Aarin preparation for injection and preparing process thereof

A technology for asarone and injection, which is applied in the field of asarone preparation for injection and its preparation, which can solve the problems of complex preparation process, unstable product, unreasonable injection formula, etc., and achieve good resolubility, full shape, The effect of product stability

Inactive Publication Date: 2005-11-23
许群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing preparations, especially injection formulations are unreasonable, the preparation process is complicated, and the product is unstable. In order to solve the above problems and facilitate portability and storage, the invention provides asarone freeze-dried powder for injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Asarum 4.0g

[0098] Tween-80 60.0g

[0099] Sodium bisulfite 1.5g

[0100] Edetate Calcium Sodium 0.3g

[0101] Mannitol 200.0g

[0102] Water for injection up to 2500ml

[0103] A total of 1000 bottles were made after freeze-drying

[0104] After washing the rubber stopper, carry out silicon treatment, dry and sterilize, and then cool for later use; wash the vial and aluminum cap, carry out dry and sterilize, and cool for later use.

[0105] Weigh the prescribed amount of asarone and Tween-80 in a beaker, heat and stir in a water bath (about 50°C) until α-asarone is completely dissolved, then add the prescribed amount of mannitol, sodium bisulfite and calcium sodium edetate , and then add water for injection and stir until a clear solution.

[0106] Add 0.2% (w / v) activated carbon, stir at room temperature for 20 minutes, and then decarbonize and filter; the obtained crude filtrate is then filtered with a 0.22 μm microporous membrane, and water for injection is ...

Embodiment 2

[0109] Asarum 16g

[0110] Tween-80 60.0g

[0111] Sodium bisulfite 1.5g

[0112] Edetate Calcium Sodium 0.3g

[0113] Mannitol 200.0g

[0114] Water for injection up to 2500ml

[0115] A total of 1000 bottles were made after freeze-drying

[0116] After washing the rubber stopper, carry out silicon treatment, dry and sterilize, and then cool for later use; wash the vial and aluminum cap, carry out dry and sterilize, and cool for later use.

[0117] Weigh the prescribed amount of asarone and Tween-80 in a beaker, heat and stir in a water bath (about 50°C) until α-asarone is completely dissolved, then add the prescribed amount of mannitol, sodium bisulfite and calcium sodium edetate , and then add water for injection and stir until a clear solution.

[0118] Add 0.2% (w / v) activated carbon, stir at room temperature for 20 minutes, and then decarbonize and filter; the obtained crude filtrate is then filtered with a 0.22 μm microporous membrane, and water for injection is...

Embodiment 3

[0121] Asarum 8g

[0122] Tween-80 60.0g

[0123] Sodium bisulfite 1.5g

[0124] Edetate Calcium Sodium 0.3g

[0125] Mannitol 200.0g

[0126] Water for injection up to 2500ml

[0127] A total of 1000 bottles were made after freeze-drying

[0128] After washing the rubber stopper, carry out silicon treatment, dry and sterilize, and then cool for later use; wash the vial and aluminum cap, carry out dry and sterilize, and cool for later use.

[0129] Weigh the prescribed amount of asarone and Tween-80 in a beaker, heat and stir in a water bath (about 50°C) until α-asarone is completely dissolved, then add the prescribed amount of mannitol, sodium bisulfite and calcium sodium edetate , and then add water for injection and stir until a clear solution.

[0130] Add 0.2% (w / v) activated carbon, stir at room temperature for 20 minutes, and then decarbonize and filter; the obtained crude filtrate is filtered with a 0.22 μm microporous membrane, and water for injection is added...

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PUM

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Abstract

The invention relates to an Aarin preparation for injection and preparing process wherein the formula comprises asarone 4.0-16g, Twain-80 60.0g, sodium acid sulfite 1.5g, calcium disodium edeate 0.3g, mannitol 200.0g, and water for injection to 2500ml.

Description

Technical field: [0001] The invention relates to a medicine injection, in particular to a preparation of asarone for injection and a preparation method thereof. Background technique: [0002] Asarone (2,4,5-trimethoxy-1-propenylbenzene), also known as α-asarone or α-asarone (Alpha-Asaronum), mainly exists in the Araceae plant Acorus calamus (Acorus Graninues Soland) and other plant volatile oils were successfully synthesized by Liuzhou Pharmaceutical Factory for the first time in 1982. Since the 1960s, it has been confirmed that it has strong pharmacological activity, and has cough, expectorant, asthma, sedative, antispasmodic and anticonvulsant effects. It also has different degrees of inhibitory effect on the growth of pneumococcus, staphylococcus aureus and Escherichia coli, and has received good results in clinical applications such as pneumonia, asthma, and grand mal epilepsy. [0003] Asarum is rapidly absorbed after oral administration, reaching the peak blood conce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09
Inventor 许群
Owner 许群
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