578 results about "Drug control" patented technology

The invention discloses a preparation method of multiple cross-linked polysaccharide injectable hydrogel. Modified water-soluble chitosan with carboxyl or hydroxyl groups as a first component and a hydroformylation-modified polysaccharide polymer or polysaccharide polymer mixer as a second component produce electrostatic action with each other and undergo a Schiff-base reaction to produce the hydrogel with a multiple cross-linked net structure. The multiple cross-linked polysaccharide injectable hydrogel has gelling time of 5-200s and has good mechanical properties. Through change of a chitosan and polysaccharide modification rate, a mole ratio of two components and solid content of hydrogel, gelling time, mechanical strength, microscopic morphology and water content are adjusted and controlled. The gel network contains a large amount of amino, carboxyl and aldehyde groups as active groups, the active groups can be bonded to drugs and proteins by covalent bonds, the multiple cross-linked polysaccharide injectable hydrogel as a novel medical material with excellent biocompatibility has a good application prospect in the fields of regeneration medical science, tissue engineering and drug controlled release.

The invention discloses a cellulose fiber-supported nano silver antibacterial material and a preparation method thereof. The preparation method comprises the steps of: conducting chemical pretreatment on cellulose fibers, then conducting TEMPO (2, 2, 6, 6-tetramethylpiperidine-1-oxyl) selective oxidization on the cellulose fibers, and finally on the premise that not any reducing agent is added, enabling the oxidized cellulose fibers to react with silver nitrate in silver nitrate water solution through a short-time microwave heating method to prepare the cellulose fiber-supported nano silver antibacterial material with small-diameter and even-structure nano silver particles. By adopting the preparation method, on the premise that not any reducing agent is added, in-situ reduction and growth of nano silver on carboxylated cellulose fiber supporters are realized. The prepared cellulose fiber-supported nano silver antibacterial material has the advantages of small nano grain size and even size, and can be widely applied to the fields of antibacterial operation clothes, wound dressing, drug controlled release, textile coating and the like.

The invention provides a polymeric hydrogel grafted on fibers by calcium ion crosslinking and a preparation method thereof. The polymeric hydrogel comprises the following components in percentage by mass: 3-8% of sodium polyacrylate grafted fiber, 0.96-4% of sodium alginate, 0-2% of water-solubility polymeric additive, 0.96-8% of calcium chloride and 75-95% of deionized water. The preparation method comprises the following steps: grafting polyacrylic acid on fibers by ultraviolet radiation; neutralizing with sodium hydroxide to obtain sodium polyacrylate-grafted fibers; soaking sodium polyacrylate-grafted fibers in an aqueous sodium alginate solution; taking out and scraping off the superabundant adherent viscous solution; and crosslinking in an aqueous calcium chloride solution to obtain the calcium alginate hydrogel grafted on the fibers. The preparation method is simple to operate, and the prepared polymeric hydrogel grafted on fibers has application prospects in the fields of adsorption separation, drug control and release, immobilized enzyme, tissue engineering and the like.

The invention relates to a method for preparing multifunctional three-layer core-shell structure micro/nano particles. The particles are of spherical structures, the thickness of each shell layer is controllable, multiple materials or medicines having different properties can be effectively and independently coated simultaneously, multifunctional characteristic compounding can be realized by adding functional auxiliary materials into each phase, the advantages of multilayer core-shell structures and excellent optical, electrical, magnetic, acoustic and biological characteristics are integrated into a whole, drug controlled release and medical contrast imaging application can be realized, and particularly the core-shell structure has excellent application prospects in the aspects of disease treatment and medical imaging. The preparation method is a coaxial electrostatic spraying method, the process and equipment are simple, the generated particles are controllable in forms, the particle size, shape and core-shell thickness of the obtained core-shell structure particles can be controlled by changing the operating parameters, the particle size is uniform, and the core-shell structure has good application prospects. In addition, the core-shell structure particles can serve as a precursor for preparing a hollow and special ring structure.

The invention discloses a preparation method of graphene oxide/poly(N-isopropylacrylamide) composite hydrogel. The preparation method comprises the steps of: firstly, placing the graphene oxide in water and ultrasonically dispersing the graphene oxide for 30-60 min to obtain a graphene oxide colloidal solution; then adding N-isopropylacrylamide, a cross-linking agent and an initiator 1 in the graphene oxide colloidal solution; stirring for dissolving so as to obtain a mixed solution; then inflating nitrogen in the mixed solution to deoxidize fully, then adding an initiator 2 in the deoxidized mixed solution, mixing uniformly and placing the mixture in a thermostatic water bath at 25+/-1 DEG C so as to obtain the graphene oxide/poly(N-isopropylacrylamide) composite hydrogel. The graphene oxide/poly(N-isopropylacrylamide) composite hydrogel prepared by the method disclosed by the invention has the advantages of good temperature responsiveness and mechanical property and wide application prospect in the biomedical field (such as tissue engineering and drug controlled release).

The invention relates to a preparation method of inorganic/organic multi-drug controlled release composite nano fiber scaffold, which includes the steps of preparing drug loading nanoparticle with particle size of 5-500 nm, preparing mixed solution of high molecular polymer and drug, adding multiple drug loading nanoparticles into the polymer solution, ultrasonically stirring, and carrying out electrostatic spinning to obtain inorganic/organic multi-drug controlled release composite nano fiber scaffold with diameter of 50-800 nm. The preparation method provided by the invention has the advantages of mild reaction conditions, simple operation, and easy experimental apparatus, and is in favor or large-scale production; the obtained multi-drug controlled release composite nano fiber scaffold has good stability and good biocompatibility and biodegradability, and can be stored for a long period of time, and the degradation product is non-toxic. The inorganic/organic multi-drug controlled release composite nano fiber scaffold can be widely applied in the fields of tissue engineering, biomedical engineering, drug therapy and the like.

Thermosensitive liposomes encapsulating paramagnetic iron oxide nanoparticles are used as a drug controlled release system. Paramagnetic iron oxide nanoparticles are used to generate heat by applying alternative magnetic field to cause leakage of drugs in the liposomes.

The invention relates to a porous material and a method for preparing the same and discloses a method for preparing a silk fibroin three-dimensional porous material. The method comprises the following steps of: slowly concentrating a water solution of silk fibroin, uniformly mixing the water solution of silk fibroin with alcohol, and freezing and drying the misture to directly obtain a water-insoluble silk fibroin porous support material; regulating and controlling the secondary structure and the mechanical properties of the porous support by selectively using after-treatment means, and controlling the porosity, the pore diameter and the like of the porous material by changing the parameters of silk fibroin concentration, freezing temperature and the like; and finally, soaking the silk fibroin porous support material in water to remove alcohol. The invention has mild preparation process conditions, no addition of any cross-linking agent, any hole making agent and other toxic organic solvents, simple, convenient and controllable process and easy realization of industrialization; the biocompatibility of silk fibroin can be effectively maintained, and the silk fibroin can be applied to the tissue repair of bone, cartilage, anadesma, nerves, skin and the like, the drug controlled-release carriers and the like.

The invention provides a collagen matrix freezing gel used for biomedical materials and a preparation method thereof. The collagen matrix freezing gel is the collagen extracted from skins or tendons of healthy domestic animals using the enzyme method with the molecular weight of 280 to 320kDa and a well maintained triple helical structure; the collagen reacts for 1 to 7 days in the condition of low temperature of 0 to minus 50 DEG C in a die after through cross linked and modified reaction with hydroformylation polysaccharide, then extrudes the die and is defrosted, thus forming the collagen matrix freezing gel. The preparation of the collagen matrix freezing gel of the invention in particular relates to the extraction of the collagen, the preparation of the hydroformylation polysaccharide and the synthesis of hydroformylation polysaccharide-collagen matrix freezing gel. The hydroformylation polysaccharide-collagen matrix freezing gel prepared by the invention improves the mechanical property, thermal stability and anti-enzyme degradation, etc., of pure collagen gels, and the freezing gel has the advantages of porosity, plasticity, hydrophilic property and non-toxicity, and can be used as biomedical materials such as bio-scaffold, cell cultivation, drug controlled release and biological dressings.

The invention discloses a preparation method of electrical stimulation-near infrared dual response high strength hydrogel. The preparation method comprises the following steps: with taking a thermosensitive polymer monomer as a main raw material, adding a natural polymer to prepare thermosensitive deformable hydrogel with a semi-interpenetrating network structure; and then sequentially adsorbing an oxidizing agent and a pyrrole monomer by utilizing the swelling effect of the hydrogel so that the pyrrole monomer sufficiently permeates into a hydrogel network and is oxidized into polypyrrole by the oxidizing agent. Due to the introduction of polypyrrole, the prepared hydrogel has conductivity and near-infrared responsibility. When the hydrogel is in an energized state or is irradiated by near infrared light, temperature of the hydrogel rises, and the thermosensitive polymer network in the hydrogel structure contracts, so that volume and shape change, and light-electricity dual stimulation response is realized; meanwhile, stimulation response behaviour of the hydrogel has good sensitivity. The prepared hydrogel also has good mechanical properties and biocompatibility and can be applied to multiple fields of drug controlled release systems, memory element switches and the like.

The invention discloses applications of multi-component super-molecule hydrogel as a stress response material and a self-healing material. The hydrogel consists of a component with a strong hydrogen bond, a component with a weak hydrogen bond and water, wherein the component with the strong hydrogen bond is one or more of a carbon oxide nano tube, graphene oxide, carboxylic ferroferric oxide nano particles, carboxylic silver nano particles, carboxylic quantum dots, polyacrylic acid, polypropylene glycol, polyurethane, polyamide and poly(sodium-p-styrenesulfonate); and the component with the weak hydrogen bond is a small molecule compound or a macromolecular compound. The hydrogel provided by the invention simultaneously has multiple response and self-healing functions, and environment-dependent reversible adhesion behavior, and can be importantly applied to the fields of sensors, actuators, drug controlled release, self-healing materials, photo-thermal therapy, movable smart adhesion agents and artificial joints.

The invention relates to a preparation method of chitosan microcapsule with uniform size and controllable size using a microfluidic device based on gas-liquid shearing principle. The preparation method specifically comprises the steps: firstly assembling the microfluidic device, then introducing a chitosan or chitosan quaternary ammonium salt solution as an internal phase, and a gas as an external phase into the microfluidic device, under the strong shearing action of the gas, forming micro-droplets by the internal phase solution at an outlet of the microfluidic device, dripping the micro-droplets into receptor fluid of an anionic surfactant or polyanion electrolyte, and precipitating and condensing chitosan or chitosan quaternary ammonium salt to form a layer of polymer film shell on outer layers of the micro-droplets, thus finally obtaining the chitosan microcapsule. The chitosan microcapsule prepared by the preparation method is regular in shape and uniform in size distribution, the size of the microcapsule can be effectively controlled by changing flow velocity conditions, and the preparation process is convenient and easy, and strong in operability. The obtained microcapsule can be used in the fields of active material microencapsulation and drug controlled release.

The invention discloses carboxymethyl chitosan quaternary ammonium salt/PAMAM(Polyamidoamine) core-shell nanoparticles and a preparation method. The nanoparticles are chitosan derivatives which are formed in a way that amino-terminated polyamidoamine dendritic macromolecule is grafted with carboxymethyl chitosan quaternary ammonium salt, and the chitosan derivatives are self-aggregated to form core-shell nanoparticles in water solution. The preparation method comprises the following steps: performing quaterisation decoration to amino at a second position of chitosan by CTA (3-Chloro-2-hydroxypropyltrimethyl ammonium chloride); performing carboxymethyl decoration to hydroxy at a sixth position of chitosan quaternary ammonium salt to synthetize carboxymethyl chitosan quaternary ammonium salt; activating carboxyl of the carboxymethyl chitosan quaternary ammonium salt by using NHS(N-Hydroxysuccinimide)/EDC(carbodiimide) to link the amino-terminated polyamidoamine dendritic macromolecule to synthetize the dendritic chitosan derivatives. The preparation process condition is simple and mild, and the product is easy to purify; and the core-shell nanoparticles of the prepared dendritic chitosan derivatives have the advantages of excellent water-solubility and functionality and has the attractive application prospect in the fields of antibiosis, gene transfer and drug controlled release.

The invention relates to a novel preparation method for a monodisperse porous polymer nano microcapsule. The porous polymer nano microcapsule is prepared by the steps: self-assembly of a polymer core microsphere and an amino modified silica crown microsphere which have different particle sizes is carried out to obtain a strawberry-shaped core-crown microsphere as a template for next step polymerization, and a core-shell composite microsphere is prepared; and the polymer microcapsule with a porous structure is obtained through etching and dialyzing the core-shell composite microsphere. The size of an internal cavity of the obtained microcapsule is controllable in the range of 500-1500 nm, the diameter of pores on the wall is controllable in the range of 30-150 nm, the wall thickness is controllable in the range of 20-100 nm, and especially the microcapsule size is monodisperse. The preparation method has the characteristics of simple equipment and controllable operation, and allows the product to be pure and monodisperse and to have uniform pore diameter. The porous polymer microcapsule can be used as a carrier widely applied in drug control release, coatings, micro-reactors, selective catalysis, composite materials and separation and other fields; and moreover, the porous polymer microcapsule also has extremely important value in cell-like structure construction, disease diagnosis, target treatment and the like.

The invention provides a method for preparing a temperature-responsive adhesive injectable hydrogel. The method comprises the following steps: synthesizing a temperature-responsive polymer with different dopamine contents from dopamine methacrylamide used as an adhesive monomer and ethyl 2-(2-methoxyethoxy)methacrylate and oligo(ethylene glycol)methyl ether methacrylate as temperature-sensitive monomers, and carrying out enzyme catalytic crosslinking on the polymer and a dopamine group under the catalysis of horseradish peroxidase and hydrogen peroxide to prepare the temperature-responsive adhesive hydrogel. The hydrogel prepared in the invention has the characteristics of fastness in gel formation, realization of in-situ injection molding, realization of regulating the gelation time and the gel strength by regulating the concentrations of the polymer, horseradish peroxidase and hydrogen peroxide, and convenience in use; and the adhesion strength of the hydrogel is enhanced with the rising of the temperature, so the temperature-responsive characteristic makes the obtained hydrogel applied to fields of tissue adhesives, wound dressings, cell culture media and drug controlled releasecarriers.

The invention discloses a metal-doped hollow mesoporous silicon oxide nanosphere and a preparation method thereof. The nanosphere is characterized in that a doped metal element is one or two or more of group IIIA elements, group IVA elements, group VA elements, transition metals and rare earth metals in the periodical table, and a molar ratio of the doped metal element to silicon atoms is 0.01-0.2; and the nanosphere has a uniform two-dimensional hexagonal porous structure, the particle size is 60-200nm, the cavity diameter is 40-180nm, the spherical wall thickness is 10-30nm, the aperture of mesopores is 2.0-4.0nm, the specific surface area is 600-1600m<2>.g<-1>, and the pore volume is 2.0-4.0cm<3>.g<-1>. The metal doped hollow mesoporous silicon oxide nanosphere material can be directly synthesized through a sol-gel technology without a hard template, so etching and other post-treatment steps are avoided, thereby the preparation method has the advantages of simple process, mild conditions, cheap raw materials, high reaction efficiency, strong operability and easy industrial production. The hollow mesoporous nanosphere prepared in the invention has a highly ordered mesoporous structure and a large pore volume, so internal and external transportation and storage of guest molecules are facilitated, and the nanosphere can be used in catalysis, adsorption, separation an drug controlled release processes.

The invention belongs to the field of polymer material and biomedical engineering and in particular relates to a method for preparing temperature-sensitive amphipathic graft copolymer with chitosan as the main chain. The method comprises the following steps: with the protection of inert gases such as nitrogen and argon, hydroxide group or aminogroup in chitosan main chain are adopted to trigger ring opening polymerization of cyclic ester monomer; then the obtained terminal hydroxide group or aminogroup of aliphatic polyester are converted to bromine group; the bromine group is taken as macroinitiator to polymerize atomic transfer radical of N-isopropyl acrylamide, hydrophilic allyl monomer, thus obtaining the needed product. The temperature-sensitive amphipathic graft copolymer with chitosan as the main chain is provided with biological degradability, biocompatibility, biological activity and temperature sensibility, can be automatically assembled into stable nano micelle in water, thus enjoying wide application in fields such as drug controlled release carrier, soft tissue engineering support material, immunoassay, memory element switch, biosensor and the like. The synthetic method of the invention is simple and feasible, the raw materials can all be applied to industrialized production, thus enjoying very good value in popularization and application.

The invention relates to a monodisperse surface functionalized polymer microsphere resin and a preparation method thereof. The polymer microsphere resin is a gel polyene monomer homopolymer having a cross linking degree more than 30%, or a copolymer microsphere formed through a polyene monomer and a compound selected from other functional monoene monomers, and has a particle size of 300 nm to 5 [mu]m, a dispersity of 1.010-1.082. The polymer microsphere resin is prepared through a precipitation polymerization initiated through an iniferter; the microsphere surface has iniferter active groups (a content range from 0.05-0.3 mmol/g ) so as to be further subjected to surface modifications. The method provided by the present invention has characteristics of simple conditions, easy operation, cheap raw materials and controllable surface functional group content. The prepared monodisperse surface functionalized nanometer/micrometer polymer microsphere can be applicable for a filling material of a chromatographic column, drug controlled release and carriers for catalysts and bioactive molecules.

The invention relates to injectable silk fibroin-alginate double cross-linking hydrogel which comprises a solution A: a silk fibroin solution and a solution B: a modified alginate solution, wherein the solution A comprises the following components in parts by weight: 1.0*10<-1>-3.0 parts of silk fibroin, 1.4*10<-3>-2.0*10<-3> part of a divalent metal ion cross-linking agent, and the balance of water containing 1-5wt% of silk fibroin; the solution B comprises the following components in parts by weight: 5.0*10<-1>-4.0 parts of alginate, 2.5*10<-3>-4.0*10<-1> part of a carboxyl activating cross-linking agent and the balance of water containing 1-5wt% of alginate. By adopting a double cross-linking method of covalent cross-linking and ion cross-linking, the double cross-linking hydrogel is quick to polymerize in situ and has an application prospect in the fields such as engineering stents, drug controlled release and regenerative medicines. The invention further provides a preparation method and a use method of the double cross-linking hydrogel.

The invention relates to a phase change material microcapsule coating method and application. The method adopts cellulose nanocrystal stabilized Pickering emulsion as the template, and carries out Pickering emulsion polymerization, or sol-gel reaction, etc. to prepare a shell of organic polymer or inorganic oxide, thus realizing coating of an organic phase change material, and obtaining an organicpolymer or inorganic oxide coated organic phase change material microcapsule. The microcapsule with coated phase change material can be applied to buildings, textiles, hot compress, vacuum cups, rechargeable hand warmers and other fields to realize storage, conversion and the like of heat energy. In addition, by adding other reagents into the edible phase change material coconut oil, the preparedphase change material Pickering emulsion or microcapsule can be applied to temperature controlled drug controlled release, etc.

The invention discloses a multifunctional multilayered micro/nano core-shell structure. The core-shell structure is a micro/nanoscale spherical structure, and the ''multilayer'' includes three or more layers. At least one layer of material is a liquid phase. The liquid phase can selectively be removed. Thickness of each shell is controllable, and each shell can effectively and independently coat multiple materials or anti-cancer drugs with different properties at the same time. By adding functional auxiliary materials into each phase, combination of multifunctional characteristics can be realized. By integrating advantages of the multilayered core-shell structure and excellent optical, electrical, magnetic, sound and biological characteristics, drug controlled release and medical imaging application can be realized. The multifunctional multilayered micro/nano core-shell structure has an application prospect especially in aspects of disease treatment and medical imaging and is used as a bimodal ultrasonic/magnetic imaging diagnosis contrast agent and drug release control carrier.

The invention provides preparation of a keratin-sodium alginate composite microporous gel, belonging to the fields of composite materials and biotechnology. The preparation method comprises the following step: carrying out self-crosslinking polymerization on the raw materials biocompatible natural high-polymer protein and polysaccharide (keratin and sodium alginate) under the actions of an organic crosslinking agent, an inorganic crosslinking agent an initiator. The composite microporous gel has favorable swelling and deswelling properties, is sensitive to pH value, and has slow-release effects on both low-molecular and high-molecular drugs. The in-vitro drug release performance experiment indicates that the composite microporous gel can implement controlled release of drug molecules by utilizing the acid sensitiveness, and thus, can be used as a drug carrier in drug controlled release.

The invention provides a preparation method for a temperature stimuli-responsive nanofiber membrane carrying with a precious-metal nanorod. The preparation method is characterized in that the preparation method comprises the steps that temperature stimuli-responsive polymer of active groups in molecule side chain zone is prepared; the precious-metal nanorod is synthesized through a seed growing method; the temperature stimuli-responsive polymer is dissolved in distilled water and is mixed with aqueous dispersion liquid of the precious-metal nanorod, stirring is conducted to form spinning solution, electrostatic spinning is conducted on the spinning solution, and a hybrid nanofiber membrane carrying with the precious-metal nanorod is formed; heat treatment is conducted on the hybrid nanofiber membrane formed through electrostatic spinning, and the temperature stimuli-responsive nanofiber membrane carrying with the precious-metal nanorod is acquired. The prepared hybrid nanofiber membrane carrying with the precious-metal nanorod is swelled in aqueous medium, so that dissolution does not occur, the temperature stimuli responsiveness is possessed, and the temperature of volume phase transformation ranges from 40 DEG C to 43 DEG C. The hybrid nanofiber membrane possesses a potential application prospect in a surface-enhanced Raman spectroscopy detecting base, a drug control delivery carrier, a sensor and the like.

Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.

The invention belongs to the surface modification polymer superfine fiber film field, in particular to a polyester superfine fiber film material with surface graft modification, biological degradation and biological absorption, a chemical surface modification method thereof, a device for preparing the film and an application of the film in biomedicine. In the invention, non-woven fabric materials composed by fibers with the diameter of between tens of nanometers to thousands of nanometers are prepared by utilizing an electrostatic spinning process, and the non-woven fabric materials are combined with substrate materials by the polymerization of functional polymers on material surfaces in a covalent bond mode, and a plurality of functional groups are introduced on surfaces of superfine fiber film materials, which improves the hydrophilic performance and the hydrophobic performance of material surfaces and improves the biocompatibility of materials with tissue cells. The materials prepared by the invention can be applied to the production of surgical suture materials, fixing materials for plastic surgery, drug-controlled release materials and other macromolecule implants materials; and the surface modification method of the invention can be applied to the surface modification of micro channels of microfluidic devices and can better keep features of channels.

The invention relates to a preparation method of microcapsules coated with liquid alkene. An oil-in-water type Pickering emulsion is prepared with solid particles being stabilizers, a mercaptan, isocyanate and alkene monomer mixture serves as an oil phase, and the microcapsules coated with alkene monomers can be fast prepared due to the characteristics that mercaptan-isocyanate has a click reaction under the condition of alkali catalysts and the alkene monomers do not participate in the reaction. By means of the method, the capsule preparation process is greatly shortened and simplified, and a new, fast and efficient preparation method is provided for preparing the microcapsules. Due to the fact that the reaction is fast, the requirement for the stability of the emulsion is low, and microcapsules coated with different core materials can be prepared through the same preparing technology. The method has very great application potential in the aspect of microcapsule preparation in the fields of drug-controlled release, phase transformation materials, catalysis and the like.