18results about How to "Improve limitations" patented technology

The present application relates to the field of pharmaceutical preparations, in particular to a long-acting eye composite preparation for improving the symptoms of blepharitis. The preparation comprises a combination of two active ingredients in a therapeutically effective amount, and one or more ion-sensitive polymers or their complex systems, which are used to treat the symptoms of blepharitis caused by Demodex through a special double-cavity drug delivery bottle. By using a specific ion gel matrix concentration and regulating the viscosity of the drug solution before it reaches the eye, the limitations of traditional eye preparations are overcome, the retention time of the drug in the eye is prolonged, the bioavailability is improved, the probability of adverse events is reduced, and the medication compliance is increased.

The utility model relates to the technical field of chemical fiber yarn disc defect detection equipment, in particular to a chemical fiber yarn disc inner supporting type clamp which comprises a grabbing part, a telescopic part and a rotating part, and the grabbing part, the telescopic part and the rotating part are used in cooperation to achieve the grabbing telescopic and rotating functions. According to the utility model, an internal supporting type clamping mode is adopted, so that extra damage to the chemical fiber scroll is effectively avoided; the supporting claw structure with the protruding points can be in multi-point contact with the inner wall of the paper tube after being opened, clamping friction force is improved, clamping stability is guaranteed, the paper tube deformation risk is reduced, meanwhile, the control capacity of the clamp for a scroll in the rotating process is improved, and the clamping device is particularly suitable for occasions needing high-precision image collecting and positioning. Through cooperation of the grabbing part, the telescopic part and the rotating part, the rotating part drives the whole to rotate, the telescopic part controls stretching, and the grabbing part is responsible for grabbing a scroll and is used for stably clamping the scroll during detection.

The application discloses a kind of for the method, device, equipment and medium of tab abnormality detection in battery cell production process, comprising: the tab area image collected in battery cell production process is segmented to generate tab mask;Based on the tab mask extraction multi-scale pixel-level feature vector, and the multi-scale pixel-level feature vector is input into unsupervised probability GMM model to identify pixel-level abnormal point;The pixel-level abnormal point is analyzed to obtain candidate abnormal area, and the parameter index of the candidate abnormal area is obtained;Determine whether the parameter index meets the set tab abnormality judgment rule, if meet, it is judged as tab abnormality, and tab abnormality result is output.Therefore, the application can be widely applied to the detection of tab folding, crease, fracture, misplacement and other abnormalities on battery cell production line.

The application discloses a kind of based on three-dimensional phase diagram straight writing line topography regulation and control method, device, equipment and medium, it is related to printing technical field, comprising: by obtaining the rheological test result of different viscosity ink, printing process parameters and line form characterization data, apparent viscosity and boundary parameter are obtained by integration and power law fitting, construct with normalized height, normalized velocity, apparent viscosity as three-dimensional dimension process phase diagram, then by matching adaptive parameter or ink rheological property obtains target form.This introduces apparent viscosity as the third dimension, optimizes the limitation that two-dimensional phase diagram only adapts specific viscosity ink, quantifies the correlation of process parameters, rheological property and line form, only three core parameters can realize cross-ink system form accurate prediction and regulation, compatible with multiple viscosity inks, significantly reduce parameter optimization time consumption, avoid experience trial and error, accurately identify material process window, provide quantitative target for ink formula optimization, improve printing process adaptability.

The application relates to the technical field of new materials, and discloses a quasi-zero stiffness unit suitable for different tensile loads, a metamaterial vibration isolation structure and a design method, which comprise a first rigid side wall and a second rigid side wall, a positive stiffness unit is arranged in the center of the first rigid side wall, a negative stiffness unit is arranged at the opening of the top of the first rigid side wall, and one end of the second rigid side wall is connected with the vertex of the positive stiffness unit and extends upwards through the negative stiffness unit. The application realizes the regulation and control of the stiffness response of the structure under the action of different loads by parameterizing the design and multi-level combination of the tensile unit configuration and combining the interaction of the positive stiffness and the negative stiffness, the quasi-zero stiffness platform of the structure can be adjusted with the change of the tensile load, so that the stable low dynamic stiffness characteristics of the structure can be maintained within a wide load range, and then the adaptive regulation and control and flexible control of the low-frequency vibration isolation performance are realized.

The application belongs to the technical field of solid-state dielectric material testing, and particularly relates to a ferroelectric capacitor ultrafast hysteresis loop measuring method. The application proposes an equivalent circuit, which can obtain the stray inductance in the circuit and the voltage division of the stray inductance changing with time; and proposes a ferroelectric capacitor hysteresis loop correction method; first, different polarity electric pulses are applied on a standard capacitor or a ferroelectric capacitor, the voltage division in the circuit in the nanosecond time is measured by a high-bandwidth oscilloscope, including the voltage division of the total resistance of the circuit and the voltage division of the ferroelectric capacitor; then, the influence of the stray inductance is corrected to obtain the circuit current at each moment, and then the charging and discharging current and the domain reversal current of the ferroelectric capacitor are obtained, and they are converted into the ferroelectric hysteresis loop in the nanosecond time range, and the ferroelectric polarization intensity and the coercive field size under different periods are obtained from the ferroelectric hysteresis loop. The application accurately measures the ferroelectric hysteresis loop with a period of nanoseconds by establishing an equivalent circuit model.

This invention discloses a method for identifying land cover in highly heterogeneous areas. The method includes: collecting heterogeneous historical land cover products of the target area and obtaining stable regions of different cover types through overlay analysis; dividing the target area into blocks based on its latitude and longitude information with a spatial constraint of 1°×1°, then setting three thresholds of 50, 70, and 100, and using a stratified sampling strategy to obtain uniformly distributed sample data of the target area; acquiring temporal optical, radar, and digital elevation data of the target area, and addressing the influence of clouds and rain through data synthesis; and finally constructing a tile-based classification model for classification. The tile-based classification model constructed in this invention addresses the heterogeneity of plateau regions, fully considering the similarity of adjacent land features and the large climate span of the plateau. Simultaneously, a strategy for stable, rapid, and uniform sample data generation is developed, saving material and financial resources. The mapping results provide data support for ecological civilization construction and biodiversity conservation.

This invention discloses a novel method and system for constructing a three-dimensional numerical model of the foot and shoe. The method first acquires foot and shoe data from a subject wearing footwear in three postures: toe-landing, static standing, and heel-landing, using spiral CT scans. Based on the acquired scan data, and after mesh generation and material property assignment, a three-dimensional finite element numerical model of the foot and shoe is established. Static simulations are performed by inputting different ligament elastic moduli and Poisson's ratio parameters into the three-dimensional finite element numerical model of the foot and shoe, and setting boundary conditions for the corresponding postures, to obtain simulated values ​​of peak pressure on the sole and shoe sole and deformation in specific areas. Simultaneously, physical tests are conducted to obtain measured values. Error analysis is performed between the simulated and measured values, and the optimal set of parameters with the smallest total error is selected by adjusting the ligament parameters to construct a standard three-dimensional numerical model of the foot and shoe. This invention combines multi-posture mechanical response and ligament parameter optimization to achieve high-precision verification and correction of the foot and shoe model.

The application relates to a simulation experiment system of canyon river and alluvial fan interaction, which comprises a groundwater reservoir, a water inlet pool, a water and sand mixing narrow slot, a sediment deposition pool and a water outlet pool. The simulation experiment system can meet the research needs of river and alluvial fan interaction, can inversely analyze the process of alluvial fan development forming an alluvial plain, and has the advantages of simple operation, precise control, convenient measurement, low cost and the like.

This invention relates to the fields of biomedical technology and pharmaceutical formulations, and discloses a sustained-release powder spray for oral ulcers based on milk exosomes and its preparation method. The spray uses milk exosomes as the active ingredient, combined with an extracellular matrix-simulated network composed of sodium hyaluronate and collagen, and the stabilizer trehalose. It is prepared into a dry powder with a particle size of 2-15 μm through a microdroplet freeze-drying process. During preparation, the components are mixed and formed into microdroplets using a microfluidic device, then instantaneously frozen in liquid nitrogen at -80°C, and finally freeze-dried to obtain the powder. This formulation can be stably stored for a long time at 2-8°C. When used, it is sprayed onto the ulcer surface using a quantitative spray device. Upon contact with moisture, the gel network is reconstructed in situ, achieving sustained release and protection of the exosomes. It has the advantages of convenient use, accurate dosage, and long-lasting healing promotion.

The application belongs to the technical field of biological medicine, and particularly relates to a carrier-free nanoparticle based on chemotherapy-gene therapy synergy and preparation and anti-liver cancer application thereof. The carrier-free nanoparticle comprises an inner core and a shell coated outside the inner core. The inner core is co-assembled by ursolic acid, sorafenib and a CRISPR system Cas9 / RNP complex through multiple coordination, pi-pi stacking, electrostatic and hydrophobic force, with protamine sulfate as an auxiliary agent. The shell is a HepG2 cell membrane. The CRISPR system Cas9 / RNP complex comprises a Cas9 protein and sgRNA which specifically targets a PD-L1 gene. The carrier-free nanoparticle can be specifically accumulated at a liver cancer site through cell membrane homologous recognition, and reaches the cell nucleus under the action of a gene drug nuclear localization sequence to perform gene editing, realizes chemotherapy-gene therapy combined anti-liver cancer effect, has a significant inhibitory effect on the growth of liver cancer, and has a wide application prospect in the preparation of anti-liver cancer drugs.

The present application relates to the technical field of heat digital twinborn analysis, in particular to a three-dimensional electro-catalytic oxidation device temperature field collaborative regulation method based on digital twinborn. The specific implementation process includes: extracting current ripple features and fluid damping fluctuation data in the operation process of the three-dimensional electro-catalytic oxidation device, and constructing an energy distribution domain in the digital twinborn body; tracking the energy accumulation center in the energy distribution domain and correcting the heat conduction; carrying out evolution simulation to predict the spatial migration and temperature change trend; superimposing based on the prediction result to generate control waveform flow for device regulation; constructing an energy interaction link to collaboratively regulate the global temperature field. The present application combines multi-source data fusion, full-field reconstruction and prediction-driven control strategy, improves the limitations of relying on limited measurement points and lag feedback regulation, realizes high-precision perception, prediction and collaborative optimization control of the three-dimensional electro-catalytic oxidation device temperature field, and improves the stability of the device operation.

This invention relates to an integrally woven pile sandwich mesh fabric and its weaving method. The integrally woven pile sandwich mesh fabric is woven in one piece using a warp knitting machine equipped with no fewer than seven ground comb bars. It includes a face layer, a middle layer, and a bottom layer. The face layer is woven using the chain blocks of the jacquard or ground comb on the machine in any weave pattern. The middle layer is woven using yarns connected to the face and bottom layers in a weave pattern. The bottom layer is woven using the chain blocks of the jacquard or ground comb on the machine in any weave pattern. This invention, through reasonable process design of each comb bar, fully utilizes the advantages of jacquard and ground combs, combines the variations in yarn threading of the comb bars, and employs precise design and the use of synthetic fibers to produce an integrally woven sandwich three-dimensional pile mesh fabric with characteristics of being skin-friendly and soft, lightweight, high-performance, and structurally stable.

The present application relates to a targeted ileum delivery endotoxin sequestering agent drug and its preparation method and application, belong to the technical field of pharmaceutical preparation, the drug includes specific high molecular copolymer, the high molecular copolymer includes the three-dimensional framework of organic carbon-carbon chemical bond, and includes amino group. It is aimed at transporting high molecular chelating agent to the distal small intestine and releasing, and chelating pathogen-associated molecular patterns including endotoxin and CpG-DNA produced by intestinal microorganisms. The complex formed by the high molecular chelating agent released in the ileum and the pathogenic molecular pattern can be discharged from the digestive tract, so as to reduce the body inflammation and be used for relieving various metabolic diseases.

The application belongs to the technical field of air logistics station operation control, and provides a station operation autonomous decision scheduling method based on a multi-modal perception model, specifically comprising the following steps: obtaining a plurality of regions of cargo sorting types in an air logistics station operation scene, obtaining the characteristic properties of each region, respectively determining the initial weights of the multi-modal data allocated to each region, constructing an initial multi-modal perception model, extracting regions similar in initial weight distribution as an initial similar region group; in the actual logistics sorting process, obtaining the real-time running characteristics of each region, extracting regions similar in real-time running characteristics in the initial similar region group as a running similar region group; extracting the region with the largest change in real-time running characteristics in the running similar region group to determine the precision evaluation target of the initial multi-modal perception model, and evaluating the precision of the initial multi-modal perception model.

The invention discloses a seabed target detection method and system based on a double-frequency side-scan sonar image, and the method comprises the steps: carrying out the imaging of a seabed target region through a double-frequency side-scan sonar, and obtaining high and low frequency seabed image data; a single-mode modeling module, a cross-mode modeling module and a shadow highlight matching modeling module are introduced, and a dual-frequency side-scan sonar image target detection model is constructed; and performing target detection on the high and low frequency seabed image data based on the dual-frequency side-scan sonar image target detection model to obtain a seabed target detection result. According to the invention, the target detection result of the sonar image can be improved through complementary modeling of high and low frequency imaging features. The seabed target detection method and system based on the double-frequency side-scan sonar image can be widely applied to the technical field of image target detection.

This application discloses an image filtering method, apparatus, electronic device, and computer storage medium. The method calculates pixel values ​​of a target image using multiple filters in a preprocessing sub-model of the image filtering model to obtain a residual image. This residual image is then input into a filtering sub-model of the image filtering model. The filtering sub-model uses convolution kernels and a general feature extractor to calculate multiple statistical features, which are then used to determine the filtering result of the target image. By using multiple filters, the limitations of using a single filter to capture the dependencies between adjacent pixels are avoided, allowing for better capture of these dependencies and thus better understanding of the impact of secondary processing on the image. The multiple statistical features output by the filtering sub-model determine the filtering information used to indicate whether the target image has been modified, thereby improving the efficiency of the image filtering method.

The application discloses a kind of urban space net red phenomenon determination method, it is related to urban space technical field, including the following steps: collection short video check-in data, obtain the online traffic and offline traffic of multiple net red check-in points;Based on the ratio of offline traffic and online traffic, obtain the traffic conversion rate of multiple net red check-in points in the preset research range;The surrounding area of net red check-in point is researched, and the influence factor of urban space net red phenomenon is determined and corresponding data is obtained;Based on the traffic conversion rate of net red check-in point and each influence factor, linear regression model is established respectively, and multiple regression analysis equation is obtained;The weight of each influence factor is obtained by using principal component regression analysis method, and weight analysis result is obtained.The application can analyze the correlation between urban net red phenomenon and influence factor, help to develop urban space potential, and help to promote the development of urban space net red phenomenon by optimizing space quality targetedly.