezoelectric sensing module for physiological detection. The second chamber guides the medicine to the microneedle array for accurate delivery to realize real-time monitoring of physiological indexes and automatic medicine delivery, the piezoelectric sensing module guides a body fluid sample to the sensing unit and detects physiological parameters based on the acoustic surface wave effect, and the signal processing module controls the dosage of the medicine according to the detection result. And precise drug release is realized through the drug controlled release module.

The invention discloses a viscous tussah silk gland protein gel dressing with microenvironment response and antibacterial property and a preparation method thereof, N-isopropylacrylamide is polymerized to form poly-N-isopropylacrylamide through in-situ free radical polymerization, and meanwhile, the poly-N-isopropylacrylamide, tussah silk gland protein and sodium alginate form gel in a stable form through intermolecular interaction; on one hand, the gel dressing has good temperature-sensitive response performance and realizes intelligent drug controlled release, and on the other hand, the hydrogel can be well adhered to the skin surface, can promote growth and reproduction of human skin fibroblasts, shows good biocompatibility and mechanical properties, has better adhesion stress than commercial wound dressings, and has good application prospects. An application basis is provided for the application of the sodium alginate group in the intelligent medicine controlled release medical wound dressing; finally, the gel dressing is loaded with a natural antibacterial agent and Chinese herbal medicines, and has the effects of resisting bacteria, diminishing inflammation and the like at the affected part; therefore, the gel dressing disclosed by the invention has great application potential in the medical field.

The invention provides a porous tissue engineering scaffold with a drug controlled release function as well as preparation and application of the porous tissue engineering scaffold. The preparation method of the porous tissue engineering scaffold comprises the following steps: S1) preparing double-layer nanoparticles by PLGA-PEG; and S2) preparing a composite scaffold by a low-temperature 3D printing technology. The stent prepared by the method has efficient drug controlled release capability, excellent mechanical properties, good biocompatibility and controllable degradation. The optimized porous structure promotes cell proliferation and tissue regeneration, meanwhile, low-temperature printing keeps the stability and activity of materials and drugs, and the material is widely applied to the fields of bone tissue engineering, local drug delivery and the like and shows remarkable clinical application value and market potential.

The application discloses a targeted magnetic nano-composite of palygorskite, a preparation method and application thereof in preparation of an in-vitro drug controlled release medicine. In the application, an anti-tumor drug DOX is loaded through an acid-cleavable acylhydrazone bond, and the drug release rate is lower in a normal physiological environment and higher in a tumor acid environment compared with electrostatic adsorption and pore storage of the DOX with HPal, so that the drug controlled release performance is obviously improved. In addition, loading of magnetic Fe3O4 nanoparticles and grafting of FA enrich the means of transporting the DOX to a designated area by the carrier, that is, the tumor cells can be positioned by external magnetic field control or receptor-ligand interaction targeting. MTT analysis and cell uptake research prove the targeting effect of the FA, and the therapeutic effect of the DOX can be effectively improved.

The invention relates to the field of medicine informatization management, and discloses an informatization medicine accurate regulation and control method and system for hemodialysis anemia patients, and the method comprises the steps: randomly dividing the collected patient information into a research group and a control group, comparing and analyzing the treatment effect difference caused by the anemia index change of the two groups of patients, and determining the accuracy of the treatment effect. The anemia improvement effect is evaluated by analyzing the relationship between the anemia index level change before and after the adjustment of the drug dose and injection frequency of a research group patient, whether the drug regulation direction is correct or not is judged, and the drug dose and injection frequency are adjusted according to the anemia index level change in the body of the patient. According to the method, the drug dosage and the injection frequency are dynamically optimized, and the difference of patients in a research group and patients in a control group in the aspect of anemia index level improvement is analyzed based on a model prediction result, so that drug regulation is further tracked and monitored, the drug use process is accurately regulated, the treatment quality is improved, and the treatment cost is reduced. And the workload of medical staff is reduced.

The present invention discloses a functionalized platelet-based drug control system, its preparation method, and application, relating to the field of pharmaceutical technology. The drug control system comprises a functionalized platelet matrix, a chemotherapy drug loaded within the functionalized platelet matrix, and protein sphere nanoparticles grafted onto the surface of the functionalized platelet matrix. The present invention utilizes the advantages of platelets, such as their lack of nuclei, ability to serve as natural carriers, ability to evade macrophage phagocytosis, ability to target tumor cells, and good biosafety, to prepare a reduction-responsive functionalized platelet-based drug controlled-release system co-loaded with the chemotherapy drug DOX, the immunosuppressant Gal, and the enzyme HAase, a degrading enzyme for hyaluronic acid, a major component of ECM, to regulate combined chemotherapy and immunotherapy for tumors.

The invention discloses a drug controlled release system based on optimal drug delivery sequence optimization and a preparation method and application thereof, and belongs to the field of pharmaceutics. The preparation method comprises the following steps: preparing a docetaxel nano preparation, and preparing poloxamer F-127 gel by adopting a cold dissolving method; metformin is dissolved in PBS to prepare a metformin solution, poloxamer F-127 gel, the metformin solution and an aqueous solution of a docetaxel nano preparation are stirred and dispersed uniformly in proportion to a homogeneous sol state, and the drug controlled release system optimized based on the optimal drug delivery sequence is obtained. According to the innovatively designed drug controlled release system MD (at) Gel, based on drug molecular weight and hydrophilic and hydrophobic differences, the metformin released firstly can block tumor cells in a mitosis G2 / M region, and the anti-tumor effect of docetaxel is remarkably improved by improving the immunosuppression microenvironment of tumors. The invention provides an innovative administration strategy and implantable instrument support for sequential chemotherapy of solid tumors.

The invention discloses preparation and application of a supramolecular nano-micelle based on gossypol (GP). A preparation method comprises the following steps: (1) preparing a polymer PGP; (2) preparation of a polymer PGPP; and (3) preparing the PGPP supramolecular nano-micelle. The prepared micelle has the advantages of stable particle size, uniform dispersion, drug controlled release behavior, high drug loading capacity, low toxic and side effects, good biological safety and the like. The gossypol drug belonging to polyphenol has a certain anti-cancer effect but has toxic and side effects, and research shows that the toxic and side effects of gossypol on normal cells are reduced by modifying the aldehyde group on gossypol, and meanwhile, the gossypol drug has a certain anti-cancer effect but has toxic and side effects. The supramolecular nano-micelle is triggered by glutathione (GSH) and a pH microenvironment in cancer cells to realize double-response controllable release, so that gossypol is effectively enriched at a tumor site, the cancer cells are killed, and a new strategy and a systematic theoretical support are provided for development of a supramolecular prodrug delivery system.

The invention discloses photodegradable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of intelligent high polymer materials. The photodegradable hydrogel is formed by polymerizing a macromonomer containing a light-controlled bond breaking unit; wherein the macromonomer containing the light-controlled broken bond unit is formed by covalently connecting a macromolecular chain, a light response breaking functional group and a molecular fragment containing a catechol structure through a chemical bond. The preparation method specifically comprises the following steps: (1) synthesizing an intermediate A containing a photoresponse fracture functional group; (2) carrying out a coupling reaction with a molecular fragment containing a catechol structure; (3) carrying out a coupling reaction with a polymer chain containing an active functional group in a solvent under the catalytic action of a condensing agent; (4) dissolving in a dispersion medium; (5) dissolving an oxidizing agent in water; and (6) uniformly mixing, and standing to obtain the product. The photodegradable hydrogel disclosed by the invention is suitable for various scenes such as biological tissue adhesion, flexible electronic packaging, drug controlled release and implantable medical equipment.

The invention discloses a medicine patch and a medicine controlled release method, and belongs to the technical field of clinical medicine. The medicine patch comprises a substrate, a microneedle assembly arranged at the bottom of the substrate and a controlled release layer arranged at the top of the substrate, the controlled release layer can release medicine to the microneedle assembly layer at a first speed, then the microneedle assembly layer can penetrate through the cuticle of the skin and deliver the medicine to the corium layer of the skin, and diffusion of the medicine to the skin is completed; therefore, the medicine diffusion efficiency can be improved without depending on a chemical penetration enhancer, and skin irritation is avoided. And the controlled release layer can also control the first speed of releasing the medicine to the microneedle assembly layer according to the skin state, so that the effect of dynamically controlling the medicine release is realized.

The invention provides a composite membrane for vascular transplantation and a preparation method of the composite membrane. The composite membrane comprises stacked degradable coatings, the degradable coatings comprise a first degradable coating, a second degradable coating, a third degradable coating and a fourth degradable coating; each layer of degradable coating comprises a drug sustained-release matrix and a drug dispersed in the drug sustained-release matrix; the drug sustained-release matrix is a PVA (Polyvinyl Alcohol) film; the medicines comprise antibiotics and / or antibacterial agents. The composite membrane for vascular transplantation has good drug controlled release ability, has high anti-infection and anti-adhesion ability, is almost suitable for all types of vascular grafts, and breaks through the limitation of a coating technology in application.

The invention discloses an inhibitor-loaded oncolytic microgel as well as a preparation method and application thereof, and the inhibitor-loaded oncolytic microgel is an oncolytic microgel (OMG) with similar activity and immune activation capability to an oncolytic peptide, and can efficiently entrap an immune checkpoint inhibitor and realize adjustable drug sustained release so as to enhance the cancer immunotherapy effect. The oncolytic microgel can effectively maintain the biological activity of entrapped drugs and antibodies, and has wide application prospects in the fields of drug controlled release and the like. Meanwhile, single injection of OMG (P1C4-OMG) loaded with anti-PD-1 and anti-CTLA-4 in a tumor can effectively reverse an inhibitory tumor microenvironment, enhance anti-tumor immune response and realize a remarkable tumor inhibition effect and outstanding survival benefits, and the oncolytic microgel with the adjustable antibody release function is a safe and unique cancer immunotherapy platform.

The present application belongs to the environmental governance technical field, and particularly relates to a method for removing Microcystis aeruginosa by using rose Bengal. Rose Bengal is added in an environment containing Microcystis aeruginosa; the final concentration of rose Bengal is 5 mg / L-10 mg / L, and Microcystis aeruginosa is removed under visible light. After adding rose Bengal, the highest algae density can remove 85.37% of Microcystis aeruginosa; at 168 h, the effect of stably inhibiting Microcystis aeruginosa is still maintained. The present application discloses a mild drug control mode by using the characteristics of high singlet oxygen yield of RB to target damage the photosynthetic system and core metabolic pathway of Microcystis aeruginosa, and discloses a three-damage mechanism of physiological and biochemical, photosynthetic system and metabolic network of RB photodynamic algae inhibition.

The invention belongs to the technical field of medical instruments, and discloses a drug controlled release drainage device for intracranial hematoma, which comprises a drainage catheter, a catheter end, an auxiliary tube and a connecting cylinder, a drug storage tube is arranged in the catheter end, a plurality of groups of prefabricated micropores are formed in a sealing head of the drug storage tube, a drug delivery piston is arranged in the drug storage tube, and the drug storage tube is connected with one end of the auxiliary tube; a driven piston and a driving piston are arranged in the auxiliary pipe, a pipeline between the driven piston and the driving piston is filled with liquid, an adjusting valve is arranged, and a piston push rod on the driven piston is in contact with the dosing piston; a push plate and a lead screw are arranged in the connecting cylinder in a penetrating mode, a fixing rod on one side of the push plate makes contact with the driving piston, the push plate is connected with a compression spring, and the compression spring is connected with a moving block on the lead screw. The screw rod is rotated, the movable block extrudes the compression spring, pressure is stored, and during drug administration, drug administration can be stopped by opening the adjusting valve, pushing the driving piston through the push plate, synchronously moving all the pistons through liquid transmission, discharging the drug in the drug storage pipe and closing the adjusting valve.