167 results about "Drug control" patented technology

The invention relates to the technical field of livestock medicine management and control, in particular to a medicine delivery system based on livestock veterinary epidemic prevention, and the system comprises a data collection and fluctuation rate analysis module which is used for collecting livestock farm environment data and animal health data, aggregating the environment data and the health data layer by layer in a recursive layering manner, and obtaining a multi-level livestock farm data set, calculating the change range of the animal health data in the multi-level data set, determining the range of volatility, and generating abnormal fluctuation mark data. According to the method and the system, the environmental data and the animal health parameters of the livestock farm are subjected to recursive hierarchical aggregation, so that the fluctuation condition of the data is comprehensively monitored. By marking the high fluctuation item with the abnormal fluctuation range exceeding the safety threshold, the potential epidemic disease risk can be quickly identified. By referring to influence factors of high fluctuation items on epidemic disease occurrence and dynamically adjusting risk values, the system can reflect potential influences of changes of environment and health conditions on epidemic disease transmission in real time.

The invention discloses a sewage treatment drug delivery control method based on reinforcement learning and particle swarm optimization, and the method achieves the precise control of turbidity and the optimization of drug cost through the dynamic adjustment of particle swarm parameters and the fusion of a reinforcement learning strategy. According to the technical scheme, the method comprises the following steps: combining a PSO algorithm with a DDPG algorithm to construct a drug control model; designing a reward function; the empirical data with the state coverage rate higher than a first preset threshold value are stored in a full-reservation empirical pool, the empirical data with the current policy access larger than a second preset threshold value are reserved in a first-in first-out mode through a policy empirical pool, and mixed sampling is carried out according to a preset proportion; training a drug control model; and inputting the current turbidity value, the drug delivery amount of the last time step, the water inlet flow, the parameters of the water quality detection camera and the future turbidity value into a trained drug control model, and outputting the current drug delivery amount. Through prediction-control closed-loop integration, a raw water turbidity prediction result is fed back to the optimizer, and the method is suitable for real-time adaptive control of a sewage treatment system.

The invention provides a bionic flexible force sensor based on a tenon-and-mortise structure and a high-performance medical patch material, belongs to the technical field of biomedical engineering, and can be used for multiple organ tissues such as myocardium and skin. The bionic flexible force sensor is provided with an upper base and a lower base; the upper base and the lower base are of a concave-convex interlocking tenon-and-mortise structure. A plurality of convex tenons are designed on the bottom surface of the upper base, a plurality of concave mortises corresponding to the tenons are designed on the top surface of the lower base, and the tenons and the mortises are precisely matched to form stable locking; the tenons and the mortises are connected through buckle structures, and sliding and loosening are prevented. The bionic flexible force sensor is integrated and fixed on the surface or inside the medical patch through a micro-adhesion technology. A renewable wood-based enhanced visible light 3D printing technology is adopted, and nanofibers, nanocrystals and composite nanoparticles are combined, so that the patch material has excellent mechanical properties, electrical conductivity and drug controlled release property.

The invention relates to the field of wound dressings and the field of flexible strain sensors, in particular to an intelligent wound dressing with drug controlled release and motion detection functions and a preparation method of the intelligent wound dressing. The wound dressing comprises thermoplastic polyurethane, liquid metal, lauric acid and curcumin, a TPU elastic material serves as a substrate, the liquid metal serves as a photo-thermal agent and a sensor flexible circuit part, the motion monitoring function can be achieved, and good biocompatibility is achieved; lauric acid is used as a thermal phase change material, curcumin is used as a bioactive drug, and photo-thermal response drug controlled release is achieved; the intelligent wound dressing with photo-thermal drug controlled release and motion monitoring functions is prepared by combining electrostatic spinning, electrostatic spraying and template printing technologies, and has a wide application prospect in the field of wound dressings.

The invention discloses a pesticide spraying control method and device, electronic equipment and a storage medium. The method is applied to a main controller of a vehicle pesticide spraying control system and comprises the steps that in the pesticide spraying work process, driving parameters and pesticide spraying work parameters of a pesticide spraying vehicle are collected, and the driving parameters comprise the driving speed and the vehicle position; according to the running speed and the pesticide spraying operation parameters, the real-time theoretical pesticide spraying amount and the real-time actual pesticide spraying amount at the current moment are determined; controlling the opening degree of a proportional control valve of the pesticide spraying control system according to the deviation between the real-time theoretical pesticide spraying amount and the real-time actual pesticide spraying amount so as to adjust the pesticide spraying flow; and according to the vehicle position, determining an abnormal condition of an actual pesticide spraying operation area, and according to the abnormal condition of the actual pesticide spraying operation area, correspondingly controlling to close a spraying rod of the pesticide spraying control system. According to the technical scheme, the pesticide spraying control precision is improved, and thus the pesticide spraying operation quality is improved.

The present invention relates to the field of intelligent control technology, and specifically to an intelligent dosing control method and system for a sewage treatment plant based on carbon neutrality. The method comprises: collecting a pH value data sequence, taking the average of the noise levels of all extreme points between any two extreme points as the noise level between any two extreme points, setting the initial interpolation density of the extreme point sequence, adaptively adjusting the initial interpolation density using the noise level to obtain the interpolation density between any two extreme points, performing interpolation fitting between any two extreme points using the adjusted interpolation density to generate upper and lower envelopes, performing subsequent denoising based on the envelope to obtain a denoised data sequence, predicting future pH values ​​based on the denoised data sequence, and controlling the input amount of a pH regulator, thereby improving the denoising effect. Based on the high-quality denoised data, the system can provide more accurate pH value prediction and control of the input amount of a reagent.

The invention discloses an exosome engineered targeted drug delivery system and a preparation method and application thereof, and belongs to the field of biomedices.The exosome engineered targeted drug delivery system is prepared by mixing and reacting surface modified exosome and pH response type drug controlled release nanoparticles; the pH response type drug controlled release nanoparticles react with the surface modified exosome through a click chemical reaction; the surface of the membrane of which the surface is modified with the exosome is modified with a maleimide group and an azide group; the novel nano-drug has pH responsiveness; the click chemical reaction is thiol-ene click reaction. Bifunctional groups (MAL and N3) are directionally grafted on the surface of an exosome membrane, uniform drug particles are prepared in combination with a micro-fluidic technology, an efficient bimodal targeting drug delivery system is successfully constructed, and remarkable technical advantages are shown in the aspects of improving targeting precision, enhancing antitumor activity, controlling drug release, inhibiting tumor metastasis and the like; and a new technical approach is provided for precise treatment of adenoid cystic carcinoma.

The invention belongs to the technical field of hydrogel preparation, and relates to a cartilage-imitating multifunctional drug release hydrogel material and a preparation method thereof. According to the invention, biocompatible high polymer materials such as polyvinyl alcohol, chitosan, grape seed protein, acyl chloride, sulphobetaine methacrylate and lecithin are used as raw materials, a cartilage structure is simulated to prepare the multilayer hydrogel, gelatin and plant polyphenol are mixed as an adhesive to improve the binding capacity with subosseous bones, and a drug is loaded to improve the biological activity. The preparation method of the hydrogel material comprises the five steps of preparation of high-strength anti-swelling precursor hydrogel, introduction of double bonds through surface modification, introduction of a poly SBMA molecular brush through interfacial polymerization, drug loading and preparation of an adhesion layer. The hydrogel has excellent anti-swelling ability, lubricating property, anti-pollution ability, free radical scavenging ability, self-adhesion characteristic, drug controlled release ability and biocompatibility, and has important significance for widening the application of the hydrogel in the field of artificial cartilage.

The invention discloses a method for testing the non-inferior performance of a new drug when curative effect data obeys partial normal distribution, aiming at the condition that the curative effect data obeys partial normal distribution, the non-inferior performance of the new drug is tested so as to determine the non-inferior performance of the new drug relative to a standard drug, and meanwhile, the reliability of a detection result is ensured. The method comprises the following steps: S1, acquiring drug curative effect data in clinical tests: in a three-arm non-inferior clinical test, based on drug curative effect indexes, respectively acquiring drug curative effect data of three groups of clinical test results of a new drug group, a standard drug control group and a placebo control group, the curative effect data obeying partial normal distribution; s2, probability calculation of first-class errors: in the three-arm non-inferior hypothesis test model, a frequency method or a Bayesian method is used to calculate the drug curative effect data of the three groups of test results to obtain the probability of first-class errors, and the probability of first-class errors is the probability of occurrence of a standby hypothesis H1 when an original hypothesis H0 is established; and S3, non-inferior determination of the new drug: if the probability of making the first type of errors is greater than a given reference value, determining that the new drug has non-inferior relative to the standard drug, and the reference value is a critical value which is given in advance and has clinical significance.

The invention belongs to the field of biomedical materials, and discloses a preparation method and application of a mesoporous polydopamine nano preparation loaded with ultra-small nano enzyme. The nano preparation takes mesoporous polydopamine nanoparticles as a carrier skeleton and is combined with ultra-small nano enzyme through an in-situ reaction: the mesoporous polydopamine nanoparticles can efficiently carry drugs and accurately deliver the drugs to inflammatory tissues such as psoriasis, gout, colitis and the like by virtue of a modified targeting ligand by virtue of high specific surface area, biocompatibility and modifiability; the ultra-small nano enzyme has catalytic activity of catalase and the like, and can remove active oxygen and relieve oxidative stress. The two components are combined to achieve a synergistic effect, so that the catalytic efficiency of the enzyme is improved by virtue of the characteristics of the carrier, the high activity of the enzyme under different conditions is maintained by virtue of the stability of the carrier, and the platform can synchronously realize targeted delivery, enzymatic treatment and drug controlled release, and has a wide application prospect in the fields of inflammatory disease intervention and wound repair. And an efficient, accurate and low-toxicity universal treatment strategy is provided for chronic inflammatory diseases.

The invention discloses a preparation method and application of oxidative stress microenvironment response intelligent semi-conversion hydrogel, and belongs to the technical field of biological medicine. According to the preparation method disclosed by the invention, a therapeutic drug can be wrapped in the drug and placed in a local injury part, and a large amount of ROS released by oxidative stress in the early stage of spinal cord injury (SCI) is responded, so that conversion from a gel state to a semi-gel sol state is realized, and explosive release of the drug is caused while the ROS is consumed; the medicine treatment concentration is quickly reached in the acute stage of SCI; after the SCI oxidative stress period, ROS release is reduced, and under the action of in-vivo reducing substances, the hydrogel can be recovered from a semi-sol-gel state to a gel state, so that long-term slow release of to-be-released drugs is realized, and later-stage neural restoration of SCI is promoted; through the conversion from the gel state to the semi-sol gel state to the gel state, intelligent drug controlled release responding to oxidative stress can be achieved, and therefore the optimal SCI treatment effect is achieved.

The invention relates to the technical field of dental intelligent adjuvant therapy, and discloses an adjuvant therapy system and method for difficult-to-inverse suppurative periapical periodontitis, and the system comprises a multi-modal image fusion module which fuses CT / OCT images to generate a three-dimensional diagram, segments an infected region through a lightweight CNN, and outputs a probability diagram; the reinforcement learning debridement navigation module is used for optimizing the dentin injury risk by combining a biological membrane thickness dynamic planning path on the basis of a DDPG algorithm; the intelligent medicine control module is used for positioning a catheter according to an infection map, triggering medicine release by a pH / enzyme sensor and adjusting delivery pressure by PID; the biosensor monitoring module is used for detecting inflammatory factors, predicting the recurrence risk through LSTM, and triggering image rescanning and path updating when a threshold value is exceeded. Through multi-modal image fusion, reinforcement learning dynamic debridement navigation, microenvironment response type drug control and time sequence prediction closed-loop feedback, accurate elimination and relapse active inhibition of periapical periodontitis focuses are realized.

The invention provides a nano-drug delivery system for treating fatty liver based on liposome, exosome and metal organic framework synergistic targeting and a preparation method of the nano-drug delivery system, and relates to the technical field of novel nano-material preparation, the nano-drug delivery system comprises liposome, mesenchymal stem cell exosome and metal organic framework nanoparticles; the liposome is used as a carrier and entraps the metal organic framework nano-particles, the mesenchymal stem cell exosome and the miR-204-3p which have a slow release characteristic. By integrating the advantages of the liposome, the exosome and the metal organic framework, the synergistic treatment of the MASLD is realized. According to the system, lipidosome is adopted as an intelligent carrier, MOF nanoparticles and mesenchymal stem cell exosomes with slow release characteristics are entrapped, and therapeutic miR-204-3p is loaded at the same time. The MOF material has functions of drug controlled release and active oxygen removal, and synergistically exerts anti-oxidation, anti-inflammatory and anti-fibrosis effects with the exosome and miRNA. The system has a pH response characteristic, and can intelligently release drugs in an acidic microenvironment of an MASLD focus to realize targeted treatment of the liver.

The invention discloses a drug controlled release layer-by-layer self-assembly nano hydrogel boron carrying agent and application thereof, and belongs to the technical field of biomedicine. According to the method, calcium alginate nano-particles, calcium alginate nano-particles modified by polyallylamine hydrochloride, calcium alginate nano-particles modified by boric acid and polyallylamine hydrochloride, and calcium alginate nano-particles modified by polyallylamine hydrochloride, boric acid and polyallylamine hydrochloride are prepared in sequence. According to the invention, boric acid is loaded into the layer-by-layer self-assembled nano hydrogel material, so that intelligent controlled release can be realized, and the material is applied to boron neutron capture therapy. The material has good water solubility, good dispersity in an aqueous solution, small size and uniform particle size. The material also has good biocompatibility, intelligent and accurate release control is realized, and important technical progress is brought to cancer treatment.

The invention relates to the technical field of hydrogel, in particular to protein powder and a preparation method thereof, and hydrogel wound dressing and a preparation method thereof. The invention provides protein powder. The protein powder is prepared from the following components: giant salamander collagen freeze-dried powder, a natural eutectic solvent and water, the mass ratio of the giant salamander collagen freeze-dried powder to the natural eutectic solvent is 1: (45-55); the mass volume ratio of the giant salamander collagen freeze-dried powder to the water is 1g: (5-15) mL. The invention further provides the hydrogel wound dressing, the hydrogel wound dressing has good antibacterial performance and anti-inflammatory performance, has the effects of wound monitoring and drug controlled release, and can effectively improve the healing state of a wound.

The invention discloses a clean coal flotation reagent regulation and control method and a reagent regulation and control system thereof.The method comprises the steps that in the clean coal flotation process, an image sample file is recorded by a visual module; the central processing module processes the sample file to obtain a flotation state judgment reference set; performing size calculation on a plurality of foam objects in the flotation state judgment reference set, and drawing a foam size distribution proportion diagram of the generated sample unit; then comprehensively judging the flotation effect in a sampling time period according to the uniformity change trend of a foam layer, the thickness change trend of the foam layer, the relative proportion condition of foam objects in an ideal foam size range in each sample unit and the foam stability in a plurality of continuous sample units, and calculating to obtain an agent adjustment addition amount; and the medicine adding adjusting module adjusts and controls the medicine adding amount in real time according to the obtained medicine adjusting adding amount. The agent adding amount can be regulated and controlled according to the real-time dynamic change of the foam layer, so that the flotation effect and stability are improved.

The invention relates to the technical field of hydrogel microspheres, and particularly discloses hydrogel microspheres as well as a preparation method and application thereof. Sodium alginate and acrylamide are used for constructing a stable hydrogel skeleton structure with a certain mechanical property, and in a specific oil phase-hydrogel solution system, the release time and the release rate of Fe ions from an EDTA-Fe complex are accurately controlled by adjusting the pH value, so that the stability and the stability of the hydrogel are improved. The iron ions are released at proper time and rate and participate in the crosslinking reaction of the hydrogel, so that the hydrogel microspheres which are uniform in crosslinking, stable in performance and capable of accurately regulating and controlling the metal ions are prepared; besides, the lithium chloride can enhance the structural stability of a hydrogel network and adjust the plasticity of the hydrogel, so that the hydrogel is more flexible, and a uniform microsphere structure is favorably formed in the stirring and dispersing processes. The hydrogel microspheres prepared by the method have wide application prospects in the fields of drug controlled release, biosensing, environmental restoration and the like.

Intelligent control of patient-controlled drug delivery is disclosed. An infusion control device detects a patient-controlled drug request device in operable communication with the infusion control device. The infusion control apparatus identifies a sensor apparatus in operable communication with the infusion control apparatus and a drug delivery device separate from the infusion control apparatus. The infusion control device selects a drug control algorithm for approving a drug request received by a patient-controlled drug request device. The infusion control device identifies a patient using a patient-controlled drug request device and receives patient physiological data from a sensor device. The infusion control apparatus receives a request for a medicament to be delivered to a patient by a medicament delivery device. The infusion control device determines whether the patient is authorized to perform the medication request. And based on a determination that the patient is authorized, the infusion control device causes delivery of the medicament to the patient.

The invention discloses a preparation method and application of a myofibrillar protein emulsion based on enzymatic modification. According to the technology, a myofibrillar protein aqueous suspension is subjected to enzymatic deamidation and glycosylation reaction through protein glutaminase and glucan, a protein-polysaccharide compound with good emulsifying performance is constructed, soybean oil serves as an oil phase, and emulsion systems with different oil phase volume fractions are constructed through a controllable homogenizing technology. The obtained emulsion has the characteristics of natural degradability, excellent rheological property, uniform particle size distribution, long-term physical stability and the like. Compared with a traditional chemical modification technology, the technology adopts a whole bio-based raw material combined enzyme method green technology, the problems of organic solvent residues and the like are effectively solved, and the production cost is reduced while the product safety is ensured. The emulsion has remarkable application advantages in the fields of functional food active ingredient delivery, drug controlled release carriers, cosmetic transdermal absorption systems and the like, and a new thought is provided for development of a biomacromolecule-based delivery system.

The invention relates to the field of macromolecules, and discloses a polymer as well as a preparation method and application thereof. The polymer has a chemical structural unit as shown in a formula 1. Compared with polyester, the polymer disclosed by the invention has the characteristics of higher degradation rate in a water environment, large molecular weight and good heat resistance or mechanical property, and can be applied to the fields of degradable packaging materials, drug controlled release carriers and the like.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The invention belongs to the technical field of internet big data, and particularly relates to a method for screening same-name and same-party drug control drugs, which comprises the following steps: S1, acquiring basic information of listed drugs, performing data processing and standardization processing, and storing the basic information into a database A; s2, acquiring and processing admission-related data of drugs, and storing the data into a database B; s3, taking medicine names as keywords, and respectively matching basic data and access related data of each medicine from the database A and the database B; establishing a medicine entry of each medicine in the database C, and integrating the matched basic information of the medicine and the admission related data into the corresponding medicine entry; s4, according to research and development requirements of the same-name and same-prescription medicines, establishing screening conditions of the same-name and same-prescription control medicines; screening the data in the database C according to the screening conditions to obtain the same-name and same-prescription control drug data meeting the use requirements; the method can be used for rapidly and accurately screening out the same-name and same-prescription control drugs meeting various conditions.

The invention relates to the technical field of medical instruments, in particular to a closed anesthesia nasal mask. According to the technical scheme, the device comprises an anesthesia nose mask and further comprises an attaching unit, the attaching unit comprises flexible sealing gaskets, the flexible sealing gaskets are symmetrically connected to the anesthesia nose mask in a sliding mode, a medicine control unit is arranged above the anesthesia nose mask and comprises a medicine control pipe, the anesthesia nose mask is communicated with the medicine control pipe, and the medicine control pipe is connected with the attaching unit in a sliding mode. A mounting ring is connected to one side of the pesticide control pipe, and a rotating frame is rotationally connected into the mounting ring. Through the design of the flexible sealing gasket, sealing between the anesthesia nasal mask and the skin around the nose of a patient can be achieved, and therefore the situation that when the patient inhales, external air enters the anesthesia nasal mask, and the anesthetic absorbing efficiency of the patient is reduced is effectively prevented; the throughput of the anesthetic can be accurately adjusted according to the breathing speed of the patient, so that the patient is assisted to quickly stabilize the emotion.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention discloses application of loganin and / or hydroxygenkwanin in preparation of an EGFR (epidermal growth factor receptor) inhibitor for treating inflammatory bowel diseases. Molecular docking experiments find that loganin and hydroxygenkwanin can be specifically bound with EGFR protein, the binding energy is lower than-5kcal / mol, and the loganin and hydroxygenkwanin can inhibit EGFR protein expression, block downstream RAS / ERK signal channels, relieve intestinal inflammation and repair mucosal barriers. Animal experiments show that in a DSS-induced UC mouse model, the pathological manifestation of a mouse can be remarkably improved by administration of loganin, and the effect of a 100mg / kg dose group is remarkably superior to that of a positive drug control. The two natural small molecule compounds are used for preparing the EGFR inhibitor for treating the inflammatory bowel disease for the first time, a low-toxicity and high-efficiency brand-new scheme is provided for IBD treatment, the problems of drug resistance and toxic and side effects of existing drugs are hopefully solved, and wide clinical application prospects are achieved.

The application discloses a preparation method of a temperature-ultraviolet light double response type functional polymer, specifically comprising the following steps: preparing a macromolecular initiator PEG2-ABCPA; preparing a p-styrylmethyl diethanolamine borate monomer VMAB; and performing a free radical polymerization reaction on the macromolecular initiator PEG2-ABCPA, the p-styrylmethyl diethanolamine borate monomer VMAB and 7-(4-vinylbenzyloxy)-4-methyl coumarin VBC to obtain a block copolymer, i.e. the temperature-ultraviolet light double response type functional polymer. The polymer not only has unique amphiphilic properties, but also exhibits double response to temperature and ultraviolet light, thereby showing wide application prospects in the fields of drug controlled release, intelligent materials, photoelectric devices and the like.

The present invention relates to the technical field of contaminated groundwater treatment, and in particular to a self-adaptive intelligent dosing purification control system and method for contaminated groundwater. By acquiring groundwater quality parameters in real time, the pumping and dosing rates are intelligently adjusted according to monitoring data through a reinforcement learning model, so as to achieve real-time response to water quality changes and avoid unstable treatment effects and secondary pollution. The system uses a preset drug matching database to quickly identify excessive water quality parameters and intelligently match agents, accurately calculate the proportion of agent addition based on the degree of excess, and achieve precise dosing through a metering pump device. The reinforcement learning model takes water quality monitoring data, dosing treatment effects, pumping rates, dosing rates, and output and discharge rates as inputs, and outputs the optimal pumping and dosing control strategy through continuous learning and optimization. The dosing strategy is adjusted in real time according to water quality changes, effectively solving the problems of unstable treatment effects, waste of agents, and high costs in traditional contaminated groundwater treatment systems.

The application provides an antibacterial and anti-inflammatory drug controllable release hydrogel and a preparation method and application thereof, solves the problems of complex preparation process of photo-induced imine crosslinking hydrogel and lack of antibacterial and anti-inflammatory functions, and provides an effective way for treating chronic refractory wounds. The photo-crosslinking hydrogel designed in the application uses an amino-modified polymer derivative as a crosslinking matrix, and uses a double-branched small molecule compound as a crosslinking agent. The crosslinking system is simple to prepare, and can be quickly gelled under 395nm ultraviolet light. By further introducing a double-branched photo-crosslinking agent-antibacterial drug co-carrier and an anti-inflammatory drug slow-release particle into the above crosslinking system, the photo-crosslinking hydrogel of the application exhibits two drug release mechanisms of burst release of antibacterial drugs and slow release of anti-inflammatory drugs, thereby effectively solving the problems of bacterial infection in the early stage and chronic inflammation in the middle stage in the treatment process of chronic refractory wounds.

The invention relates to an aspirin sustained-release tablet and a preparation method, belongs to the technical field of medicines, and adopts three dissolution modes for cooperative use to carry out gradient step-by-step controlled release. One group is composed of celery stem dry powder, xanthan gum and ethyl cellulose, and the acetylsalicylic acid with the mass percentage of 40%-50% is subjected to controlled release; the hydroxypropyl methylcellulose, the chitosan and the beta-cyclodextrin form a group and are used for simultaneously carrying out controlled release on 40-50% by mass of acetylsalicylic acid and the rest 50-60% by mass of acetylsalicylic acid; isomaltooligosacharide and resistant dextrin form a group, and the outermost layer of the group is coated with granules, so that the dissolution speed of all acetylsalicylic acid is delayed; in addition, the corn starch is added as a disintegrating component, and the proper addition of the corn starch can prevent the drug from being dissolved out too slowly, so that the drug dissolution amounts in the early and middle stages are ensured; all the components are matched for use, so that the stable controlled release speed of the medicine can be ensured, the problem that the dissolution speed is too high or too low in a certain time period is avoided, and the preparation is safer and more reliable.

The invention belongs to the technical field of bioengineering, and provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, a preparation method and an application, aiming at the technical problem that complications are easily caused by the existing treatment means of endometriosis, so that the invention provides a drug-loaded targeted nano platform for targeted delivery of ZIF-8 drug-loaded nanoparticles by macrophages, and a preparation method and application of the drug-loaded targeted nano platform. According to the invention, the ZIF-8 nano-particles and the drugs aiming at the energy metabolism level are combined to be used as the carrier, so that endometriosis cells with acidic cell microenvironment can be targeted, drug controlled release can be realized in the acidic environment of lesions, and the effective uptake of the endometriosis cells to the drugs is enhanced, thereby effectively increasing the uptake rate and the drug concentration at the target position, and improving the curative effect of the drug on the endometriosis cells. Meanwhile, the distribution of the medicine in normal tissues or cells is reduced, and the toxic and side effects of the medicine are reduced; and through the design of combining the macrophages with the ZIF-8 nano-particle carrier, the drug targeting property of the ZIF-8 nano-particle carrier can be obviously improved.