Method for synthesizing 4, 4-difluorobenzophenone from fluorobenzene

Abstract

The invention discloses a method for synthesizing 4, 4 '-difluorobenzophenone from fluorobenzene, which comprises the following steps: 1) adding p-fluorotoluene into a reactor, adding a catalyst and a solvent, and introducing oxygen to obtain p-fluorobenzoic acid; 2) adding p-fluorobenzoic acid into a first four-mouth bottle, then adding thionyl chloride, and heating by adopting an oil bath to obtain p-fluorobenzoyl chloride; 3) adding fluorobenzene and a solvent into a second four-opening bottle, weighing anhydrous aluminum chloride, adding the weighed anhydrous aluminum chloride into the second four-opening bottle, adding p-fluorobenzoyl chloride into the second four-opening bottle, and heating in a water bath; 4) after the reaction is finished, pouring into ice water, stirring, layering, separating liquid, and washing with water to separate an oil phase; and 5) adding the oil phase into a third four-neck flask for distillation, adding methanol and activated carbon, decolorizing, carrying out suction filtration, crystallizing and drying to obtain the 4, 4 '-difluorobenzophenone. The process steps are simple, the purity of the 4, 4 '-difluorobenzophenone product is higher than 99%, the yield is 90% or above, byproducts are reduced, the purification difficulty is low, and the industrial production cost is reduced.

Description

technical field [0001] The invention relates to a method for synthesizing 4,4'-difluorobenzophenone from fluorobenzene. Background technique [0002] 4,4'-Difluorobenzophenone is the main intermediate for the preparation of engineering plastic polyether ether ketone (PEEK). Polyetheretherketone (PEEK) is a semi-crystalline aromatic plastic engineering plastic with high heat resistance, radiation resistance, corrosion resistance, high impact strength, good wear resistance and fatigue resistance, excellent flame retardancy and electrical properties With its excellent physical and mechanical properties, it can replace metals, ceramics and other materials in many fields. It is one of the most popular high-performance engineering plastics today. It has been widely used in various fields such as coatings and coatings, and has become an indispensable key material. [0003] In the pharmaceutical industry, 4,4'-difluorobenzophenone, as a pharmaceutical intermediate, is mainly used ...

AI Technical Summary

Problems solved by technology

However, the existing 4,4'-difluorobenzophenone preparation process is complex and produces more by-products

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