13results about How to "Good resolubility" patented technology

The invention discloses an epoxy modified room-temperature self-crosslinking water-based acrylate dispersion as well as a preparation method and application thereof, and belongs to the field of water-based acrylic resin. The dispersoid is obtained by extracting an organic solvent from an acrylate polymer, adjusting the pH value to 7.5-8.5, mixing with ionized water and binary hydrazide, dispersing and filtering. The acrylate polymer is obtained by carrying out solution polymerization on a mixed solution of a part of initiator, a hard monomer, a soft monomer, a first type of hydrophilic monomer, a second type of hydrophilic monomer, epoxy resin and a combined cross-linking monomer and a residual initiator dissolved in an organic solvent at 80-83 DEG C, wherein the mixed solution is prepared from the initiator, the hard monomer, the soft monomer, the first type of hydrophilic monomer, the second type of hydrophilic monomer, epoxy resin and the combined cross-linking monomer. The main solvent of the dispersion is water, the viscosity is low, and the content of the organic solvent is 1t; the water-based ink has the advantages of low content of VOCs (volatile organic compounds), multiple cross-linked network structure, high cross-linking degree (78-83%), excellent resolubility after being prepared into ink, good adhesive force on a plastic film, good water resistance, good storage stability and high glossiness.

The invention discloses a preparation method of stability-enhanced alginic acid-keratin-based double-coated nanoparticles. The preparation method comprises the following steps: carrying out controllable enzymolysis, enzyme deactivation, centrifugation and freeze-drying on keratin to obtain keratin nanoparticles formed by self-assembly; dispersing the keratin nanoparticles in an acidic buffer solution to carry out structure development, adding bioactive molecules, and adjusting the pH to be neutral to recombine and close the keratin nanoparticle structure to obtain a keratin nanoparticle solution loaded with the bioactive molecules; the preparation method comprises the following steps: taking keratin as a template, dispersing the keratin into a sodium alginate solution, dropwise adding into a calcium chloride solution, cross-linking to form a calcium alginate shell, dialyzing or centrifuging to remove free bioactive molecules, and freeze-drying to obtain the bioactive molecule loaded alginic acid-keratin-based double-coated nanoparticles. The invention also discloses double-coated nanoparticles and application thereof, through controllable enzymolysis and pH regulation and control, the self-assembly and bioactive molecule encapsulation of the keratin nanoparticles are improved, and the double-coated nanoparticles with regular shape, good dispersibility, good redissolvability and good environmental stability are formed.

The invention relates to the field of biological immunity and pharmaceutical preparations, and particularly discloses a human growth hormone (GH) freeze-drying protective agent. The invention further discloses a freeze-drying preparation prepared from the freeze-drying protective agent. The freeze-drying preparation mainly comprises the following components in parts by weight: 10-100 mM of a buffer solution, 1-30 parts of a protective agent, a stabilizer and an excipient, 0.01-1.5 parts of a surfactant, 0.1-0.8 part of an antioxidant and 0.05-3 parts of a preservative. The invention provides a specific preparation method of the freeze-dried preparation, the preparation has the advantages of long preservation period, short redissolution time compared with a common reagent, good form and good structural stability after freeze-drying, provides favorable protection conditions for preparation of ELISA standard substances and internal control substances, is beneficial to maintenance of the stability of proteins, and has good application prospects. The specificity and the sensitivity of the ELISA kit are improved.

The application discloses a vaccine heat-resistant protective agent, a preparation method and application thereof, and belongs to the technical field of vaccines. The vaccine heat-resistant protective agent comprises the following raw materials: polycarboxybetaine, taurine, a sugar substance, polysarcosine, erythritol, gelatin enzymatic hydrolysate, a metal ion chelating agent and a buffer. The application also provides a preparation method. Compared with the prior art, the synergistic effect of polycarboxybetaine, taurine, a sugar substance, polysarcosine, gelatin enzymatic hydrolysate, erythritol and EDTA-Na2 can significantly improve the freeze-dried cake forming and reconstitution performance, shorten the reconstitution time, reduce the turbidity and insoluble particles. After 2-8 DEG C, 25 DEG C and 37 DEG C storage and multiple freeze-thaw cycle investigations, the antigen content residual rate and glass transition temperature are obviously superior to those of a traditional sucrose and mannitol system, and the inactivation risk caused by cold chain fluctuation can be effectively buffered.

The present invention provides a gonadotropin freeze-dried preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The gonadotropin freeze-dried preparation of the present invention comprises the following components in parts by weight: 0.01-0.15 parts of gonadotropin, 10-20 parts of buffer, 0.1-1 parts of surfactant, 200-300 parts of trehalose, 100-350 parts of mannitol, and 50-100 parts of glycine. The present invention adopts a specific formula to prepare a gonadotropin freeze-dried preparation, which has high biological activity, good stability during freeze-drying and storage, and short re-dissolution time during use. The freeze-dried preparation of the present invention can have good stability and re-solubility at the same time. The present invention is particularly suitable for preparing freeze-dried preparations of luteinizing hormone (LH) and its variants, and has good application prospects.

The invention provides the temperature-resistant freeze-dried chocolate capable of inhibiting appetite, and the temperature-resistant freeze-dried chocolate is high in grease content, fluffy in taste and silky in mouth feel; the product is loose and porous, so that the product is good in re-dissolvability and can melt in the mouth without chewing, and good sensory experience is brought to consumers; the product has a stable structural framework, does not have obvious morphology change at a high temperature of 80 DEG C, does not deform, crack and blacken due to grease melting and crystal transformation, does not have the problem that grease leaks and adheres to a packaging bag, and has excellent thermal stability.

The present application relates to the technical field of collagen, in particular to a kind of active collagen lyophilized preparation and its preparation method and application.The preparation method includes the following steps: S1, the aqueous solution of freeze-drying protective agent is prepared;S2, the initial emulsion of active collagen is diluted with physiological saline, to obtain the first solution, then mixed with the aqueous solution obtained in step S1, to obtain the second solution;S3, the second solution obtained in step S2 is added to the aqueous solution of step S1, and the third solution is prepared after mixing and emulsifying, to obtain mixed emulsion;S4, the mixed emulsion in step S3 is filled and freeze-dried, wherein the freeze-drying protective agent includes glycine, and the concentration of active collagen in the third solution is 5-15 mg / mL.The lyophilized preparation prepared by the preparation method has excellent reconstitution effect, and is convenient for transportation and storage.

The invention discloses a vacuum aluminizing water-based coating liquid for paper printing. The coating liquid comprises a low-Tg / high-hardness water-based acrylic emulsion and a polycarbonate type and / or acrylic acid modified water-based polyurethane dispersion which are used as film-forming materials, and is matched with substances such as a water-based auxiliary agent, a film-forming auxiliary agent, a wax emulsion and water. The low-Tg / high-hardness water-based acrylic emulsion is a styrene-acrylic emulsion with a core-shell structure, which is synthesized by adopting alkali-soluble acrylate solid resin under specific selection as a reactive macromolecular rheology control emulsifier and adopting a seeded emulsion polymerization method. The coating liquid disclosed by the invention has excellent rheological property, excellent sealing property and film-forming property, ultrahigh aluminizing gloss and wear resistance, excellent anti-sticking and anti-light-reversing property, chemical resistance, redissolving property, printing adaptability and environmental protection property, and is suitable for various printing and coating modes; the printing ink is especially suitable for the printing industries of tobacco, wine and the like which have extremely strict requirements on printing speed, drying speed, wear resistance, sticking resistance and aluminized appearance.

The invention discloses an otiammonium bromide freeze-dried preparation for injection and a preparation method of the otiammonium bromide freeze-dried preparation. The preparation method comprises the following steps: firstly, preparing an otilonium bromide solution from otilonium bromide, an excipient, cyclodextrin, a hydrochloric acid solution and water for injection, filling and then adopting an ultrasonic-assisted freeze-drying technology to obtain the otilonium bromide freeze-dried preparation for injection, and the prepared product is loose, porous, few in appearance defect, good in resolubility and stable in quality.

The present invention relates to an inhalation preparation of an efficient and broad-spectrum anti-coronavirus polypeptide and a preparation method thereof. The prepared inhalation preparation has good stability, reconstitution effect, and inhalation characteristics, and has the best delivery effect and atomization effect in different modes; it has the characteristics of high bioavailability, easy to carry, convenient administration, and no pollution; and the preparation method is simple, suitable for industrial production, and has good application value.

The present invention belongs to the field of biomedical materials, and relates to a modified polyphenol carrier material, a targeted nano-delivery system, a preparation method and use thereof, and specifically relates to a preparation method of tea polyphenol modified with hyaluronic acid (hereinafter referred to as HA-EGCG) and a preparation method and application of nanoparticles loaded with microtubule inhibitors thereof, specifically, the active targeting effect of hyaluronic acid (HA) and the biological activity of epigallocatechin gallate (EGCG) synergistically promote the application of spinal cord injury repair and anti-tumor. The modified polyphenol carrier material of the present invention is hereinafter referred to as HA-EGCG carrier, and the structural formula of the HA-EGCG carrier of the present invention is as shown in Formula I. The carrier material prepared by the present invention can also reduce the hemolyticity of EGCG, retain the biological activity of EGCG, and has good biosafety. #imgabs0# In Formula I; n is a positive integer.

The invention provides a creatine kinase isoenzyme freeze-dried product as well as a preparation method and application thereof. The creatine kinase isoenzyme freeze-dried product is prepared from the following raw materials: a creatine kinase isoenzyme antigen, polygonatum polysaccharide and a chelating agent; the chelating agent comprises any one of citric acid, iminodiacetic acid and 1-hydroxyethylidene-1, 1-diphosphonic acid. The components such as the polygonatum polysaccharide and the chelating agent are adopted, so that double protection of oxidation resistance and dimer stability is realized, and the creatine kinase isoenzyme is good in activity after freeze-drying, stable in long-term storage and good in detection accuracy and repeatability.