Pemetrexed disodium freeze-dried powder injection for injection and preparation method thereof
A technology for pemetrexed disodium and freeze-dried powder injection, which is applied in the field of medicine, can solve the problems of increasing drug safety hazards, existing safety hazards, and insignificant improvement effects, and meets the requirements, types and dosages suitable for large-scale production. Less, pH-constant effect
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Embodiment 1
[0033] Embodiment 1 Pemetrexed disodium freeze-dried powder injection and its preparation process
[0034]
[0035] Process preparation:
[0036] Bottle washing, sterilizing and drying: the vials are first cleaned by an ultrasonic bottle washing machine, then sterilized and dried by a sterilizing dryer, and sent to the filling room for later use.
[0037] Butyl rubber stopper treatment: After the butyl rubber stopper is cleaned by a rubber stopper cleaning machine, it is sterilized by steam at 121°C for 20 minutes, and dried for later use.
[0038] Aluminum-plastic cover treatment: wash the aluminum-plastic cover with an aluminum cover washing machine, sterilize, dry, and take it out for use.
[0039] Preparation of medicinal solution: Weigh the prescribed amount of pemetrexed disodium, add it to water for injection cooled to 15-30°C, stir to dissolve, add the prescribed amount of disodium hydrogen phosphate and potassium dihydrogen phosphate, stir to dissolve, hydrogen A...
Embodiment 2
[0042] Embodiment 2 Pemetrexed disodium freeze-dried powder injection and its preparation process
[0043]
[0044] Process preparation:
[0045] Bottle washing, sterilizing and drying: the vials are first cleaned by an ultrasonic bottle washing machine, then sterilized and dried by a sterilizing dryer, and sent to the filling room for later use.
[0046] Butyl rubber stopper treatment: After the butyl rubber stopper is cleaned by a rubber stopper cleaning machine, it is sterilized by steam at 121°C for 20 minutes, and dried for later use.
[0047] Aluminum-plastic cover treatment: wash the aluminum-plastic cover with an aluminum cover washing machine, sterilize, dry, and take it out for use.
[0048] Preparation of medicinal solution: Weigh the prescribed amount of pemetrexed disodium, add it to water for injection cooled to 15-30°C, stir to dissolve, add the prescribed amount of disodium hydrogen phosphate and potassium dihydrogen phosphate, stir to dissolve, hydrogen Sod...
Embodiment 3
[0051] Embodiment 3 pemetrexed disodium freeze-dried powder injection and its preparation process
[0052]
[0053] Process preparation:
[0054] Bottle washing, sterilizing and drying: the vials are first cleaned by an ultrasonic bottle washing machine, then sterilized and dried by a sterilizing dryer, and sent to the filling room for later use.
[0055] Butyl rubber stopper treatment: After the butyl rubber stopper is cleaned by a rubber stopper cleaning machine, it is sterilized by steam at 121°C for 20 minutes, and dried for later use.
[0056] Aluminum-plastic cover treatment: wash the aluminum-plastic cover with an aluminum cover washing machine, sterilize, dry, and take it out for use.
[0057] Preparation of medicinal solution: Weigh the prescribed amount of pemetrexed disodium, add it to water for injection cooled to 15-30°C, stir to dissolve, add the prescribed amount of disodium hydrogen phosphate and potassium dihydrogen phosphate, stir to dissolve, hydrogen A...
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