The invention relates to the technical field of medical auxiliary instruments, and particularly discloses a sterilization disc and a sterilization device.The sterilization disc comprises a frame, a base plate, a grid plate and a supporting block, the base plate is arranged in the frame, the grid plate and the supporting block are arranged above the base plate, the grid plate and the supporting block are arranged at intervals in the first direction, and a gap area is formed between the grid plate and the supporting block; the two ends of the infusion soft bag are supported on the grid plate and the supporting block respectively, a first through hole penetrating through the base plate is formed in the base plate, a second through hole penetrating through the grid plate is formed in the grid plate, and the aperture of the second through hole is smaller than that of the first through hole; according to the scheme, when the infusion soft bag is subjected to high-temperature sterilization, the grid plate and the supporting block jointly play a role in supporting the infusion soft bag, high-temperature steam can penetrate through the first through hole, the second through hole and the gap area to rapidly make contact with all parts of the infusion soft bag, and in other words, the structure enables the high-temperature steam to have good and uniform penetrability; the sterilization efficiency is obviously improved.