The invention relates to a novel preparation method for a monodisperse porous
polymer nano microcapsule. The porous
polymer nano microcapsule is prepared by the steps: self-
assembly of a
polymer core
microsphere and an amino modified silica crown
microsphere which have different particle sizes is carried out to obtain a strawberry-shaped core-crown
microsphere as a template for next step
polymerization, and a core-shell composite microsphere is prepared; and the polymer microcapsule with a porous structure is obtained through
etching and dialyzing the core-shell composite microsphere. The size of an
internal cavity of the obtained microcapsule is controllable in the range of 500-1500 nm, the
diameter of pores on the wall is controllable in the range of 30-150 nm, the wall thickness is controllable in the range of 20-100 nm, and especially the microcapsule size is monodisperse. The preparation method has the characteristics of simple equipment and controllable operation, and allows the product to be pure and monodisperse and to have uniform
pore diameter. The porous polymer microcapsule can be used as a carrier widely applied in
drug control release, coatings, micro-reactors, selective
catalysis, composite materials and separation and other fields; and moreover, the porous polymer microcapsule also has extremely important value in
cell-like structure construction,
disease diagnosis, target treatment and the like.