50results about How to "The synthesis process steps are simple" patented technology

The invention discloses a metal doped mesoporous silicon-based molecular sieve nanosphere and a preparation method thereof. The doped metal ion is one or more than two of IA, IIA, IIIA, VA, VIA, excess metal and rare earth metal in a periodic table, the mole ratio of the doped metal ion to silicon ion is 0.01 to 0.2; a nanosphere material has an uniform hexagonal tunnel structure, the average granularity is 60-200nm, specific surface area is 600-1600m<2>.g<-1>, and mesoporous aperture is 2.0-3.0nm. According to the invention, common silicon source, metal source and a surfactant are taken as raw materials, an alkalescence medium is used for adjusting pH value of a reaction mixture, a sol-gel method is used for direct synthesis of the metal doped mesoporous silicon-based molecular sieve nanosphere (MSN-M) material. The method has the advantages of simple technology and safe operation, continuous adjustment of pH value is not required, thermal crystallisation process under high pressure water and high temperature is not required, raw materials are easy to obtain, and the industrial production is easy.

The invention relates to a new process for preparing telmisartan, which uses 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2'-yl)-benzimidazole and 4' -Bromomethyl-biphenyl-2-carboxylate alkyl ester or 4'-bromomethyl-biphenyl-2-carbonitrile undergoes a one-step reaction to complete the two-step synthesis reaction of condensation and hydrolysis to directly obtain Telmisartan. Compared with other processes, it has the advantages of solving the technical difficulties of industrial production, simple operation, green synthesis, high purity of telmisartan, high yield and low cost, and has been successfully applied in industrial production.

The invention which discloses an emergent adsorption material prepared through utilizing waste PET fibers and a preparation method thereof belongs to the environmental material synthesis and application field. The material comprise a PET skeleton, amino groups grafted to the surface of the PET skeleton, and finally modified basic aluminum chloride, the average of the material is 40-60mum, the content of basic aluminum chloride in the material is 13.4-16.7%, the adsorption material is fibrous in shape, the surface contains basic aluminum chloride, the contact angle between the material and water is 52DEG, and the adsorption quantity of the material to arsenic is 9.982-14.989mg/g. The preparation method comprises the following steps: preprocessing the waste PET fibers, preparing a reaction emulsion, carrying out a grafting reaction, and carrying out a PET-AA-NN fiber loading metal reaction. The material is suitable for the emergent processing of emergent heavy metal water pollution events of natural water of rivers, lakes and the like. When the emergent adsorption material is prepared, the recovery and the utilization of the waste PET fibers are also realized.

The invention discloses a phthalonitrile and amino acid cyclopeptide copolymer resin and a preparation method thereof, wherein the phthalonitrile and amino acid cyclopeptide copolymer resin is prepared by blending and curing a phthalonitrile monomer and an amino acid cyclopeptide as raw materials, and the mass ratio of the phthalonitrile monomer to the amino acid cyclopeptide is 1 : (1-9). The preparation method of the copolymer resin comprises the following steps: weighing the phthalonitrile monomer and the amino acid cyclopeptide according to the mass ratio, dissolving in a solvent, uniformly mixing the components, drying the mixture to remove the solvent to obtain a blend, and curing the blend at the temperature lower than the decomposition temperature of the blend. The phthalonitrile and amino acid cyclopeptide copolymer resin provided by the invention is high-performance bio-based thermosetting resin with high crosslinking density and excellent high temperature resistance, thermal stability, thermal oxidation stability and chemical corrosion resistance.

The invention discloses a preparation method of CBZ-valganciclovir, and belongs to the field of preparation of valganciclovir. The preparation method includes the following steps: feeding a starting material in a reactor and carrying out condensation reaction; evaporating to remove a catalyst and a first solvent; adding a second solvent and carrying out hydrolysis; evaporating to remove the second solvent, adding water for making a solution to be clear, decolorizing and filtering, crystallizing, and centrifugally drying to obtain a crude product of ganciclovir; and placing the crude product of the ganciclovir and a third solvent in a reactor and heating and stirring, cooling and filter-pressing to obtain a first filter cake and first filtrate, and directly synthesizing the valganciclovir by using the first filtrate. By the preparation method of the CBZ-valganciclovir, ganciclovir condensation compound isomer is treated effectively, furthermore, the CBZ valganciclovir is synthesized directly in the filtrate synthesized by the 9-bit ganciclovir, a 'one-pot' type preparation technology is adopted, steps of a synthesis technology of the CBZ valganciclovir are simplified, residual raw materials are reduced, production cost is reduced, synthesis quality of the CBZ valganciclovir is improved, production efficiency is high, and the CBZ-valganciclovir is suitable for being industrially produced in a large scale.

The invention discloses an acidizing fluid thickener synthetic process based on control of the reaction monomer ratio. The process comprises the following steps: (a) purifying a reaction monomer; (b) preparing an initiator liquor; (c) weighing 2-methyl-2-acrylamidyl propanesulfonic acid solid and dissolving the solid in distilled water; (d) adding acrylic acid and dimethyl diallyl ammonium chloride and controlling the content of dimethyl diallyl ammonium chloride with 11-13%, and dissolving adequately; (e) adjusting the pH value of the liquor; (f) shifting the mixed liquid for reaction to a reaction container, and stirring; (g) adding the initiator liquor; and (h) heating the reaction system for polymerization reaction for 4-5 hours to obtain a target product. According to the process provided by the invention, the acidizing fluid thickener can be successfully synthesized, and the synthetic process is simple in step, simple to operate, short in synthetic time, high in synthetic efficiency and low in synthetic cost. Performance parameters of the synthetic product are superior to those of current acidizing fluid thickener, and the intrinsic viscosity of the target product is improved by controlling the content of dimethyl diallyl ammonium chloride.

The invention discloses a spongy emergency adsorbing material and a preparation method thereof, and belongs to the field of environment material synthesis and application. Artificially-synthesized high molecular materials are adopted as a matrix, according to graft polymerization and a nucleophilic substitution reaction of amine derivatives, a polyvinyl alcohol sponge is used as a skeleton, a grafting reaction and modified synthesis are carried out on the surface, and the spongy emergency adsorbing material is obtained. The preparation method is simple and low in raw material price, the obtained spongy adsorbing material is large in toughness, is provided with pore passages and surfaces with the high hydrophilic performance and can rapidly and efficiently remove various heavy metal ions in water under the group action of the pore passages and the surfaces, the time for equilibrium adsorption of the heavy metal ions such as nickel, copper and lead is only about 10min, and the absorbed sponge is easily recycled and reused after being reproduced. The spongy emergency adsorbing material is particularly suitable for the emergency disposal of an emergency heavy metal water contamination accident which happens in natural water such as a riverway and a lake.

The invention discloses an acid liquor thickener synthesizing technology for controlling the proportion of a reaction monomer. The technology comprises the following steps of: (a) purifying the reaction monomer; (b) preparing an initiator solution; (c) weighing and dissolving 2-methyl-2-acrylamide propanesulfonic acid solid; (d) adding acrylic acid and dimethyl diallyl ammonium chloride, controlling the content of 2-methyl-2-acrylamide propanesulfonic acid to be 24 to 26 percent, and fully dissolving; (e) regulating the pH value of the solution; (f) transferring the mixed solution to a container and stirring; (g) adding the initiator solution; and (h) heating the reaction system to carry out polymerization reaction, and thus obtaining a target product. By adopting the technology, the acid liquor thickener can be successfully synthesized; the synthesizing technology is simple, easy to operate and short in time; various performance parameters of the synthesized product are superior to those of the conventional acid liquor thickener; and by controlling the content of the 2-methyl-2-acrylamide propanesulfonic acid serving as the reaction monomer, the intrinsic viscosity of the target product is improved.

The invention relates to the technical field of concrete admixtures, and in particular, relates to preparation methods of a polyether monomer and a polycarboxylate water reducer. The polyether monomeris prepared by the following method: 1) in the presence of a basic catalyst, reacting an unsaturated compound with at least one active hydrogen atom with alkylene oxide to obtain an alkoxylation product I; and 2) in the presence of a basic catalyst, reacting the alkoxylation product I with alkylene oxide to obtain an alkoxylation product II, wherein the reaction temperature of the alkoxylation product I and alkylene oxide in the step 2) is 25 DEG C or above. The polyether monomer prepared by the method disclosed by the invention has good polymerization activity and high double bond retentionrate, has lower synthesis temperature than common polyether monomers, can be stored and used for a long time without neutralization, and simplifies the synthesis process steps of the polyether monomer.

The invention discloses a preparation method for a beraprost intermediate. The preparation method comprises the following steps: (1) preparation of cyclopentadiene: a step of weighing dicyclopentadiene, adding BHT, carrying out heating to 180-200 DEG C for distilling, collecting fractions at 40-50 DEG C, and after collection is finished, carrying out secondary distillation so as to obtain the cyclopentadiene; and (2) preparation of the beraprost intermediate: a step of adding the cyclopentadiene into a solvent A, carrying out cooling in a cold trap to minus 72 DEG C, diluting a bromine reagentwith the solvent A, slowly dropwise adding a solvent A solution of the bromine reagent, controlling a temperature at minus 70 DEG C, and carrying out a reaction so as to obtain 3,5-dibromocyclopentene, then dissolving 2,4,6-tribromophenol into an anhydrous solvent B, carrying out a reaction, and carrying out post-treatment operation B so as to prepare the beraprost intermediate. By adoption of the preparation method disclosed by the invention, impurities generated in the process production process are effectively reduced; the yield is improved; meanwhile, the process is green and environmentally-friendly; and the cost of environmentally-friendly treatment is reduced.

The invention discloses a method for preparing furfuryl alcohol through furfural liquid-phase catalytic hydrogenation. A hydrogenation catalyst adopted in the method is prepared through the followingsteps: uniformly mixing a solid nickel source and a solid nitrogen source according to the molar ratio of nickel element to nitrogen element of 1: 4-1: 12, and roasting at 300-550 DEG C in a roastingatmosphere for 1-6 hours to synthesize the hydrogenation catalyst. The hydrogenation catalyst is used in the reaction process of preparing furfuryl alcohol through furfural liquid phase hydrogenation,and the hydrogenation catalyst has high catalytic activity and catalytic selectivity. The hydrogenation catalyst contains no chromium, and has the advantages of simple preparation method, wide raw material source and the like.

The invention discloses an acidizing fluid thickener synthetic process based on control of reaction time. The process comprises the following steps: (a) purifying a reaction monomer; (b) preparing an initiator liquor; (c) weighing a certain amount of 2-methyl-2-acrylamidyl propanesulfonic acid solid and dissolving the solid in distilled water; (d) adding a certain amount of acrylic acid and dimethyl diallyl ammonium chloride into the liquor in the step (c), and dissolving adequately; (e) adjusting the pH value of the liquor; (f) shifting the mixed liquid for reaction to a reaction container, deoxygenating and stirring; (g) adding the initiator liquor; and (h) heating the reaction system for polymerization reaction for 4-5 hours to obtain a target product. According to the process provided by the invention, the acidizing fluid thickener can be successfully synthesized, and the synthetic process is simple in step, simple to operate, short in synthetic time, high in synthetic efficiency and low in synthetic cost. Performance parameters of the synthetic product are superior to those of current acidizing fluid thickener, and the conversion rate and intrinsic viscosity are improved by controlling the polymerization reaction time.