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Novel preparation method for monodisperse porous polymer nano microcapsule

A technology of porous polymers and nano-microcapsules, which is applied in the field of organic porous materials and can solve problems such as increasing the application range of porous polymer microcapsules

Inactive Publication Date: 2014-02-19
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Larger pore size can solve the mass transfer problem of existing polymer hollow microcapsules, allowing larger-sized molecules to enter and exit the shell while increasing the mass transfer rate, thereby increasing the application range of porous polymer microcapsules

Method used

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  • Novel preparation method for monodisperse porous polymer nano microcapsule
  • Novel preparation method for monodisperse porous polymer nano microcapsule
  • Novel preparation method for monodisperse porous polymer nano microcapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Preparation of PMAA-nuclear microspheres

[0038]Take 0.04g of azobisisobutyronitrile (AIBN) and 2mL of α-methacrylic acid (MAA) into a 100mL two-necked flask, disperse them in 80mL of anhydrous acetonitrile, add zeolite, connect the thorn-type fractionation column and straight condenser and receiving bottle. Heat with a 100mL electric heating mantle, control boiling within 15 minutes, until about 40mL of acetonitrile is evaporated, stop heating, and complete the first polymerization; then take 10mL of the polymer after the first distillation in a flask, add 70mL of acetonitrile, and ultrasonically Make it evenly mixed, add 0.04g AIBN, and 2mL α-methacrylic acid monomer, conduct the second distillation, repeat the first polymerization process, stop heating when 40mL of acetonitrile is evaporated; finally take 10mL of the second distillation Put the polymer in the flask, add 70mL of acetonitrile, mix it evenly by ultrasonic, add 0.04g of AIBN, and 2mL of α-methacryli...

Embodiment 2

[0046] 1. Preparation of PMAA-nuclear microspheres

[0047] Take 0.04g of azobisisobutyronitrile (AIBN) and 5mL of α-methacrylic acid (MAA) into a 100mL two-necked flask, disperse in 80mL of anhydrous acetonitrile, add zeolite, connect the thorn-type fractionation column, straight condenser and receiving bottle. Heat with a 100mL electric heating mantle, control boiling within 30 minutes, and stop heating until about 40mL of acetonitrile is evaporated. After the product was cooled, the product was centrifuged at 8000 rpm, and after being washed three times continuously with anhydrous acetonitrile, the obtained PMAA microspheres had a particle size of 500 nm, and were dispersed in 40 mL of anhydrous acetonitrile for subsequent use.

[0048] 2. Preparation of SiO2 crown microspheres

[0049] Add 50mL ethanol, 1mL distilled water and 1.2mL concentrated ammonia water into a 100mL flask, stir at 25°C for 20min, add 1mL TEOS, continue stirring for 5h, add APTES0.05mL, continue sti...

Embodiment 3

[0055] Steps 1, 2, and 3 are the same as in Example 2.

[0056] 4. Preparation of porous polymer nanocapsules

[0057] Using the core-corona microspheres with the strawberry structure prepared in step 3 as a template, measure 10mL into a 100mL two-necked flask, add 70mL of acetonitrile, fully sonicate, add AIBN 0.04g, 4-vinylpyridine (4-Vp) 0.02mL , 0.2 mL of hydroxyethyl methacrylate (HEMA) and 0.8 mL of ethylene glycol dimethacrylate (EGDMA) were subjected to seed distillation precipitation polymerization. Add zeolite, connect the thorny fractionation column, straight condenser and receiving bottle, heat with a 100mL electric heating mantle, control boiling within 15 minutes, until about 15mL of acetonitrile is evaporated, and stop heating. After the polymer product was suction-filtered with a G-6 sand core funnel, it was placed in a 100mL tetrafluoro beaker, and 40% HF solution was added, and after magnetic stirring for 1 hour, the SiO2 part was removed by etching. Pour t...

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Abstract

The invention relates to a novel preparation method for a monodisperse porous polymer nano microcapsule. The porous polymer nano microcapsule is prepared by the steps: self-assembly of a polymer core microsphere and an amino modified silica crown microsphere which have different particle sizes is carried out to obtain a strawberry-shaped core-crown microsphere as a template for next step polymerization, and a core-shell composite microsphere is prepared; and the polymer microcapsule with a porous structure is obtained through etching and dialyzing the core-shell composite microsphere. The size of an internal cavity of the obtained microcapsule is controllable in the range of 500-1500 nm, the diameter of pores on the wall is controllable in the range of 30-150 nm, the wall thickness is controllable in the range of 20-100 nm, and especially the microcapsule size is monodisperse. The preparation method has the characteristics of simple equipment and controllable operation, and allows the product to be pure and monodisperse and to have uniform pore diameter. The porous polymer microcapsule can be used as a carrier widely applied in drug control release, coatings, micro-reactors, selective catalysis, composite materials and separation and other fields; and moreover, the porous polymer microcapsule also has extremely important value in cell-like structure construction, disease diagnosis, target treatment and the like.

Description

technical field [0001] The invention relates to a preparation method of monodisperse porous polymer nano-microcapsules, especially the controllable thickness of the capsule wall, cavity diameter and pore size, and belongs to the technical field of organic porous materials. Background technique [0002] As people's understanding of the microstructure of matter is becoming more and more mature, it has become the consensus of scientists to obtain corresponding macroscopic properties through the construction of fine structure of materials. As the cornerstone of the development of materials science, the development and research of new structural materials not only promotes the development of basic research, but also plays an important role in industrial technological innovation. Among them, porous materials with ordered structure and uniform pore size have attracted much attention. [0003] Among polymer materials, polymer microcapsules can be used in many fields due to their sma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/36C08F226/06C08F222/14C08F220/28C08J9/26C08F120/06B01J13/02B01J13/20
Inventor 刘巍王静魏俊富张仁兰金莎
Owner TIANJIN POLYTECHNIC UNIV
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