Lyophilized emulsion preparation for injection of levo-gossypol and acetate of levo-gossypol

A technology of L-gossypol and acetate, which is applied in the direction of freeze-drying transportation, emulsion transportation, active ingredients of aldehydes, etc. It can solve the problems of poor stability and achieve the effect of strong stability, low moisture content and full appearance
CN102525954BActive Publication Date: 2013-06-05大荷医药科技(山东)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
大荷医药科技(山东)有限公司
Publication Date
2013-06-05

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Abstract

The invention discloses lyophilized emulsion preparation for injection of levo-gossypol and acetate of the levo-gossypol and a preparation method thereof. The lyophilized emulsion preparation for the injection of the levo-gossypol and the acetate of the levo-gossypol consists of levo-gossypol or levo gossypol acetate, oleic acid, glycerol, emulsifying agent, cryoprotectant, oil for injection, potential of hydrogen (pH) conditioning agent, antioxidant and water for injection. Mixture of granulesten and Span 80 serves as the emulsifying agent, mixture of trehalose and human serum albumin servesas the cryoprotectant, and the prepared lyophilized emulsion preparation is strong in salability and high in bioavailability.
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Description

technical field

[0001] The invention relates to a pharmaceutical preparation of L-gossypol and its acetate, in particular to a freeze-dried milk preparation for injection of L-gossypol and its acetate. Background technique

[0002] Gossypol (Gossypol), CAS No. 303-45-7, is a yellow phenolic compound composed of two optical isomers, L-gossypol and D-gossypol. Natural gossypol exists in the seeds, leaves, stems and roots of the Malvaceae cotton plant.

[0003] Gossypol is known for its spermicidal properties and can be used as a male birth control. At present, gossypol acetate oral preparations have been marketed as male contraceptives or for the treatment of gynecological diseases, including endometriosis, menorrhagia or disorders. Chinese patent 200510022777.9 (applicant: Shenyang Pharmaceutical University, publication number CN1827117, publication date: September 06, 2006, date of authorization announcement: December 16, 2009) discloses a gossypol acetate slow for the tre...

Claims

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