The invention relates to a preparation method of cetyl trimethyl ammonium bromide modified montmorillonite. According to the preparation method, sodium-based montmorillonite is taken as a raw material, the montmorillonite and water are first mixed according to a certain proportion, and after the montmorillonite is expanded by a large amount of water, a sol is formed and a Tyndall phenomenon is generated, wherein colloidal particles in the sol are all nano-sheets or nano-particles, and nanocrystallization is realized; then hexadecyl trimethyl ammonium bromide is taken as an intercalation agent,and the cetyl trimethyl ammonium bromide is intercalated into stripped nano sodium montmorillonite layers through a cation exchange reaction by mechanical stirring, so that the cetyl trimethyl ammonium bromide modified montmorillonite is obtained. According to the preparation method, the adopted raw materials are few and have low prices, operation is simple, production cost is low, performance such as mechanical strength, gas barrier property, hydrophobicity and the like of the montmorillonite are greatly improved, and the prepared organic montmorillonite can be widely used as a corrosion inhibitor in the field of corrosion prevention.