5 results about "Pemetrexed disodium" patented technology

The invention relates to the technical field of pharmaceutical preparations, and discloses an organic-solvent-free pemetrexed disodium ready-to-use injection and a preparation method thereof.The preparation method comprises the following steps that raw materials are pretreated, pemetrexed disodium raw materials are smashed and sieved through a 200-mesh sieve in the environment with the humidity smaller than 30% RH, raw material powder with the particle size D90 smaller than 50 micrometers is obtained and dissolved, and the pemetrexed disodium ready-to-use injection is obtained in a liquid preparation tank under nitrogen charging protection; the preparation method comprises the following steps: firstly, adding 50-70% of the total dosage of water for injection, cooling to 10-15 DEG C, adding an isotonic agent, a stabilizer and an antioxidant, stirring for dissolving, then adding pemetrexed disodium raw material powder, setting an organic solvent-free formula system, adopting a synergistic combination of the specific stabilizer and the antioxidant in the preparation process of the pemetrexed disodium ready-to-use injection, and preparing the pemetrexed disodium ready-to-use injection. The alkaline environment range is strictly limited, and the addition of a traditional organic solvent can be avoided, so that the injection site pain, hemolysis and liver and kidney toxicity risks caused by the organic solvent are eliminated.

The present invention discloses a pemetrexed disodium liquid composition, its preparation method and application. The pemetrexed disodium liquid composition provided by the present invention comprises a pharmaceutical active ingredient and a stabilizer, the pharmaceutical active ingredient being one or more of pemetrexed disodium, pharma- ceutically acceptable complexes, salts, solvates and hydrates of pemetrexed disodium, and the stabilizer being one or more of an organic solvent, a pH adjuster and an antioxidant. The pemetrexed disodium liquid composition of the present invention has the advantages of a simple preparation process, good physical and chemical stability, clinical ease of use without the need for reconstitution, low risk of microbial contamination during the preparation process, and suitability for industrial production.

The invention discloses a method for detecting related substances in pemebenzoic acid by HPLC (High Performance Liquid Chromatography), and belongs to the technical field of chemical engineering and pharmacy, the related substances in pemebenzoic acid are detected by high performance liquid chromatography, a phosphate buffer solution (a potassium dihydrogen phosphate solution with the concentration of 0.04 mol / L and the pH value of a sodium hydroxide solution with the concentration of 1 mol / L is regulated to 5.5) is used as a mobile phase A, acetonitrile is used as a mobile phase B, gradient elution is performed, the flow rate is 0.8 ml / min, the column temperature is 20 DEG C, and the detection wavelength is 250nm. According to the present invention, the column temperature is 30 DEG C, the detection wavelength is 250 nm, the contents of 2, 4, 6-trihydroxypyrimidine, N-methyl-2, 4-diamino-6-hydroxypyrimidine and 4-(4-butyric acid) methyl benzoate in pemebenzoic acid can be effectively separated and quantitatively detected, the method has characteristics of simple operation, strong specificity, high sensitivity, high accuracy and good linearity, and the method can be widely used in the field of detection of pemebenzoic acid. The quality of the pemebenzoic acid product can be effectively controlled, and the method is suitable for pemebenzoic acid quality control.

1. Name of the product in this design: Packaging box (Pemetrexed disodium for injection). 2. Intended use of this design: for pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a cisplatin sustained-release implant as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, and the cisplatin sustained-release implant comprises the following raw materials in parts by mass: 5-60 parts of cisplatin; 0 to 30 parts of pemetrexed disodium; and 40-95 parts of a degradable polymer auxiliary material. According to the cis-platinum sustained-release implant disclosed by the invention, the second active pharmaceutical ingredient pemetrexed disodium is added into the cis-platinum sustained-release implant, so that the release of cis-platinum is improved, the delayed release period is shortened, and the burst release in the later stage of implantation is eliminated. In addition, the invention provides the optimal mass ratio range of cis-platinum and pemetrexed disodium in the cis-platinum sustained-release implant, and collaborative optimization of release and anti-tumor effects of active ingredients of the two medicines is realized.