12results about How to "Good process reproducibility" patented technology

The invention relates to the technical field of biological medicines, and discloses hyaluronic acid modified metal coordination albumin nanoparticles as well as a preparation method and application thereof. The hyaluronic acid modified metal coordination albumin nanoparticle comprises a core and a hyaluronic acid shell layer, wherein the core is formed by self-assembly of an albumin-drug compound, poly-L-aspartic acid and ferric ions through coordination, and the hyaluronic acid shell layer is connected to the surface of the core through coordination or adsorption. According to the hyaluronic acid modified metal coordination albumin nanoparticles as well as the preparation method and the application thereof, the preparation method is simple, convenient and rapid, does not need complex covalent modification, is mild in condition and is easy for large-scale production, and the prepared nanoparticles are uniform in particle size, good in stability and high in stability. In addition, due to the fact that the hyaluronic acid is modified on the surface, the active targeting capacity on CD44 receptor high-expression tumor cells is achieved, the enrichment and treatment effects of the medicine on the tumor site are remarkably improved, and the application prospect in preparation of the anti-tumor medicine is wide.

The invention discloses a high-capacity long-cycle lanthanum-doped sodium vanadium phosphate positive electrode material and a preparation method thereof, relates to the technical field of sodium ion batteries, and aims to solve the problem that an existing NVP material is difficult to have high capacity and structural stability at the same time. The technical key points of the invention are as follows: the high-capacity long-cycle lanthanum-doped sodium vanadium phosphate positive electrode material is provided, the high-capacity long-cycle lanthanum-doped sodium vanadium phosphate positive electrode material contains an NVP type material with a composition formula (I) and Na < 3 + x > V < 2-y > Lay (PO4) 3 / C (I), x and y meet the following formula, x is more than 0 and less than or equal to 0.5, y is more than or equal to 0.01 and less than or equal to 0.06, and C is an amorphous carbon layer which is formed by in-situ carbonization and uniformly coats the surfaces of material particles. The rare earth La element is introduced to dope the V site, crystal lattices are expanded, a wider channel is provided for de-intercalation of sodium ions, meanwhile, La doping is beneficial to stabilization of the crystal structure, and the transmission behavior of the sodium ions is optimized; on the basis of inheriting the advantage of ultrahigh capacity of a sodium-rich strategy, the cycling stability of the material is remarkably improved.

The invention relates to the field of hair dyes, in particular to a hydrogen peroxide mixed solution for a hair dye and a preparation method thereof.The hydrogen peroxide mixed solution is prepared from, by mass, 68-70 parts of an aqueous phase solution, 0.4-0.5 part of a gel matrix, 24-26 parts of self-made shampoo and 5-6 parts of a hydrogen peroxide aqueous solution; according to the invention, the aqueous phase solution composed of specific buffering and curing components, the gel matrix with thickening and stabilizing effects, the mild self-made shampoo carrier and the core oxidant are precisely compounded, so that the obtained mixed solution can maintain efficient oxidation performance, and at the same time, the storage stability and the mildness during use are obviously improved; according to the present invention, with the application of the composition, the thixotropy and the smearing experience of the paste are effectively improved, the process reproducibility is good, the product quality is uniform, the organic combination of the oxidation function and the hair care function is achieved, and the composition is suitable for various oxidation type hair dyes, and has wide application prospects in home and professional hair dyeing markets.

The invention discloses a dyeing process of tencel / flax blended yarn for light and thin denim fabric. The dyeing process comprises the steps of warp preparation and warp beam dyeing. Sequentially carrying out pre-wetting, multi-stage indigo dyeing, mild oxidation and alternate washing, post-treatment and drying; the warp beam dyeing is specifically as follows: warp yarns sequentially pass through a pre-wetting tank, at least four dyeing tanks, an oxidation zone, a rinsing tank and a post-treatment tank. By controlling the dyeing liquid to be alkalescent, low-temperature and low-tension technologies, chemical damage and physical stretching to tencel fibers are reduced, and fuzzing and broken ends are reduced. The pre-treated activated fiber and the gradient decreasing dye liquor concentration are matched with sufficient oxidation, the dye is promoted to diffuse into the fiber, the good dye penetration effect is achieved, the colored light is pure, and the color uniformity is guaranteed. And the weaving property of the yarn is improved through the post-treatment softening procedure. Due to hydrophilic softness and anti-wrinkle finishing, the yarn is soft and full in hand feeling and perfectly meets the comfort requirement of light and thin denim.

The application discloses a synthesis method of xylulose-5-phosphate. The method takes a commercially available compound 1 as a starting material, and obtains the target product xylulose-5-phosphate through seven independent step-by-step reactions. The intermediates are compound 2 to compound 7 in turn. The synthesis method provided by the application is a step-by-step reaction, each reaction is an independent unit, the process parameters are accurately controllable and suitable for industrial operation errors, the side reactions are few, and the product selectivity is high. The method innovatively uses tetrabenzyl pyrophosphate as a phosphorylation reagent, replaces expensive reagents, and reduces the synthesis cost. The reaction condition of the method is mild, the operation is convenient, the crude compound 2 and the crude compound 4 can be directly used in the next step reaction, the post-treatment process is simple, and the route is simple and easy to be industrialized. The synthesis method of xylulose-5-phosphate has stable yield and accurate product structure, is suitable for large-scale industrialized preparation of xylulose-5-phosphate, and can effectively meet the market demand in the field of biological medicines.

This invention discloses an in-situ nano-duplex reinforced Al-Zn-Mg-Cu-Y alloy. The chemical composition of the alloy, by mass percentage, comprises: Zn 4-8%, Mg 1.2-2.8%, Cu 1.2-2.0%, Y 0.1-0.6%, and Al 86.6-93.5%, with the total mass percentage of each chemical component being 100%. The alloy microstructure contains uniformly distributed nano-scale η-phase and nano-scale T-phase. This invention also discloses a high-pressure preparation method for the above-mentioned in-situ nano-duplex reinforced Al-Zn-Mg-Cu-Y alloy, comprising the following steps: subjecting the billet to high-temperature and high-pressure treatment to obtain the in-situ nano-duplex reinforced Al-Zn-Mg-Cu-Y alloy. This invention adds rare earth element Y and combines this with high-temperature and high-pressure treatment to form uniformly distributed nano-scale η-phase and nano-scale T-phase in-situ within the alloy microstructure.

This invention discloses a color-tunable room-temperature phosphorescent carbon dot composite material based on minoxidil, its preparation method, and its applications. The composite material is synthesized in situ through a one-step thermal treatment of the clinical drug minoxidil (MND) and boric acid (BA) in an aqueous phase. Minoxidil, as a carboxyl-free aminopyrimidine molecule, partially forms nitrogen-doped carbon dots during pyrolysis, while some exist in an incompletely carbonized molecular state. Both are firmly anchored in a BA-derived rigid borosilicate glass matrix via B–N covalent bonds, effectively suppressing nonradiative transitions of triplet excitons. By controlling the doping amount of minoxidil (preferably an MND:BA mass ratio of 1:60 to 1:3), the phosphorescent emission color of the material can be continuously tunable from blue to green, achieving a maximum photoluminescence quantum yield of 20.9% and a room-temperature phosphorescent lifetime of up to 1.43 seconds. This composite material has significant application value in fields such as multi-level dynamic information encryption, time-resolved anti-counterfeiting, and intelligent optical devices.

The application discloses a skin-nourishing powder cream composition and a preparation method thereof, and the skin-nourishing powder cream composition is a water-in-oil emulsion system, and contains, in parts by weight, 22.5-62.5 parts of an oil phase component, 4-14 parts of a powder component, 15-50 parts of an aqueous phase component and 0.1-2 parts of a skin conditioner; and the application uses high-content natural plant oils such as jojoba seed oil and olive fruit oil and high-quality emollient esters such as caprylic acid / capric acid triglyceride as core oil phases, thereby replacing a large amount of mineral oil or volatile silicone oil used in traditional powder creams. The plant oils are rich in unsaturated fatty acids and antioxidant components, and can provide long-lasting moisturizing, repair the sebum membrane and relieve dryness for the skin.

The invention relates to the technical field of health-care food and functional food, and discloses a liver-protecting and hangover-alleviating composition which comprises the following components in parts by weight: the active component comprises 10-30 parts, preferably 20 parts, of a radix puerariae extract (puerarin content is greater than or equal to 40%); the content of total flavonoids is larger than or equal to 7%, and the content of dihydromyricetin is larger than or equal to 1%. The hovenia dulcis thunb extract is 10-30 parts, preferably 20 parts, and the oyster extract is 5-15 parts, preferably 10 parts, of the taurine content is larger than or equal to 10%, and the zinc content is larger than or equal to 0.5%. According to the liver-protecting and hangover-alleviating composition as well as the preparation method and the application thereof, based on the monarch, minister, assistant and guide theory of traditional Chinese medicine and the precise proportioning of modern pharmacological research, the triple effects of alleviating hangover, protecting liver and relieving discomfort are realized through the synergistic effect of the six active ingredients, animal experiments show that the ALT level of a rat with alcoholic liver injury can be reduced by 42.4%, the SOD activity can be improved by 39.4%, and the liver-protecting and hangover-alleviating composition can be used for preventing and treating alcoholic liver injury. And the effect is better than that of similar products with single component or simple compatibility.

The invention discloses a compound water-based working solution for cleaning and passivating the inner wall of a stainless steel pipeline and a use method thereof. The working solution is prepared by compounding an organic acid complexing agent, a fluorine-containing inorganic acid dissolving agent, an oxidizing inorganic acid passivating agent, a nitrogen-containing heterocyclic metal corrosion inhibitor, an anionic surfactant and water. The use method comprises the following steps: carrying out alkaline pretreatment and flushing on the stainless steel pipeline system; the preheated working solution is pumped into a system to be circularly cleaned and passivated; and finally, neutralizing and finally washing. Through the synergistic effect of all the components, powerful rust removal and high-quality passivation are integrated into one step, three kinds of stubborn red rust can be thoroughly removed, meanwhile, a stainless steel substrate is effectively protected against over corrosion, the treated surface keeps the original silvery white luster and smoothness of metal, a compact passivation film is formed, the water quality of a system is recovered quickly, and the service life of the system is prolonged. The method is suitable for regeneration maintenance of old purified water systems.

This invention relates to the field of traditional Chinese medicine external preparations, and discloses a bone-setting and blood-stasis-removing paste and its preparation process, comprising the following traditional Chinese medicine raw materials in parts by weight: 90-110 parts of Trichosanthes kirilowii root, 45-60 parts of Angelica dahurica root, 45-60 parts of rhubarb, 45-60 parts of Phellodendron chinense bark, 8-12 parts of dried tangerine peel, 8-12 parts of Magnolia officinalis bark, 8-12 parts of licorice root, 8-12 parts of stir-fried Atractylodes lancea rhizome, and pharmaceutically acceptable excipients. This bone-setting and blood-stasis-removing paste uses Trichosanthes kirilowii as the main ingredient to clear heat, reduce swelling, disperse blood stasis, and drain pus, targeting local redness, swelling, heat, and pain in the early stages of fractures. Rhubarb, Phellodendron chinense, and Angelica dahurica are used as adjuvants to enhance the effects of clearing heat, drying dampness, promoting blood circulation, and removing blood stasis. Tangerine peel, Magnolia officinalis, and stir-fried Atractylodes lancea regulate qi, dry dampness, strengthen the spleen, and harmonize the stomach to prevent the bitter and cold herbs from damaging the stomach. Licorice harmonizes all the herbs, achieving a comprehensive approach that addresses both the "blood stasis, heat, swelling, and pain" in the early stages of fractures and the "qi and blood stagnation and bone failure" in the middle and later stages. This reflects the characteristics of traditional Chinese medicine orthopedics in its staged treatment approach and overcomes the technical shortcomings of existing preparations that focus on a single treatment aspect.

The present application relates to the field of drug crystal forms, in particular to a new crystal form of a compound of formula 1 and a preparation method thereof. The new crystal form of the compound of formula 1 of the present application has excellent physical stability and chemical stability, high solubility and bioavailability, good flowability and low hygroscopicity. In addition, the new crystal form of the compound of formula 1 of the present application has mild preparation conditions, simple operation, good process reproducibility, high purity and is suitable for industrial production.