Surface graft modification biodegradable bioabsorbable polyester superfine fibre, and preparation, apparatus and use thereof

A surface graft modification and biodegradation technology, applied in the field of surface modified polymer microfiber membranes, can solve the problems of material surface etching, inability to achieve uniform modification, and achieve good biocompatibility and shape retention. appearance, the effect of good appearance

Inactive Publication Date: 2008-11-12
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Plasma treatment may cause material surface etching, so that the modified surface cannot achieve uniform modification effect in small holes

Method used

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  • Surface graft modification biodegradable bioabsorbable polyester superfine fibre, and preparation, apparatus and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] For the grafting reaction device that can be used to prepare the biodegradable and absorbable polyester microfiber membrane modified by surface grafting of the present invention, please refer to figure 1 .

[0060] A glass connecting two-body reaction connecting device 2, one end of the connecting two-body reaction connecting device is a container with an opening, and the other end is a container without an opening; there is a Teflon with a hole in the open container Long original plate 4, and the teflon original plate is positioned at below the communicating pipe that communicates with the two-body reaction connector, and the hole of the teflon original plate is polyester microfiber membrane material or composite ultrafine fiber membrane 5, one can see through The ultraviolet quartz cover 3 is covered on the opening of the container, and the vacuum pump interface 7 of the container is connected with the vacuum pump through a pipeline; grafted functional monomers and in...

Embodiment 2

[0071] The equipment is the same as in Example 1.

[0072] (1) Polycaprolactone (PCL) is prepared into a PCL ultrafine fiber membrane with a fiber diameter of 200nm by an electrospinning process;

[0073] (2) the microfiber membrane prepared by step (1) polymer material polycaprolactone (PCL) is horizontally put into one of the Teflon discs with holes in it of a connected two-body reaction connector (grafting reaction device) The container is placed in the hole in the middle of the Teflon plate, and then the open container is covered with a quartz cover that can pass through ultraviolet rays and is coated with vacuum ester on the joint part of the container;

[0074] (3) preparation of grafting monomer and initiator mixed solution: preparation maleic anhydride and benzophenone mol ratio are 80: 1 mixed solution 40ml, mix homogeneously, place mixed solution in step ( 2) in another container in the connected two-body reaction connector;

[0075] (4) the air in the reactor of s...

Embodiment 3

[0082] The equipment is the same as in Example 1.

[0083] (1) Poly(lactic acid-glycolic acid) copolymer (PLGA) is prepared into a polyester ultrafine fiber membrane with a fiber diameter of 1000 nm by electrospinning process;

[0084] (2) Put the microfiber membrane prepared by the polymer material poly(lactic acid-glycolic acid) copolymer (PLGA) in step (1) horizontally into one of the connected two-body reaction connectors (grafting reaction device) with holes In the container of the Teflon disk, it is placed in the hole in the middle of the Teflon disk, and then the open container is covered with a quartz cover that can pass through ultraviolet rays and is coated with vacuum ester on the joint part of the container;

[0085] (3) Preparation of grafted monomer and initiator mixed solution: prepare N-vinylpyrrolidone and benzophenone molar ratio as 20: 1 mixed solution 40ml, mix well, place mixed solution in reactor through reactor Step (2) is connected in another container...

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Abstract

The invention belongs to the surface modification polymer superfine fiber film field, in particular to a polyester superfine fiber film material with surface graft modification, biological degradation and biological absorption, a chemical surface modification method thereof, a device for preparing the film and an application of the film in biomedicine. In the invention, non-woven fabric materials composed by fibers with the diameter of between tens of nanometers to thousands of nanometers are prepared by utilizing an electrostatic spinning process, and the non-woven fabric materials are combined with substrate materials by the polymerization of functional polymers on material surfaces in a covalent bond mode, and a plurality of functional groups are introduced on surfaces of superfine fiber film materials, which improves the hydrophilic performance and the hydrophobic performance of material surfaces and improves the biocompatibility of materials with tissue cells. The materials prepared by the invention can be applied to the production of surgical suture materials, fixing materials for plastic surgery, drug-controlled release materials and other macromolecule implants materials; and the surface modification method of the invention can be applied to the surface modification of micro channels of microfluidic devices and can better keep features of channels.

Description

technical field [0001] The invention belongs to the field of surface-modified polymer ultrafine fiber membranes, in particular to surface graft-modified biodegradable and bioabsorbable polyester ultrafine fiber membrane materials, chemical surface modification methods and membrane preparation devices , and the use of membranes in biomedicine. Background technique [0002] Electrospinning is a polymer jet electrostatic stretching spinning method, which is a commonly used technology for preparing polymer ultrafine fibers. This method is obviously different from the traditional spinning method. First, the polymer fluid (such as a charged polymer sub-concentrated solution or a charged polymer melt) is charged with thousands to tens of thousands of volts of high-voltage static electricity, and the charged polymer droplets are Under the action of the electric field force, the apex of the capillary cone is accelerated. When the electric field is strong enough, the polymer droplets...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18D01F6/62C08K5/14C08K5/23A61L17/10A61L27/18A61L31/06A61K47/34
Inventor 韩志超贺爱华许杉杉刘昕
Owner INST OF CHEM CHINESE ACAD OF SCI
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