The present invention discloses a
pemetrexed disodium
liquid composition, its preparation method and application. The
pemetrexed disodium
liquid composition provided by the present invention comprises a pharmaceutical
active ingredient and a stabilizer, the pharmaceutical
active ingredient being one or more of
pemetrexed disodium, pharma- ceutically acceptable complexes, salts, solvates and hydrates of
pemetrexed disodium, and the stabilizer being one or more of an
organic solvent, a pH adjuster and an
antioxidant. The
pemetrexed disodium liquid composition of the present invention has the advantages of a simple preparation process, good physical and
chemical stability, clinical ease of use without the need for reconstitution, low risk of
microbial contamination during the preparation process, and suitability for industrial production.