59 results about "Drug control" patented technology

The invention belongs to the field of biomedical materials, and discloses a preparation method and application of a mesoporous polydopamine nano preparation loaded with ultra-small nano enzyme. The nano preparation takes mesoporous polydopamine nanoparticles as a carrier skeleton and is combined with ultra-small nano enzyme through an in-situ reaction: the mesoporous polydopamine nanoparticles can efficiently carry drugs and accurately deliver the drugs to inflammatory tissues such as psoriasis, gout, colitis and the like by virtue of a modified targeting ligand by virtue of high specific surface area, biocompatibility and modifiability; the ultra-small nano enzyme has catalytic activity of catalase and the like, and can remove active oxygen and relieve oxidative stress. The two components are combined to achieve a synergistic effect, so that the catalytic efficiency of the enzyme is improved by virtue of the characteristics of the carrier, the high activity of the enzyme under different conditions is maintained by virtue of the stability of the carrier, and the platform can synchronously realize targeted delivery, enzymatic treatment and drug controlled release, and has a wide application prospect in the fields of inflammatory disease intervention and wound repair. And an efficient, accurate and low-toxicity universal treatment strategy is provided for chronic inflammatory diseases.

The invention relates to the field of macromolecules, and discloses a polymer as well as a preparation method and application thereof. The polymer has a chemical structural unit as shown in a formula 1. Compared with polyester, the polymer disclosed by the invention has the characteristics of higher degradation rate in a water environment, large molecular weight and good heat resistance or mechanical property, and can be applied to the fields of degradable packaging materials, drug controlled release carriers and the like.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention discloses application of loganin and / or hydroxygenkwanin in preparation of an EGFR (epidermal growth factor receptor) inhibitor for treating inflammatory bowel diseases. Molecular docking experiments find that loganin and hydroxygenkwanin can be specifically bound with EGFR protein, the binding energy is lower than-5kcal / mol, and the loganin and hydroxygenkwanin can inhibit EGFR protein expression, block downstream RAS / ERK signal channels, relieve intestinal inflammation and repair mucosal barriers. Animal experiments show that in a DSS-induced UC mouse model, the pathological manifestation of a mouse can be remarkably improved by administration of loganin, and the effect of a 100mg / kg dose group is remarkably superior to that of a positive drug control. The two natural small molecule compounds are used for preparing the EGFR inhibitor for treating the inflammatory bowel disease for the first time, a low-toxicity and high-efficiency brand-new scheme is provided for IBD treatment, the problems of drug resistance and toxic and side effects of existing drugs are hopefully solved, and wide clinical application prospects are achieved.

The application discloses a preparation method of a temperature-ultraviolet light double response type functional polymer, specifically comprising the following steps: preparing a macromolecular initiator PEG2-ABCPA; preparing a p-styrylmethyl diethanolamine borate monomer VMAB; and performing a free radical polymerization reaction on the macromolecular initiator PEG2-ABCPA, the p-styrylmethyl diethanolamine borate monomer VMAB and 7-(4-vinylbenzyloxy)-4-methyl coumarin VBC to obtain a block copolymer, i.e. the temperature-ultraviolet light double response type functional polymer. The polymer not only has unique amphiphilic properties, but also exhibits double response to temperature and ultraviolet light, thereby showing wide application prospects in the fields of drug controlled release, intelligent materials, photoelectric devices and the like.

The application provides an antibacterial and anti-inflammatory drug controllable release hydrogel and a preparation method and application thereof, solves the problems of complex preparation process of photo-induced imine crosslinking hydrogel and lack of antibacterial and anti-inflammatory functions, and provides an effective way for treating chronic refractory wounds. The photo-crosslinking hydrogel designed in the application uses an amino-modified polymer derivative as a crosslinking matrix, and uses a double-branched small molecule compound as a crosslinking agent. The crosslinking system is simple to prepare, and can be quickly gelled under 395nm ultraviolet light. By further introducing a double-branched photo-crosslinking agent-antibacterial drug co-carrier and an anti-inflammatory drug slow-release particle into the above crosslinking system, the photo-crosslinking hydrogel of the application exhibits two drug release mechanisms of burst release of antibacterial drugs and slow release of anti-inflammatory drugs, thereby effectively solving the problems of bacterial infection in the early stage and chronic inflammation in the middle stage in the treatment process of chronic refractory wounds.

The invention belongs to the technical field of bioengineering, and provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, a preparation method and an application, aiming at the technical problem that complications are easily caused by the existing treatment means of endometriosis, so that the invention provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, and a preparation method and application of the drug-loaded targeted nano platform. According to the invention, the ZIF-8 nano-particles and the drugs aiming at the energy metabolism level are combined to be used as the carrier, so that endometriosis cells with acidic cell microenvironment can be targeted, drug controlled release can be realized in the acidic environment of lesions, and the effective uptake of the endometriosis cells to the drugs is enhanced, thereby effectively increasing the uptake rate and the drug concentration at the target position, and improving the curative effect of the drug on the endometriosis cells. Meanwhile, the distribution of the medicine in normal tissues or cells is reduced, and the toxic and side effects of the medicine are reduced; and through the design of combining the macrophages with the ZIF-8 nano-particle carrier, the drug targeting property of the ZIF-8 nano-particle carrier can be obviously improved.

The invention relates to preparation and application of a malignant tumor targeting gambogic acid preparation. An inner core-middle layer-shell three-layer structure is adopted, wherein the inner core is a gambogic acid-black phosphorus quantum dot compound and has chemical treatment and photo-thermal treatment functions; the middle layer is nano vesicles derived from frozen NK92 MI cells and provides natural immune targeting and killing ability; a shell is a hyaluronic acid chelate, and active targeting and pH / photo-thermal response type drug controlled release are achieved. The core of the preparation method is that a coaxial electrojet technology is adopted, three layers of materials are formed in one step, the process is efficient, and the preparation stability is good. The preparation can realize photo-thermal-chemical-immune triple synergistic treatment, has near-infrared fluorescence and photo-acoustic multimode imaging functions, effectively solves the problems of poor targeting property, large toxic and side effects and lack of real-time monitoring of traditional chemotherapy, and shows significant advantages and application potential in precise treatment and diagnosis of solid tumors.

The invention discloses a physiological index monitoring and drug delivery integrated system and an application thereof in wearable equipment, through integration of a microneedle array, a fluid chamber area, a piezoelectric sensing module, a drug controlled release module and a signal processing module, real-time monitoring of physiological indexes and automatic drug delivery are realized by using a double-chamber structure. The fluid chamber area is composed of a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber guide the flowing direction of a body fluid sample and medicine in a one-way mode through a microfluid channel and a one-way valve, and the first chamber is used for receiving and guiding the body fluid sample to the piezoelectric sensing module for physiological detection. The second chamber guides the medicine to the microneedle array for accurate delivery to realize real-time monitoring of physiological indexes and automatic medicine delivery, the piezoelectric sensing module guides a body fluid sample to the sensing unit and detects physiological parameters based on the acoustic surface wave effect, and the signal processing module controls the dosage of the medicine according to the detection result. And precise drug release is realized through the drug controlled release module.

The invention provides a porous tissue engineering scaffold with a drug controlled release function as well as preparation and application of the porous tissue engineering scaffold. The preparation method of the porous tissue engineering scaffold comprises the following steps: S1) preparing double-layer nanoparticles by PLGA-PEG; and S2) preparing a composite scaffold by a low-temperature 3D printing technology. The stent prepared by the method has efficient drug controlled release capability, excellent mechanical properties, good biocompatibility and controllable degradation. The optimized porous structure promotes cell proliferation and tissue regeneration, meanwhile, low-temperature printing keeps the stability and activity of materials and drugs, and the material is widely applied to the fields of bone tissue engineering, local drug delivery and the like and shows remarkable clinical application value and market potential.

The invention provides a composite membrane for vascular transplantation and a preparation method of the composite membrane. The composite membrane comprises stacked degradable coatings, the degradable coatings comprise a first degradable coating, a second degradable coating, a third degradable coating and a fourth degradable coating; each layer of degradable coating comprises a drug sustained-release matrix and a drug dispersed in the drug sustained-release matrix; the drug sustained-release matrix is a PVA (Polyvinyl Alcohol) film; the medicines comprise antibiotics and / or antibacterial agents. The composite membrane for vascular transplantation has good drug controlled release ability, has high anti-infection and anti-adhesion ability, is almost suitable for all types of vascular grafts, and breaks through the limitation of a coating technology in application.

The invention discloses an inhibitor-loaded oncolytic microgel as well as a preparation method and application thereof, and the inhibitor-loaded oncolytic microgel is an oncolytic microgel (OMG) with similar activity and immune activation capability to an oncolytic peptide, and can efficiently entrap an immune checkpoint inhibitor and realize adjustable drug sustained release so as to enhance the cancer immunotherapy effect. The oncolytic microgel can effectively maintain the biological activity of entrapped drugs and antibodies, and has wide application prospects in the fields of drug controlled release and the like. Meanwhile, single injection of OMG (P1C4-OMG) loaded with anti-PD-1 and anti-CTLA-4 in a tumor can effectively reverse an inhibitory tumor microenvironment, enhance anti-tumor immune response and realize a remarkable tumor inhibition effect and outstanding survival benefits, and the oncolytic microgel with the adjustable antibody release function is a safe and unique cancer immunotherapy platform.

The present application belongs to the environmental governance technical field, and particularly relates to a method for removing Microcystis aeruginosa by using rose Bengal. Rose Bengal is added in an environment containing Microcystis aeruginosa; the final concentration of rose Bengal is 5 mg / L-10 mg / L, and Microcystis aeruginosa is removed under visible light. After adding rose Bengal, the highest algae density can remove 85.37% of Microcystis aeruginosa; at 168 h, the effect of stably inhibiting Microcystis aeruginosa is still maintained. The present application discloses a mild drug control mode by using the characteristics of high singlet oxygen yield of RB to target damage the photosynthetic system and core metabolic pathway of Microcystis aeruginosa, and discloses a three-damage mechanism of physiological and biochemical, photosynthetic system and metabolic network of RB photodynamic algae inhibition.

The invention belongs to the technical field of medical instruments, and discloses a drug controlled release drainage device for intracranial hematoma, which comprises a drainage catheter, a catheter end, an auxiliary tube and a connecting cylinder, a drug storage tube is arranged in the catheter end, a plurality of groups of prefabricated micropores are formed in a sealing head of the drug storage tube, a drug delivery piston is arranged in the drug storage tube, and the drug storage tube is connected with one end of the auxiliary tube; a driven piston and a driving piston are arranged in the auxiliary pipe, a pipeline between the driven piston and the driving piston is filled with liquid, an adjusting valve is arranged, and a piston push rod on the driven piston is in contact with the dosing piston; a push plate and a lead screw are arranged in the connecting cylinder in a penetrating mode, a fixing rod on one side of the push plate makes contact with the driving piston, the push plate is connected with a compression spring, and the compression spring is connected with a moving block on the lead screw. The screw rod is rotated, the movable block extrudes the compression spring, pressure is stored, and during drug administration, drug administration can be stopped by opening the adjusting valve, pushing the driving piston through the push plate, synchronously moving all the pistons through liquid transmission, discharging the drug in the drug storage pipe and closing the adjusting valve.

The invention discloses macroporous silicon dioxide microspheres as well as a preparation method and application thereof, and belongs to the technical field of nano high-tech materials. The main aperture of the silicon dioxide microsphere is about 100nm, the primary particle size is 50nm, the agglomerated particle size D50 is 100mu m, and the specific surface area is gt; the pore volume is 1.0 to 1.75 cm / g. According to the preparation method, rice hull-based high-purity sodium silicate with the modulus of 3.25 and carbon dioxide are used as main raw materials, and the designed core technology is that a double-template system composed of polystyrene microspheres and a macromolecular block copolymer is adopted, and under specific conditions, processes such as carbon dioxide carbonization gel, spray drying granulation, oil-phase thermocuring and programmed roasting are used. The rice hull-based green high-tech material obtained by the method has the advantages of mild reaction process, good controllability of aperture and particle size, and high mechanical strength of the product. The macroporous silica microspheres prepared by the method are particularly suitable for the fields of drug controlled release systems, biological macromolecule chromatographic separation, immobilized enzyme carriers, high-performance catalyst carriers and the like.

The invention discloses a self-generating controlled-drug-release surgical suture for promoting healing of diabetic wounds and a preparation method and application of the self-generating controlled-drug-release surgical suture. The preparation method comprises the following steps: respectively preparing PVDF and PLLA nanofibers through an electrostatic spinning process, curling a nanofiber membrane by taking the PVDF fibers as an inner core until the surface of the nanofiber membrane is completely covered with one or more layers of PLLA nanofibers, and then enhancing the fiber orientation and mechanical strength through hot stretching to obtain the composite fiber inner core with excellent performance and piezoelectric effect. The silk fibroin solution and the sodium alginate solution are mixed, metformin hydrochloride is added, the mixture is evenly mixed and then coated on the composite fiber inner core, and finally the absorbable surgical suture with the metformin-loaded sodium alginate / silk fibroin gel coating is obtained through ionic crosslinking treatment. The suture has the triple functions of mechanical suture, electrical stimulation treatment and drug controlled release, can remarkably improve the closing speed and healing quality of diabetic wound surfaces, and has a wide application prospect.

The invention discloses ultrasonic response type modular acoustic printing ink, a printing platform and application of the printing platform, and relates to the technical field of biomedical engineering and biological manufacturing. The ultrasonic response element is a hollow nanocage formed by fluoridized silk fibroin, and the critical response sound pressure can be set by regulating and controlling the fluorination degree; the modular acoustic printing ink comprises the ultrasonic response element, a biopolymer prepolymer matrix and an optional functional additive. The printing platform integrates a focused ultrasonic transducer, an ink applying device, an ultrasonic imaging module and a control system. An ultrasonic triggering mode is adopted, the depth limitation of traditional photocuring printing is broken through, minimally invasive in-situ printing of subcutaneous deep tissue of several centimeters is achieved, high temporal-spatial resolution, good biocompatibility and mechanical adaptability are achieved, the functions of electric conduction, medicine carrying and the like can be flexibly achieved, the method is suitable for biological electrode preparation, visceral wound plugging, medicine controlled release and other scenes, and the application prospect is wide. And a novel tool is provided for precision medical treatment.

The application discloses a kind of temperature response degradable polymer and preparation method thereof, the polymer is the terpolymer P (AAm-co-MI-co-MDO) of AAm, MI and MDO.It is prepared by the radical ring-opening polymerization of RAFT control, and is reacted in DMSO after being purified with initiator AIBN, chain transfer reagent CDSPA.The critical solubility temperature characteristics are given to polymer by hydrogen bond interaction between AAm and MI unit, and by changing monomer molar ratio, polymer phase transition temperature can be controlled in 20~65 ℃ interval;Meanwhile, the ring-opening rate of MDO is increased to more than 85% by using the donor-acceptor copolymerization effect of MI and MDO, and the hydrolyzable ester bond is efficiently embedded in the main chain to realize degradability.The polymer has temperature response and controllable degradability, and the synthesis method is simple and efficient, which has application potential in the field of drug controlled release, tissue engineering and other biomedical fields.

This invention provides a modular injectable dynamic hydrogel, its preparation method, and its applications, belonging to the field of medical preparation technology. By designing specific preparation schemes and combining different functional modules, this invention successfully obtained a series of injectable dynamic hydrogels with tunable performance. These hydrogels generally possess good injectability and self-healing capabilities, ensuring their convenience in minimally invasive surgery and structural integrity after implantation. Simultaneously, by adjusting the types and ratios of modules, the degradation rate, cell adhesion, and specific biological functions of the hydrogel can be precisely controlled, all exhibiting excellent biocompatibility and reactive oxygen species scavenging capabilities. This invention broadens the applicability of single hydrogel systems, enabling them to flexibly adapt to various differentiated medical scenarios, from drug controlled release and nerve repair to tissue regeneration, providing an efficient platform for the development of personalized and functional biomaterials.

The application discloses a kind of Zaijieliu extract / chitosan composite nanometer film and preparation method thereof.The method uses traditional Chinese medicine Zaijieliu extract as raw material, carboxymethyl chitosan as film forming agent, and aldehyde sodium alginate as microcoagulant, to prepare Zaijieliu extract / chitosan composite nanometer film by combining film casting technology and solvent evaporation method.The preparation method is simple, low in cost, avoids the use of toxic chemical crosslinking agent, and the prepared Zaijieliu extract / chitosan composite nanometer film material has good mechanical properties, hydrophilicity, stability and drug release performance, and has wide application prospect in wound repair, drug controlled release and tissue engineering.

The invention belongs to the technical field of medicines, and discloses choline glycerophosphate-carboxymethyl-beta-cyclodextrin as well as a preparation method and application thereof. The glycerophosphorylcholine-carboxymethyl-beta-cyclodextrin is prepared by the following steps: introducing nitrogen into glycerophosphorylcholine, sealing, melting at 137-142 DEG C to obtain molten glycerophosphorylcholine, adding carboxymethyl-beta-cyclodextrin and a catalyst, and reacting at the temperature of 137-142 DEG C to obtain the glycerophosphorylcholine-carboxymethyl-beta-cyclodextrin. And adding distilled water for dissolving after the reaction, separating out a product by using an organic solvent, washing, filtering, and drying in vacuum to obtain the product. The glycerophosphorylcholine-carboxymethyl-beta-cyclodextrin has a cyclodextrin cavity structure and good solubility, can improve the bioavailability of indissolvable drugs, contains a phosphorylcholine chain segment, has good biocompatibility, and has good application potential in the field of drug controlled release or drug solubilization.

The invention relates to the technical field of biological medicines, in particular to an ATP (adenosine triphosphate) response type multifunctional DNA (deoxyribonucleic acid) immune nano-drug as well as preparation and application thereof. The ATP response type multifunctional DNA immune nano-drug provided by the invention has a DNAzyme nano-structure with a cascade response function, and a gene therapy module and an immune therapy module are organically integrated into the same delivery system; accurate drug controlled release can be achieved, and the targeted accumulation efficiency of tumor tissue is remarkably improved; and meanwhile, by integrating DDR1 gene silencing and immune regulation functions, two key links of a tumor physical barrier and an immune barrier are synergistically acted. The multi-target collaborative intervention strategy not only effectively improves the permeability of the medicine in the tumor tissue, but also enhances the therapeutic response by remodeling the tumor immune microenvironment.

This utility model discloses a drug mixing device for water treatment, belonging to the field of wastewater treatment technology. The device includes a mixing mechanism, a drug control mechanism fixedly installed at the upper end of the mixing mechanism, and a drug inlet mechanism fixedly installed on the outer side of the drug control mechanism. The drug control mechanism includes a drug tank, with a reagent inlet on the left outer side of the tank, a powder inlet on the front outer side of the tank, and a water inlet on the right outer side of the tank. A motor is installed at the upper end of the tank, and a rotating shaft is installed at the lower end of the motor. An impeller is connected to the front end of the rotating shaft, and a slide is connected to the lower end of the impeller. This drug mixing device for water treatment, by setting up the impeller and slide, pre-dissolves the added drug and allows it to slide orderly into the mixing pipe along the slide, making the drug addition more uniform and improving the uniformity of wastewater treatment.

The invention discloses a dual-network hydrogel microneedle with a photo-thermal conversion function and a preparation method and application thereof, and belongs to the field of biological materials.The preparation method comprises the steps that firstly, sulfobetaine metacrylic acid ester and hydroxyethyl methylacrylate are subjected to cross-linking polymerization to form a first network hydrogel microneedle preform; 2, the first network hydrogel microneedle preform is sequentially soaked in a chitosan solution, a dopamine hydrochloride solution and an oxidizing agent solution, dopamine hydrochloride is subjected to oxidative polymerization in the oxidizing agent solution to form polydopamine, and the first network hydrogel microneedle preform is obtained; the polydopamine and the chitosan penetrating into the first network hydrogel microneedle preform are subjected to a cross-linking reaction, a second network is formed in situ inside and on the surface of the first network hydrogel microneedle preform, and the double-network hydrogel microneedle is obtained. The microneedle disclosed by the invention has the advantages of high strength, high photothermal conversion efficiency, good drug controlled release capability, capability of shielding harmful light and the like.

The invention discloses a Spartina alterniflora drug control technology, and relates to the technical field of coastal wetland ecological management, the early stage of bud differentiation of Spartina alterniflora is monitored through dynamic opportunity selection, and the soil salinity is adjusted by selecting a time window 2 hours after ebb tide and with a sunny day probability greater than 80% in combination with tide forecast. The method comprises the following steps: preparing a composite synergistic agent containing 25% imazapyr, soya bean lecithin, sodium humate and other materials, uniformly spraying the composite synergistic agent to leaf surface and root soil of plants by adopting high-pressure atomization equipment after ebb tide, supplementing an agent containing double nano titanium dioxide in case of rainfall, and reducing environmental interference and improving agent absorption efficiency through tide synergy and salinity adjustment; the adhesive force and the durability are enhanced through the synergistic effect of all the components in the composite agent; high-pressure atomization is combined with a calculation model to ensure uniform deposition of liquid medicine at the rhizome junction; the cloudy and rainy emergency mechanism dynamically responds to sudden weather, and the control continuity is maintained, so that the overall control effect, the resource utilization rate and the environmental adaptability are improved.

The invention discloses a photoelectric microneedle system with bionic electrical stimulation and drug controlled release functions, comprising: a silicon film which is a silicon film array of two different doping types; the hydrogel microneedle is arranged on the surface of the silicon film, and the hydrogel microneedle contains medicine. By arranging semiconductor films with different polarities in an array mode, a photo-generated electric field with the adjustable direction can be generated under illumination, the direction of the photo-generated electric field is kept consistent with an endogenous electric field formed after tissue damage, and therefore wireless, accurate and controllable bionic electrical stimulation is achieved. Different doping types of semiconductor films generate different-direction electric fields under illumination, and directional migration and on-demand release of drug molecules with different charge properties can be realized. The photogenerated electric field not only can simulate and enhance endogenous electric signals after skin injury and regulate and control cell migration, proliferation and reconstruction processes, but also can synchronously drive drugs to be accurately released from the microneedle hydrogel.

The invention discloses a flexible cross-linked polyester material as well as a preparation method and application thereof, relates to the technical field of biomedical polymer materials, and overcomes the defects of the existing PPDO-PDLLA material in the aspects of flexibility, thermal responsiveness, dimensional stability and the like. The preparation method comprises the following steps: mixing PPDO-PDLLA-diol polyol with diisocyanate, and enabling excessive-NCO to react with-OH, so as to obtain a polyurethane prepolymer of which the end group is-NCO; after a chain extension reaction, polyurethane containing-NCO end groups is obtained; the preparation method comprises the following steps: reacting polyurethane containing-NCO terminal groups with an acrylate compound containing hydroxyl to obtain vinyl functionalized polyurethane, and blending and dispersing the vinyl functionalized polyurethane with PPDO-PDLLA to obtain a blend; and carrying out irradiation crosslinking on the blend to obtain the flexible crosslinked polyester material. The method can be applied to preparation of medical positioning devices, drug controlled release systems, soft tissue engineering scaffolds, flexible implants and intelligent medical materials.